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Sample records for american lung association

  1. AMERICAN STATISTICAL ASSOCIATION

    Energy Information Administration (EIA) (indexed site)

    AMERICAN STATISTICAL ASSOCIATION + + + + + COMMITTEE ON ENERGY STATISTICS + + + + + FALL MEETING + + + + + FRIDAY OCTOBER 17, 2003 + + + + + The Committee met in Room 8E089 in the Forrestal Building, 1000 Independence Avenue, S.W., Washington, D.C., at 8:30 a.m., Jay Breidt, Chair, presiding. PRESENT F. JAY BREIDT Chair NICOLAS HENGARTNER Vice Chair JOHNNY BLAIR Committee Member MARK BURTON Committee Member JAE EDMONDS Committee Member MOSHE FEDER Committee Member JAMES K. HAMMITT Committee

  2. Comments of the Southern Environmental Law Center and the American Lung

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Association in response to the Department of Energy's Emergency Order to Resume Operations at the Potomac River Generating Station in Alexandria, VA | Department of Energy the Southern Environmental Law Center and the American Lung Association in response to the Department of Energy's Emergency Order to Resume Operations at the Potomac River Generating Station in Alexandria, VA Comments of the Southern Environmental Law Center and the American Lung Association in response to the Department

  3. American Gas Association | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Association American Gas Association Memorandum Summarizing Ex Parte Communication 111011_Ex_Parte.pdf (691.79 KB) More Documents & Publications Ex Parte Memorandum - Natural Resources Defense Council American Gas Association Ex Parte Communication Microsoft Word - AGA Comments on 2011 Regulatory Burden RFI

  4. American Evaluation Association Guiding Principles for Evaluators...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Five principles developed by American Evaluation Associ intended to guide professional practice of evaluators & to inform evaluation clients and the general public about principles ...

  5. Terwilliger named American Crystallographic Association Fellow

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Terwilliger Named ACA Fellow Terwilliger named American Crystallographic Association Fellow ACA Fellows serve as scientific ambassadors to the broader scientific community and the general public to advance science education, research, knowledge, interaction and collaboration. January 4, 2013 Thomas Terwilliger Thomas Terwilliger The ACA Fellows program celebrates the excellence of its members and promotes their recognition worldwide. The American Crystallographic Association (ACA) honored Thomas

  6. Workplace Charging Challenge Partner: American Lung Association...

    Office of Environmental Management (EM)

    The ALAC was the first organization to install a charging station through the Charge Ahead Colorado grant program in 2013. The ALAC offers two charging stations to employees and ...

  7. American Evaluation Association Guiding Principles for Evaluators

    SciTech Connect

    None

    2009-01-18

    Five principles developed by American Evaluation Associ intended to guide professional practice of evaluators & to inform evaluation clients and the general public about principles they can expect to be upheld by professional evaluators.

  8. Los Alamos' Terwilliger named American Crystallographic Association

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    president Terwilliger named American Crystallographic Association president Los Alamos' Terwilliger named American Crystallographic Association president The ACA is the home to more than 1,000 scientists around the country who use X-rays, neutrons and electrons to see the shapes of molecules. April 27, 2016 Tom Terwilliger Tom Terwilliger Contact Nick Njegomir Communications Office (505) 665-9394 Email "This is an exciting time for crystallography because there are new ways to look at

  9. American Wind Energy Association (AWEA) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    AWEA) Jump to: navigation, search Logo: American Wind Energy Association (AWEA) Name: American Wind Energy Association (AWEA) Address: 1501 M Street, NW, Suite 1000 Place:...

  10. White Paper Developed by the American Gas Association and American Public Gas Association

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Paper Developed by the American Gas Association and American Public Gas Association - 1 - ME1 19099445v.1 In the Upcoming Rulemaking on Amendments to the Minimum Efficiency Standards for Non- Weatherized Residential Gas Furnaces, DOE Should Employ Separate Product Classes for Condensing and Noncondensing Furnaces October 22, 2014 The Department of Energy should, in pursuing the rulemaking on amended residential furnace standards required by the court's order in American Public Gas Association v.

  11. Los Alamos' Terwilliger named American Crystallographic Association

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Terwilliger named American Crystallographic Association president April 27, 2016 LOS ALAMOS, N.M., April 27, 2016-Tom Terwilliger, the developer of software enabling clear X-ray imaging of protein molecules, is the 2016 President of the American Crystallographic Association. The ACA is the home to more than 1,000 scientists around the country who use X-rays, neutrons and electrons to see the shapes of molecules."This is an exciting time for crystallography because there are new ways to look

  12. Comments of The American Public Power Association | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    The American Public Power Association Comments of The American Public Power Association The American Public Power Association responds to the U.S Department of Energy's Request for Information on addressing policy and logistical challenges to the implementation of smart grid technologies. Comments of The American Public Power Association (826.11 KB) More Documents & Publications Comments of the American Public Power Association Re: Comments on NBP RFI: Data Access Comments of the National

  13. American Gas Association Memorandum Summarizing Ex Parte Communication...

    Energy Saver

    Memorandum Summarizing Ex Parte Communication American Gas Association Memorandum Summarizing Ex Parte Communication On October 9, 2014, a workshop was hosted by the American Gas ...

  14. Kelly named Fellow of the American Statistical Association

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Kelly named ASA Fellow Kelly named Fellow of the American Statistical Association The American Statistical Association (ASA) has honored Elizabeth Kelly with the title of Fellow. August 2, 2016 Elizabeth Kelly Elizabeth Kelly Communications Office (505) 667-7000 Kelly is a member of the American Statistical Society and the American Society for Quality. The American Statistical Association (ASA) has honored Elizabeth Kelly of the Lab's Statistical Sciences group with the title of Fellow. The ASA

  15. American Wind Energy Association AWEA | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Energy Association AWEA Jump to: navigation, search Name: American Wind Energy Association (AWEA) Place: Washington DC, Washington, DC Zip: 20001 Sector: Wind energy Product:...

  16. American Bar Association Section on Environment | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Bar Association Section on Environment Jump to: navigation, search Name: American Bar Association Section on Environment Place: Chicago, Illinois Zip: 60610 Product: The Section of...

  17. American Evaluation Association Guiding Principles for Evaluators, 2004 |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy American Evaluation Association Guiding Principles for Evaluators, 2004 American Evaluation Association Guiding Principles for Evaluators, 2004 Five principles developed by American Evaluation Associ intended to guide professional practice of evaluators & to inform evaluation clients and the general public about principles they can expect to be upheld by professional evaluators. Guiding Principles for Evaluators (204.88 KB) More Documents & Publications ORSSAB

  18. Comments of the American Public Power Association | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    party use, and privacy as related to the implementation of smart grid technology. Comments of the American Public Power Association (211.62 KB) More Documents & Publications Re: ...

  19. SRS employees raise funds for American Heart Association | National...

    National Nuclear Security Administration (NNSA)

    SRS employees raise funds for American Heart Association Tuesday, April 1, 2014 - 10:00am About 300 employees of Savannah River Site management and operation contractor Savannah ...

  20. Sandia highlighted at the 2016 American Wind Energy Association...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    highlighted at the 2016 American Wind Energy Association (AWEA) Conference, May 23-26th - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy ...

  1. American Wind Energy Association Wind Energy Finance and Investment Seminar

    Energy.gov [DOE]

    The American Wind Energy Association Wind Energy Finance and Investment Seminar will be attended by representatives in the financial sector, businesses, bankers, government and other nonprofit...

  2. Two Sandia Leaders Elected American Association for the Advancement...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Sandia Leaders Elected American Association for the Advancement of Science Fellows - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & ...

  3. QER- Comment of American Wind Energy Association 1

    Office of Energy Efficiency and Renewable Energy (EERE)

    Attached please find the comments of the American Wind Energy Association (AWEA) on the QER. Please don’t hesitate to contact me if you have any questions. Thank you. Tom

  4. American Gas Association (AGA) for DOE Furnace Product Class

    Energy.gov [DOE]

    Thank you for the opportunity to brief your staff in recent weeks on an impact analysis of a national condensing furnace standard, which was conducted jointly by the American Gas Association (AGA),...

  5. Energy Department and American Public Power Association Sign Agreement to

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Accelerate Growth of Electric Vehicle Market | Department of Energy American Public Power Association Sign Agreement to Accelerate Growth of Electric Vehicle Market Energy Department and American Public Power Association Sign Agreement to Accelerate Growth of Electric Vehicle Market July 22, 2016 - 1:47pm Addthis News Media Contact 202-586-8604 DOENews@hq.doe.gov WASHINGTON - Today, Acting Assistant Secretary for the Office of Energy Efficiency and Renewable Energy David Friedman signed a

  6. American Gas Association Ex Parte Communication | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Ex Parte Communication American Gas Association Ex Parte Communication On March 30, 2015, representatives of the American Gas Association (AGA) met with officials and staff of the U.S. Department of Energy (DOE) to discuss the notice of proposed rulemaking (NOPR) on minimum energy efficiency standards for residential natural gas furnaces. AGA Memorandum Ex Parte Communication 4-3-15 (211.37 KB) AGA Summary Statement for March 27 2015 Public Meeting FINAL (295.63 KB) More Documents &

  7. American Gas Association Memorandum Summarizing Ex Parte Communication |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Memorandum Summarizing Ex Parte Communication American Gas Association Memorandum Summarizing Ex Parte Communication On October 9, 2014, a workshop was hosted by the American Gas Association and Washington Gas Light (WGL) at WGLs Training Facility in Springfield, VA. AGA Memorandum Summarizing Ex Parte Communication (90.19 KB) Condensing Heating and Water Heating Equipment Workshop Agenda (69.08 KB) October 9th Workshop Presentation - Melissa Adams (1.12 MB) October 9th

  8. The respiratory health and lung function of Anglo-American children in a smelter town

    SciTech Connect

    Dodge, R.

    1983-02-01

    Cooper smelters are large, usually isolated, sources of air pollution. Arizona has several such plants on the periphery of small communities. The smelters emit predominantly sulfur oxides and particulates, and the residents of these communities intermittently are exposed to high concentrations (24-h sulfur dioxide (SO2) . 250 to 500 micrograms/m3) of smelter smoke but little other pollution. This study compared the respiratory health of Anglo-American school children who lived in one smelter community with children living in another small community in Arizona that was free of smelter air pollution. The prevalence of cough, as determined by questionnaire, was 25.6% in the smelter town children and 14.3% in the nonsmelter town children (p less than 0.05). Pulmonary function at the study onset was equal in the two groups. Over the course of the 4 yr of study, lung function growth (measured as actual forced expiratory volume in one second (FEV1) after 4 yr of study minus predicted FEV1) was also equal in the smelter town and nonsmelter town children. These results suggest that children in smelter communities have slightly more cough when compared with children living in other communities, but no differences in initial lung function or lung function at yearly testing over the period of the study.

  9. Workplace Charging Challenge Partner: American Lung Association in Colorado

    Energy.gov [DOE]

    Joined the Challenge: September 2015Headquarters: Greenwood Village, COCharging Location: Greenwood Village, CODomestic Employees: 14

  10. OSTIblog Articles in the American Association for the Advancement of

    Office of Scientific and Technical Information (OSTI)

    Science Topic | OSTI, US Dept of Energy Office of Scientific and Technical Information American Association for the Advancement of Science Topic Join OSTI at the AAAS Annual Meeting, February 17-21 by Dr. Walt Warnick 01 Feb, 2011 in Science Communications 3076 OSTIhpArchitecture.jpg Join OSTI at the AAAS Annual Meeting, February 17-21 Read more about 3076 The Department of Energy's Office of Scientific and Technical Information (OSTI) will be at the American Association for the Advancement

  11. QER- Comment of American Public Power Association 6

    Office of Energy Efficiency and Renewable Energy (EERE)

    To whom it may concern: Please find attached comments jointly filed by the American Public Power Association, Large Public Power Council, and Transmission Access Policy Study Group, in relation to the issues discussed at the October 6, 2014, QER Public Stakeholder Meeting on Finance (Transmission, Storage and Distribution).

  12. Comments of the Southern Environmental Law Center and the American...

    Energy.gov [DOE] (indexed site)

    : The Southern Environmental Law Center ("SELC") submits these comments on behalf of ... Comments of the Southern Environmental Law Center and the American Lung Association in ...

  13. Multi-walled carbon nanotube-induced gene expression in the mouse lung: Association with lung pathology

    SciTech Connect

    Pacurari, M.; Qian, Y.; Porter, D.W.; Wolfarth, M.; Wan, Y.; Luo, D.; Ding, M.; Castranova, V.; Guo, N.L.

    2011-08-15

    Due to the fibrous shape and durability of multi-walled carbon nanotubes (MWCNT), concerns regarding their potential for producing environmental and human health risks, including carcinogenesis, have been raised. This study sought to investigate how previously identified lung cancer prognostic biomarkers and the related cancer signaling pathways are affected in the mouse lung following pharyngeal aspiration of well-dispersed MWCNT. A total of 63 identified lung cancer prognostic biomarker genes and major signaling biomarker genes were analyzed in mouse lungs (n = 80) exposed to 0, 10, 20, 40, or 80 {mu}g of MWCNT by pharyngeal aspiration at 7 and 56 days post-exposure using quantitative PCR assays. At 7 and 56 days post-exposure, a set of 7 genes and a set of 11 genes, respectively, showed differential expression in the lungs of mice exposed to MWCNT vs. the control group. Additionally, these significant genes could separate the control group from the treated group over the time series in a hierarchical gene clustering analysis. Furthermore, 4 genes from these two sets of significant genes, coiled-coil domain containing-99 (Ccdc99), muscle segment homeobox gene-2 (Msx2), nitric oxide synthase-2 (Nos2), and wingless-type inhibitory factor-1 (Wif1), showed significant mRNA expression perturbations at both time points. It was also found that the expression changes of these 4 overlapping genes at 7 days post-exposure were attenuated at 56 days post-exposure. Ingenuity Pathway Analysis (IPA) found that several carcinogenic-related signaling pathways and carcinogenesis itself were associated with both the 7 and 11 gene signatures. Taken together, this study identifies that MWCNT exposure affects a subset of lung cancer biomarkers in mouse lungs. - Research Highlights: > Multi-Walled Carbon Nanotubes affect lung cancer biomarkers in mouse lungs. > The results suggest potentially harmful effects of MWCNT exposure on human lungs. > The results could potentially be used for

  14. Comments of the American Public Gas Association on the Smart Grid RFI |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy the American Public Gas Association on the Smart Grid RFI Comments of the American Public Gas Association on the Smart Grid RFI Comments from The American Public Gas Association on the Smart Grid RFI: Addressing policy and logisitcal challenges to smart grid implementation The American Public Gas Association comments (17.7 KB) More Documents & Publications Okaloosa Gas District Smart Grid RFI: Addressing Policy and Logistical Challenges to Smart Grid Implementation

  15. QER- Comment of American Public Power Association 1

    Office of Energy Efficiency and Renewable Energy (EERE)

    Attached are the American Public Power Association 's (APPA) statement for the April 11 QER public meeting, Duane Highley's statement for the same meeting since we reference it, and Sue Kelly's (APPA President & CEO) testimony from last Thursday's (April 10) Senate Energy and Natural Resources Committee hearing entitled "Keeping the Lights On – Are We Doing Enough to Ensure the Reliability and Security of the US Electric Grid?" since her testimony covers everything in regards to this meeting. Thank you in advance for your consideration of our attached documents for the QER. Please let me know if you have any questions. Best, Seth Seth Voyles Director, Government Relations 1875 Connecticut Ave., NW, Suite 1200, Washington, D.C. 20009-5715 www.publicpower.org

  16. Home Energy Score Program Overview for the American Gas Association Webinar

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    (Text Version) | Department of Energy Overview for the American Gas Association Webinar (Text Version) Home Energy Score Program Overview for the American Gas Association Webinar (Text Version) Below is the text version of the webinar, Home Energy Score Program Overview for the American Gas Association, presented on July 30, 2013. In addition to this text version of the audio, you can access the presentation slides and a recording of the webinar. Elizabeth Noll: Good afternoon. This is

  17. Y-12 receives American Heart Association award | Y-12 National Security

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Complex American ... Y-12 receives American Heart Association award Posted: November 22, 2012 - 9:00am Kathy Jetton, senior regional director of the American Heart Association, presents the Platinum award to Chuck Spencer, B&W Y-12 president and general manager. B&W Y-12 was honored as a Platinum-level award recipient of the American Heart Association's Fit-Friendly Companies program. Only eight companies in the Knoxville area are Fit-Friendly workplaces, and B&W Y-12 is the only

  18. 2007 American Coal Ash Association membership directory as of June 21, 2007

    SciTech Connect

    2007-07-01

    A listing of names, addresses, contact numbers and websites is given for 101 members of the American Coal Ash Association. Honorary members are also named. Included are power generation companies, combustion by-product manufacturers and university departments.

  19. African American Federal Executive Association, Inc. 9th Annual Training Workshop

    Energy.gov [DOE]

    The African American Federal Executive Association, Inc. (AAFEA) will hold its 9th Annual Training Workshop (TW) September 16-17, 2013 in Washington, DC.  The theme of this year’s TW is “LEADING...

  20. Predicting the Risk of Secondary Lung Malignancies Associated With Whole-Breast Radiation Therapy

    SciTech Connect

    Ng, John; Shuryak, Igor; Xu Yanguang; Clifford Chao, K.S.; Brenner, David J.; Burri, Ryan J.

    2012-07-15

    Purpose: The risk of secondary lung malignancy (SLM) is a significant concern for women treated with whole-breast radiation therapy after breast-conserving surgery for early-stage breast cancer. In this study, a biologically based secondary malignancy model was used to quantify the risk of secondary lung malignancies (SLMs) associated with several common methods of delivering whole-breast radiation therapy (RT). Methods and Materials: Both supine and prone computed tomography simulations of 15 women with early breast cancer were used to generate standard fractionated and hypofractionated whole-breast RT treatment plans for each patient. Dose-volume histograms (DVHs) of the ipsilateral breast and lung were calculated for each patient on each plan. A model of spontaneous and radiation-induced carcinogenesis was used to determine the relative risks of SLMs for the different treatment techniques. Results: A higher risk of SLMs was predicted for supine breast irradiation when compared with prone breast irradiation for both the standard fractionation and hypofractionation schedules (relative risk [RR] = 2.59, 95% confidence interval (CI) = 2.30-2.88, and RR = 2.68, 95% CI = 2.39-2.98, respectively). No difference in risk of SLMs was noted between standard fractionation and hypofractionation schedules in either the supine position (RR = 1.05, 95% CI = 0.97-1.14) or the prone position (RR = 1.01, 95% CI = 0.88-1.15). Conclusions: Compared with supine whole-breast irradiation, prone breast irradiation is associated with a significantly lower predicted risk of secondary lung malignancy. In this modeling study, fractionation schedule did not have an impact on the risk of SLMs in women treated with whole-breast RT for early breast cancer.

  1. Remarks by Secretary Moniz to the American Association for the Advancement

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    of Science -- As prepared for delivery | Department of Energy to the American Association for the Advancement of Science -- As prepared for delivery Remarks by Secretary Moniz to the American Association for the Advancement of Science -- As prepared for delivery April 14, 2016 - 4:24pm Addthis Dr. Ernest Moniz Dr. Ernest Moniz Secretary of Energy Thank you for having me this morning, and thank you, Dr. [Rush] Holt. Today I want to talk primarily about the future of a set of institutions that

  2. Lung cancer-derived Dickkopf1 is associated with bone metastasis and the mechanism involves the inhibition of osteoblast differentiation

    SciTech Connect

    Chu, Tianqing; Teng, Jiajun; Jiang, Liyan; Zhong, Hua; Han, Baohui

    2014-01-17

    Highlights: DKK1 level was associated with NSCLC bone metastases. Lung tumor cells derived DKK1 inhibited osteoblast differentiation. Lung tumor cells derived DKK1 modulates ?-catenin and RUNX2. -- Abstract: Wnt/?-catenin signaling and Dickkopf1 (DKK1) play important roles in the progression of lung cancer, which preferably metastasizes to skeleton. But the role of them in bone dissemination is poorly understood. This study aims to define the role of DKK1 in lung cancer bone metastases and investigate the underlying mechanism. Our results demonstrated that DKK1 over-expression was a frequent event in non-small-cell lung cancer (NSCLC) blood samples, and serous DKK1 level was much higher in bone metastatic NSCLC compared to non-bone metastatic NSCLC. We also found that conditioned medium from DKK1 over-expressing lung cancer cells inhibited the differentiation of osteoblast, determined by alkaline phosphatase activity and osteocalcin secretion, whereas the conditioned medium from DKK1 silencing lung cancer cells exhibited the opposite effects. Mechanistically, DKK1 reduced the level of ?-catenin and RUNX2, as well as inhibiting the nuclear translocation of ?-catenin. Taken together, these results suggested that lung cancer-produced DKK1 may be an important mechanistic link between NSCLC and bone metastases, and targeting DKK1 may be an effective method to treat bone metastase of NSCLC.

  3. Comment submitted by the North American Association of Food Equipment Manufacturers (NAFEM) regarding the Energy Star Verification Testing Program

    Energy.gov [DOE]

    This document is a comment submitted by the North American Association of Food Equipment Manufacturers (NAFEM) regarding the Energy Star Verification Testing Program

  4. Source apportionment of particulate matter in the US and associations with lung inflammatory markers

    SciTech Connect

    Duvall, R.M.; Norris, G.A.; Dailey, L.A.; Burke, J.M.; McGee, J.K.; Gilmour, M.I.; Gordon, T.; Devlin, R.B.

    2008-07-01

    Size-fractionated particulate matter (PM) samples were collected from six U.S. cities and chemically analyzed as part of the Multiple Air Pollutant Study. Particles were administered to cultured lung cells and the production of three different proinflammatory markers was measured to explore the association between the health effect markers and PM. Ultrafine, fine, and coarse PM samples were collected between December 2003 and May 2004 over a 4-wk period in each city. Filters were pooled for each city and the PM samples were extracted then analyzed for trace metals, ions, and elemental carbon. Particle extracts were applied to cultured human primary airway epithelial cells, and the secreted levels of interleukin-8 (IL-8), heme oxygenase-1, and cyclooxygenase-2 were measured 1 and 24 h following exposure. Fine PM sources were quantified by the chemical mass balance (CMB) model. The relationship between toxicological measures, PM sources, and individual species were evaluated using linear regression. Ultrafine and fine PM mass were associated with increases in IL-8 (r{sup 2} = .80 for ultrafine and r{sup 2} = .52 for fine). Sources of fine PM and their relative contributions varied across the sampling sites and a strong linear association was observed between IL-8 and secondary sulfate from coal combustion (r{sup 2} = .79). Ultrafine vanadium, lead, copper, and sulfate were also associated with increases in IL-8. Increases in inflammatory markers were not observed for coarse PM mass and source markers. These findings suggest that certain PM size fractions and sources are associated with markers of lung injury or inflammation.

  5. Blood cadmium levels are associated with a decline in lung function in males

    SciTech Connect

    Oh, Chang-Mo; Oh, In-Hwan; Lee, Jong-Keun; Park, Yoon Hyung; Choe, Bong-Keun; Yoon, Tai-Young; Choi, Joong-Myung

    2014-07-15

    Background: Cadmium exposure was found to cause a decline in lung function among the general population, but these findings were limited to smokers and gender differences were not explored. Objectives: To examine the relationship between cadmium and chronic obstructive pulmonary disease (COPD) according to gender and smoking status in Korea. Methods: Cross-sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2011 were analyzed. COPD was defined by a pre-bronchodilator forced expiratory volume in 1 s divided by forced vital capacity of <0.70. A logistic regression model was used to elucidate the association between blood cadmium levels and COPD according to gender and smoking status. Results: Among 3861 eligible participants, 3622 were included in the analysis. The prevalence of COPD demonstrated an increasing trend in males (P for trend<0.001), but not in females (P for trend=0.67). After adjusting for covariates, a higher blood cadmium level, but within the normal range, was associated with COPD in males, including those who had never-smoked (P for trend <0.001 and P for trend=0.008). However, a higher blood cadmium level was not significantly associated with COPD in females, including those who had never smoked (P for trend=0.39 and P for trend=0.43). Conclusions: A higher blood cadmium level, within the normal range, was associated with COPD in males, including those who had never smoked. However, there was no significant association between blood cadmium levels and COPD in females. - Highlights: • Elevated blood cadmium level is associated with chronic obstructive pulmonary disease in male. • This association can be seen even in never smoked male. • However, this association is present only in male, but not in female.

  6. Workforce and Salary Survey Trends: Opportunities and Challenges for the American Association of Medical Dosimetrists

    SciTech Connect

    Mills, Michael D.

    2015-07-01

    The American Association of Medical Dosimetrists (AAMD) designed and directed 2 surveys of the AAMD membership. The first was in 2011 and the second in 2014. There were a number of questions common to both surveys, and this article seeks to evaluate these common questions to determine trends among the professional membership of the AAMD. It is demonstrated that the observed trends are consistent with the goals and objectives established by the leadership of the AAMD and the Medical Dosimetry Certification Board (MDCB) for the medical dosimetry community. In addition, certain challenges and opportunities involving the scope of practice for the medical dosimetry profession are discussed.

  7. Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer

    SciTech Connect

    Li, Weina; He, Fei

    2014-07-18

    Highlights: • Expression of MMD is increased in lung cancer tissues. • Knockdown of MMD inhibits growth of A549 and LLC cells in vitro and in vivo. • MMD is a direct functional target of miR-140-5p. • MiR-140-5p/MMD axis regulates Erk1/2 signaling. - Abstract: Monocyte to macrophage differentiation-associated (MMD) is identified in macrophages as a gene associated with the differentiation from monocytes to macrophages. Recent microarray analysis for non-small cell lung cancer (NSCLC) suggests that MMD is an important signature associated with relapse and survival among patients with NSCLC. Therefore, we speculate that MMD likely plays a role in lung cancer. In this study, we found that the protein level of MMD was increased in lung cancer compared to benign lung tissues, and knockdown of MMD inhibited the growth of A549 and Lewis lung cancer cells (LLC) in vitro and in vivo. Integrated analysis demonstrated that MMD was a direct functional target of miR-140-5p. Furthermore, we found that miR-140-5p/MMD axis could affect the cell proliferation of lung cancer cells by regulating Erk signaling. Together, our results highlight the significance of miR-140-5p/MMD axis in lung cancer, and miR-140-5p/MMD axis could serve as new molecular targets for the therapy against lung cancer.

  8. CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells

    SciTech Connect

    Chen, Tian Jun; Gao, Fei; Yang, Tian; Thakur, Asmitanand; Ren, Hui; Li, Yang; Zhang, Shuo; Wang, Ting; Chen, Ming Wei

    2013-07-19

    Highlights: CDK-associated Cullin 1 (CAC1) expression increases in human lung carcinoma. CAC1 promotes the proliferation of lung cancer A549 cells. CAC1 promotes human lung cancer A549 cell proliferation with activation of ERK1/2. -- Abstract: Lung cancer is one of the most common causes of cancer-related death in the world, but the mechanisms remain unknown. In this study, we investigated the expression of CDK-associated Cullin 1 (CAC1) in lung cancer, the effect of CAC1 on the proliferation of human lung cancer A549 cells, and the activation of signaling pathways of mitogen-activated protein kinases (MAPKs). Results showed that CAC1 expression was higher levels in human lung carcinoma than normal lung tissue, and CAC1 siRNA reduced the proliferation of lung cancer A549 cells by decreasing cell activity and cell division in vitro. The proportion of cells treated with CAC1 siRNA increased in the G1 phase and decreased in the S and G2/M phase, indicative of G1 cell cycle arrest. Furthermore, the proportions of early/late apoptosis in lung cancer A549 cells were enhanced with CAC1 siRNA treatment. It was also found that activation of extracellular signal-regulated protein kinase (ERK) and p38 signaling pathways were involved in the proliferation of A549 cells. After CAC1 siRNA treatment, p-ERK1/2 levels decreased, and meanwhile p-p38 level increased, A549 cell proliferation increased when ERK1/2 signaling is activated by PMA. Our findings demonstrated that CAC1 promoted the proliferation of human lung cancer A549 cells with activation of ERK1/2 signaling pathways, suggesting a potential cure target for treatment of human lung cancer.

  9. Association Between White Blood Cell Count Following Radiation Therapy With Radiation Pneumonitis in Non-Small Cell Lung Cancer

    SciTech Connect

    Tang, Chad; Gomez, Daniel R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wang, Hongmei [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou (China); Levy, Lawrence B. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhuang, Yan [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Xu, Ting; Nguyen, Quynh; Komaki, Ritsuko [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Liao, Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2014-02-01

    Purpose: Radiation pneumonitis (RP) is an inflammatory response to radiation therapy (RT). We assessed the association between RP and white blood cell (WBC) count, an established metric of systemic inflammation, after RT for non-small cell lung cancer. Methods and Materials: We retrospectively analyzed 366 patients with non-small cell lung cancer who received ?60 Gy as definitive therapy. The primary endpoint was whether WBC count after RT (defined as 2 weeks through 3 months after RT completion) was associated with grade ?3 or grade ?2 RP. Median lung volume receiving ?20 Gy (V{sub 20}) was 31%, and post-RT WBC counts ranged from 1.7 to 21.2 10{sup 3} WBCs/?L. Odds ratios (ORs) associating clinical variables and post-RT WBC counts with RP were calculated via logistic regression. A recursive-partitioning algorithm was used to define optimal post-RT WBC count cut points. Results: Post-RT WBC counts were significantly higher in patients with grade ?3 RP than without (P<.05). Optimal cut points for post-RT WBC count were found to be 7.4 and 8.0 10{sup 3}/?L for grade ?3 and ?2 RP, respectively. Univariate analysis revealed significant associations between post-RT WBC count and grade ?3 (n=46, OR=2.6, 95% confidence interval [CI] 1.4?4.9, P=.003) and grade ?2 RP (n=164, OR=2.0, 95% CI 1.2?3.4, P=.01). This association held in a stepwise multivariate regression. Of note, V{sub 20} was found to be significantly associated with grade ?2 RP (OR=2.2, 95% CI 1.2?3.4, P=.01) and trended toward significance for grade ?3 RP (OR=1.9, 95% CI 1.0-3.5, P=.06). Conclusions: Post-RT WBC counts were significantly and independently associated with RP and have potential utility as a diagnostic or predictive marker for this toxicity.

  10. Colorectal Histology Is Associated With an Increased Risk of Local Failure in Lung Metastases Treated With Stereotactic Ablative Radiation Therapy

    SciTech Connect

    Binkley, Michael S.; Trakul, Nicholas; Jacobs, Lisa Rose; Eyben, Rie von; Le, Quynh-Thu; Maxim, Peter G.; Loo, Billy W.; Shultz, David Benjamin; Diehn, Maximilian

    2015-08-01

    Purpose: Stereotactic ablative radiation therapy (SABR) is increasingly used to treat lung oligometastases. We set out to determine the safety and efficacy of this approach and to identify factors associated with outcomes. Methods and Materials: We conducted a retrospective study of patients treated with SABR for metastatic lung tumors at our institution from 2003 to 2014. We assessed the association between various patient and treatment factors with local failure (LF), progression, subsequent treatment, systemic treatment, and overall survival (OS), using univariate and multivariate analyses. Results: We identified 122 tumors in 77 patients meeting inclusion criteria for this study. Median follow-up was 22 months. The 12- and 24-month cumulative incidence rates of LF were 8.7% and 16.2%, respectively; the 24-month cumulative incidence rates of progression, subsequent treatment, and subsequent systemic treatment were 75.2%, 64.5%, and 35.1%, respectively. Twenty-four-month OS was 74.6%, and median OS was 36 months. Colorectal metastases had a significantly higher cumulative incidence of LF at 12 and 24 months (25.5% and 42.2%, respectively), than all other histologies (4.4% and 9.9%, respectively; P<.0004). The 24-month cumulative incidences of LF for colorectal metastases treated with a biologically effective dose at α/β = 10 (BED{sub 10}) of <100 Gy versus BED{sub 10} of ≥100 Gy were 62.5% and 16.7%, respectively (P=.08). Toxicity was minimal, with only a single grade 3 or higher event observed. Conclusions: SABR for metastatic lung tumors appears to be safe and effective with excellent local control, treatment-free intervals, and OS. An exception is metastases from colorectal cancer, which have a high LF rate consistent with a radioresistant phenotype, suggesting a potential role for dose escalation.

  11. Prosperity Games prototyping with the American Electronics Association, March 8--9, 1994

    SciTech Connect

    Berman, M.; VanDevender, J.P.

    1994-08-01

    Prosperity Games are an outgrowth and adaptation of move/countermove and seminar War Games. Prosperity Games are simulations that explore complex issues in a variety of areas including economics, politics, sociology, environment, education and research. These issues can be examined from a variety of perspectives ranging from a global, macroeconomic and geopolitical viewpoint down to the details of customer/supplier/market interactions in specific industries. All Prosperity Games are unique in that both the game format and the player contributions vary from game to game. This report documents the Prosperity Game conducted under the sponsorship of the American Electronics Association in conjunction with the Electronics Subcommittee of the Civilian Industrial Technology Committee of the National Science and Technology Council. Players were drawn from government, national laboratories, and universities, as well as from the electronics industry. The game explored policy changes that could enhance US competitiveness in the manufacturing of consumer electronics. Two teams simulated a presidentially appointed commission comprised of high-level representatives from government, industry, universities and national laboratories. A single team represented the foreign equivalent of this commission, formed to develop counter strategies for any changes in US policies. The deliberations and recommendations of these teams provide valuable insights as to the views of this diverse group of decision makers concerning policy changes, foreign competition, and the development, delivery and commercialization of new technologies.

  12. Complications associated with brachytherapy alone or with laser in lung cancer

    SciTech Connect

    Khanavkar, B.; Stern, P.; Alberti, W.; Nakhosteen, J.A. )

    1991-05-01

    Relatively little has been reported about destruction through brachytherapy of mucosa-perforating and extraluminary tumors with probable large vessel involvement causing major hemorrhagic or fistular complications. We report 12 patients subjected to laser and brachytherapy for centrally occluding lung cancer, whom we have periodically followed up from June 1986 until they died. Although all laser procedures were free from complications, necrotic cavitation in five cases, two of which were accompanied by large bronchoesophageal fistulas, and massive fatal hemoptysis occurred in six. Minor complications included radiation mucositis (two), noncritical mucosal scarring (two), and cough (four). Characteristics that will identify patients at risk of developing fatal hemoptysis and fistulas should be better defined by imaging and endoscopic techniques. In such cases, modifying the protocol or using alternative procedures should be considered. Minor complications, such as cough, can be avoided by using topical steroid therapy (eg, beclomethasone dipropionate).

  13. EV Community Readiness projects: American Lung Association of the Southwest (CO); Oregon Business Development Department (OR, WA)

    Office of Energy Efficiency and Renewable Energy (EERE)

    2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  14. Small Wind Electric Systems: A Guide for the American Corn Growers Association

    Energy Information Administration (EIA) (indexed site)

    A Guide Produced for the American Corn Growers Foundation Small Wind Electric Systems Small Wind Electric Systems U.S. Department of Energy Energy Efficiency and Renewable Energy Wind and Hydropower Technologies Program Small Wind Electric Systems Cover photo: This AOC 15/50 wind turbine on a farm in Clarion, Iowa, saves the Clarion-Goldfield Community School about $9,000 per year on electrical purchase and provides a part of the school's science curriculum. Photo credit - Robert Olson/PIX11649

  15. Downregulated TIPE2 is associated with poor prognosis and promotes cell proliferation in non-small cell lung cancer

    SciTech Connect

    Li, Yuexia; Li, Xiaohui; Liu, Gang; Sun, Rongqing; Wang, Lirui; Wang, Jing; Wang, Hongmin

    2015-01-30

    Highlights: • TIPE2 is down-regulated in NSCLC tissues. • TIPE2 inhibits NSCLC cell proliferation, colony formation and invasion. • TIPE2 reduces the anti-apoptotic Bcl-XL protein and mesenchymal marker N-cadherin expression. - Abstract: The present study aims to investigate the expression pattern of TIPE2 protein and its clinical significance in human non-small cell lung cancer (NSCLC). We investigated the expression levels of TIPE2 in 96 NSCLC tumor samples by immunohistochemistry and then analyzed its clinical significance. Furthermore, the role of TIPE2 on the biological properties of the NSCLC cell line H1299 and A549 was experimentally tested in vitro and in vivo. We found that the expression level of TIPE2 was significantly higher in normal lung tissues compared with NSCLC tissues (P < 0.001), and TIPE2 downregulation was significantly correlated with advanced TNM stage (P = 0.006). TIPE2 expression was lower in lung cancer cell lines than normal bronchial cell line HBE. Transfection of TIPE2 plasmid was performed in H1299 and A549 cells. TIPE2 overexpression inhibited lung cancer cell proliferation, colony formation and cell invasive in vitro, and prevented lung tumor growth in vivo. In addition, TIPE2 transfection reduced the anti-apoptotic Bcl-XL protein and mesenchymal marker N-cadherin expression. Taken together, our results demonstrate that TIPE2 might serve as a tumor suppressor in NSCLC progression.

  16. Functional Promoter Variant rs2868371 of HSPB1 Is Associated With Risk of Radiation Pneumonitis After Chemoradiation for Non-Small Cell Lung Cancer

    SciTech Connect

    Pang, Qingsong; Department of Radiation Oncology and Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin ; Wei, Qingyi; Xu, Ting; Yuan, Xianglin; Lopez Guerra, Jose Luis; Levy, Lawrence B.; Liu, Zhensheng; Gomez, Daniel R.; Zhuang, Yan; Wang, Li-E.; Mohan, Radhe; Komaki, Ritsuko; Liao, Zhongxing

    2013-04-01

    Purpose: To date, no biomarkers have been found to predict, before treatment, which patients will develop radiation pneumonitis (RP), a potentially fatal toxicity, after chemoradiation for lung cancer. We investigated potential associations between single nucleotide polymorphisms (SNPs) in HSPB1 and risk of RP after chemoradiation for non-small cell lung cancer (NSCLC). Methods and Materials: Subjects were patients with NSCLC treated with chemoradiation at 1 institution. The training data set comprised 146 patients treated from 1999 to July 2004; the validation data set was 125 patients treated from August 2004 to March 2010. We genotyped 2 functional SNPs of HSPB1 (rs2868370 and rs2868371) from all patients. We used Kaplan-Meier analysis to assess the risk of grade ≥2 or ≥3 RP in both data sets and a parametric log-logistic survival model to evaluate the association of HSPB1 genotypes with that risk. Results: Grade ≥3 RP was experienced by 13% of those with CG/GG and 29% of those with CC genotype of HSPB1 rs2868371 in the training data set (P=.028); corresponding rates in the validation data set were 2% CG/GG and 14% CC (P=.02). Univariate and multivariate analysis confirmed the association of CC of HSPB1 rs2868371 with higher risk of grade ≥3 RP than CG/GG after adjustment for sex, age, performance status, and lung mean dose. This association was validated both in the validation data set and with Harrell's C statistic. Conclusions: The CC genotype of HSPB1 rs2868371 was associated with severe RP after chemoradiation for NSCLC.

  17. SUPPORT FOR CHEMISTRY SYMPOSIA AT THE 2011 AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE MEETING FEBRUARY 17-21, 2011

    SciTech Connect

    Prof. Charles Casey, University of Wisconsin-Madison

    2011-08-20

    This proposal supported Chemistry Symposia at the 2011 American Association for the Advancement of Science (AAAS) Meeting in Washington, DC February 17-21, 2011. The Chemistry Section of AAAS presented an unusually strong set of symposia for the 2011 AAAS meeting to help celebrate the 2011 International Year of Chemistry. The AAAS meeting provided an unusual opportunity to convey the excitement and importance of chemistry to a very broad audience and allowed access to a large contingent of the scientific press. Excellent suggestions for symposia were received from AAAS Chemistry Fellows and from the chairs of the American Chemical Society Technical Divisions. The AAAS Chemistry executive committee selected topics that would have wide appeal to scientists, the public, and the press for formal proposals of symposia. The symposia proposals were peer reviewed by AAAS. The Chemistry Section made a strong case to the program selection committee for approval of the chemistry symposia and 6 were approved for the 2011 annual meeting. The titles of the approved symposia were: (1) Powering the Planet: Generation of Clean Fuels from Sunlight and Water, (2) Biological Role and Consequences of Intrinsic Protein Disorder, (3) Chemically Speaking: How Organisms Talk to Each Other, (4) Molecular Self-Assembly and Artificial Molecular Machines, (5) Frontiers in Organic Materials for Information Processing, Energy and Sensors, and (6) Celebrating Marie Curie's 100th Anniversary of Her Nobel Prize in Chemistry. The Chemistry Section of AAAS is provided with funds to support only 1-2 symposia a year. Because of the much greater number of symposia approved in conjunction with observance of the 2011 International Year of Chemistry, additional support was sought from DOE to help support the 30 invited speakers and 8 symposia moderators/organizers. Support for the symposia provided the opportunity to highlight the excitement of current chemical research, to educate the public about the

  18. AMERICAN STATISTICAL ASSOCIATION

    Energy Information Administration (EIA) (indexed site)

    ... And eighty-eight percent said the conference facilities were excellent or good. Again, we ... MR. CLEVELAND: I'd like to hear about nuclear power in terms of what, as the industry ...

  19. AMERICAN STATISTICAL ASSOCIATION (ASA)

    Energy Information Administration (EIA) (indexed site)

    ... surveys like renewables, alternative fuel vehicles. ... data analysis, forecast, education, and documentation. ... And we always talk about that in our long-term and even some ...

  20. AMERICAN STATISTICAL ASSOCIATION

    Energy Information Administration (EIA) (indexed site)

    ... Rolling in new data is often very difficult. I was actually at BLS when cell phones became ... really have as much data -- but it's also an interesting area, is solar energy equipment. ...

  1. AMERICAN STATISTICAL ASSOCIATION

    Energy Information Administration (EIA) (indexed site)

    Department of Mathematics and Statistics 4 ... 11 MOSHE FEDER Research Triangle Institute International 12 WALTER W. HILL ... He died in December of 2006. 21 In the Journal of ...

  2. Jefferson Lab Leadership Council - Dr. Allison Lung

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Associate Director, Dr. Allison Lung Allison Lung Associate Director, 12 GeV Upgrade Project Allison Lung was appointed the assistant director for the Thomas Jefferson National Accelerator Facility in October 2002. As assistant director, Lung is responsible for formulating and leading the JLab Continual Improvement Program, and responding to requests from JLab stakeholders. She organizes support and documentation for funding campaigns and collaborates closely with the lab director in matters

  3. Associations of symptoms related to isocyanate, ureaformol, and formophenolic exposures with respiratory symptoms and lung function in coal miners

    SciTech Connect

    Bertrand, J.P.; Simon, V.; Chau, N.

    2007-04-15

    The respiratory effects of diphenylmethane diisocyanate (MDI)-based resins and ureaformol- and formophenolic-based resins, used in coal mining, are unknown. This cross-sectional study of 354 miners evaluated respiratory health in miners with MDI-related symptoms (IS) and ureaformol/formophenolic-related symptoms (UFS). The protocol included clinical examination, chest radiograph, questionnaire on respiratory symptoms, smoking habit, job history, resin handling, and spirometry. Resin handling concerned 27.7% of the miners. IS affected 5.6%, and 1.4% also after work. UFS affected 22.6%, and 2.3% also after work. Wheezing affected 35.6%; chronic cough, expectoration, or bronchitis about 10%; dyspnea 5.4%; and asthma 2.8%. The miners with UFS had significantly more frequent chronic cough, expectoration, chronic bronchitis, dyspnea, and wheezing, whereas those with IS at and after work had markedly lower FVC, FEV1, MMEF, FEF50% and FEF25%. These findings raise the possibility of deleterious effects of exposures to MDI and ureaformol/ ormophenolic resins on respiratory health and lung function in coal miners during their working life.

  4. Influence of radiation therapy on the lung-tissue in breast cancer patients: CT-assessed density changes and associated symptoms

    SciTech Connect

    Rotstein, S.; Lax, I.; Svane, G. )

    1990-01-01

    The relative electron density of lung tissue was measured from computer tomography (CT) slices in 33 breast cancer patients treated by various techniques of adjuvant radiotherapy. The measurements were made before radiotherapy, 3 months and 9 months after completion of radiation therapy. The changes in lung densities at 3 months and 9 months were compared to radiation induced radiological (CT) findings. In addition, subjective symptoms such as cough and dyspnoea were assessed before and after radiotherapy. It was observed that the mean of the relative electron density of lung tissue varied from 0.25 when the whole lung was considered to 0.17 when only the anterior lateral quarter of the lung was taken into account. In patients with positive radiological (CT) findings the mean lung density of the anterior lateral quarter increased 2.1 times 3 months after radiotherapy and was still increased 1.6 times 6 months later. For those patients without findings, in the CT pictures the corresponding values were 1.2 and 1.1, respectively. The standard deviation of the pixel values within the anterior lateral quarter of the lung increased 3.8 times and 3.2 times at 3 months and 9 months, respectively, in the former group, as opposed to 1.2 and 1.1 in the latter group. Thirteen patients had an increase in either cough or dyspnoea as observed 3 months after completion of radiotherapy. In eleven patients these symptoms persisted 6 months later. No significant correlation was found between radiological findings and subjective symptoms. However, when three different treatment techniques were compared among 29 patients the highest rate of radiological findings was observed in patients in which the largest lung volumes received the target dose. A tendency towards an increased rate of subjective symptoms was also found in this group.

  5. Joshua DeLung

    Energy.gov [DOE]

    Joshua DeLung is an Account Manager at ENC Marketing & Communications and the Executive Editor at Relatively Journalizing.

  6. Statistical Association

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Kelly named Fellow of the American Statistical Association August 2, 2016 The American Statistical Association (ASA) has honored Elizabeth Kelly of the Lab's Statistical Sciences group with the title of Fellow. The ASA recognized her for providing exemplary statistical leadership of and collaboration on multidisciplinary teams dealing with environmental restoration, weapon quality, and nuclear materials storage to ensure the safety and security of the Nation. She will receive the Fellow award at

  7. Sandia Energy - American Institute of Aeronautics and Astronautics...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    as Associate Fellow Home Renewable Energy Energy News Wind Energy News & Events American Institute of Aeronautics and Astronautics Elects Sandian as Associate Fellow Previous...

  8. Higher Biologically Effective Dose of Radiotherapy Is Associated With Improved Outcomes for Locally Advanced Non-Small Cell Lung Carcinoma Treated With Chemoradiation: An Analysis of the Radiation Therapy Oncology Group

    SciTech Connect

    Machtay, Mitchell; Movsas, Benjamin; Paulus, Rebecca; Gore, Elizabeth M.; Komaki, Ritsuko; Albain, Kathy; Sause, William T.; Curran, Walter J.

    2012-01-01

    Purpose: Patients treated with chemoradiotherapy for locally advanced non-small-cell lung carcinoma (LA-NSCLC) were analyzed for local-regional failure (LRF) and overall survival (OS) with respect to radiotherapy dose intensity. Methods and Materials: This study combined data from seven Radiation Therapy Oncology Group (RTOG) trials in which chemoradiotherapy was used for LA-NSCLC: RTOG 88-08 (chemoradiation arm only), 90-15, 91-06, 92-04, 93-09 (nonoperative arm only), 94-10, and 98-01. The radiotherapeutic biologically effective dose (BED) received by each individual patient was calculated, as was the overall treatment time-adjusted BED (tBED) using standard formulae. Heterogeneity testing was done with chi-squared statistics, and weighted pooled hazard ratio estimates were used. Cox and Fine and Gray's proportional hazard models were used for OS and LRF, respectively, to test the associations between BED and tBED adjusted for other covariates. Results: A total of 1,356 patients were analyzed for BED (1,348 for tBED). The 2-year and 5-year OS rates were 38% and 15%, respectively. The 2-year and 5-year LRF rates were 46% and 52%, respectively. The BED (and tBED) were highly significantly associated with both OS and LRF, with or without adjustment for other covariates on multivariate analysis (p < 0.0001). A 1-Gy BED increase in radiotherapy dose intensity was statistically significantly associated with approximately 4% relative improvement in survival; this is another way of expressing the finding that the pool-adjusted hazard ratio for survival as a function of BED was 0.96. Similarly, a 1-Gy tBED increase in radiotherapy dose intensity was statistically significantly associated with approximately 3% relative improvement in local-regional control; this is another way of expressing the finding that the pool-adjusted hazard ratio as a function of tBED was 0.97. Conclusions: Higher radiotherapy dose intensity is associated with improved local-regional control and

  9. American Chemical Society Fellows

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    selected as American Chemical Society Fellows August 7, 2014 Chamberlin and Porterfield ... group, have been selected as a 2014 Fellows of the American Chemical Society (ACS). ...

  10. Celebrating Asian American Pacific Islander Heritage Month at...

    Energy Saver

    James Meng, Executive Director of the Naval Sea System Command; Afroze Mohammed, Associate Director of Virginia Tech University; Emily Duong, 2013 Pacific Miss Asian American and ...

  11. Legacy Guidance: The Buy American Provision of the Recovery Act |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Legacy Guidance: The Buy American Provision of the Recovery Act Legacy Guidance: The Buy American Provision of the Recovery Act Projects funded by the American Recovery and Reinvestment Act of 2009 (Recovery Act) were required to follow the Buy American Provision. This guidance only applied to Funding Opportunity Announcements (FOAs) associated with the Recovery Act. If the FOA received another source of funding-not from the Recovery Act-then the Buy America provision

  12. American Recovery and Reinvestment Act

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    American Recovery and Reinvestment Act American Recovery and Reinvestment Act LANL was able to accelerate demolition and cleanup thanks to a 212 million award from the American...

  13. Lung pair phantom

    DOEpatents

    Olsen, P.C.; Gordon, N.R.; Simmons, K.L.

    1993-11-30

    The present invention is a material and method of making the material that exhibits improved radiation attenuation simulation of real lungs, i.e., an ``authentic lung tissue`` or ALT phantom. Specifically, the ALT phantom is a two-part polyurethane medium density foam mixed with calcium carbonate, potassium carbonate if needed for K-40 background, lanthanum nitrate, acetone, and a nitrate or chloride form of a radionuclide. This formulation is found to closely match chemical composition and linear attenuation of real lungs. The ALT phantom material is made according to established procedures but without adding foaming agents or preparing thixotropic concentrate and with a modification for ensuring uniformity of density of the ALT phantom that is necessary for accurate simulation. The modification is that the polyurethane chemicals are mixed at a low temperature prior to pouring the polyurethane mixture into the mold.

  14. Lung pair phantom

    DOEpatents

    Olsen, Peter C.; Gordon, N. Ross; Simmons, Kevin L.

    1993-01-01

    The present invention is a material and method of making the material that exhibits improved radiation attenuation simulation of real lungs, i.e., an "authentic lung tissue" or ALT phantom. Specifically, the ALT phantom is a two-part polyurethane medium density foam mixed with calcium carbonate, potassium carbonate if needed for K-40 background, lanthanum nitrate, acetone, and a nitrate or chloride form of a radionuclide. This formulation is found to closely match chemical composition and linear attenuation of real lungs. The ALT phantom material is made according to established procedures but without adding foaming agents or preparing thixotropic concentrate and with a modification for ensuring uniformity of density of the ALT phantom that is necessary for accurate simulation. The modification is that the polyurethane chemicals are mixed at a low temperature prior to pouring the polyurethane mixture into the mold.

  15. Early Lung Cancer Detection Program

    Energy.gov [DOE]

    Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

  16. Lung inflammation biomarkers and lung function in children chronically exposed to arsenic

    SciTech Connect

    Olivas-Calderón, Edgar; Recio-Vega, Rogelio; Gandolfi, A. Jay; Lantz, R. Clark; González-Cortes, Tania; Gonzalez-De Alba, Cesar; Froines, John R.; Espinosa-Fematt, Jorge A.

    2015-09-01

    Evidence suggests that exposure to arsenic in drinking water during early childhood or in utero has been associated with an increase in respiratory symptoms or diseases in the adulthood, however only a few studies have been carried out during those sensitive windows of exposure. Recently our group demonstrated that the exposure to arsenic during early childhood or in utero in children was associated with impairment in the lung function and suggested that this adverse effect could be due to a chronic inflammation response to the metalloid. Therefore, we designed this cross-sectional study in a cohort of children associating lung inflammatory biomarkers and lung function with urinary As levels. A total of 275 healthy children were partitioned into four study groups according with their arsenic urinary levels. Inflammation biomarkers were measured in sputum by ELISA and the lung function was evaluated by spirometry. Fifty eight percent of the studied children were found to have a restrictive spirometric pattern. In the two highest exposed groups, the soluble receptor for advanced glycation end products' (sRAGE) sputum level was significantly lower and matrix metalloproteinase-9 (MMP-9) concentration was higher. When the biomarkers were correlated to the urinary arsenic species, negative associations were found between dimethylarsinic (DMA), monomethylarsonic percentage (%MMA) and dimethylarsinic percentage (%DMA) with sRAGE and positive associations between %DMA with MMP-9 and with the MMP-9/tissue inhibitor of metalloproteinase (TIMP-1) ratio. In conclusion, chronic arsenic exposure of children negatively correlates with sRAGE, and positively correlated with MMP-9 and MMP-9/TIMP-1 levels, and increases the frequency of an abnormal spirometric pattern. Arsenic-induced alterations in inflammatory biomarkers may contribute to the development of restrictive lung diseases. - Highlights: • First study in children evaluating lung inflammatory biomarkers and As levels

  17. Historical review of lung counting efficiencies for low energy photon emitters

    DOE PAGES [OSTI]

    Jeffers, Karen L.; Hickman, David P.

    2014-03-01

    This publication reviews the measured efficiency and variability over time of a high purity planar germanium in vivo lung count system for multiple photon energies using increasingly thick overlays with the Lawrence Livermore Torso Phantom. Furthermore, the measured variations in efficiency are compared with the current requirement for in vivo bioassay performance as defined by the American National Standards Institute Standard.

  18. Moore honored with American Statistical Association award

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Before his death in 1991, Professor Owen was the Distinguished Professor of Statistics at Southern Methodist University in Dallas, Texas. His illustrious career serves as the ...

  19. QER- Comment of American Gas Association 3

    Office of Energy Efficiency and Renewable Energy (EERE)

    Dear Ms. Pickett: Attached please find AGA's comments on natural gas vehicle fueling infrastructure as part of our response to the first phase of the DOE Quadrennial Energy Review (QER), consisting of a cover letter and attachments. Respectfully submitted, Kathryn Clay

  20. Los Alamos' Terwilliger named American Crystallographic Association...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    the structures of molecules using X-ray lasers and new methods for obtaining clear ... Many members of the ACA look at the shapes of protein molecules, which are the molecular ...

  1. QER- Comment of American Gas Association 1

    Office of Energy Efficiency and Renewable Energy (EERE)

    Attached please find AGA's comments on methane emissions issues in the first phase of the DOE Quadrennial Energy Review (QER), consisting of a cover letter and attachments. Dr. Kathryn Clay will be submitting AGA's comments on other aspects of the QER. Please let me know if you have any questions.

  2. QER- Comment of American Gas Association 4

    Office of Energy Efficiency and Renewable Energy (EERE)

    From: Peterson, Christopher (EIA)Sent: Tuesday, October 14, 2014 12:11 PMTo: Pierpoint, LaraSubject: FW: AGA comments to QER: Natural Gas Emissions Section

  3. Los Alamos' Terwilliger named American Crystallographic Association

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    companies can see their new drugs bound to protein molecules quickly and accurately. ... with others and how pharmaceutical drugs can bind to them and turn them on and off. ...

  4. Native American Finance Officers Association Conference

    Energy.gov [DOE]

    This event will take place on March 20-21, 2012, in New Orleans, Louisiana. Learn more and register on the NAFOA website.

  5. American Public Power Association Statement Quadrennial Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... market is a mechanism to provide revenue to a power plant owner to stand ready to supply power when needed, or to customers who agree to curtail their load (i.e., demand response). ...

  6. Moore honored with American Statistical Association award

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Monthly gasoline price to dip below $2 this winter The nationwide average price for gasoline is expected to fall below $2 per gallon in January, as refiners have switched over to making the less expensive winter gasoline blend and because seasonal motor fuel consumption is typically lower than during the summer months. In its new forecast, the U.S. Energy Information Administration estimates that gasoline demand in September alone hit a record high for that month and highway travel reached

  7. QER- Comment of American Gas Association 2

    Office of Energy Efficiency and Renewable Energy (EERE)

    Attached please find AGA's comments relating to critical issues facing the natural gas distribution industry, which we believe could be usefully addressed in the first phase of the DOE Quadrennial Energy Review (QER). Our comments as submitted here consist of a cover letter and four additional attachments. My colleague Pam Lacey has previously submitted AGA's comments relating to methane emissions under separate cover.

  8. American Venture Acceleration Fund

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    regional businesses receive Native American Venture Acceleration Fund grants February 1, 2016 Investing in Northern New Mexico's economy through jobs, new revenue LOS ALAMOS, N.M., Feb. 1, 2016-Four Northern New Mexico Native American- owned and operated businesses received a total of $60,000 in grants through a Native American Venture Acceleration Fund created by Los Alamos National Security, LLC (LANS) and the Regional Development Corporation. The grants are designed to help the recipients

  9. Native American Venture Acceleration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Native American Venture Acceleration Fund provides boost to six regional businesses February 26, 2013 LANS, LANL fostering economic development in Northern New Mexico LOS ALAMOS, New Mexico, Feb. 26, 2013-Six Native American businesses received grants through a new Native American Venture Acceleration Fund created by Los Alamos National Security, LLC (LANS) and the Regional Development Corporation. The grants are designed to help the recipients create jobs, increase their revenue base and help

  10. Petroleo moderno. [Latin American

    SciTech Connect

    Berger, B.; Anderson, K.

    1980-01-01

    The Latin American petroleum industry is discussed. Emphasis is placed upon the business aspects of the industry as well as the present stage of industrial development. (JMT)

  11. American Chemical Society Fellow

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Chemical Society Fellow August 30, 2012 LOS ALAMOS, NEW MEXICO, August 30, 2012-Los Alamos National Laboratory (LANL) scientist Kristin Omberg was named as an American Chemical ...

  12. Native American Heritage Month

    Energy.gov [DOE]

    This month, we celebrate the rich heritage and myriad contributions of American Indians and Alaska Natives, and we rededicate ourselves to supporting tribal sovereignty, tribal self-determination,...

  13. Crystallographic Association Fellow

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    named American Crystallographic Association Fellow January 4, 2013 The American Crystallographic Association (ACA) honored Thomas Terwilliger of LANL's Biosecurity and Public Health group with the rank of Fellow. He was inducted during the ACA annual meeting in Boston. The ACA Fellows program celebrates the excellence of its members and promotes their recognition worldwide. ACA Fellows serve as scientific ambassadors to the broader scientific community and the general public to advance science

  14. Residential radon and lung cancer incidence in a Danish cohort

    SciTech Connect

    Braeuner, Elvira V.; Andersen, Claus E.; Sorensen, Mette; Jovanovic Andersen, Zorana; Center for Epidemiology Screening, Department of Public Health, University of Copenhagen ; Gravesen, Peter; Ulbak, Kaare; Hertel, Ole; Pedersen, Camilla; Overvad, Kim; Tjonneland, Anne; Raaschou-Nielsen, Ole

    2012-10-15

    High-level occupational radon exposure is an established risk factor for lung cancer. We assessed the long-term association between residential radon and lung cancer risk using a prospective Danish cohort using 57,053 persons recruited during 1993-1997. We followed each cohort member for cancer occurrence until 27 June 2006, identifying 589 lung cancer cases. We traced residential addresses from 1 January 1971 until 27 June 2006 and calculated radon at each of these addresses using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for lung cancer risk associated with residential radon exposure with and without adjustment for sex, smoking variables, education, socio-economic status, occupation, body mass index, air pollution and consumption of fruit and alcohol. Potential effect modification by sex, traffic-related air pollution and environmental tobacco smoke was assessed. Median estimated radon was 35.8 Bq/m{sup 3}. The adjusted IRR for lung cancer was 1.04 (95% CI: 0.69-1.56) in association with a 100 Bq/m{sup 3} higher radon concentration and 1.67 (95% CI: 0.69-4.04) among non-smokers. We found no evidence of effect modification. We find a positive association between radon and lung cancer risk consistent with previous studies but the role of chance cannot be excluded as these associations were not statistically significant. Our results provide valuable information at the low-level radon dose range.

  15. American Photovoltaics | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Photovoltaics Jump to: navigation, search Logo: American Photovoltaics Name: American Photovoltaics Place: Houston, Texas Zip: 77002 Region: Texas Area Sector: Solar Product: Will...

  16. H-1 Nuclear Magnetic Resonance Metabolomics Analysis Identifies Novel Urinary Biomarkers for Lung Function

    SciTech Connect

    MCClay, Joseph L.; Adkins, Daniel E.; Isern, Nancy G.; O'Connell, Thomas M.; Wooten, Jan B.; Zedler, Barbara K.; Dasika, Madhukar S.; Webb, B. T.; Webb-Robertson, Bobbie-Jo M.; Pounds, Joel G.; Murrelle, Edward L.; Leppert, Mark F.; van den Oord, Edwin J.

    2010-06-04

    Chronic obstructive pulmonary disease (COPD), characterized by chronic airflow limitation, is a serious and growing public health concern. The major environmental risk factor for COPD is tobacco smoking, but the biological mechanisms underlying COPD are not well understood. In this study, we used proton nuclear magnetic resonance (1H-NMR) spectroscopy to identify and quantify metabolites associated with lung function in COPD. Plasma and urine were collected from 197 adults with COPD and from 195 adults without COPD. Samples were assayed using a 600 MHz NMR spectrometer, and the resulting spectra were analyzed against quantitative spirometric measures of lung function. After correcting for false discoveries and adjusting for covariates (sex, age, smoking) several spectral regions in urine were found to be significantly associated with baseline lung function. These regions correspond to the metabolites trigonelline, hippurate and formate. Concentrations of each metabolite, standardized to urinary creatinine, were associated with baseline lung function (minimum p-value = 0.0002 for trigonelline). No significant associations were found with plasma metabolites. Two of the three urinary metabolites positively associated with baseline lung function, i.e. hippurate and formate, are often related to gut microflora. This suggests that the microbiome composition is variable between individuals with different lung function. Alternatively, the nature and origins of all three associated metabolites may reflect lifestyle differences affecting overall health. Our results will require replication and validation, but demonstrate the utility of NMR metabolomics as a screening tool for identifying novel biomarkers of lung disease or disease risk.

  17. QER- Comment of American Hydrogen Northeast, Inc.

    Office of Energy Efficiency and Renewable Energy (EERE)

    Dear Sir or Madam, Attached please find the Hydrogen Association and the American Hydrogen Northeast,inc's Comments on the first round of QER review. I wish to thank Secretary Moniz and Senator Reed for attending the Providence hearing and providing this opportunity to submit these comments.

  18. Buy American Program Guidance

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... cut down to a 2x4 lumber used to frame a structure would be subject to the Recovery Act Buy American provisions. Similarly, copper piping used to plumb a building would be covered. ...

  19. American Physical Society

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Los Alamos scientists honored by American Physical Society November 12, 2015 LOS ALAMOS, N.M., Nov. 12, 2015-Ten Los Alamos National Laboratory scientists are new Fellows of the American Physical Society. Tariq Aslam, Steven Batha, Eric Bauer, Hou-Tong Chen, Diego Alejandro Dalvit, Dinh Nguyen, Alan Perelson, Filip Ronning, Alexander Saunders and Glen Wurden were named this week by the national organization. "We're extremely pleased that the technical accomplishments of our talented staff

  20. American Venture Acceleration Fund

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    February 4, 2014 LANS, LANL fostering economic development in Northern New Mexico LOS ALAMOS, N.M., Feb. 4, 2014-Six Northern New Mexico Native American-owned and operated businesses received a total of $60,000 in grants through a new Native American Venture Acceleration Fund created by Los Alamos National Security, LLC (LANS) and the Regional Development Corporation. The grants are designed to help the recipients create jobs, increase their revenue base and help diversify the area economy. - 2

  1. American Nuclear Society Awards

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ans awards American Nuclear Society Awards Established in 1999 by the Fusion Energy Division of the American Nuclear Society (ANS) and named after LLNL's co-founder, the Edward Teller Medal recognizes pioneering research and leadership in the use of laser and ion-particle beams to produce unique high-temperature and high-density matter for scientific research and for controlled thermonuclear fusion. Name Year Name of Award and Citation Susana Reyes 2012 Mary Jane Oestmann Professional Women's

  2. American Physical Society Awards

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    aps awards American Physical Society Awards American Physical Society (APS) is one of the most important professional societies for gauging the quality of R&D done at the Laboratory. The APS sponsors a number of awards including the John Dawson Award of Excellence in Plasma Physics, James Clerk Maxwell Prize for Plasma Physics, as well as Dinstinguised Lectuerer and Doctoral Dissertation prizes. Name Year Name of Award and Citation Yu-hsin Chen 2012 Marshall N. Rosenbluth Outstanding

  3. American Physical Society Fellows

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    aps fellows American Physical Society Fellows American Physical Society (APS) Fellowships recognize those who have made advances in knowledge through original research or have made significant and innovative contributions in the application of physics to science and technology. Each year, no more than one-half of one percent of APS's current membership is recognized by their peers for election to the status of Fellow. The hundred-year-old society numbers tens of thousands of physicists

  4. at American Geophysical Union

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Mars rover findings revealed at American Geophysical Union conference December 17, 2015 Much higher concentrations of silica indicate "considerable water activity" LOS ALAMOS, N.M., Dec. 17, 2015-New findings by NASA's Mars Curiosity rover are the focus of a press conference this morning at the American Geophysical Union (AGU) meeting in San Francisco, Calif. A group of scientists, including one from Los Alamos National Laboratory, revealed that the Curiosity rover found much higher

  5. Tiny plastic lung mimics human pulmonary function

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Tiny plastic lung mimics human pulmonary function Tiny plastic lung mimics human pulmonary function Scientists are developing a miniature, tissue-engineered artificial lung that mimics the response of the human lung to drugs, toxins and other agents. April 25, 2016 The full PuLMo artificial lung system in operation. The full PuLMo artificial lung system in operation. Contact Kevin Roark Communications Office (505) 665-9202 Email "When we build our lung, we not only take into account the

  6. Economic Impact of 8(a) and Native American Contractors

    Energy.gov [DOE]

    Editor's Note: This blog post was guest written by Jennine Elias, Director of External Affairs for the Native American Contractors Association (www.nativecontractors.org)

  7. Kathryn Clay, Ph.D. Vice President of Policy Strategy American...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Remarks of Kathryn Clay, Ph.D. Vice President of Policy Strategy American Gas Association PUBLIC MEETING ON ENERGY INFRASTRUCTURE SITING DEPARTMENT OF ENERGY QUADRENNIAL ENERGY ...

  8. American Agri diesel LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    American Agri diesel LLC Jump to: navigation, search Name: American Agri-diesel LLC Place: Colorado Springs, Colorado Product: Biodiesel producer in Colorado. References: American...

  9. Lienert named American Welding Society Fellow

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Lienert Named American Welding Society Fellow Lienert named American Welding Society Fellow Lienert was inducted into the American Welding Society's 2012 Class of Fellows during...

  10. American Ag Fuels LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    American Ag Fuels LLC Jump to: navigation, search Name: American Ag Fuels LLC Place: Defiance, Ohio Zip: 43512 Product: Biodiesel producer in Defiance, Ohio. References: American...

  11. Central American electrical interconnection

    SciTech Connect

    Not Available

    1988-12-01

    A technical cooperation grant of $2.25 million, designed to strengthen the capacity of Central American countries to operate their regional interconnected electrical system, was announced by the Inter-American Development Bank (IDB). The grant, extended from the banks Fund for Special Operations, will help improve the capacity of the regions electric power companies to achieve economical, safe operation of the interconnected electric power systems. The funds will also be used to finance regional studies of the accords, procedures, regulations, and supervisory mechanisms for the system, as well as program development and data bases.

  12. American Disabilities Act

    Energy.gov [DOE]

    The Americans with Disabilities Act prohibits private employers, state and local governments, employment agencies and labor unions from discriminating against qualified individuals with disabilities in job application procedures, hiring, firing, advancement, compensation, job training, and other terms, conditions, and privileges of employment.

  13. American Recovery and Reinvestment Act

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    American Recovery and Reinvestment Act American Recovery and Reinvestment Act LANL was able to accelerate demolition and cleanup thanks to a $212 million award from the American Recovery and Reinvestment Act. August 1, 2013 Excavation trench and enclosure at TA-21. To protect air quality, MDA B is excavated under a dome. By September 2011, all projects were complete. In 2010 and 2011, LANL received $212 million in funding from the American Recovery and Reinvestment Act to complete three

  14. Wind Energy for Native Americans

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    for Native Americans Wind Energy for Native Americans Larry Flowers Larry Flowers Golden, CO Golden, CO November 20, 2003 November 20, 2003 Native American Wind Native American Wind Development Development * NA wind resources * On-site loads vs. export * Investment vs. private developer royalties * Tribal utility business development policies * Transmission constraints vs. green tags opportunity * Tax advantages/limitations * (perceived) Private sector development risk * Federal load

  15. Buy American | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Buy American Buy American * What is the Buy American Act? * Buy America requirements for lighting components for projects funded by the Recovery Act * Does Buy America apply to ARRA grants to investor-owned utility companies? * Applicability of the Recovery Act Buy American provisions to rebates provided to homeowners * How flexible is the "unreasonable cost" exception in subpart 25.603? * Can a subrecipient seek a nonavailability waiver based on substandard energy efficiency of a U.S.

  16. Buy American Guidance Documents | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Buy American Guidance Documents Buy American Guidance Documents Projects funded by the American Recovery and Reinvestment Act of 2009 (Recovery Act) were required to follow the Buy American Provision. Below are Buy American guidance documents. Buy American Desk Guide (2 MB) OMB Interim Final Regulations (162.3 KB) Guidance on the Term "Project" Under the Recovery Act Buy American Provisions (51.33 KB) Guidance on Documenting Compliance with the Recovery Act Buy American Provisions

  17. Iron supplementation at high altitudes induces inflammation and oxidative injury to lung tissues in rats

    SciTech Connect

    Salama, Samir A.; Omar, Hany A.; Maghrabi, Ibrahim A.; AlSaeed, Mohammed S.; EL-Tarras, Adel E.

    2014-01-01

    Exposure to high altitudes is associated with hypoxia and increased vulnerability to oxidative stress. Polycythemia (increased number of circulating erythrocytes) develops to compensate the high altitude associated hypoxia. Iron supplementation is, thus, recommended to meet the demand for the physiological polycythemia. Iron is a major player in redox reactions and may exacerbate the high altitudes-associated oxidative stress. The aim of this study was to explore the potential iron-induced oxidative lung tissue injury in rats at high altitudes (6000 ft above the sea level). Iron supplementation (2 mg elemental iron/kg, once daily for 15 days) induced histopathological changes to lung tissues that include severe congestion, dilatation of the blood vessels, emphysema in the air alveoli, and peribronchial inflammatory cell infiltration. The levels of pro-inflammatory cytokines (IL-1?, IL-6, and TNF-?), lipid peroxidation product and protein carbonyl content in lung tissues were significantly elevated. Moreover, the levels of reduced glutathione and total antioxidant capacity were significantly reduced. Co-administration of trolox, a water soluble vitamin E analog (25 mg/kg, once daily for the last 7 days of iron supplementation), alleviated the lung histological impairments, significantly decreased the pro-inflammatory cytokines, and restored the oxidative stress markers. Together, our findings indicate that iron supplementation at high altitudes induces lung tissue injury in rats. This injury could be mediated through excessive production of reactive oxygen species and induction of inflammatory responses. The study highlights the tissue injury induced by iron supplementation at high altitudes and suggests the co-administration of antioxidants such as trolox as protective measures. - Highlights: Iron supplementation at high altitudes induced lung histological changes in rats. Iron induced oxidative stress in lung tissues of rats at high altitudes. Iron increased

  18. The American Recovery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    American Recovery and Reinvestment Act Smart Grid Highlights Jumpstarting a Modern Grid October 2014 2 The Office of Electricity Delivery and Energy Reliability (OE) provides national leadership to ensure that the nation's energy delivery system is secure, resilient, and reliable. OE works to develop new technologies to improve the infrastructure that brings electricity into our homes, offices, and factories in partnership with industry, other federal agencies, and state and local governments.

  19. Overview of North American Hydrogen Sensor Standards

    SciTech Connect

    O'Malley, Kathleen; Lopez, Hugo; Cairns, Julie; Wichert, Richard; Rivkin, Carl; Burgess, Robert; Buttner, William

    2015-08-11

    An overview of the main North American codes and standards associated with hydrogen safety sensors is provided. The distinction between a code and a standard is defined, and the relationship between standards and codes is clarified, especially for those circumstances where a standard or a certification requirement is explicitly referenced within a code. The report identifies three main types of standards commonly applied to hydrogen sensors (interface and controls standards, shock and hazard standards, and performance-based standards). The certification process and a list and description of the main standards and model codes associated with the use of hydrogen safety sensors in hydrogen infrastructure are presented.

  20. Buy American Program Guidance | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Buy American Program Guidance Buy American Program Guidance Provides information on the December 17, 2009, Buy American Guidance eere_program_guidance_buy_american_121709.pdf (122 KB) More Documents & Publications Projects Funded by the American Recovery and Reinvestment Act of 2009 and Administered by the Office of Energy Efficiency and Renewable Energy (EERE) Notice Buy American Guidance Documents FAQs Docs for the Buy American Provision

  1. Central American update

    SciTech Connect

    Hodgson, S.F.

    1987-07-01

    The Central American Energy Resources Project is designed to help the countries of Honduras, Costa Rica, El Salvador, Guatemala, and Panama develop their geothermal resources. Auxiliary project goals are to increase economic development and employment in Central America; to provide a scientific basis for the private sector to develop natural resources; and to provide scientific training to in-country scientists, engineers, and technicians. The energy resources project began in March 1985. The progress being made in El Salvador (production well logging and geophysical operations), Panama (site selection for the first temperature-gradient well), and Honduras (well drilling of temperature-gradient wells) is summarized.

  2. Central American resource studies

    SciTech Connect

    Van Eeckhout, E.; Laughlin, A.W.

    1989-01-01

    Los Alamos National Laboratory has been working with five Central American countries to assist in the development of their energy and mineral resources. Since 1985, mineral resources in Costa Rica, peat resources in Costa Rica and Panama, geothermal energy resources in Honduras and Guatemala, and geothermal field development in El Salvador and Costa Rica have been topics of study. This paper presents an overview of this work -- within these proceedings are papers that deal with specific aspects of each topic, and these will be duly noted. 15 refs., 4 figs.

  3. Native American Leadership Forum- East

    Energy.gov [DOE]

    The Native American Leadership Forum - East is a hands-on training to provide opportunities to practice and master leadership and management communications for tribal and organizational success.

  4. American Elements | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Elements Jump to: navigation, search Name: American Elements Place: Los Angeles, California Zip: 90024 Product: US-based manufacturer and supplier of PV feedstocks such as silicon,...

  5. New American Home 2009 (Brochure)

    SciTech Connect

    Not Available

    2008-12-01

    This brochure details the New American Home 2009, which demonstrates the use of innovative building materials, cutting-edge design, and the latest construction techniques.

  6. Real-Time Tumor Tracking in the Lung Using an Electromagnetic Tracking System

    SciTech Connect

    Shah, Amish P.; Kupelian, Patrick A.; Waghorn, Benjamin J.; Willoughby, Twyla R.; Rineer, Justin M.; Maon, Rafael R.; Vollenweider, Mark A.; Meeks, Sanford L.

    2013-07-01

    Purpose: To describe the first use of the commercially available Calypso 4D Localization System in the lung. Methods and Materials: Under an institutional review board-approved protocol and an investigational device exemption from the US Food and Drug Administration, the Calypso system was used with nonclinical methods to acquire real-time 4-dimensional lung tumor tracks for 7 lung cancer patients. The aims of the study were to investigate (1) the potential for bronchoscopic implantation; (2) the stability of smooth-surface beacon transponders (transponders) after implantation; and (3) the ability to acquire tracking information within the lung. Electromagnetic tracking was not used for any clinical decision making and could only be performed before any radiation delivery in a research setting. All motion tracks for each patient were reviewed, and values of the average displacement, amplitude of motion, period, and associated correlation to a sinusoidal model (R{sup 2}) were tabulated for all 42 tracks. Results: For all 7 patients at least 1 transponder was successfully implanted. To assist in securing the transponder at the tumor site, it was necessary to implant a secondary fiducial for most transponders owing to the transponder's smooth surface. For 3 patients, insertion into the lung proved difficult, with only 1 transponder remaining fixed during implantation. One patient developed a pneumothorax after implantation of the secondary fiducial. Once implanted, 13 of 14 transponders remained stable within the lung and were successfully tracked with the tracking system. Conclusions: Our initial experience with electromagnetic guidance within the lung demonstrates that transponder implantation and tracking is achievable though not clinically available. This research investigation proved that lung tumor motion exhibits large variations from fraction to fraction within a single patient and that improvements to both transponder and tracking system are still necessary

  7. South American oil

    SciTech Connect

    Not Available

    1992-06-01

    GAO reviewed the petroleum industries of the following eight South American Countries that produce petroleum but are not major exporters: Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Peru, and Trinidad and Tobago. This report discusses the amount of crude oil the United States imports from the eight countries, expected crude oil production for these countries through the year 2010, and investment reforms that these countries have recently made in their petroleum industries. In general, although the United States imports some oil from these countries, as a group, the eight countries are currently net oil importers because combined domestic oil consumption exceeds oil production. Furthermore, the net oil imports are expected to continue to increase through the year 2010, making it unlikely that the United States will obtain increased oil shipments from these countries.

  8. American Clean Coal Fuels | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    American Clean Coal Fuels Retrieved from "http:en.openei.orgwindex.php?titleAmericanCleanCoalFuels&oldid768408" Categories: Organizations Energy Generation Organizations...

  9. Energy Innovation: Green Button Initiative Empowering Americans...

    Energy Saver

    Energy Innovation: Green Button Initiative Empowering Americans to Save Energy and Money Energy Innovation: Green Button Initiative Empowering Americans to Save Energy and Money...

  10. Four Snapshots of American Energy Use

    Energy.gov [DOE]

    Americans used more energy in 2013 than they did in 2012, including more renewable, nuclear and fossil energy. Learn other facts about American energy use trends.

  11. NORTH AMERICAN ELECTRIC RELIABILITY COUNCIL: Preliminary Disturbance...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    NORTH AMERICAN ELECTRIC RELIABILITY COUNCIL: Preliminary Disturbance Report (40.43 KB) More Documents & Publications North American Electric Reliability Council Power Outage Update ...

  12. Thomas selected as American Chemical Society Fellow

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Thomas selected as ACS Fellow Thomas selected as American Chemical Society Fellow Kimberly ... first Los Alamos researcher to be named a Fellow of the American Chemical Society (ACS). ...

  13. President Obama's Commitment to American Energy | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    President Obama's Commitment to American Energy President Obama's Commitment to American Energy Addthis Speakers President Barack Obama Duration 4:38 Topic Energy Sector Jobs ...

  14. American Veterans Hiring Event | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    American Veterans Hiring Event American Veterans Hiring Event May 18, 2016 10:00AM to 2:20PM EDT AMVETS, Takoma, WA Contact Ed Agodoa

  15. Energy Innovation: Green Button Initiative Empowering Americans...

    Office of Environmental Management (EM)

    Innovation: Green Button Initiative Empowering Americans to Save Energy and Money Energy Innovation: Green Button Initiative Empowering Americans to Save Energy and Money February ...

  16. American Solar Energy | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    American Solar Energy Name: American Solar Energy Address: 11497 Columbia Drive West, Suite 10 Place: Jacksonville, Florida Zip: 32258 Sector: Solar Product: solar energy systems...

  17. American Renewable Energy | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Energy Jump to: navigation, search Name: American Renewable Energy Place: Evanston, Illinois Zip: 60202 Sector: Geothermal energy, Renewable Energy, Solar Product: American...

  18. American Solar Energy Society | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    American Solar Energy Society Name: American Solar Energy Society Address: 2400 Central Ave Place: Boulder, Colorado Zip: 80301 Region: Rockies Area Website: www.ases.org...

  19. American Wind Capital | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Capital Jump to: navigation, search Name: American Wind Capital Place: Essex, Connecticut Zip: 64260 Sector: Wind energy Product: Connecticut-based American Wind Capital buys wind...

  20. American Capital Energy | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Energy Jump to: navigation, search Logo: American Capital Energy Name: American Capital Energy Address: 15 Tyngsboro Rd. Suite 4A Place: North Chelmsford, Massachusetts Zip: 01863...

  1. American Alternative Energy Systems | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Alternative Energy Systems Jump to: navigation, search Name: American Alternative Energy Systems Place: Denton, Texas Zip: 76209 Product: An American company involved in project...

  2. American Way Solar AWS | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    navigation, search Name: American Way Solar (AWS) Place: Plzen, Czech Republic Sector: Solar Product: Czech subsidiary of US PV panel manufacturer, American Way Solar (AWS)....

  3. North American Electric Reliability Corporation Interconnections...

    Energy.gov [DOE] (indexed site)

    Map of the North American Electric Reliability Corporation Interconnection showing the Eastern, Western, and Teaxs Interconnectins. North American Electric Reliability Corporation...

  4. American Transmission Systems Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    American Transmission Systems Inc Jump to: navigation, search Name: American Transmission Systems Inc Place: Ohio Website: www.atcllc.com Twitter: @amertransco References: EIA...

  5. American Electric Vehicles Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Vehicles Inc Jump to: navigation, search Name: American Electric Vehicles Inc Place: Palmer Lake, Colorado Zip: 80133 Sector: Vehicles Product: American Electric Vehicles (AEV)...

  6. Lienert named American Welding Society Fellow

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Lienert named American Welding Society Fellow November 29, 2012 Thomas J. Lienert of the Lab's Metallurgy group was inducted into the American Welding Society's 2012 Class of...

  7. American Electric Technologies Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Technologies Inc Jump to: navigation, search Name: American Electric Technologies Inc Place: Houston, Texas Zip: TX 77087 Sector: Services Product: American Electric Technologies...

  8. Manufacturing Institutes Exhibit American Innovation at Hannover...

    Office of Environmental Management (EM)

    Manufacturing Institutes Exhibit American Innovation at Hannover Messe Manufacturing Institutes Exhibit American Innovation at Hannover Messe April 25, 2016 - 4:30pm Addthis The ...

  9. Comments of North American Electric Reliability Corporation ...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    North American Electric Reliability Corporation (NERC) to DOE Smart Grid RFI: Addressing Policy and Logistical Challenges Comments of North American Electric Reliability Corporation ...

  10. North American Electric Reliability Corporation (NERC): Ensuring...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    North American Electric Reliability Corporation (NERC): Ensuring a Reliable Bulk Electric System North American Electric Reliability Corporation (NERC): Ensuring a Reliable Bulk ...

  11. Cars af Tomorrow and the American Community

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Cars of Tomorrow and the American Community High School Curriculum Created by Northeast Sustainable Energy Association (NESEA) Click on the links below to take you to the Chapter heading: Cover Page and Orientation Availability and Distribution of Alternative Fuels Health, Pollution, and Safety Operation, Maintenance, and Refueling Fuel Fact Sheets H I G H S C H O O L C U R R I C U L U M O N A L T E R N A T I V E F U E L S 50 Miles Street, Suite 3, Greenfield, MA 01301 www.nesea.org June, 2002

  12. Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor...

    Office of Scientific and Technical Information (OSTI)

    Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of ... Citation Details In-Document Search Title: Structures of Lung Cancer-Derived EGFR Mutants ...

  13. Response of Human Lung Epithelial Cells to Engineered Nanoparticles...

    Office of Scientific and Technical Information (OSTI)

    Response of Human Lung Epithelial Cells to Engineered Nanoparticles. Citation Details In-Document Search Title: Response of Human Lung Epithelial Cells to Engineered Nanoparticles. ...

  14. American Samoa Energy Action Plan

    SciTech Connect

    Haase, Scott; Esterly, Sean; Herdrich, David; Bodell, Tim; Visser, Charles

    2013-08-01

    Describes the five near-term strategies selected by the American Samoa Renewable Energy Committee (ASREC) during action planning workshops conducted in May 2013, and outlines the actions being taken to implement those strategies. Each option is tied to a priority identified in the earlier draft American Samoa Strategic Energy Plan as being an essential component of reducing American Samoa'spetroleum energy consumption. The actions described for each strategy provide a roadmap to facilitate the implementation of each strategy. This document is intended to evolve along with the advancement of the projects, and will be updated to reflect progress.

  15. Crisis in American mining

    SciTech Connect

    Not Available

    1984-05-01

    The crisis in American mining is discussed. The discussion focuses on the outlook for coal in the overall energy picture. Because of the Arab oil embargo of 1973, the Iranian disruption of 1979, and the tenfold increase in oil prices over the past decade, radical changes have taken place in energy supply and demand patterns. Two of the most important of these changes relate to investment. First, large investments have been made in energy-efficient plants, equipment, buildings, and vehicles. Their effect will restrain energy demand growth for the foreseeable future. Second, investments have been made in fuel-switching, from oil to coal and nuclear power. As a result the oil demand at the end of this century will be at approximately the same level as it is today. Natural gas demand is also likely to be flat. Coal demand, on the other hand, is expected to increase steadily over the long term. Recent conditions in the coal industry are reviewed, and a specific 10-year forecast is given.

  16. Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning

    SciTech Connect

    Sunil, Vasanthi R.; Shen, Jianliang; Patel-Vayas, Kinal; Gow, Andrew J.; Laskin, Jeffrey D.; Laskin, Debra L.

    2012-05-15

    Pulmonary toxicity induced by sulfur mustard and related vesicants is associated with oxidative stress. In the present studies we analyzed the role of reactive nitrogen species (RNS) generated via inducible nitric oxide synthase (iNOS) in lung injury and inflammation induced by vesicants using 2-chloroethyl ethyl sulfide (CEES) as a model. C57Bl/6 (WT) and iNOS ?/? mice were sacrificed 3 days or 14 days following intratracheal administration of CEES (6 mg/kg) or control. CEES intoxication resulted in transient (3 days) increases in bronchoalveolar lavage (BAL) cell and protein content in WT, but not iNOS ?/? mice. This correlated with expression of Ym1, a marker of oxidative stress in alveolar macrophages and epithelial cells. In contrast, in iNOS ?/? mice, Ym1 was only observed 14 days post-exposure in enlarged alveolar macrophages, suggesting that they are alternatively activated. This is supported by findings that lung tumor necrosis factor and lipocalin Lcn2 expression, mediators involved in tissue repair were also upregulated at this time in iNOS ?/? mice. Conversely, CEES-induced increases in the proinflammatory genes, monocyte chemotactic protein-1 and cyclooxygenase-2, were abrogated in iNOS ?/? mice. In WT mice, CEES treatment also resulted in increases in total lung resistance and decreases in compliance in response to methacholine, effects blunted by loss of iNOS. These data demonstrate that RNS, generated via iNOS play a role in the pathogenic responses to CEES, augmenting oxidative stress and inflammation and suppressing tissue repair. Elucidating inflammatory mechanisms mediating vesicant-induced lung injury is key to the development of therapeutics to treat mustard poisoning. -- Highlights: ? Lung injury, inflammation and oxidative stress are induced by the model vesicant CEES ? RNS generated via iNOS are important in the CEES-induced pulmonary toxicity ? iNOS ?/? mice are protected from CEES-induced lung toxicity and altered lung functioning.

  17. Molecular Markers of Lung Cancer in MAYAK Workers

    SciTech Connect

    Steven A. Belinsky, PhD

    2007-02-15

    The molecular mechanisms that result in the elevated risk for lung cancer associated with exposure to radiation have not been well characterized. Workers from the MAYAK nuclear enterprise are an ideal cohort in which to study the molecular epidemiology of cancer associated with radiation exposure and to identify the genes targeted for inactivation that in turn affect individual risk for radiation-induced lung cancer. Epidemiology studies of the MAYAK cohort indicate a significantly higher frequency for adenocarcinoma and squamous cell carcinoma (SCC) in workers than in a control population and a strong correlation between these tumor types and plutonium exposure. Two hypotheses will be evaluated through the proposed studies. First, radiation exposure targets specific genes for inactivation by promoter methylation. This hypothesis is supported by our recent studies with the MAYAK population that demonstrated the targeting of the p16 gene for inactivation by promoter methylation in adenocarcinomas from workers (1). Second, genes inactivated in tumors can serve as biomarkers for lung cancer risk in a cancer-free population of workers exposed to plutonium. Support for this hypothesis is based on exciting preliminary results of our nested, case-control study of persons from the Colorado cohort. In that study, a panel of methylation markers for predicting lung cancer risk is being evaluated in sputum samples from incident lung cancer cases and controls. The first hypothesis will be tested by determining the prevalence for promoter hypermethylation of a panel of genes shown to play a critical role in the development of either adenocarcinoma and/or SCC associated with tobacco. Our initial studies on adenocarcinoma in MAYAK workers will be extended to evaluate methylation of the PAX5 {alpha}, PAX5 {beta}, H-cadherin, GATA5, and bone morphogenesis 3B (BMP3B) genes in the original sample set described under Preliminary studies. In addition, studies will be initiated in SCC

  18. African-American Partner Program

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Careers, Jobs » Inclusion & Diversity » AAPP African-American Partner Program Graduate career research experiences for African-American students in STEM disciplines Contacts Tommy Rockward Michelle B. Lee Contact Us Email AAPP intern Lawrence Fomundam and his Lab mentors Dan Rees and Charles Farrar AAPP intern Lawrence Fomundam, center, an engineering graduate student at the University of Florida, is working on wireless power transmission for biomedical implants at Los Alamos. He is shown

  19. Working In Indian Country: Building Successful Business Relationships with American Indian Tribes

    Energy.gov [DOE]

    Sponsored by Association on American Indian Affairs, this interactive one-day workshop is designed for federal, state, and local government officials and business leaders who need or are required to develop working relationships with Indian tribes and organizations.

  20. Working in Indian Country: Building Successful Business Relationships with American Indian Tribes Workshop

    Energy.gov [DOE]

    Sponsored by the Association on American Indian Affairs, this one-day conference is for federal, state, and local government officials and business leaders who have a need to develop working relationships with tribes and organizations.

  1. Working in Indian Country: Building Successful Business Relationships with American Indian Tribes Workshop

    Energy.gov [DOE]

    Sponsored by the Association on American Indian Affairs, this one-day conference is for federal, state, and local government officials and business leaders who have a need to develop working...

  2. S100A4 is frequently overexpressed in lung cancer cells and promotes cell growth and cell motility

    SciTech Connect

    Chen, Na; Sato, Daisuke; Saiki, Yuriko; Sunamura, Makoto; Fukushige, Shinichi; Horii, Akira

    2014-05-09

    Highlights: • We observed frequent overexpression of S100A4 in lung cancer cell lines. • Knockdown of S100A4 suppressed proliferation in lung cancer cells. • Forced expression of S100A4 accelerated cell motility in lung cancer cells. • PRDM2 was found to be one of the downstream suppressed genes of S100A4. - Abstract: S100A4, a small calcium-binding protein belonging to the S100 protein family, is commonly overexpressed in a variety of tumor types and is widely accepted to associate with metastasis by regulating the motility and invasiveness of cancer cells. However, its biological role in lung carcinogenesis is largely unknown. In this study, we found that S100A4 was frequently overexpressed in lung cancer cells, irrespective of histological subtype. Then we performed knockdown and forced expression of S100A4 in lung cancer cell lines and found that specific knockdown of S100A4 effectively suppressed cell proliferation only in lung cancer cells with S100A4-overexpression; forced expression of S100A4 accelerated cell motility only in S100A4 low-expressing lung cancer cells. PRDM2 and VASH1, identified as novel upregulated genes by microarray after specific knockdown of S100A4 in pancreatic cancer, were also analyzed, and we found that PRDM2 was significantly upregulated after S100A4-knockdown in one of two analyzed S100A4-overexpressing lung cancer cells. Our present results suggest that S100A4 plays an important role in lung carcinogenesis by means of cell proliferation and motility by a pathway similar to that in pancreatic cancer.

  3. Principal Associate Director - Science, Technology, and Engineering

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Science, Technology, and Engineering As Principal Associate Director for Science, Technology, and Engineering, Alan Bishop leads programs to ensure a world-class science and technology base that underpins all the national security missions of the Lab. Contact Operator Los Alamos National Laboratory (505) 667-5061 Bishop is a Fellow of the American Physical Society, the Institute of Physics, and the American Association for the Advancement of Science; a recipient of the Department of Energy's

  4. Imaging of occupational and environmental lung diseases

    SciTech Connect

    Akira, M.

    2008-03-15

    The chest radiograph is the basic tool for identifying occupational and environmental lung diseases; however, its sensitivity and specificity for the diagnosis of occupational and environmental lung diseases are low. High-resolution CT is the optimal method of recognizing parenchymal abnormalities in occupational and environmental disease. With the exception of pleural plaques, the CT findings of occupational and environmental lung diseases are nonspecific. Therefore, correlation of imaging features with history of exposure, other clinical features, and sometimes pathology is needed for the diagnosis of pneumoconiosis.

  5. SUPPLEMENT ANALYSIS FOR THE ENVIRONMENTAL ASSESSMENT ENTITLED PROPOSED CONVEYANCE OF THE AMERICAN MUSEUM OF

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 SUPPLEMENT ANALYSIS FOR THE ENVIRONMENTAL ASSESSMENT ENTITLED PROPOSED CONVEYANCE OF THE AMERICAN MUSEUM OF SCIENCE AND ENERGY AND ASSOCIATED PROPERTY, PARCEL G, AND PARCEL 279.01 (DOE/EA-1415) December 30, 2015 In March 2007, the U.S. Department of Energy (DOE) completed an Environmental Assessment (EA) for the proposed conveyance of the American Museum of Science and Energy (AMSE) and associated property, Parcel G, and Parcel 279.01 to the City of Oak Ridge, Tennessee, (Oak Ridge), American

  6. Emerging Latin American air quality regulation

    SciTech Connect

    Hosmer, A.W.; Vitale, E.M.; Guerrero, C.R.; Solorzano-Vincent, L.

    1998-12-31

    Latin America is the most urbanized region in the developing world. In recent years, significant economic growth has resulted in population migration from rural areas to urban centers, as well as in a substantial rise in the standard of living within the Region. These changes have impacted the air quality of Latin American countries as increased numbers of industrial facilities and motor vehicles release pollutants into the air. With the advent of new free trade agreements such as MERCOSUR and NAFTA, economic activity and associated pollutant levels can only be expected to continue to expand in the future. In order to address growing air pollution problems, many Latin America countries including Argentina, Brazil, Chile, Columbia, Costa Rica, and Mexico have passed, or will soon pass, new legislation to develop and strengthen their environmental frameworks with respect to air quality. As a first step toward understanding the impacts that this increased environmental regulation will have, this paper will examine the regulatory systems in six Latin American countries with respect to ambient air quality and for each of these countries: review a short history of the air quality problems within the country; outline the legal and institutional framework including key laws and implementing institutions; summarize in brief the current status of the country in terms of program development and implementation; and identify projected future trends. In addition, the paper will briefly review the international treaties that have bearing on Latin American air quality. Finally, the paper will conclude by identifying and exploring emerging trends in individual countries and the region as a whole.

  7. Predicting Pneumonitis Risk: A Dosimetric Alternative to Mean Lung Dose

    SciTech Connect

    Tucker, Susan L.; Mohan, Radhe; Liengsawangwong, Raweewan; Martel, Mary K.; Liao Zhongxing

    2013-02-01

    Purpose: To determine whether the association between mean lung dose (MLD) and risk of severe (grade {>=}3) radiation pneumonitis (RP) depends on the dose distribution pattern to normal lung among patients receiving 3-dimensional conformal radiation therapy for non-small-cell lung cancer. Methods and Materials: Three cohorts treated with different beam arrangements were identified. One cohort (2-field boost [2FB]) received 2 parallel-opposed (anteroposterior-posteroanterior) fields per fraction initially, followed by a sequential boost delivered using 2 oblique beams. The other 2 cohorts received 3 or 4 straight fields (3FS and 4FS, respectively), ie, all fields were irradiated every day. The incidence of severe RP was plotted against MLD in each cohort, and data were analyzed using the Lyman-Kutcher-Burman (LKB) model. Results: The incidence of grade {>=}3 RP rose more steeply as a function of MLD in the 2FB cohort (N=120) than in the 4FS cohort (N=138), with an intermediate slope for the 3FS group (N=99). The estimated volume parameter from the LKB model was n=0.41 (95% confidence interval, 0.15-1.0) and led to a significant improvement in fit (P=.05) compared to a fit with volume parameter fixed at n=1 (the MLD model). Unlike the MLD model, the LKB model with n=0.41 provided a consistent description of the risk of severe RP in all three cohorts (2FB, 3FS, 4FS) simultaneously. Conclusions: When predicting risk of grade {>=}3 RP, the mean lung dose does not adequately take into account the effects of high doses. Instead, the effective dose, computed from the LKB model using volume parameter n=0.41, may provide a better dosimetric parameter for predicting RP risk. If confirmed, these findings support the conclusion that for the same MLD, high doses to small lung volumes ('a lot to a little') are worse than low doses to large volumes ('a little to a lot').

  8. Linear dimensions and volumes of human lungs

    DOE PAGES [OSTI]

    Hickman, David P.

    2012-03-30

    TOTAL LUNG Capacity is defined as “the inspiratory capacity plus the functional residual capacity; the volume of air contained in the lungs at the end of a maximal inspiration; also equals vital capacity plus residual volume” (from MediLexicon.com). Within the Results and Discussion section of their April 2012 Health Physics paper, Kramer et al. briefly noted that the lungs of their experimental subjects were “not fully inflated.” By definition and failure to obtain maximal inspiration, Kramer et. al. did not measure Total Lung Capacity (TLC). The TLC equation generated from this work will tend to underestimate TLC and does notmore » improve or update total lung capacity data provided by ICRP and others. Likewise, the five linear measurements performed by Kramer et. al. are only representative of the conditions of the measurement (i.e., not at-rest volume, but not fully inflated either). While there was significant work performed and the data are interesting, the data does not represent a maximal situation, a minimal situation, or an at-rest situation. Moreover, while interesting, the linear data generated by this study is limited by the conditions of the experiment and may not be fully comparative with other lung or inspiratory parameters, measures, or physical dimensions.« less

  9. Transcription factor FOXA2-centered transcriptional regulation network in non-small cell lung cancer

    SciTech Connect

    Jang, Sang-Min; An, Joo-Hee; Kim, Chul-Hong; Kim, Jung-Woong Choi, Kyung-Hee

    2015-08-07

    Lung cancer is the leading cause of cancer-mediated death. Although various therapeutic approaches are used for lung cancer treatment, these mainly target the tumor suppressor p53 transcription factor, which is involved in apoptosis and cell cycle arrest. However, p53-targeted therapies have limited application in lung cancer, since p53 is found to be mutated in more than half of lung cancers. In this study, we propose tumor suppressor FOXA2 as an alternative target protein for therapies against lung cancer and reveal a possible FOXA2-centered transcriptional regulation network by identifying new target genes and binding partners of FOXA2 by using various screening techniques. The genes encoding Glu/Asp-rich carboxy-terminal domain 2 (CITED2), nuclear receptor subfamily 0, group B, member 2 (NR0B2), cell adhesion molecule 1 (CADM1) and BCL2-associated X protein (BAX) were identified as putative target genes of FOXA2. Additionally, the proteins including highly similar to heat shock protein HSP 90-beta (HSP90A), heat shock 70 kDa protein 1A variant (HSPA1A), histone deacetylase 1 (HDAC1) and HDAC3 were identified as novel interacting partners of FOXA2. Moreover, we showed that FOXA2-dependent promoter activation of BAX and p21 genes is significantly reduced via physical interactions between the identified binding partners and FOXA2. These results provide opportunities to understand the FOXA2-centered transcriptional regulation network and novel therapeutic targets to modulate this network in p53-deficient lung cancer. - Highlights: • Identification of new target genes of FOXA2. • Identifications of novel interaction proteins of FOXA2. • Construction of FOXA2-centered transcriptional regulatory network in non-small cell lung cancer.

  10. Americans for Solar Power ASPv | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Americans for Solar Power ASPv Jump to: navigation, search Name: Americans for Solar Power (ASPv) Place: Tempe, Arizona Zip: 85282 Sector: Solar Product: Americans for Solar Power...

  11. U.S. Department of Energy - American Recovery & Reinvestment...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    U.S. Department of Energy - American Recovery & Reinvestment Act U.S. Department of Energy - American Recovery & Reinvestment Act Waivers Issued by DOE under the Buy American...

  12. EIS-0468: American Centrifuge Plant in Piketon, OH | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    8: American Centrifuge Plant in Piketon, OH EIS-0468: American Centrifuge Plant in Piketon, OH May 20, 2011 EIS-0468: Final Environmental Impact Statement Proposed American...

  13. EA-200-A American Electric Power Service Corporation | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    -A American Electric Power Service Corporation EA-200-A American Electric Power Service Corporation Order authorizing American Electric Power Service Corporation to export electric ...

  14. Society of American Indian Government Employees Annual National Training Program

    Energy.gov [DOE]

    Event includes plenary session, American Indian law classes, Native American youth workshops, cultural presentations, and a veterans program. Sponsored by the Society of American Indian Government...

  15. American Indian Policy and Relevant DOE and Executive Orders...

    Office of Environmental Management (EM)

    Tribal Programs American Indian Policy and Relevant DOE and Executive Orders American Indian Policy and Relevant DOE and Executive Orders Over the course of American history, ...

  16. Radiation-induced lung injury

    SciTech Connect

    Rosiello, R.A.; Merrill, W.W. )

    1990-03-01

    The use of radiation therapy is limited by the occurrence of the potentially fatal clinical syndromes of radiation pneumonitis and fibrosis. Radiation pneumonitis usually becomes clinically apparent from 2 to 6 months after completion of radiation therapy. It is characterized by fever, cough, dyspnea, and alveolar infiltrates on chest roentgenogram and may be difficult to differentiate from infection or recurrent malignancy. The pathogenesis is uncertain, but appears to involve both direct lung tissue toxicity and an inflammatory response. The syndrome may resolve spontaneously or may progress to respiratory failure. Corticosteroids may be effective therapy if started early in the course of the disease. The time course for the development of radiation fibrosis is later than that for radiation pneumonitis. It is usually present by 1 year following irradiation, but may not become clinically apparent until 2 years after radiation therapy. It is characterized by the insidious onset of dyspnea on exertion. It most often is mild, but can progress to chronic respiratory failure. There is no known successful treatment for this condition. 51 references.

  17. LOS ALAMOS, New Mexico, December 15, 2011-The American Association...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    and understanding the biochemical and biophysical processes of algae and other energy plants. John Gordon, Chemistry Division, for distinguished contributions to chemistries...

  18. Fall 2006 Meeting of theAmerican Statistical Association

    Energy Information Administration (EIA) (indexed site)

    ... EIA what their fuel costs are and that ... changes in consumer price sensitivities ... of long term forecasts is complicated by the length of time between the forecast ...

  19. OSTIblog Articles in the American Association for the Advancement...

    Office of Scientific and Technical Information (OSTI)

    The theme of this year's meeting is "Science without Borders." OSTI will have a booth (201 floor plan) at the meeting. Our central theme is "Ensuring Global Science Access." Join ...

  20. QER- Comment of American Wind Energy Association 2

    Energy.gov [DOE]

    QER Task Force – Attached please find brief supplemental comments that AWEA would like to submit for your consideration as you continuing drafting the QER.

  1. Home Energy Score Program Overview for the American Gas Association...

    Energy.gov [DOE] (indexed site)

    ... making changes to the scale in particular to allow greater mobility. We are bringing in a bunch of experts, actually, at this time from Yale and from some behavioral science ...

  2. QER - Comment of American Public Power Association 5 | Department...

    Energy Saver

    Attached are several documents for consideration for the QER Public ... These documents are being submitted herein to demonstrate the importance of recognizing ...

  3. QER - Comment of American Public Power Association 7 | Department...

    Energy.gov [DOE] (indexed site)

    Attached are several documents for consideration for the QER Public Meeting on the ... These documents are being submitted herein to demonstrate the importance of the concerns ...

  4. QER- Comment of American Public Power Association 3

    Energy.gov [DOE]

    Attached are APPA’s comments for the Second public QER meeting. I have tried to submit these before too, so please send me a confirmation e-mail. Thanks in advance for your consideration of my request.

  5. QER- Comment of American Public Power Association 4

    Office of Energy Efficiency and Renewable Energy (EERE)

    I am not sure these made the record for the QER either, so I am sending them again. Sorry for all the e-mail, but I want to make sure these documents make the record. Thanks, and please enjoy the rest of your Sunday.

  6. OSTIblog Articles in the American Association for the Advancement...

    Office of Scientific and Technical Information (OSTI)

    web portals, such as: Science Accelerator (DOE resources) Science.gov(U.S. federal agency science information) WorldWideScience.org (global science information) OSTI offers web-b...

  7. QER- Comment of American Public Power Association 2

    Office of Energy Efficiency and Renewable Energy (EERE)

    Attached are APPA’s comments for the first public QER meeting. I have tried to submit these before, so please send me a confirmation e-mail. Thanks in advance for your consideration of my request.

  8. Remarks by Secretary Moniz to the American Association for the...

    Energy.gov [DOE] (indexed site)

    ... And that high-performance computing will soon help support Vice President Biden's cancer taskforce. Science of Energy includes everything from next-generation biofuels, to nuclear ...

  9. American Wind Energy Association Offshore WINDPOWER Conference & Exhibition

    Energy.gov [DOE]

    AWEA Offshore WINDPOWER 2014 Conference & Exhibition is the largest offshore wind energy event in North America. The conference and exhibition will be held at the Atlantic City Convention...

  10. Energy Department and American Public Power Association Sign...

    Energy.gov [DOE] (indexed site)

    and national security benefits of using electricity as a transportation fuel and expanding the electric vehicle (EV) market by bringing utilities directly into the fold. ...

  11. The New American Home 2011

    SciTech Connect

    2010-12-01

    The New American Home® is built annually as a showcase home for the International Builders’ Show® to demonstrate innovative technologies, construction techniques, products, and design trends for the homebuilding industry to use in any new or remodeled home.

  12. American Valve: Order (2010-CW-1411)

    Energy.gov [DOE]

    DOE ordered American Valve, Inc. to pay a $5,000 civil penalty after finding American Valve had failed to certify that certain showerhead models comply with the applicable water conservation standards.

  13. American Samoa Power Authority | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Samoa Power Authority Jump to: navigation, search Name: American Samoa Power Authority Place: American Samoa References: EIA Form EIA-861 Final Data File for 2010 - File1a1 EIA...

  14. American Range: Order (2014-CE-23006)

    Energy.gov [DOE]

    DOE ordered American Range Corporation to pay a $8,000 civil penalty after finding American Range had failed to certify that certain models of cooking products comply with the applicable energy conservation standards.

  15. QER- Comment of American Water

    Office of Energy Efficiency and Renewable Energy (EERE)

    Dear QER Team; Thank you for the opportunity to provide comments to the Quadrennial Energy Review Task Force to discuss the water and energy nexus, advances in water innovative technologies, and the impact of climate change on water issues. On behalf of American Water, I wish to submit the following White Papers which we have prepared on these critical issues: Innovations in Energy Use Sustainability and Resiliency Planning for Water Utilities One Water Water/Energy Correlation The Value of Water Challenges in the Water Industry: Climate Change Challenges in the Water Industry: Meeting Demand in the West Innovation Solutions Within the Water Industry: Desalination Innovation Solutions Within the Water Industry: Going Green Innovation Solutions Within the Water Industry: Water Reuse Bridging the Water Innovation Gap. Founded in 1886, American Water is the largest publicly traded U.S. water and wastewater utility company. With headquarters in Voorhees, NJ, the company employs approximately 6,600 dedicated professionals who provide drinking water, wastewater and other related services to an estimated 14 million people in more than 40 states. Please feel free to contact me if you have any questions or if there is any way American Water can be helpful to your mission. Respectfully Yours, Martin (See attached file: White Papers.pdf) Martin D. Kerckhoff Vice President and Divisional General Counsel Central Division American Water CONFIDENTIAL & PRIVILEGED COMMUNICATION This email and any attachments hereto constitute a legally confidential communication from the Legal Department of American Water. The information contained herein is subject to attorney-client privilege and is for the sole use of the intended original addressee. If you are not the intended original addressee, you are hereby notified that any reading, disclosure, copying, distribution, use, or taking of any action in reliance on the contents contained herein is strictly prohibited. If you have received this

  16. Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor

    SciTech Connect

    Malaviya, Rama; Venosa, Alessandro; Hall, LeRoy; Gow, Andrew J.; Sinko, Patrick J.; Laskin, Jeffrey D.; Laskin, Debra L.

    2012-12-15

    Nitrogen mustard (NM) is a toxic vesicant known to cause damage to the respiratory tract. Injury is associated with increased expression of inducible nitric oxide synthase (iNOS). In these studies we analyzed the effects of transient inhibition of iNOS using aminoguanidine (AG) on NM-induced pulmonary toxicity. Rats were treated intratracheally with 0.125 mg/kg NM or control. Bronchoalveolar lavage fluid (BAL) and lung tissue were collected 1 d28 d later and lung injury, oxidative stress and fibrosis assessed. NM exposure resulted in progressive histopathological changes in the lung including multifocal lesions, perivascular and peribronchial edema, inflammatory cell accumulation, alveolar fibrin deposition, bronchiolization of alveolar septal walls, and fibrosis. This was correlated with trichrome staining and expression of proliferating cell nuclear antigen (PCNA). Expression of heme oxygenase (HO)-1 and manganese superoxide dismutase (Mn-SOD) was also increased in the lung following NM exposure, along with levels of protein and inflammatory cells in BAL, consistent with oxidative stress and alveolar-epithelial injury. Both classically activated proinflammatory (iNOS{sup +} and cyclooxygenase-2{sup +}) and alternatively activated profibrotic (YM-1{sup +} and galectin-3{sup +}) macrophages appeared in the lung following NM administration; this was evident within 1 d, and persisted for 28 d. AG administration (50 mg/kg, 2 /day, 1 d3 d) abrogated NM-induced injury, oxidative stress and inflammation at 1 d and 3 d post exposure, with no effects at 7 d or 28 d. These findings indicate that nitric oxide generated via iNOS contributes to acute NM-induced lung toxicity, however, transient inhibition of iNOS is not sufficient to protect against pulmonary fibrosis. -- Highlights: ? Nitrogen mustard (NM) induces acute lung injury and fibrosis. ? Pulmonary toxicity is associated with increased expression of iNOS. ? Transient inhibition of iNOS attenuates acute lung injury

  17. NREL: North American Renewable Integration Study

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    North American Renewable Integration Study Subscribe Stay up to date on NREL's North American Renewable Integration Study with periodic emails regarding progress and reports. Name*: Organization*: Email*: * Indicates a required field. Submit NREL's North American Renewable Integration Study (NARIS) will analyze pathways to modernize the North American power system through the efficient planning of transmission, generation, and demand. As wind, solar, hydropower, and natural gas continue to grow,

  18. American Vanadium | Energy Systems Integration | NREL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    American Vanadium NREL researchers are collaborating with American Vanadium, an integrated energy storage company, to evaluate and demonstrate the first North American CellCube battery management system. Photo of the American Vanadium CellCube device in a laboratory in the Energy Systems Integration Facility Photo by Dennis Schroeder CellCubes can store megawatts of energy, providing an uninterrupted supply of power from solar and wind power stations, no matter the outdoor conditions. Work at

  19. North American Electric Reliability Corporation Interconnections...

    Energy Saver

    Map of the North American Electric Reliability Corporation Interconnection showing the ... MB) More Documents & Publications Interconnection Transmission Planning: Awards 2009 ...

  20. Clean Energy Manufacturing Initiative: Increasing American Competitive...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Manufacturing Initiative: Increasing American Competitiveness Through Innovation Clean ... Manufacturing Initiative (CEMI), a collaborative effort between the federal government, ...

  1. American Superconductor Corporation AMSC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Superconductor Corporation AMSC Jump to: navigation, search Name: American Superconductor Corporation (AMSC) Place: Westborough, Massachusetts Zip: 15810 Sector: Wind energy...

  2. Competition and Reliability in North American Electricity Markets...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Electricity Markets Technical Workshop Competition and Reliability in North American Electricity Markets Technical Workshop Competition and Reliability in North American ...

  3. Section 1605 Buy American Provision under ARRA | Department of Energy

    Energy Saver

    605 Buy American Provision under ARRA Section 1605 Buy American Provision under ARRA Additional information on the Buy American Provision under ARRA. Section 1605 Buy American Provision under ARRA (9.71 KB) More Documents & Publications Nationwide Limited Public Interest Waiver for LED and HVAC Units Questions and Answers for the Smart Grid Investment Grant Program: Buy American Buy American Guidance Documents

  4. DOE Tour of Zero: The 2016 New American Home by Element Design Build |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy The 2016 New American Home by Element Design Build DOE Tour of Zero: The 2016 New American Home by Element Design Build 1 of 20 Element Design Build constructed this 6,541-square-foot show home in Henderson, Nevada, to the performance criteria of the U.S. Department of Energy Zero Energy Ready Home (ZERH) program. 2 of 20 The home was constructed in partnership with the National Association of Home Builders as The New American Home for 2016. 3 of 20 The two-story

  5. Associate director for Physical and Life Sciences, Lawrence Livermore

    National Nuclear Security Administration (NNSA)

    National Laboratory | National Nuclear Security Administration | (NNSA) Associate director for Physical and Life Sciences, Lawrence Livermore National Laboratory William Goldstein William Goldstein American Association for the Advancement of Science (AAAS) Fellow William Goldstein has been awarded the distinction of American Association for the Advancement of Science (AAAS) Fellow. Election as a fellow is an honor bestowed upon AAAS members by their peers. Goldstein was elected for

  6. Central American geologic map project

    SciTech Connect

    Dengo, G.

    1986-07-01

    During the Northeast Quadrant Panel meeting of the Circum-Pacific Map Project held in Mexico City, February 1985, Central American panel members proposed and adopted plans for compiling a geologic map of Central America, probably at a scale of 1:500,000. A local group with participants from each country was organized and coordinated by Rolando Castillo, director, Central American School of Geology, University of Costa Rica, for the geologic aspects, and Fernando Rudin, director, Geographic Institute of Costa Rica, for the topographic base. In 1956, the US Geological Survey published a geologic map of the region at a scale of 1:1 million. Subsequent topographic and geologic mapping projects have provided a large amount of new data. The entire area is now covered by topographic maps at a scale of 1:50,000, and these maps have been used in several countries as a base for geologic mapping. Another regional map, the Metallogenic Map of Central America (scale = 1:2 million), was published in 1969 by the Central American Research Institute for Industry (ICAITI) with a generalized but updated geologic base map. Between 1969 and 1980, maps for each country were published by local institutions: Guatemala-Belize at 1:500,000, Honduras at 1:500,000, El Salvador at 1:100,000, Nicaragua at 1:1 million, Costa Rica at 1:200,000, and Panama at 1:1 million. This information, in addition to that of newly mapped areas, served as the base for the Central American part of the Geologic-Tectonic Map of the Caribbean Region (scale = 1:2.5 million), published by the US Geological Survey in 1980, and also fro the Northeast Quadrant Maps of the Circum-Pacific Region. The new project also involves bathymetric and geologic mapping of the Pacific and Caribbean margins of the Central American Isthmus. A substantial amount of new information of the Middle America Trench has been acquired through DSDP Legs 67 and 84.

  7. Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene

    SciTech Connect

    Wang, Yang; Xu, Zhidong; Mao, Jian -Hua; Hung, Ming -Szu; Hsieh, David; Au, Alfred; Jablons, David M.; You, Liang

    2015-06-08

    Background: Lung cancer is the leading cause of morbidity and death worldwide. Although the available lung cancer animal models have been informative and further propel our understanding of human lung cancer, they still do not fully recapitulate the complexities of human lung cancer. The pathogenesis of lung cancer remains highly elusive because of its aggressive biologic nature and considerable heterogeneity, compared to other cancers. The association of Cul4A amplification with aggressive tumor growth and poor prognosis has been suggested. Our previous study suggested that Cul4A is oncogenic in vitro, but its oncogenic role in vivo has not been studied. Methods: Viral delivery approaches have been used extensively to model cancer in mouse models. In our experiments, we used Cre-recombinase induced overexpression of the Cul4A gene in transgenic mice to study the role of Cul4A on lung tumor initiation and progression and have developed a new model of lung tumor development in mice harboring a conditionally expressed allele of Cul4A. Results: Here we show that the use of a recombinant adenovirus expressing Cre-recombinase (“AdenoCre”) to induce Cul4A overexpression in the lungs of mice allows controls of the timing and multiplicity of tumor initiation. Following our mouse models, we are able to study the potential role of Cul4A in the development and progression in pulmonary adenocarcinoma as well. Conclusion: Our findings indicate that Cul4A is oncogenic in vivo, and this mouse model is a tool in understanding the mechanisms of Cul4A in human cancers and for testing experimental therapies targeting Cul4A.

  8. Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene

    DOE PAGES [OSTI]

    Wang, Yang; Xu, Zhidong; Mao, Jian -Hua; Hung, Ming -Szu; Hsieh, David; Au, Alfred; Jablons, David M.; You, Liang

    2015-06-08

    Background: Lung cancer is the leading cause of morbidity and death worldwide. Although the available lung cancer animal models have been informative and further propel our understanding of human lung cancer, they still do not fully recapitulate the complexities of human lung cancer. The pathogenesis of lung cancer remains highly elusive because of its aggressive biologic nature and considerable heterogeneity, compared to other cancers. The association of Cul4A amplification with aggressive tumor growth and poor prognosis has been suggested. Our previous study suggested that Cul4A is oncogenic in vitro, but its oncogenic role in vivo has not been studied. Methods:more » Viral delivery approaches have been used extensively to model cancer in mouse models. In our experiments, we used Cre-recombinase induced overexpression of the Cul4A gene in transgenic mice to study the role of Cul4A on lung tumor initiation and progression and have developed a new model of lung tumor development in mice harboring a conditionally expressed allele of Cul4A. Results: Here we show that the use of a recombinant adenovirus expressing Cre-recombinase (“AdenoCre”) to induce Cul4A overexpression in the lungs of mice allows controls of the timing and multiplicity of tumor initiation. Following our mouse models, we are able to study the potential role of Cul4A in the development and progression in pulmonary adenocarcinoma as well. Conclusion: Our findings indicate that Cul4A is oncogenic in vivo, and this mouse model is a tool in understanding the mechanisms of Cul4A in human cancers and for testing experimental therapies targeting Cul4A.« less

  9. North American Natural Gas Markets

    SciTech Connect

    Not Available

    1989-02-01

    This report summarizes die research by an Energy Modeling Forum working group on the evolution of the North American natural gas markets between now and 2010. The group's findings are based partly on the results of a set of economic models of the natural gas industry that were run for four scenarios representing significantly different conditions: two oil price scenarios (upper and lower), a smaller total US resource base (low US resource case), and increased potential gas demand for electric generation (high US demand case). Several issues, such as the direction of regulatory policy and the size of the gas resource base, were analyzed separately without the use of models.

  10. North American Natural Gas Markets

    SciTech Connect

    Not Available

    1988-12-01

    This report sunnnarizes the research by an Energy Modeling Forum working group on the evolution of the North American natural gas markets between now and 2010. The group's findings are based partly on the results of a set of economic models of the natural gas industry that were run for four scenarios representing significantly different conditions: two oil price scenarios (upper and lower), a smaller total US resource base (low US resource case), and increased potential gas demand for electric generation (high US demand case). Several issues, such as the direction of regulatory policy and the size of the gas resource base, were analyzed separately without the use of models.

  11. Lienert named American Welding Society Fellow

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Lienert Named American Welding Society Fellow Lienert named American Welding Society Fellow Lienert was inducted into the American Welding Society's 2012 Class of Fellows during the recent FABTECH meeting in Las Vegas, Nevada. November 29, 2012 Thomas J. Lienert Thomas J. Lienert Thomas J. Lienert has served the welding community and industry with great distinction as an individual who contributed significantly to the knowledge, science, and application of welding. Thomas J. Lienert of the Lab's

  12. The American Jobs Act | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    The American Jobs Act The American Jobs Act September 9, 2011 - 6:30am Addthis Auto industry workers retrain on wind installation in Elyria, Ohio | Energy Department Image | Photo by Quentin Kruger (Contractor) Auto industry workers retrain on wind installation in Elyria, Ohio | Energy Department Image | Photo by Quentin Kruger (Contractor) Secretary Chu Secretary Chu Former Secretary of Energy Last night the President laid out the American Jobs Act, a specific, tangible, bi-partisan strategy

  13. Effects of effluents of coal combustion and gasification upon lung structure and function. Annual report

    SciTech Connect

    Hinton, D.E.

    1980-01-01

    The overall objective of the proposed research is to correlate both structural and functional alterations in cells and tissues of the lung brought about by exposure to fluidized bed combustion and fixed bed gasification effluents and reagent grade oxides of metals known to be associated with coal combustion gasification. Projected milestones are described. Progress during the first year in setting up aerosol exposure facilities, intratracheal instillations, pulmonary mechanics, and morphometric examinations is reported. (DMC)

  14. Role of p53–fibrinolytic system cross-talk in the regulation of quartz-induced lung injury

    SciTech Connect

    Bhandary, Yashodhar P.; Shetty, Shwetha K.; Marudamuthu, Amarnath S.; Fu, Jian; Pinson, Barbara M.; Levin, Jeffrey; Shetty, Sreerama

    2015-03-01

    Silica is the major component of airborne dust generated by wind, manufacturing and/or demolition. Chronic occupational inhalation of silica dust containing crystalline quartz is by far the predominant form of silicosis in humans. Silicosis is a progressive lung disease that typically arises after a very long latency and is a major occupational concern with no known effective treatment. The mechanism of silicosis is not clearly understood. However, silicosis is associated with increased cell death, expression of redox enzymes and pro-fibrotic cytokines and chemokines. Since alveolar epithelial cell (AEC) death and disruption of alveolar fibrinolysis is often associated with both acute and chronic lung injuries, we explored whether p53-mediated changes in the urokinase-type plasminogen activator (uPA) system contributes to silica-induced lung injury. We further sought to determine whether caveolin-1 scaffolding domain peptide (CSP), which inhibits p53 expression, mitigates lung injury associated with exposure to silica. Lung tissues and AECs isolated from wild-type (WT) mice exposed to silica exhibit increased apoptosis, p53 and PAI-1, and suppression of uPA expression. Treatment of WT mice with CSP inhibits PAI-1, restores uPA expression and prevents AEC apoptosis by suppressing p53, which is otherwise induced in mice exposed to silica. The process involves CSP-mediated inhibition of serine-15 phosphorylation of p53 by inhibition of protein phosphatase 2A-C (PP2A-C) interaction with silica-induced caveolin-1 in AECs. These observations suggest that changes in the p53–uPA fibrinolytic system cross-talk contribute to lung injury caused by inhalation of silica dust containing crystalline quartz and is protected by CSP by targeting this pathway. - Highlights: • Chronic exposure to quartz dusts is a major cause of lung injury and silicosis. • The survival of patients with silicosis is bleak due to lack of effective treatments. • This study defines a new role of

  15. North American Biodiesel | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    North American Biodiesel Place: Menmonee Falls, Wisconsin Product: Biodiesel producer currently developing a biodiesel plant in Butler, Wisconsin and with plans to develop another...

  16. Asian American Pacific Islander Heritage Month

    Energy.gov [DOE]

    Generations of Asian Americans and Pacific Islanders (AAPIs) have helped make America what it is today. Their histories recall bitter hardships and proud accomplishments -- from the laborers who...

  17. American Valve: Proposed Penalty (2010-CW-1411)

    Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that American Valve, Inc. failed to certify a variety of showerheads as compliant with the applicable water conservation standards.

  18. American Fusion News | Princeton Plasma Physics Lab

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    American Fusion News General Atomics (GA) December 4, 2012 The Scorpion's Strategy: "Catch and Subdue" December 4, 2012 Frozen Bullets Tame Unruly Edge Plasmas in Fusion Experiment ...

  19. American Lithium Energy Corp | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Lithium Energy Corp Jump to: navigation, search Name: American Lithium Energy Corp Place: San Marcos, California Zip: 92069 Product: California-based developer of lithium ion...

  20. 2005 American Conference on Theoretical Chemistry

    SciTech Connect

    Carter, Emily A

    2006-11-19

    The materials uploaded are meant to serve as final report on the funds provided by DOE-BES to help sponsor the 2005 American Conference on Theoretical Chemistry.

  1. American Wind Manufacturing | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    American Wind Manufacturing Addthis 1 of 9 Nordex USA -- a global manufacturer of wind turbines -- delivered and installed turbine components for the Power County Wind...

  2. New American Home 2011, Orlando, Florida (Brochure)

    SciTech Connect

    Not Available

    2010-12-01

    This brochure details the New American Home 2011, which demonstrates the use of innovative building materials, cutting-edge design, and the latest construction techniques.

  3. North American Biofuels | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Biofuels Jump to: navigation, search Name: North American Biofuels Place: Bohemia, New York Product: Biodiesel eqwuipment manufacturer and producer of biodiesel Coordinates:...

  4. American Capital Energy Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Capital Energy Inc Jump to: navigation, search Name: American Capital Energy Inc Place: North Chelmsford, Massachusetts Zip: 1863 Sector: Services Product: Full-service PV...

  5. Sandia Energy - North American Electric Reliability Corporation...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    North American Electric Reliability Corporation (NERC) Report Posted Home Energy Assurance Infrastructure Security Grid Integration News News & Events Transmission Grid Integration...

  6. American Battery Charging Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Battery Charging Inc Jump to: navigation, search Name: American Battery Charging Inc Place: Smithfield, Rhode Island Zip: 2917 Product: Manufacturer of industrial and railroad...

  7. Americans with Disabilities Act Signed (1990)

    Energy.gov [DOE]

    The Americans with Disabilities Act of 1990 (ADA) prohibits discrimination and ensures equal opportunity for persons with disabilities in employment, State and local government services, public...

  8. American Energy Technologies Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Technologies Inc Jump to: navigation, search Name: American Energy Technologies Inc Place: Wayne, New Jersey Zip: 74700 Product: New Jersey-based clean energy system designer and...

  9. Native American Concerns | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    to: navigation, search Retrieved from "http:en.openei.orgwindex.php?titleNativeAmericanConcerns&oldid612161" Feedback Contact needs updating Image needs updating...

  10. American Distillation Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Distillation Inc Jump to: navigation, search Name: American Distillation Inc. Place: Leland, North Carolina Zip: 28451 Product: Biodiesel producer in North Carolina. References:...

  11. American Solar Electric Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Electric Inc Jump to: navigation, search Name: American Solar Electric Inc Place: Scottsdale, Arizona Zip: 85251 Product: US installer of residential, commercial and industrial PV...

  12. American Energy Systems Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Systems Inc Jump to: navigation, search Name: American Energy Systems Inc Place: Minnesota Zip: 55350 Product: Biofuel burning appliance manufacturer (pellets & corn). References:...

  13. American Process Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Process Inc Jump to: navigation, search Name: American Process Inc Place: Atlanta, Georgia Zip: 30309 Product: Consulting engineering specialist firm dedicated to energy cost...

  14. American Renewable Fuels | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Fuels Jump to: navigation, search Name: American Renewable Fuels Place: Dallas, Texas Zip: TX 75201 Sector: Renewable Energy Product: Developer of commercial scale renewable fuels...

  15. Native American companies receive economic development grants

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Native American VAF Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue: Dec. 2015-Jan. 2016 all issues All Issues submit...

  16. North American Hydro | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hydro Jump to: navigation, search Name: North American Hydro Place: Schofield, Wisconsin Zip: 54476 Sector: Hydro Product: Focused on developing, upgrading, owning, and operating...

  17. American Municipal Power | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Municipal Power Jump to: navigation, search Name: American Municipal Power Place: Columbus, Ohio Zip: 43219 Product: AMP is a non-profit corporation that owns and operates electric...

  18. AMREL American Reliance ARI | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    AMREL American Reliance ARI Jump to: navigation, search Name: AMRELAmerican Reliance (ARI) Place: El Monte, California Zip: 91731 Product: Manufacturer of programmable power...

  19. American Renewables LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Renewables LLC Jump to: navigation, search Name: American Renewables LLC Place: Boston, Massachusetts Sector: Biomass Product: US developer of biomass-fueled power generating...

  20. North American Coating Laboratories | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Coating Laboratories Jump to: navigation, search Name: North American Coating Laboratories Address: 9450 Pineneedle Drive Place: Mentor, Ohio Zip: 44060 Sector: Services, Solar...

  1. 2014 American Energy & Manufacturing Competitiveness Summit in...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Summit. Image: John Harrington, Council on Competitiveness 6 of 10 Local Motors CEO Jay Rogers demonstrates the 3D-printed car during the American Energy & Manufacturing...

  2. American Range: Proposed Penalty (2014-CE-23006)

    Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that American Range Corporation failed to certify cooking products as compliant with the applicable energy conservation standards.

  3. American Hydrogen Corporation | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hydrogen Corporation Jump to: navigation, search Name: American Hydrogen Corporation Address: OU Innovation Center, 340 W State St. Unit 40 Place: Athens, Ohio Zip: 45701 Sector:...

  4. Weatherization Formula Grants - American Recovery and Reinvestment...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    More Documents & Publications Microsoft Word - nDE-FOA-0000051.rtf Weatherization Formula Grants - American Recovery and Reinvestment Act (ARRA) WPN 10-9: Amendment to ...

  5. 2015 American Energy and Manufacturing Competitiveness Summit

    Office of Energy Efficiency and Renewable Energy (EERE)

    The 2015 American Energy & Manufacturing Competitiveness (AEMC) Summit is a gathering of preeminent leaders from industry, academia, labor, the national laboratories, government and media to:

  6. American Energy and Manufacturing Competitiveness Summit

    Office of Energy Efficiency and Renewable Energy (EERE)

    The American Energy and Manufacturing Competitiveness Summit will bring together leaders and perspectives from industry, government, academia, national laboratories, labor, and policy organizations...

  7. Hypo-Elastic Model for Lung Parenchyma

    SciTech Connect

    Freed, Alan D.; Einstein, Daniel R.

    2012-03-01

    A simple elastic isotropic constitutive model for the spongy tissue in lung is derived from the theory of hypoelasticity. The model is shown to exhibit a pressure dependent behavior that has been interpreted by some as indicating extensional anisotropy. In contrast, we show that this behavior arises natural from an analysis of isotropic hypoelastic invariants, and is a likely result of non-linearity, not anisotropy. The response of the model is determined analytically for several boundary value problems used for material characterization. These responses give insight into both the material behavior as well as admissible bounds on parameters. The model is characterized against published experimental data for dog lung. Future work includes non-elastic model behavior.

  8. Polycyclic aromatic hydrocarbons (PAHs): a possible cause of lung cancer mortality among nickel/copper smelter and refinery workers

    SciTech Connect

    Verma, D.K.; Julian, J.A.; Roberts, R.S.; Muir, D.C.; Jadon, N.; Shaw, D.S. )

    1992-05-01

    A retrospective industrial hygiene investigation was undertaken to explain the cause of a statistically significant excess lung cancer mortality observed in a subset of a large cohort of nickel workers involved in mining, smelting, and refining of nickel and copper in Ontario. The focus of this paper is to demonstrate how an industrial hygiene follow-up assessment of an epidemiologic finding can help to identify a likely cause. Polycyclic aromatic hydrocarbons (PAHs) alone or in association with particulate and gaseous contaminants (e.g., SO2) were likely the causative agents of the excess lung cancer observed among the lead welders, cranemen, and arc furnace workers of the copper refinery.

  9. Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile

    SciTech Connect

    Melak, Dawit; Ferreccio, Catterina; Kalman, David; Parra, Roxana; Acevedo, Johanna; Pérez, Liliana; Cortés, Sandra; Smith, Allan H.; Yuan, Yan; Liaw, Jane; Steinmaus, Craig

    2014-01-15

    In humans, ingested inorganic arsenic is metabolized to monomethylarsenic (MMA) then to dimethylarsenic (DMA), although this process is not complete in most people. The trivalent form of MMA is highly toxic in vitro and previous studies have identified associations between the proportion of urinary arsenic as MMA (%MMA) and several arsenic-related diseases. To date, however, relatively little is known about its role in lung cancer, the most common cause of arsenic-related death, or about its impacts on people drinking water with lower arsenic concentrations (e.g., < 200 μg/L). In this study, urinary arsenic metabolites were measured in 94 lung and 117 bladder cancer cases and 347 population-based controls from areas in northern Chile with a wide range of drinking water arsenic concentrations. Lung cancer odds ratios adjusted for age, sex, and smoking by increasing tertiles of %MMA were 1.00, 1.91 (95% confidence interval (CI), 0.99–3.67), and 3.26 (1.76–6.04) (p-trend < 0.001). Corresponding odds ratios for bladder cancer were 1.00, 1.81 (1.06–3.11), and 2.02 (1.15–3.54) (p-trend < 0.001). In analyses confined to subjects only with arsenic water concentrations < 200 μg/L (median = 60 μg/L), lung and bladder cancer odds ratios for subjects in the upper tertile of %MMA compared to subjects in the lower two tertiles were 2.48 (1.08–5.68) and 2.37 (1.01–5.57), respectively. Overall, these findings provide evidence that inter-individual differences in arsenic metabolism may be an important risk factor for arsenic-related lung cancer, and may play a role in cancer risks among people exposed to relatively low arsenic water concentrations. - Highlights: • Urine arsenic metabolites were measured in cancer cases and controls from Chile. • Higher urine %MMA values were associated with increased lung and bladder cancer. • %MMA-cancer associations were seen at drinking water arsenic levels < 200 μg/L.

  10. TH-E-BRF-07: Raman Spectroscopy for Radiation Treatment Response Assessment in a Lung Metastases Mouse Model

    SciTech Connect

    Devpura, S; Barton, K; Brown, S; Siddiqui, F; Chetty, I; Sethi, S; Klein, M

    2014-06-15

    Purpose: Raman spectroscopy is an optical spectroscopic method used to probe chemical information about a target tissue. Our goal was to investigate whether Raman spectroscopy is able to distinguish lung tumors from normal lung tissue and whether this technique can identify the molecular changes induced by radiation. Methods: 4T1 mouse breast cancer cells were implanted subcutaneously into the flanks of 6 Balb/C female mice. Four additional mice were used as “normal lung” controls. After 14 days, 3 mice bearing tumors received 6Gy to the left lung with 6MV photons and the other three were treated as “unirradiated tumor” controls. At a 24-hour time point, lungs were excised and the specimens were sectioned using a cryostat; alternating sections were either stained with hematoxylin and eosin (H and E) for evaluation by a pathologist or unstained for Raman measurements. 240 total Raman spectra were collected; 84 from normal lung controls; 63 from unirradiated tumors and 64 from tumors irradiated with 6Gy in a single fraction. Raman spectra were also collected from normal lung tissues of mice with unirradiated tumors. Principal component analysis (PCA) and discriminant function analysis (DFA) were performed to analyze the data. Results: Raman bands assignable to DNA/RNA showed prominent contributions in tumor tissues while Raman bands associated with hemoglobin showed strong contributions in normal lung tissue. PCA/DFA analysis identified normal lung tissue and tumor with 100% and 98.4% accuracy, respectively, relative to pathologic scoring. Additionally, normal lung tissues from unirradiated mice bearing tumors were classified as normal with 100% accuracy. In a model consisting of unirradiated and irradiated tumors identification accuracy was 79.4% and 93.8% respectively, relative to pathologic assessment. Conclusion: Initial results demonstrate the promise for Raman spectroscopy in the diagnosis normal vs. lung metastases as well as the assessment of

  11. Radiation-Induced Reductions in Regional Lung Perfusion: 0.1-12 Year Data From a Prospective Clinical Study

    SciTech Connect

    Zhang Junan; Ma Jinli; Zhou Sumin; Hubbs, Jessica L.; Wong, Terence Z.; Folz, Rodney J.; Evans, Elizabeth S.; Jaszczak, Ronald J.; Clough, Robert; Marks, Lawrence B.

    2010-02-01

    Purpose: To assess the time and regional dependence of radiation therapy (RT)-induced reductions in regional lung perfusion 0.1-12 years post-RT, as measured by single photon emission computed tomography (SPECT) lung perfusion. Materials/Methods: Between 1991 and 2005, 123 evaluable patients receiving RT for tumors in/around the thorax underwent SPECT lung perfusion scans before and serially post-RT (0.1-12 years). Registration of pre- and post-RT SPECT images with the treatment planning computed tomography, and hence the three-dimensional RT dose distribution, allowed changes in regional SPECT-defined perfusion to be related to regional RT dose. Post-RT follow-up scans were evaluated at multiple time points to determine the time course of RT-induced regional perfusion changes. Population dose response curves (DRC) for all patients at different time points, different regions, and subvolumes (e.g., whole lungs, cranial/caudal, ipsilateral/contralateral) were generated by combining data from multiple patients at similar follow-up times. Each DRC was fit to a linear model, and differences statistically analyzed. Results: In the overall groups, dose-dependent reductions in perfusion were seen at each time post-RT. The slope of the DRC increased over time up to 18 months post-RT, and plateaued thereafter. Regional differences in DRCs were only observed between the ipsilateral and contralateral lungs, and appeared due to tumor-associated changes in regional perfusion. Conclusions: Thoracic RT causes dose-dependent reductions in regional lung perfusion that progress up to {approx}18 months post-RT and persists thereafter. Tumor shrinkage appears to confound the observed dose-response relations. There appears to be similar dose response for healthy parts of the lungs at different locations.

  12. Fifth Annual Native American Housing Conference

    Energy.gov [DOE]

    The Fifth Annual Native American Housing Conference will be held in conjunction with the Native American Economic Development Conference. Attendees will hear from top experts in the housing field on the state of housing in Native America and what programs are available to assist you in taking the next step.

  13. American Cooler Technologies: Order (2013-CE-5305)

    Energy.gov [DOE]

    DOE ordered American Cooler Technologies to pay a $8,000 civil penalty after finding American Cooler Technologies had failed to certify that certain models of walk-in coolers or freezers (WICF) components comply with the applicable energy conservation standards.

  14. American Standard: Order (2013-CW-3001)

    Energy.gov [DOE]

    DOE ordered AS America, Inc., d/b/a American Standard Brands to pay a $8,000 civil penalty after finding American Standard had failed to certify that certain models of water closets comply with the applicable water conservation standards.

  15. A Desk Guide to Buy American Provisions of the American Recovery and Reinvestment Act of 2009

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    a g e | 0 1 A Desk Guide to the Buy American Provisions of the Recovery Act- February 2011 2 A Desk Guide to the Buy American Provisions of the Recovery Act- February 2011 The US Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Buy American team has prepared this desk guide for Award Recipients of EERE Recovery Act Awards to assist them in applying the Buy American provisions 1 of the American Recovery and Reinvestment Act of 2009 (Recovery Act) to EERE awards

  16. Frequently Asked Questions about the Buy American Provisions | Department

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    of Energy Frequently Asked Questions about the Buy American Provisions Frequently Asked Questions about the Buy American Provisions Here you'll find definitions of the terms and acronyms used in the Buy American Provision, as well as answers to frequently asked questions about the Provision. You can find answers to the following questions: What are the Recovery Act Buy American provisions? Do the Buy American provisions apply to all projects funded by the Recovery Act? Do the Buy American

  17. Method and apparatus for measuring lung density by Compton backscattering

    DOEpatents

    Loo, Billy W.; Goulding, Frederick S.

    1991-01-01

    The density of the lung of a patient suffering from pulmonary edema is monitored by irradiating the lung by a single collimated beam of monochromatic photons and measuring the energies of photons Compton backscattered from the lung by a single high-resolution, high-purity germanium detector. A compact system geometry and a unique data extraction scheme are utilized to monimize systematic errors due to the presence of the chestwall and multiple scattering.

  18. Method and apparatus for measuring lung density by Compton backscattering

    DOEpatents

    Loo, B.W.; Goulding, F.S.

    1988-03-11

    The density of the lung of a patient suffering from pulmonary edema is monitored by irradiating the lung by a single collimated beam of monochromatic photons and measuring the energies of photons compton back-scattered from the lung by a single high-resolution, high-purity germanium detector. A compact system geometry and a unique data extraction scheme are utilized to minimize systematic errors due to the presence of the chestwall and multiple scattering. 11 figs., 1 tab.

  19. Leisure time activities related to carcinogen exposure and lung cancer risk in never smokers. A case-control study

    SciTech Connect

    Ruano-Ravina, Alberto; García-Lavandeira, José Antonio; Torres-Durán, María; Prini-Guadalupe, Luciana; Parente-Lamelas, Isaura; Leiro-Fernández, Virginia; Montero-Martínez, Carmen; González-Barcala, Francisco Javier; Golpe-Gómez, Antonio; Martínez, Cristina; Castro-Añón, Olalla; Mejuto-Martí, María José; and others

    2014-07-15

    We aim to assess the relationship between leisure time activities related to exposure to carcinogenic substances and lung cancer risk in a hospital-based case-control study performed in never smokers. We included never smoking cases with anatomopathologically confirmed lung cancer and never smoking controls undergoing trivial surgery, at 8 Spanish hospitals. The study was conducted between January 2011 and June 2013. Participants were older than 30 and had no previous neoplasms. All were personally interviewed focusing on lifestyle, environmental tobacco smoke exposure, occupational history and leisure time activities (including duration of such activities). Results were analyzed through logistic regression and adjusted also by residential radon and education level. We included 513 never smokers, 191 cases and 322 controls. The OR for those performing the studied leisure time activities was 1.43 (95%CI 0.78–2.61). When we restricted the analysis to those performing do-it-yourself activities for more than 10 years the OR was 2.21 (95%CI 0.93–5.27). Environmental tobacco smoke exposure did not modify this association. The effect for the different lung cancer histological types was very close to significance for adenocarcinoma but only when these activities were performed for more than 10 years. We encourage health professionals to recommend protective measures for those individuals while performing these hobbies to reduce the risk of lung cancer. - Highlights: • Some leisure time activities are associated with the exposure to carcinogenic substances. • These activities are model-making, painting (artistic or not), furniture refinishing or wood working. • Few studies have assessed lung cancer risk due to these hobbies and none in never-smokers. • Leisure activities related to exposure to carcinogenic substances present higher lung cancer risk. • The risk is higher when these activities are performed for more than 10 years.

  20. Report to the President on Ensuring American Leadership in Advanced...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    to the President on Ensuring American Leadership in Advanced Manufacturing Report to the President on Ensuring American Leadership in Advanced Manufacturing pcastjune2011.pdf ...

  1. Electric Cooperatives Channel Solar Resources to Rural American...

    Office of Environmental Management (EM)

    Electric Cooperatives Channel Solar Resources to Rural American Communities Electric Cooperatives Channel Solar Resources to Rural American Communities February 4, 2016 - 12:07pm ...

  2. The Smithsonian American Art Museum GATEWAY Demonstration | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Videos The Smithsonian American Art Museum GATEWAY Demonstration The Smithsonian American Art Museum GATEWAY Demonstration View the video about using LEDs in a GATEWAY ...

  3. American Recovery and Reinvestment Act of 2009 | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    American Recovery and Reinvestment Act of 2009 American Recovery and Reinvestment Act of 2009 The full version of the law: "Making supplemental appropriations for job preservation ...

  4. W&M Student Elected to Represent American Physical Society's...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    W&M Student Elected to Represent American Physical Society's Graduate Student Forum W&M Student Elected to Represent American Physical Society's Graduate Student Forum V Gray ...

  5. AE Biofuels Inc formerly American Ethanol Inc | Open Energy Informatio...

    OpenEI (Open Energy Information) [EERE & EIA]

    AE Biofuels Inc formerly American Ethanol Inc Jump to: navigation, search Name: AE Biofuels Inc. (formerly American Ethanol Inc.) Place: Cupertino, California Zip: CA 95014...

  6. Planet Resource Recovery Inc formerly American Biodiesel Fuels...

    OpenEI (Open Energy Information) [EERE & EIA]

    Planet Resource Recovery Inc formerly American Biodiesel Fuels Corp Jump to: navigation, search Name: Planet Resource Recovery, Inc. (formerly American Biodiesel Fuels Corp.)...

  7. American Ref-Fuel of Hempstead Biomass Facility | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Hempstead Biomass Facility Jump to: navigation, search Name American Ref-Fuel of Hempstead Biomass Facility Facility American Ref-Fuel of Hempstead Sector Biomass Facility Type...

  8. University of Michigan Wins North American Solar Challenge -...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    University of Michigan Wins North American Solar Challenge July 27, 2005 Calgary, Alberta, Canada - The University of Michigan won a highly-competitive 2005 North American Solar ...

  9. Department of Energy Helping Americans Find Alternative Fuel...

    Office of Environmental Management (EM)

    Helping Americans Find Alternative Fuel Stations Department of Energy Helping Americans Find ... to find fuel stations, post custom fueling location maps on their own websites, ...

  10. American Samoa Recovery Act State Memo | Department of Energy

    Energy.gov [DOE] (indexed site)

    The American Recovery & Reinvestment Act (ARRA) is making a meaningful down payment on the nation's energy and environmental future. The Recovery Act investments in American Samoa ...

  11. AMERICAN SAMOA RECOVERY ACT SNAPSHOT | Department of Energy

    Energy.gov [DOE] (indexed site)

    American Samoa are supporting a broad range of clean energy projects, from energy efficiency and the smart grid to solar power and biofuels. Through these investments, American ...

  12. Wind Projects on Native American Lands | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Native American Wind Issues Need for Energy Self-Sufficiency Although often rich in natural resources, Native American communities are the poorest in America. Their communities...

  13. Los Alamos scientists selected as American Chemical Society Fellows

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    American Chemical Society Fellows Los Alamos scientists selected as American Chemical Society Fellows Rebecca Chamberlin and Donivan Porterfield have been selected as a 2014 ...

  14. Los Alamos researcher named as American Chemical Society Fellow

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Researcher named American Chemical Society Fellow Los Alamos researcher named as American Chemical Society Fellow Kristin Omberg named for her contributions to national security as ...

  15. Scientist Named an American Chemical Society Fellow - News Releases...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Scientist Named an American Chemical Society Fellow September 1, 2010 Helena Chum Dr. Helena Chum was named a 2010 Fellow by the American Chemical Society. Dr. Helena Chum, ...

  16. EIS-0468: American Centrifuge Plant, Piketon, Ohio | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    68: American Centrifuge Plant, Piketon, Ohio EIS-0468: American Centrifuge Plant, Piketon, Ohio Summary This EIS evaluates the environmental impacts of construction, operation, and ...

  17. 2016 American Society of Heating, Refrigerating, and Air-Conditioning...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2016 American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE) Winter Conference 2016 American Society of Heating, Refrigerating, and Air-Conditioning...

  18. Society of American Military Engineers (SAME) Small Business...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Society of American Military Engineers (SAME) Small Business Conference Society of American Military Engineers (SAME) Small Business Conference November 4, 2015 9:00AM EST to...

  19. Laboratory Demonstration of a New American Low-Head Hydropower...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Laboratory Demonstration of a New American Low-Head Hydropower Turbine Laboratory Demonstration of a New American Low-Head Hydropower Turbine Laboratory Demonstration of a New ...

  20. American Society of Heating, Refrigeration, and Air Condition...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    American Society of Heating, Refrigeration, and Air Condition Engineers (ASHRAE) 2016 Annual Conference American Society of Heating, Refrigeration, and Air Condition Engineers ...

  1. State Energy Efficient Appliance Rebate Program (SEEARP) American...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    (SEEARP) American Recovery and Reinvestment Act (ARRA) Funding Opportunity Number: DE-FOA-0000119 State Energy Efficient Appliance Rebate Program (SEEARP) American Recovery and ...

  2. 2016 American Council for an Energy-Efficient Economy (ACEEE...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2016 American Council for an Energy-Efficient Economy (ACEEE) Energy Efficiency Finance Forum 2016 American Council for an Energy-Efficient Economy (ACEEE) Energy Efficiency ...

  3. Powerpoint Presentation: Fossil Energy R&D American Recovery...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Powerpoint Presentation: Fossil Energy R&D American Recovery & Reinvestment Act Projects Powerpoint Presentation: Fossil Energy R&D American Recovery & Reinvestment Act Projects A ...

  4. EERE National Lab Impact Summit: Driving American Energy Innovation...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    EERE National Lab Impact Summit: Driving American Energy Innovation and Competitiveness EERE National Lab Impact Summit: Driving American Energy Innovation and Competitiveness ...

  5. Memorandum of American High-Performance Buildings Coalition DOE...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Memorandum of American High-Performance Buildings Coalition DOE Meeting August 19, 2013 Memorandum of American High-Performance Buildings Coalition DOE Meeting August 19, 2013 This ...

  6. New Energy Efficiency Standards to Help Americans Save Money...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    to Help Americans Save Money by Saving Energy, Cut Carbon Pollution New Energy Efficiency Standards to Help Americans Save Money by Saving Energy, Cut Carbon Pollution December 31, ...

  7. Product Standards Team Saves American Consumers Energy, Money...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Product Standards Team Saves American Consumers Energy, Money Product Standards Team Saves American Consumers Energy, Money May 5, 2016 - 10:33am Addthis Amped Up magazine ...

  8. Solar Thin Films Inc formerly American United Global Inc | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    Films Inc formerly American United Global Inc Jump to: navigation, search Name: Solar Thin Films Inc (formerly American United Global Inc) Place: New York, New York Zip: 10038...

  9. EA-200 American Electric Power Service Corporation | Department...

    Energy Saver

    EA-200 American Electric Power Service Corporation (37.37 KB) More Documents & Publications EA-200-A American Electric Power Service Corporation EA-249 Exelon Generation Company ...

  10. A Proclamation: President Obama on National African American...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    men and women who took extraordinary risks to change our Nation for the better. During National African American History Month, we celebrate the rich legacy of African Americans...

  11. Celebrating National Native American Heritage Month at the Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    film series for Native American Heritage Month, co-presented by the Smithsonian's National Museum of the American Indian. Employees and contractors from the Department of...

  12. Scientific American: "Tall Trees Sucked Dry by Global Warming...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Scientific American: "Tall Trees Sucked Dry by Global Warming" Scientific American: "Tall Trees Sucked Dry by Global Warming" Climate change will challenge tall trees like ...

  13. Scientific American: "Tall Trees Sucked Dry by Global Warming...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Scientific American: "Tall Trees Sucked Dry by Global Warming" June 7, 2015 Scientific American: "Tall Trees Sucked Dry by Global Warming" A well-known scientific principle ...

  14. Etna Resources soon to be Pan American Lithium | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Etna Resources soon to be Pan American Lithium Jump to: navigation, search Name: Etna Resources (soon to be Pan American Lithium) Place: Vancouver, British Columbia, Canada Zip:...

  15. DOE American Indian and Alaska Natives Tribal Government Policy...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    American Indian and Alaska Natives Tribal Government Policy DOE American Indian and Alaska Natives Tribal Government Policy This Policy sets forth the principles to be followed by ...

  16. Frequency Control Concerns in the North American Electric Power...

    Office of Scientific and Technical Information (OSTI)

    Frequency Control Concerns in the North American Electric Power System Citation Details In-Document Search Title: Frequency Control Concerns in the North American Electric Power ...

  17. American Transmission Company LLC II Smart Grid Project | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    your syntax: * Display map References ARRA Smart Grid Investment Grants1 American Transmission Smart Grid2 American Transmission Company, LLC has been selected by the U.S....

  18. North American SynchroPhasor Initiative (NASPI) Technical Report...

    Energy Saver

    Phasor Tools Visualization North American SynchroPhasor Initiative (NASPI) Technical Report - Phasor Tools Visualization This technical report was developed by the North American ...

  19. Announcing the American Indian Research and Education Initiative...

    Office of Environmental Management (EM)

    Bill Valdez Bill Valdez Director of Workforce Management A new pilot program to connect Department of Energy Resources with American Indian students American Indian communities are ...

  20. DOE Awards Native American, Tribally-Owned Small Business Contract...

    Energy Saver

    Native American, Tribally-Owned Small Business Contract for Support Services to Savannah River Operations Office DOE Awards Native American, Tribally-Owned Small Business Contract ...

  1. Sino American Silicon Products Inc SAS | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Sino American Silicon Products Inc SAS Jump to: navigation, search Name: Sino-American Silicon Products Inc (SAS) Place: Hsinchu, Taiwan, Taiwan Product: Taiwan-based manufacturer...

  2. Sandia Energy - American Physical Society Names Four Sandians...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    News News & Events Research & Capabilities Systems Analysis Materials Science American Physical Society Names Four Sandians as Fellows Previous Next American Physical...

  3. American Windmill Museum Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Windmill Museum Wind Farm Jump to: navigation, search Name American Windmill Museum Wind Farm Facility American Windmill Museum Sector Wind energy Facility Type Community Wind...

  4. Phoenix American Rooftop Solar Technologies | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    American Rooftop Solar Technologies Jump to: navigation, search Name: Phoenix American Rooftop Solar Technologies Place: Michigan Zip: 48168 Sector: Solar Product: Manufacturer of...

  5. American Canyon Power Plant Biomass Facility | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Canyon Power Plant Biomass Facility Jump to: navigation, search Name American Canyon Power Plant Biomass Facility Facility American Canyon Power Plant Sector Biomass Facility Type...

  6. Energy Department Authorizes American LNG Marketing LLC's Application...

    Energy Saver

    American LNG Marketing LLC's Application to Export Liquefied Natural Gas Energy Department Authorizes American LNG Marketing LLC's Application to Export Liquefied Natural Gas ...

  7. american museum of science and energy | National Nuclear Security...

    National Nuclear Security Administration (NNSA)

    american museum of science and energy | National Nuclear Security Administration Facebook ... Apply for Our Jobs Our Jobs Working at NNSA Blog Home american museum of science and ...

  8. Opportunity Assessment Clean Diesels in the North American Light...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Opportunity Assessment Clean Diesels in the North American Light Duty Market Opportunity Assessment Clean Diesels in the North American Light Duty Market Presentation given at the ...

  9. Competition and Reliability in North American Energy Markets...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Markets: Issue Paper Synopses Competition and Reliability in North American Energy ... effect on the reliability of the North American power system and constitute the ...

  10. Diesel Engine Strategy & North American Market Challenges, Technology...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Strategy & North American Market Challenges, Technology and Growth Diesel Engine Strategy & North American Market Challenges, Technology and Growth Presentation given at the 2007 ...

  11. North American Market Challenges for Diesel Engines | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    North American Market Challenges for Diesel Engines North American Market Challenges for Diesel Engines 2004 Diesel Engine Emissions Reduction (DEER) Conference Presentation: Gale ...

  12. Submit a Buy American Complaint | Department of Energy

    Energy.gov [DOE] (indexed site)

    Resources Section 1605 of the American Recovery and Reinvestment Act of 2009 sets forth the Buy American requirements for recipients of Recovery Act financial assistance,...

  13. DOE Announces Cooperative Agreement with USEC for American Centrifuge...

    Office of Environmental Management (EM)

    Cooperative Agreement with USEC for American Centrifuge Demonstration Project DOE Announces Cooperative Agreement with USEC for American Centrifuge Demonstration Project March 23, ...

  14. DOE Announces Cooperative Agreement with USEC for American Centrifuge...

    Energy.gov [DOE] (indexed site)

    for the continued development and demonstration of the American Centrifuge technology. ... DOE Announces Cooperative Agreement with USEC for American Centrifuge Demonstration ...

  15. American Recovery and Reinvestment Act of 2009: Bioenergy Technologies...

    Office of Environmental Management (EM)

    American Recovery and Reinvestment Act of 2009: Bioenergy Technologies Office Investments American Recovery and Reinvestment Act of 2009: Bioenergy Technologies Office Investments ...

  16. Cerium-144-induced lung gumors in two strains of mice

    SciTech Connect

    Hahn, F.F.; Griffith, W.C.

    1995-12-01

    A major problem in the extrapolation of radiation cancer risk factors from one species or population to another is the choice of the risk model to use, either absolute or relative. The purpose of this study was to compare absolute and relative risk models in predicting the lung-tumor risks between a low lung-tumor incidence strain of mice and a high-incidence strain of mice. The conclusion from this study is that absolute risk is more accurate than relative risk for predicting lung tumor risk from high to low lung-tumor incidence strains of mice.

  17. Residential Mobility and Lung Cancer Risk: Data-Driven Exploration Using Internet Sources

    SciTech Connect

    Yoon, Hong-Jun; Tourassi, Georgia; Xu, Songhua

    2015-01-01

    Frequent relocation has been linked to health decline, particularly with respect to emotional and psychological wellbeing. In this paper we investigate whether there is an association between frequent relocation and lung cancer risk. For the initial investigation we leverage two online data sources to collect cancer and control subjects using web crawling and tailored text mining. The two data sources share different strengths and weaknesses in terms of the amount of detail, population representation, and sample size. One data source includes online obituaries. The second data source includes augmented LinkedIn profiles. For each data source, the subjects spatiotemporal history is reconstructed from the available information provided in the obituaries and from the education and work experience provided in the LinkedIn profiles. The study shows that lung cancer subjects have higher mobility frequency than the control group. This trend is consistent for both data sources.

  18. Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans

    SciTech Connect

    Lingappan, Krithika; Jiang, Weiwu; Wang, Lihua; Couroucli, Xanthi I.; Barrios, Roberto; Moorthy, Bhagavatula

    2013-10-15

    Sex-specific differences in pulmonary morbidity in humans are well documented. Hyperoxia contributes to lung injury in experimental animals and humans. The mechanisms responsible for sex differences in the susceptibility towards hyperoxic lung injury remain largely unknown. In this investigation, we tested the hypothesis that mice will display sex-specific differences in hyperoxic lung injury. Eight week-old male and female mice (C57BL/6J) were exposed to 72 h of hyperoxia (FiO{sub 2} > 0.95). After exposure to hyperoxia, lung injury, levels of 8-iso-prostaglandin F{sub 2} alpha (8-iso-PGF 2α) (LC–MS/MS), apoptosis (TUNEL) and inflammatory markers (suspension bead array) were determined. Cytochrome P450 (CYP)1A expression in the lung was assessed using immunohistochemistry and western blotting. After exposure to hyperoxia, males showed greater lung injury, neutrophil infiltration and apoptosis, compared to air-breathing controls than females. Pulmonary 8-iso-PGF 2α levels were higher in males than females after hyperoxia exposure. Sexually dimorphic increases in levels of IL-6 (F > M) and VEGF (M > F) in the lungs were also observed. CYP1A1 expression in the lung was higher in female mice compared to males under hyperoxic conditions. Overall, our results support the hypothesis that male mice are more susceptible than females to hyperoxic lung injury and that differences in inflammatory and oxidative stress markers contribute to these sex-specific dimorphic effects. In conclusion, this paper describes the establishment of an animal model that shows sex differences in hyperoxic lung injury in a temporal manner and thus has important implications for lung diseases mediated by hyperoxia in humans. - Highlights: • Male mice were more susceptible to hyperoxic lung injury than females. • Sex differences in inflammatory markers were observed. • CYP1A expression was higher in females after hyperoxia exposure.

  19. Lung deformations and radiation-induced regional lung collapse in patients treated with stereotactic body radiation therapy

    SciTech Connect

    Diot, Quentin Kavanagh, Brian; Vinogradskiy, Yevgeniy; Gaspar, Laurie; Miften, Moyed; Garg, Kavita

    2015-11-15

    Purpose: To differentiate radiation-induced fibrosis from regional lung collapse outside of the high dose region in patients treated with stereotactic body radiation therapy (SBRT) for lung tumors. Methods: Lung deformation maps were computed from pre-treatment and post-treatment computed tomography (CT) scans using a point-to-point translation method. Fifty anatomical landmarks inside the lung (vessel or airway branches) were matched on planning and follow-up scans for the computation process. Two methods using the deformation maps were developed to differentiate regional lung collapse from fibrosis: vector field and Jacobian methods. A total of 40 planning and follow-ups CT scans were analyzed for 20 lung SBRT patients. Results: Regional lung collapse was detected in 15 patients (75%) using the vector field method, in ten patients (50%) using the Jacobian method, and in 12 patients (60%) by radiologists. In terms of sensitivity and specificity the Jacobian method performed better. Only weak correlations were observed between the dose to the proximal airways and the occurrence of regional lung collapse. Conclusions: The authors presented and evaluated two novel methods using anatomical lung deformations to investigate lung collapse and fibrosis caused by SBRT treatment. Differentiation of these distinct physiological mechanisms beyond what is usually labeled “fibrosis” is necessary for accurate modeling of lung SBRT-induced injuries. With the help of better models, it becomes possible to expand the therapeutic benefits of SBRT to a larger population of lung patients with large or centrally located tumors that were previously considered ineligible.

  20. Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress

    SciTech Connect

    Sunil, Vasanthi R.; Patel-Vayas, Kinal; Shen, Jianliang; Laskin, Jeffrey D.; Laskin, Debra L.

    2012-09-01

    Ozone is a pulmonary irritant known to cause oxidative stress, inflammation and tissue injury. Evidence suggests that macrophages play a role in the pathogenic response; however, their contribution depends on the mediators they encounter in the lung which dictate their function. In these studies we analyzed the effects of ozone-induced oxidative stress on the phenotype of alveolar macrophages (AM). Exposure of rats to ozone (2 ppm, 3 h) resulted in increased expression of 8-hydroxy-2?-deoxyguanosine (8-OHdG), as well as heme oxygenase-1 (HO-1) in AM. Whereas 8-OHdG was maximum at 24 h, expression of HO-1 was biphasic increasing after 3 h and 4872 h. Cleaved caspase-9 and beclin-1, markers of apoptosis and autophagy, were also induced in AM 24 h post-ozone. This was associated with increased bronchoalveolar lavage protein and cells, as well as matrix metalloproteinase (MMP)-2 and MMP-9, demonstrating alveolar epithelial injury. Ozone intoxication resulted in biphasic activation of the transcription factor, NF?B. This correlated with expression of monocyte chemotactic protein?1, inducible nitric oxide synthase and cyclooxygenase?2, markers of proinflammatory macrophages. Increases in arginase-1, Ym1 and galectin-3 positive anti-inflammatory/wound repair macrophages were also observed in the lung after ozone inhalation, beginning at 24 h (arginase-1, Ym1), and persisting for 72 h (galectin-3). This was associated with increased expression of pro-surfactant protein-C, a marker of Type II cell proliferation and activation, important steps in wound repair. These data suggest that both proinflammatory/cytotoxic and anti-inflammatory/wound repair macrophages are activated early in the response to ozone-induced oxidative stress and tissue injury. -- Highlights: ? Lung macrophages are highly sensitive to ozone induced oxidative stress. ? Ozone induces autophagy and apoptosis in lung macrophages. ? Proinflammatory and wound repair macrophages are activated early after ozone

  1. New American Home 2008: Orlando, Florida

    SciTech Connect

    Not Available

    2007-12-01

    Each year, The New American home demonstrates innovative building materials, cutting-edge design, and the latest construction techniques. It provides production homebuilders with an example for producing more energy-efficient, durable homes without sacrificing style. This year, The New American Home celebrates its 25th anniversary. The New American Home is the official showcase house of the annual International Builders' Show, and is a for-sale product. Most features and innovations in the home are accessible to builders and consumers for integration into their own home.

  2. British American Business | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    British American Business British American Business November 20, 2007 - 4:45pm Addthis Remarks as Prepared for Secretary Bodman Thank you. It's a pleasure to be back speaking to the members of British-American Business. I want to thank Peter Hunt for convening this event and for inviting me to be a part of it. I'm winding up a trip that began in Rome at the World Energy Conference where I and six of my fellow Energy Ministers from around the world shared our views on how to increase the world's

  3. Dose impact in radiographic lung injury following lung SBRT: Statistical analysis and geometric interpretation

    SciTech Connect

    Yu, Victoria; Kishan, Amar U.; Cao, Minsong; Low, Daniel; Lee, Percy; Ruan, Dan

    2014-03-15

    Purpose: To demonstrate a new method of evaluating dose response of treatment-induced lung radiographic injury post-SBRT (stereotactic body radiotherapy) treatment and the discovery of bimodal dose behavior within clinically identified injury volumes. Methods: Follow-up CT scans at 3, 6, and 12 months were acquired from 24 patients treated with SBRT for stage-1 primary lung cancers or oligometastic lesions. Injury regions in these scans were propagated to the planning CT coordinates by performing deformable registration of the follow-ups to the planning CTs. A bimodal behavior was repeatedly observed from the probability distribution for dose values within the deformed injury regions. Based on a mixture-Gaussian assumption, an Expectation-Maximization (EM) algorithm was used to obtain characteristic parameters for such distribution. Geometric analysis was performed to interpret such parameters and infer the critical dose level that is potentially inductive of post-SBRT lung injury. Results: The Gaussian mixture obtained from the EM algorithm closely approximates the empirical dose histogram within the injury volume with good consistency. The average Kullback-Leibler divergence values between the empirical differential dose volume histogram and the EM-obtained Gaussian mixture distribution were calculated to be 0.069, 0.063, and 0.092 for the 3, 6, and 12 month follow-up groups, respectively. The lower Gaussian component was located at approximately 70% prescription dose (35 Gy) for all three follow-up time points. The higher Gaussian component, contributed by the dose received by planning target volume, was located at around 107% of the prescription dose. Geometrical analysis suggests the mean of the lower Gaussian component, located at 35 Gy, as a possible indicator for a critical dose that induces lung injury after SBRT. Conclusions: An innovative and improved method for analyzing the correspondence between lung radiographic injury and SBRT treatment dose has

  4. Continuous Positive Airway Pressure for Motion Management in Stereotactic Body Radiation Therapy to the Lung: A Controlled Pilot Study

    SciTech Connect

    Goldstein, Jeffrey D.; Lawrence, Yaacov R.; Appel, Sarit; Landau, Efrat; Ben-David, Merav A.; Rabin, Tatiana; Benayun, Maoz; Dubinski, Sergey; Weizman, Noam; Alezra, Dror; Gnessin, Hila; Goldstein, Adam M.; Baidun, Khader; Segel, Michael J.; Peled, Nir; Symon, Zvi

    2015-10-01

    Objective: To determine the effect of continuous positive airway pressure (CPAP) on tumor motion, lung volume, and dose to critical organs in patients receiving stereotactic body radiation therapy (SBRT) for lung tumors. Methods and Materials: After institutional review board approval in December 2013, patients with primary or secondary lung tumors referred for SBRT underwent 4-dimensional computed tomographic simulation twice: with free breathing and with CPAP. Tumor excursion was calculated by subtracting the vector of the greatest dimension of the gross tumor volume (GTV) from the internal target volume (ITV). Volumetric and dosimetric determinations were compared with the Wilcoxon signed-rank test. CPAP was used during treatment if judged beneficial. Results: CPAP was tolerated well in 10 of the 11 patients enrolled. Ten patients with 18 lesions were evaluated. The use of CPAP decreased tumor excursion by 0.5 ± 0.8 cm, 0.4 ± 0.7 cm, and 0.6 ± 0.8 cm in the superior–inferior, right–left, and anterior–posterior planes, respectively (P≤.02). Relative to free breathing, the mean ITV reduction was 27% (95% confidence interval [CI] 16%-39%, P<.001). CPAP significantly augmented lung volume, with a mean absolute increase of 915 ± 432 cm{sup 3} and a relative increase of 32% (95% CI 21%-42%, P=.003), contributing to a 22% relative reduction (95% CI 13%-32%, P=.001) in mean lung dose. The use of CPAP was also associated with a relative reduction in mean heart dose by 29% (95% CI 23%-36%, P=.001). Conclusion: In this pilot study, CPAP significantly reduced lung tumor motion compared with free breathing. The smaller ITV, the planning target volume (PTV), and the increase in total lung volume associated with CPAP contributed to a reduction in lung and heart dose. CPAP was well tolerated, reproducible, and simple to implement in the treatment room and should be evaluated further as a novel strategy for motion management in radiation therapy.

  5. North American Leaders Summit: Energy Deliverables | Department...

    Energy Saver

    North American Leaders Summit: Energy Deliverables August 10, 2009 - 12:00am Addthis Energy and climate change will be an important element of the trilateral discussions at the ...

  6. American Recovery and Reinvestment Act, Financial Assistance...

    Energy.gov [DOE] (indexed site)

    American Recovery and Reinvestment Act, Financial Assistance Award: 212 Degrees Consulting, LLC, Las Vegas, Nevada. Award No. DE-FC36-10GO10589, Notice of Financial Assistance ...

  7. American Standard: Proposed Penalty (2013-CW-3001)

    Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that AS America, Inc., d/b/a American Standard Brands failed to certify a variety of water closets as compliant with the applicable water conservation standards.

  8. EIS-0468: American Centrifuge Plant, Piketon, Ohio

    Energy.gov [DOE]

    This EIS evaluates the environmental impacts of construction, operation, and decommissioning of the American Centrifuge Plant (ACP), located on DOE reservation in Piketon, Ohio. (DOE adopted this EIS issued by the Nuclear Regulatory Commission on 02/16/2011.)

  9. MidAmerican Energy Commercial Rebate Program

    Energy.gov [DOE]

    MidAmerican Energy offers a variety of incentives for commercial customers to improve the energy efficiency of facilities. Rebates are generally available to both gas and electric customers....

  10. Organization of Chinese Americans Federal Leadership Training

    Energy.gov [DOE]

    The Organization of Chinese Americans (OCA) will hold its Federal Leadership Training (FLT) on July 18-19, 2013, during its National Convention in Washington, D.C.  The theme of this year’s...

  11. Transforming the American Economy Through Innovation

    Energy.gov [DOE]

    Secretary Chu joins Vice President Joe Biden as he details the role the Recovery Act has played in funding innovation that will help build a foundation for a more robust and competitive American...

  12. American PowerNet | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    PowerNet Jump to: navigation, search Name: American PowerNet Place: Pennsylvania Phone Number: (877) 977-2636 Website: www.americanpowernet.com Outage Hotline: (877) 977-2636...

  13. American Transmission Company LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    LLC Jump to: navigation, search Name: American Transmission Company LLC Place: Waukesha, WI References: SGIC1 This article is a stub. You can help OpenEI by expanding it....

  14. American Process—Alpena Biorefinery Lessons

    Energy.gov [DOE]

    Breakout Session 1D—Building Market Confidence and Understanding I: Integrated Biorefinery (Lessons Learned and Best Practices) American Process—Alpena Biorefinery Lessons Theodora Retsina, Chief Executive Officer, America Process Inc.

  15. American Power: Proposed Penalty (2010-CE-0911)

    Energy.gov [DOE]

    DOE alleged in a Notice of Proposed Civil Penalty that American Power Solutions, Inc. failed to certify a general service fluorescent lamp as compliant with the applicable energy conservation standards.

  16. Asian American Government Executives Network (AAGEN), Annual...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Asian American Government Executives Network (AAGEN), Annual Leadership Development Training June 16, 2016 7:30AM to 4:00PM EDT Location: Crystal City Double Tree Hotel, 300 Army ...

  17. American Electric Vehicles, Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Inc Jump to: navigation, search Name: American Electric Vehicles, Inc Address: P.O. Box 509 707 County Line Rd. Place: Palmer Lake, CO Zip: 80133 Region: Rockies Area...

  18. American Tower Company | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Company Jump to: navigation, search Name: American Tower Company Address: P.O. Box 29 Place: Shelby, Ohio Zip: 44875 Sector: Wind energy Product: Agriculture;Business and legal...

  19. Frequency Instability Problems in North American Interconnections

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Frequency Instability Problems in North American Interconnections May 1, 2011 DOE/NETL-2011/1473 Frequency Instability Problems in North American Interconnections Disclaimer This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness

  20. Smart Manufacturing: Transforming American Manufacturing with Information

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Technology | Department of Energy Smart Manufacturing: Transforming American Manufacturing with Information Technology Smart Manufacturing: Transforming American Manufacturing with Information Technology June 30, 2016 - 4:30pm Addthis Watch the video above to learn more about how technologies developed by the smart manufacturing institute will make U.S. manufacturing more productive, energy efficient, and competitive. Our country is known for its culture of innovation. We are a country of

  1. North American Electric Reliability Corporation (NERC): Reliability

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Considerations from the Integration of Smart Grid | Department of Energy (NERC): Reliability Considerations from the Integration of Smart Grid North American Electric Reliability Corporation (NERC): Reliability Considerations from the Integration of Smart Grid North American Electric Reliability Corporation (NERC): Reliability Considerations from the Integration of Smart Grid. NERC develops and enforces Reliability Standards; assesses adequacy annually via a ten-year forcast and winter and

  2. American Energy and Manufacturing Competitiveness Summit

    Energy.gov [DOE]

    The 2015 American Energy and Manufacturing Competitiveness Summit will be hosted September 15–16; this gathering of preeminent leaders from industry, academia, labor, the national laboratories, government, and media aims to increase American competitiveness in clean energy and manufacturing. Bioenergy Technologies Office Technology Manager Jay Fitzgerald will be representing the Office, and the Lawrence Berkeley National Lab will be exhibiting a special hands-on demonstration of the latest bioenergy equipment, models, and other research, development, and demonstration tools.

  3. Native American Renewable Energy Program Development

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    American Renewable Energy Program Development November 17, 2003 Sandra Begay-Campbell Principal Member of the Technical Staff Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under contract DE-AC04-94AL85000. Native American RE activities featured in Sandia Technology Quarterly & Lockheed Martin Customer Focus Newsletter Sandra Begay-Campbell with two Navajo electrical technicians checking an NTUA PV

  4. Moore named an American Statistical Society Fellow

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Moore named an American Statistical Society Fellow Moore named an American Statistical Society Fellow The ASA inducted Leslie (Lisa) Moore as a Fellow at the 2014 Joint Statistical Meetings. October 8, 2014 Leslie (Lisa) Moore Leslie (Lisa) Moore ASA cited Moore for "seminal and creative research on the design of computer experiments; for statistical collaboration on a wide range of problems of scientific and national importance; and for mentoring statisticians and statistical

  5. Hobart named American Chemical Society Fellow

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Hobart named American Chemical Society Fellow August 21, 2013 David Hobart, long-time Chemistry Division employee and current affiliate in the National Security Education Center (NSEC), has been elected to Fellow of the American Chemical Society (ACS). The ACS honored him for his significant contributions to f-element science. The f-elements are those that have electrons in their f orbitals (lanthanides and the actinides). The ACS noted that Hobart contributed the reduction potential for the

  6. Boosting Native American students' math scores

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Boosting Native American students' math scores Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue:November 2, 2016 all issues All Issues » submit Boosting Native American students' math scores Professional development opportunities for teachers provide essential foundation May 5, 2014 Mara Herrera teaches a young student at San Felipe Pueblo Elementary School. Mara Herrera teaches a young student at San Felipe Pueblo Elementary School.

  7. Categorical Exclusion Determinations: Native American and Alaskan Native Area

    Energy.gov [DOE]

    Categorical Exclusion Determinations issued for actions in Native American and/or Alaskan Native areas.

  8. President Obama Proclaims November National Native American Heritage Month

    Energy.gov [DOE]

    Read the Presidential Proclamation designating November 2013 National Native American Heritage Month.

  9. Ethanol Pathways in the 2050 North American Transportation Futures Study

    SciTech Connect

    2009-01-18

    A paper discussing the various ethanol pathways in the 2050 North American Transportation Futures Study

  10. Clean Cities: North Dakota Clean Cities coalition

    Alternative Fuels and Advanced Vehicles Data Center

    Clean Cities. Moffitt is the communications director for the Clean Fuel & Vehicle Technology program of the American Lung Association of the Upper Midwest. He joined the...

  11. Lisa Thurstin

    Energy.gov [DOE]

    Lisa Thurstin is the coordinator for the Twin Cities Clean Cities coalition, which is based out of the American Lung Association of the Upper Midwest.

  12. Students' Association

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Students' Association Students' Association Explore the multiple dimensions of a career at Los Alamos Lab: work with the best minds on the planet in an inclusive environment that is rich in intellectual vitality and opportunities for growth. Contact Students' Association Executive Board Email Students' Association provides support, resources The Lab has hosted students at various levels of their education since it was founded more than 60 years ago, and student programs continue to grow and

  13. Aryl hydrocarbon receptor protects lung adenocarcinoma cells against cigarette sidestream smoke particulates-induced oxidative stress

    SciTech Connect

    Cheng, Ya-Hsin; Huang, Su-Chin; Lin, Chun-Ju; Cheng, Li-Chuan; Li, Lih-Ann

    2012-03-15

    Environmental cigarette smoke has been suggested to promote lung adenocarcinoma progression through aryl hydrocarbon receptor (AhR)-signaled metabolism. However, whether AhR facilitates metabolic activation or detoxification in exposed adenocarcinoma cells remains ambiguous. To address this question, we have modified the expression level of AhR in two human lung adenocarcinoma cell lines and examined their response to an extract of cigarette sidestream smoke particulates (CSSP). We found that overexpression of AhR in the CL1-5 cell line reduced CSSP-induced ROS production and oxidative DNA damage, whereas knockdown of AhR expression increased ROS level in CSSP-exposed H1355 cells. Oxidative stress sensor Nrf2 and its target gene NQO1 were insensitive to AhR expression level and CSSP treatment in human lung adenocarcinoma cells. In contrast, induction of AhR expression concurrently increased mRNA expression of xenobiotic-metabolizing genes CYP1B1, UGT1A8, and UGT1A10 in a ligand-independent manner. It appeared that AhR accelerated xenobiotic clearing and diminished associated oxidative stress by coordinate regulation of a set of phase I and II metabolizing genes. However, the AhR-signaled protection could not shield cells from constant oxidative stress. Prolonged exposure to high concentrations of CSSP induced G0/G1 cell cycle arrest via the p53–p21–Rb1 signaling pathway. Despite no effect on DNA repair rate, AhR facilitated the recovery of cells from growth arrest when CSSP exposure ended. AhR-overexpressing lung adenocarcinoma cells exhibited an increased anchorage-dependent and independent proliferation when recovery from exposure. In summary, our data demonstrated that AhR protected lung adenocarcinoma cells against CSSP-induced oxidative stress and promoted post-exposure clonogenicity. -- Highlights: ► AhR expression level influences cigarette sidestream smoke-induced ROS production. ► AhR reduces oxidative stress by coordinate regulation of

  14. NREL: News - Scientific American' Recognizes Solar Cell Research

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Scientific American' Recognizes Solar Cell Research Monday November 11, 2002 Magazine Names NREL to its First "Scientific American 50" List Golden, CO. - The U.S. Department of Energy's National Renewable Energy Laboratory (NREL) has been named by Scientific American magazine as one of the Scientific American 50 - the noted magazine's first list recognizing annual contributions to science and technology that provide a vision of a better future. Announced today, the Scientific American

  15. Great opportunity for Native American-owned businesses

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Great opportunity for Native American-owned businesses Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue:November 2, 2016 all issues All Issues » submit Great opportunity for Native American-owned businesses Proposals for Native American Venture Acceleration Fund due October 18. September 1, 2016 Phoebe Suina of High Water Mark, LLC, was a Native American VAF winner in 2015. Phoebe Suina of High Water Mark, LLC, was a Native American VAF

  16. American Indian Research and Education Initiative (AIREI) | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy American Indian Research and Education Initiative (AIREI) American Indian Research and Education Initiative (AIREI) American Indian Research and Education Initiative (AIREI) Through a pilot program announced last year, the Energy Department, the American Indian Higher Education Consortium and the American Indian Science and Engineering Society have partnered to bring science, technology, engineering and mathematics (STEM) research and education funding to our nation's Tribal colleges

  17. Celebrating Asian American Pacific Islander Heritage Month at the Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department | Department of Energy Celebrating Asian American Pacific Islander Heritage Month at the Energy Department Celebrating Asian American Pacific Islander Heritage Month at the Energy Department May 1, 2014 - 4:22pm Addthis Celebrating Asian American Pacific Islander Heritage Month at the Energy Department Each May we celebrate Asian American and Pacific Islander Heritage Month, honoring the accomplishments of Asian Americans, Native Hawaiians, and Pacific Islanders at the Energy

  18. CXC Receptor 1 and 2 and Neutrophil Elastase Inhibitors Alter Radiation-induced Lung Disease in the Mouse

    SciTech Connect

    Fox, Jessica; Haston, Christina K.

    2013-01-01

    Purpose: We previously reported increased numbers of neutrophils to be associated with the development of the radiation-induced lung responses of alveolitis (pneumonitis) and fibrosis in mice. In the present study we investigated whether CXC receptor 1 and 2 antagonism with DF2156A, a small molecule inhibitor of neutrophil chemotaxis, or the neutrophil elastase inhibitor sivelestat decreases the lung response to irradiation. Methods and Materials: KK/HIJ mice received 14 Gy whole-thorax irradiation, and a subset of them received drug treatment 3 times per week from the day of irradiation until they were killed because of respiratory distress symptoms. Results: Irradiated mice receiving sivelestat survived 18% longer than did mice receiving radiation alone (73 vs 60 days for female mice, 91 vs 79 days for male mice), whereas postirradiation survival times did not differ between the group of mice receiving DF2156A and the radiation-only group. The numbers of neutrophils in lung tissue and in bronchoalveolar lavage fluid did not differ among groups of irradiated mice, but they significantly exceeded the levels in unirradiated control mice. The extent of alveolitis, assessed histologically, did not differ between irradiated mice treated with either drug and those receiving radiation alone, when assessed at the end of the experiment, but it was significantly reduced, as were the neutrophil measures, in sivelestat-treated mice at the common kill time of 60 days after irradiation. Mice treated with radiation and DF2156A developed significantly less fibrosis than did mice receiving radiation alone, and this difference was associated with decreased expression of interleukin-13 in lung tissue. Conclusions: We conclude that neutrophil elastase inhibition affects alveolitis and prolongs survival, whereas CXCR1/2 antagonism reduces radiation-induced fibrotic lung disease in mice without affecting the onset of distress.

  19. Celebrating National Native American Heritage Month at the Department of Energy

    Energy.gov [DOE]

    We celebrate Native American Heritage Month to honor Native Americans, their rich heritage, and their present accomplishments. Native Americans are innovators, entrepreneurs, leaders, and scholars,...

  20. American Samoa Initial Technical Assessment Report

    SciTech Connect

    Busche, S.; Conrad, M.; Funk, K.; Kandt, A.; McNutt, P.

    2011-09-01

    This document is an initial energy assessment for American Samoa, the first of many steps in developing a comprehensive energy strategy. On March 1, 2010, Assistant Secretary of the Interior Tony Babauta invited governors and their staff from the Interior Insular Areas to meet with senior principals at the National Renewable Energy Laboratory (NREL). Meeting discussions focused on ways to improve energy efficiency and increase the deployment of renewable energy technologies in the U.S. Pacific Territories. In attendance were Governors Felix Camacho (Guam), Benigno Fitial (Commonwealth of the Northern Mariana Islands), and Togiola Tulafono, (American Samoa). This meeting brought together major stakeholders to learn and understand the importance of developing a comprehensive strategic plan for implementing energy efficiency measures and renewable energy technologies. For several decades, dependence on fossil fuels and the burden of high oil prices have been a major concern but never more at the forefront as today. With unstable oil prices, the volatility of fuel supply and the economic instability in American Samoa, energy issues are a high priority. In short, energy security is critical to American Samoa's future economic development and sustainability. Under an interagency agreement, funded by the Department of Interior's Office of Insular Affairs, NREL was tasked to deliver technical assistance to the islands of American Samoa. Technical assistance included conducting an initial technical assessment to define energy consumption and production data, establish an energy consumption baseline, and assist with the development of a strategic plan. The assessment and strategic plan will be used to assist with the transition to a cleaner energy economy. NREL provided an interdisciplinary team to cover each relevant technical area for the initial energy assessments. Experts in the following disciplines traveled to American Samoa for on-island site assessments: (1) Energy

  1. Move Over, 'American Idol'... | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Over, 'American Idol'... Move Over, 'American Idol'... May 26, 2011 - 11:24am Addthis Liisa O'Neill Liisa O'Neill Former New Media Specialist, Office of Public Affairs The votes have been counted. America has spoken. 
The five finalists were so outstanding that no one cared Simon Cowell wasn't part of the action. 
 No, I'm not talking about Scotty McCreery, though we congratulate him as well. I'm talking about yesterday's "People's Choice Award" winner of the Department of Energy's

  2. Ventilation/Perfusion Positron Emission Tomography—Based Assessment of Radiation Injury to Lung

    SciTech Connect

    Siva, Shankar; Hardcastle, Nicholas; Kron, Tomas; Bressel, Mathias; Callahan, Jason; MacManus, Michael P.; Shaw, Mark; Plumridge, Nikki; Hicks, Rodney J.; Steinfort, Daniel; Ball, David L.; Hofman, Michael S.

    2015-10-01

    Purpose: To investigate {sup 68}Ga-ventilation/perfusion (V/Q) positron emission tomography (PET)/computed tomography (CT) as a novel imaging modality for assessment of perfusion, ventilation, and lung density changes in the context of radiation therapy (RT). Methods and Materials: In a prospective clinical trial, 20 patients underwent 4-dimensional (4D)-V/Q PET/CT before, midway through, and 3 months after definitive lung RT. Eligible patients were prescribed 60 Gy in 30 fractions with or without concurrent chemotherapy. Functional images were registered to the RT planning 4D-CT, and isodose volumes were averaged into 10-Gy bins. Within each dose bin, relative loss in standardized uptake value (SUV) was recorded for ventilation and perfusion, and loss in air-filled fraction was recorded to assess RT-induced lung fibrosis. A dose-effect relationship was described using both linear and 2-parameter logistic fit models, and goodness of fit was assessed with Akaike Information Criterion (AIC). Results: A total of 179 imaging datasets were available for analysis (1 scan was unrecoverable). An almost perfectly linear negative dose-response relationship was observed for perfusion and air-filled fraction (r{sup 2}=0.99, P<.01), with ventilation strongly negatively linear (r{sup 2}=0.95, P<.01). Logistic models did not provide a better fit as evaluated by AIC. Perfusion, ventilation, and the air-filled fraction decreased 0.75 ± 0.03%, 0.71 ± 0.06%, and 0.49 ± 0.02%/Gy, respectively. Within high-dose regions, higher baseline perfusion SUV was associated with greater rate of loss. At 50 Gy and 60 Gy, the rate of loss was 1.35% (P=.07) and 1.73% (P=.05) per SUV, respectively. Of 8/20 patients with peritumoral reperfusion/reventilation during treatment, 7/8 did not sustain this effect after treatment. Conclusions: Radiation-induced regional lung functional deficits occur in a dose-dependent manner and can be estimated by simple linear models with 4D-V/Q PET

  3. K-25 demolition project receives American Nuclear Society award

    Office of Energy Efficiency and Renewable Energy (EERE)

    The successful demolition of a former gaseous diffusion facility has been honored by the American Nuclear Society. The American Nuclear Society’s Decommissioning and Environmental Services Division selected the K-25 demolition project to receive its Project Excellence Award.

  4. A Presidential Proclamation - Asian American and Pacific Islander...

    Office of Environmental Management (EM)

    ... I call upon all Americans to visit www.WhiteHouse.govAAPI andwww.AsianPacificHeritage.gov to learn more about the history of Asian Americans and Pacific Islanders, and to observe ...

  5. American Samoa's Rebate Program Brings ENERGY STAR to Island

    Office of Energy Efficiency and Renewable Energy (EERE)

    Thanks to a grant through the American Recovery and Reinvestment Act, residents of American Samoa are able for the first time to purchase ENERGY STAR air conditioners – and for 30 percent off - through the Island's first appliance rebate program.

  6. Native American Graves Protection and Repatriation Act (1990...

    Office of Environmental Management (EM)

    Native American Graves Protection and Repatriation Act (1990) The Native American Graves Protection and Repatriation Act (Public Law 101-601; 25 U.S.C. 3001-3013) describes the ...

  7. American Ref-Fuel of Delaware Valley Biomass Facility | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    Ref-Fuel of Delaware Valley Biomass Facility Jump to: navigation, search Name American Ref-Fuel of Delaware Valley Biomass Facility Facility American Ref-Fuel of Delaware Valley...

  8. American Indian Science and Engineering Society Career Fair | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy American Indian Science and Engineering Society Career Fair American Indian Science and Engineering Society Career Fair November 11, 2016 10:01AM to 6:13PM EST Minneapolis Convention Center, Minneapolis, MN Website:

  9. Stephen E. Zitney Named American Institute of Chemical Engineers...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Stephen E. Zitney Named American Institute of Chemical Engineers Fellow Morgantown, W.Va. ... (NETL) has been named as a Fellow by the American Institute of Chemical Engineers (AIChE). ...

  10. Asian American and Pacific Islander Heritage Month Program

    Energy.gov [DOE]

    Asian Pacific American Heritage Month is a celebration of the culture, traditions, and history of Asian Americans and Pacific Islanders in the United States. Join the Energy Department for the...

  11. Reshaping American Energy - A Look Back At BETO's Accomplishments...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Reshaping American Energy - A Look Back At BETO's Accomplishments in 2013 Reshaping American Energy - A Look Back At BETO's Accomplishments in 2013 The U.S. bioindustry provides a ...

  12. Native American Graves Protection and Repatriation Act, as amended...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Native American Graves Protection and Repatriation Act, as amended The Native American Graves Protection and Repatriation Act (Public Law 101-601; 25 U.S.C. 3001-3013) describes ...

  13. American LNG Marketing, LLC- FE Dkt. 16-33-LNG

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Office of Fossil Energy (FE) of the Department of Energy (DOE) gives notice of receipt of an application (Application), filed on March 8, 2016, by American LNG Marketing, LLC, (American LNG) ...

  14. Financing the Growing American Auto Industry | Department of...

    Office of Environmental Management (EM)

    the Growing American Auto Industry Financing the Growing American Auto Industry March 26, 2015 - 12:01am Addthis Peter W. Davidson Peter W. Davidson Former Executive Director of ...

  15. North American Green Power,LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Jump to: navigation, search Logo: North American Green Power,LLC Name: North American Green Power,LLC Address: 1605 J.P Wright Loop Rd Place: Jacksonville, Arkansas Zip: 72076...

  16. Native American Graves Protection Act | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: Native American Graves Protection ActLegal Abstract To provide for the protection of Native American...

  17. American Indian Religious Freedom Act | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    American Indian Religious Freedom Act Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: American Indian Religious Freedom ActLegal...

  18. New Fannie Mae Energy Program Helps Americans Go Solar | Department...

    Office of Environmental Management (EM)

    Fannie Mae Energy Program Helps Americans Go Solar New Fannie Mae Energy Program Helps Americans Go Solar April 11, 2016 - 12:51pm Addthis Fannie Mae has released a new program ...

  19. White House Launches Clean Energy Savings for All Americans Initiative

    Office of Energy Efficiency and Renewable Energy (EERE)

    Today the White House announced the Clean Energy Savings for All Americans Initiative, which aims to ensure that every American family can choose to go solar and to cut their energy bills – and...

  20. Secretary Chu Visits the 2012 North American International Auto...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 North American International Auto Show Secretary Chu Visits the 2012 North American International Auto Show January 12, 2012 - 9:54am Addthis 1 of 10 Energy Secretary Steven Chu ...

  1. The American Chamber of Commerce of Trinidad & Tobago | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    The American Chamber of Commerce of Trinidad & Tobago The American Chamber of Commerce of Trinidad & Tobago May 13, 2008 - 12:00pm Addthis Remarks As Prepared for Delivery by...

  2. The SUN Project Enhances STEM Education for Native American Youth...

    Office of Environmental Management (EM)

    April 2, 2014 - 1:25pm Addthis The SUN Project Enhances STEM Education for Native American ... Last October, the Department of Energy awarded the American Indian Science and Engineering ...

  3. ENERGY STAR Residential Water Heaters to Save Americans Up to...

    Energy Saver

    STAR Residential Water Heaters to Save Americans Up to 823 Million in the Next Five Years ENERGY STAR Residential Water Heaters to Save Americans Up to 823 Million in the Next ...

  4. Launching the American Indian Research and Education Initiative |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy the American Indian Research and Education Initiative Launching the American Indian Research and Education Initiative July 27, 2011 - 5:22pm Addthis Bill Valdez Bill Valdez Director of Workforce Management What are the key facts? The Energy Department has began a unique partnership between the American Indian Higher Education Consortium and the American Indian Science and Engineering Society to bring science, technology, engineering and mathematics (STEM) research and

  5. Asian American Pacific Islander Heritage Month - HQ | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Asian American Pacific Islander Heritage Month - HQ Asian American Pacific Islander Heritage Month - HQ Asian American Pacific Islander Heritage Month - HQ May 15, 2014 3:00PM to 5:00PM EDT Department of Energy 1000 Independence Ave SW, Main Auditorium, Washington DC Speakers include Robert Gee, President of Asian Americans in Energy, the Environment, and Commerce and Ambassador to the Minorities in Energy Initiative; Dr. James Meng, Executive Director of the Naval Sea System Command; Afroze

  6. North American SynchroPhasor Initiative (NASPI) Technical Report - Model

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Validation Using Synchrophasors | Department of Energy Model Validation Using Synchrophasors North American SynchroPhasor Initiative (NASPI) Technical Report - Model Validation Using Synchrophasors This technical report was developed in October, 2013 by members of the North American SynchroPhasor Initiative, a collaboration between the North American electric industry (utilities, grid operators, vendors and consultants), the North American Electric Reliability Corporation, academics, and the

  7. A Presidential Proclamation - Asian American and Pacific Islander Heritage

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Month | Department of Energy A Presidential Proclamation - Asian American and Pacific Islander Heritage Month A Presidential Proclamation - Asian American and Pacific Islander Heritage Month May 1, 2013 - 9:25am Addthis A Presidential Proclamation - Asian American and Pacific Islander Heritage Month BY THE PRESIDENT OF THE UNITED STATES OF AMERICA A PROCLAMATION Each May, our Nation comes together to recount the ways Asian Americans and Pacific Islanders (AAPIs) helped forge our country. We

  8. Fuel Cell Manufacturing: American Energy and Manufacturing Competitiveness Summit

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation on fuel cell manufacturing by Sunita Satyapal at the American Energy and Manufacturing Competitiveness Summit on December 12, 2013.

  9. American LNG Marketing (Hialeah Facility) Order 3690 (Aug. 7, 2015)

    Energy.gov [DOE]

    American (Haileah) TerminalLong-Term Contract Information and Registrationsat U.S. LNG Export Facilities

  10. Weatherization Formula Grants - American Recovery and Reinvestment Act

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    (ARRA) | Department of Energy Formula Grants - American Recovery and Reinvestment Act (ARRA) Weatherization Formula Grants - American Recovery and Reinvestment Act (ARRA) U.S. Department of Energy Weatherization Assistance Program, funding for the states, energy efficiency for low-income families, American Recovery and Reinvestment Act of 2009 wap_recovery_act_foa.pdf (273.02 KB) More Documents & Publications Microsoft Word - nDE-FOA-0000051.rtf Weatherization Formula Grants - American

  11. Native American Heritage Month (NAHM) - Cultural Film Showing |

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Department of Energy Native American Heritage Month (NAHM) - Cultural Film Showing Native American Heritage Month (NAHM) - Cultural Film Showing November 14, 2016 10:00AM to 11:00AM EST Native American Heritage Month (NAHM) - Cultural Film Showing

  12. Competition and Reliability in North American Electricity Markets Technical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Workshop | Department of Energy Electricity Markets Technical Workshop Competition and Reliability in North American Electricity Markets Technical Workshop Competition and Reliability in North American Electricity Markets Technical Workshop Competition and Reliability in North American Electricity Markets Technical Workshop (481.75 KB) More Documents & Publications The Relationship between Competitive Power Markets and Grid Reliability. Blackout 2003: Electric System Working Group

  13. American Recovery and Reinvestment Act Payments Surge Past $5 Billion |

    Office of Environmental Management (EM)

    Department of Energy 5 Billion American Recovery and Reinvestment Act Payments Surge Past $5 Billion More than $5 billion in Recovery Act payments are accelerating environmental cleanup American Recovery and Reinvestment Act Payments Surge Past $5 Billion (1.69 MB) More Documents & Publications American Recovery and Reinvestment Act Payments Surge Past $4

  14. Markerless tracking of small lung tumors for stereotactic radiotherapy

    SciTech Connect

    Sörnsen de Koste, John R. van Dahele, Max; Senan, Suresh; Slotman, Ben J.; Verbakel, Wilko F. A. R.; Mostafavi, Hassan; Sloutsky, Alex

    2015-04-15

    .96, and 0.82 (X, Y, and Z, respectively). For case B (4.1 cm{sup 3}, 20 mm diameter), due to temporarily decreased tumor visibility preventing TTS from resolving the tumor, robust tracking data were only available between angles 300°–40° and 120°–220°. Mean motion according to TTS was X = 2.0, Y = 7.7, and Z = 8.2 mm (1 SD < 0.9 mm). Tumor motion on 4DCT was X = 1.8, Y = 7.6, and Z = 9.5 mm and correlation coefficients between TTS motion and CoM displacement were 0.59, 0.95, and 0.93 (X, Y, and Z, respectively). (2) Clinical results: TTS revealed a mean intrafraction variation in tumor motion in Y-direction of >2.0 mm (1 SD) in four of five patients. In addition, clinical tumor motion amplitude differed from that seen on planning 4DCT. Internal and external structures that create abrupt density change (e.g., table-top edge, interface between lung/mediastinum and lung/heart) were observed to prevent 360° tracking of the tumor. Correlation coefficients between TTS motion in the Y-direction and the RPM signal (22 observations) ranged from 0.78 to 0.96. In 2D, 241 TTS matches at end-inspiration and end-expiration were visually validated: mean difference was 0.8 mm (SD = 0.7) for both. Conclusions: TTS can track small lung tumors if these are visible in kV projections. A 4DCT dataset can be used to validate kV tracking of moving targets. TTS and 4DCT displacement agreed to within 2 mm. TTS and RPM motion were closely associated but tumor motion during CBCT can vary from the planning 4DCT.

  15. What is the smart grid? - by Scientific American | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    What is the smart grid? - by Scientific American What is the smart grid? - by Scientific American Addthis

  16. SU-E-J-185: Gated CBCT Imaging for Positioning Moving Lung Tumor in Lung SBRT Treatment

    SciTech Connect

    Li, X; Li, T; Zhang, Y; Burton, S; Karlovits, B; Clump, D; Heron, D; Huq, M

    2014-06-01

    Purpose: Lung stereo-tactic body radiotherapy(SBRT) treatment requires high accuracy of lung tumor positioning during treatment, which is usually accomplished by free breathing Cone-Beam computerized tomography (CBCT) scan. However, respiratory motion induced image artifacts in free breathing CBCT may degrade such positioning accuracy. The purpose of this study is to investigate the feasibility of gated CBCT imaging for lung SBRT treatment. Methods: Six Lung SBRT patients were selected for this study. The respiratory motion of the tumors ranged from 1.2cm to 3.5cm, and the gating windows for all patients were set between 35% and 65% of the respiratory phases. Each Lung SBRT patient underwent free-breathing CBCT scan using half-fan scan technique. The acquired projection images were transferred out for off-line analyses. An In-house semi-automatic algorithm was developed to trace the diaphragm movement from those projection images to acquire a patient's specific respiratory motion curve, which was used to correlate respiratory phases with each projection image. Afterwards, a filtered back-projection algorithm was utilized to reconstruct the gated CBCT images based on the projection images only within the gating window. Results: Target volumes determined by free breathing CBCT images were 71.9%±72% bigger than the volume shown in gated CBCT image. On the contrary, the target volume differences between gated CBCT and planning CT images at exhale stage were 5.8%±2.4%. The center to center distance of the targets shown in free breathing CBCT and gated CBCT images were 9.2±8.1mm. For one particular case, the superior boundary of the target was shifted 15mm between free breathing CBCT and gated CBCT. Conclusion: Gated CBCT imaging provides better representation of the moving lung tumor with less motion artifacts, and has the potential to improve the positioning accuracy in lung SBRT treatment.

  17. Dynamic Studies of Lung Fluid Clearance with Phase Contrast Imaging

    SciTech Connect

    Kitchen, Marcus J.; Williams, Ivan; Irvine, Sarah C.; Morgan, Michael J.; Paganin, David M.; Lewis, Rob A.; Pavlov, Konstantin; Hooper, Stuart B.; Wallace, Megan J.; Siu, Karen K. W.; Yagi, Naoto; Uesugi, Kentaro

    2007-01-19

    Clearance of liquid from the airways at birth is a poorly understood process, partly due to the difficulties of observing and measuring the distribution of air within the lung. Imaging dynamic processes within the lung in vivo with high contrast and spatial resolution is therefore a major challenge. However, phase contrast X-ray imaging is able to exploit inhaled air as a contrast agent, rendering the lungs of small animals visible due to the large changes in the refractive index at air/tissue interfaces. In concert with the high spatial resolution afforded by X-ray imaging systems (<100 {mu}m), propagation-based phase contrast imaging is ideal for studying lung development. To this end we have utilized intense, monochromatic synchrotron radiation, together with a fast readout CCD camera, to study fluid clearance from the lungs of rabbit pups at birth. Local rates of fluid clearance have been measured from the dynamic sequences using a single image phase retrieval algorithm.

  18. Whole Lung Irradiation for Adults With Pulmonary Metastases From Ewing Sarcoma

    SciTech Connect

    Casey, Dana L.; Alektiar, Kaled M.; Gerber, Naamit K.; Wolden, Suzanne L.

    2014-08-01

    Purpose: To evaluate feasibility and patterns of failure in adult patients with Ewing sarcoma (ES) treated with whole lung irradiation (WLI) for pulmonary metastases. Methods and Materials: Retrospective review of all ES patients treated at age 18 or older with 12-15 Gy WLI for pulmonary metastases at a single institution between 1990 and 2014. Twenty-six patients met the study criteria. Results: The median age at WLI was 23 years (range, 18-40). The median follow-up time of the surviving patients was 3.8 years (range, 1.0-9.6). The 3-year cumulative incidence of pulmonary relapse (PR) was 55%, with a 3-year cumulative incidence of PR as the site of first relapse of 42%. The 3-year event-free survival (EFS) and overall survival (OS) were 38 and 45%, respectively. Patients with exclusively pulmonary metastases had better outcomes than did those with extrapulmonary metastases: the 3-year PR was 45% in those with exclusively lung metastases versus 76% in those with extrapulmonary metastases (P=.01); the 3-year EFS was 49% versus 14% (P=.003); and the 3-year OS was 61% versus 13% (P=.009). Smoking status was a significant prognostic factor for EFS: the 3-year EFS was 61% in nonsmokers versus 11% in smokers (P=.04). Two patients experienced herpes zoster in the radiation field 6 and 12 weeks after radiation. No patients experienced pneumonitis or cardiac toxicity, and no significant acute or late sequelae were observed among the survivors. Conclusion: WLI in adult patients with ES and lung metastases is well tolerated and is associated with freedom from PR of 45% at 3 years. Given its acceptable toxicity and potential therapeutic effect, WLI for pulmonary metastases in ES should be considered for adults, as it is in pediatric patients. All patients should be advised to quit smoking before receiving WLI.

  19. Hobart named American Chemical Society Fellow

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Hobart named ACS Fellow Hobart named American Chemical Society Fellow The ACS Fellows program began in 2008 to recognize and honor members for outstanding achievements in and contributions to science, the profession, and ACS. August 21, 2013 David Hobart displays Md, the symbol for Mendelevium, the ninth transuranium element of the actinide series, named after Dimitri Mendeleev, who is honored as the "father" of the periodic table. David Hobart displays Md, the symbol for Mendelevium,

  20. Recovery Act State Memos American Samoa

    Energy.gov [DOE] (indexed site)

    American Samoa For questions about DOE's Recovery Act activities, please contact the DOE Recovery Act Clearinghouse: 1-888-DOE-RCVY (888-363-7289), Monday through Friday, 9 a.m. to 7 p.m. Eastern Time https://recoveryclearinghouse.energy.gov/contactUs.htm. All numbers and projects listed as of June 1, 2010 TABLE OF CONTENTS RECOVERY ACT SNAPSHOT................................................................................... 1 FUNDING ALLOCATION

  1. Navajo Nation: Native American Photovoltaics- 1999 Project

    Office of Energy Efficiency and Renewable Energy (EERE)

    At the end of the twentieth century there are many tens of thousands of Native American residences in the US without electricity. Most of these residences are in remote locations and to provide service by the grid is either too costly or impossible. Photovoltaics are the best way to provide power to these houses, provided certain barriers can be overcome. These include: system cost and end-user financing, maintenance, and size and quality of the systems.

  2. Energizing American Competitiveness in Solar Technologies

    Office of Energy Efficiency and Renewable Energy (EERE)

    This PowerPoint slide deck was originally presented at the 2012 SunShot Grand Challenge Summit and Technology Forum during a plenary session. Entitled "Energizing American Competitiveness in Solar Technologies," this presentation explains why grand challenges are needed and summarizes the goals of the SunShot program. It also identifies manufacturing as playing a key role in the attainment of a clean energy vision.

  3. American Reinvestment Recovery Act | Department of Energy

    Energy.gov [DOE] (indexed site)

    Office Investments | Department of Energy The Bioenergy Technologies Office rewarded about $178 million in American Recovery and Reinvestment Act of 2009 funds; the projects accelerate advanced biofuels RD&D, speed the deployment of commercialization of biofuels, and further the U.S. bioindustry through market transformation. recovery_act_factsheet.pdf (1.07 MB) More Documents & Publications Algae Biofuels Technology National Alliance for Advanced Biofuels and Bioproducts Synopsis

  4. Chapter VI: Integrating North American Energy Markets

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    -26 QER Report: Energy Transmission, Storage, and Distribution Infrastructure | April 2015 Chapter VI: Integrating North American Energy Markets QER Report: Energy Transmission, Storage, and Distribution Infrastructure | April 2015 7-1 Chapter VII This chapter focuses on the impacts of transmission, storage, and distribution (TS&D) infrastructure on the environment, complementing the discussion in Chapter II (Increasing the Resilience, Reliability, Safety, and Asset Security of TS&D

  5. A field guide to American windmills

    SciTech Connect

    Lindsay, B.T.

    1985-01-01

    The first part of this work offers a history of turbine-wheel mills in the United States from their mid-19th century origins to their present status. The next section is a field guide to over 100 kinds of windmills, each depicted in text, drawing, and photograph. The final part of the text comprises an appendix listing all known North American windmill makers, and appendix listing every known model, notes, bibliography, and index.

  6. CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to Erlotinib via transcriptional regulation of EGFR

    SciTech Connect

    Wang, Yunshan; Zhang, Pengju; Liu, Ziming; Wang, Qin; Wen, Mingxin; Wang, Yuli; Yuan, Hongtu; Mao, Jian-Hua; Wei, Guangwei

    2014-11-21

    CUL4A has been proposed as oncogene in several types of human cancer, but its clinical significance and functional role in human non-small cell lung cancer (NSCLC) remain unclear. Expression level of CUL4A was examined by RT-PCR and Western blot. Forced expression of CUL4A was mediated by retroviruses, and CUL4A silencing by shRNAs expressing lentiviruses. Growth capacity of lung cancer cells was measured by MTT in vitro and tumorigenesis in vivo, respectively. We found that CUL4A was highly expressed in human lung cancer tissues and lung cancer cell lines, and this elevated expression positively correlated with disease progression and prognosis. Overexpression of CUL4A in human lung cancer cell lines increased cell proliferation, inhibited apoptosis, and subsequently conferred resistance to chemotherapy. On other hand, silencing CUL4A expression in NSCLC cells reduced proliferation, promoted apoptosis and resulted in tumor growth inhibition in cancer xenograft model. Mechanistically, we revealed CUL4A regulated EGFR transcriptional expression and activation, and subsequently activated AKT. Targeted inhibition of EGFR activity blocked these CUL4A induced oncogenic activities. In conclusion, our results highlight the significance of CUL4A in NSCLC and suggest that CUL4A could be a promising therapy target and a potential biomarker for prognosis and EGFR target therapy in NSCLC patients.

  7. CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to Erlotinib via transcriptional regulation of EGFR

    DOE PAGES [OSTI]

    Wang, Yunshan; Zhang, Pengju; Liu, Ziming; Wang, Qin; Wen, Mingxin; Wang, Yuli; Yuan, Hongtu; Mao, Jian-Hua; Wei, Guangwei

    2014-11-21

    CUL4A has been proposed as oncogene in several types of human cancer, but its clinical significance and functional role in human non-small cell lung cancer (NSCLC) remain unclear. Expression level of CUL4A was examined by RT-PCR and Western blot. Forced expression of CUL4A was mediated by retroviruses, and CUL4A silencing by shRNAs expressing lentiviruses. Growth capacity of lung cancer cells was measured by MTT in vitro and tumorigenesis in vivo, respectively. We found that CUL4A was highly expressed in human lung cancer tissues and lung cancer cell lines, and this elevated expression positively correlated with disease progression and prognosis. Overexpressionmore » of CUL4A in human lung cancer cell lines increased cell proliferation, inhibited apoptosis, and subsequently conferred resistance to chemotherapy. On other hand, silencing CUL4A expression in NSCLC cells reduced proliferation, promoted apoptosis and resulted in tumor growth inhibition in cancer xenograft model. Mechanistically, we revealed CUL4A regulated EGFR transcriptional expression and activation, and subsequently activated AKT. Targeted inhibition of EGFR activity blocked these CUL4A induced oncogenic activities. In conclusion, our results highlight the significance of CUL4A in NSCLC and suggest that CUL4A could be a promising therapy target and a potential biomarker for prognosis and EGFR target therapy in NSCLC patients.« less

  8. 2010 American Conference on Neutron Scattering (ACNS 2010)

    SciTech Connect

    Billinge, Simon

    2011-06-17

    The ACNS provides a focal point for the national neutron user community to strengthen ties within this diverse group, while at the same time promoting neutron research among colleagues in related disciplines identified as “would-be” neutron users. The American Conference on Neutron Scattering thus serves a dual role as a national user meeting and a scientific meeting. As a venue for scientific exchange, the ACNS showcases recent results and provides forums for scientific discussion of neutron research in diverse fields such as hard and soft condensed matter, liquids, biology, magnetism, engineering materials, chemical spectroscopy, crystal structure, and elementary excitations, fundamental physics and development of neutron instrumentation through a combination of invited talks, contributed talks and poster sessions. As a “super-user” meeting, the ACNS fulfills the main objectives of users' meetings previously held periodically at individual national neutron facilities, with the advantage of a larger and more diverse audience. To this end, each of the major national neutron facilities (NIST, LANSCE, HFIR and SNS) have an opportunity to exchange information and update users, and potential users, of their facility. This is also an appropriate forum for users to raise issues that relate to the facilities. For many of the national facilities, this super-user meeting should obviate the need for separate user meetings that tax the time, energy and budgets of facility staff and the users alike, at least in years when the ACNS is held. We rely upon strong participation from the national facilities. The NSSA intends that the American Conference on Neutron Scattering (ACNS) will occur approximately every two years, but not in years that coincide with the International or European Conferences on Neutron Scattering. The ACNS is to be held in association with one of the national neutron centers in a rotating sequence, with the host facility providing local organization

  9. Determination of In-Vitro Lung Solubility and Intake-To-Dose...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Determination of In-Vitro Lung Solubility and Intake-To-Dose Conversion Factors for Tritiated LaNi4.25Al0.75 Hydride Determination of In-Vitro Lung Solubility and Intake-To-Dose ...

  10. Perfusion lung scan: an aid in detection of lymphangitic carcinomatosis

    SciTech Connect

    Bates, S.E.; Tranum, B.L.

    1982-07-15

    Lymphangitic carcinomatosis is usually a late manifestation of metastatic disease. The patient usually presents with cough or dyspnea, and the chest radiograph is often nondiagnostic. Two patients are presented who developed symptoms while on adjuvant chemotherapy. Both had abnormal perfusion lung scans. One had matching ventilation defects; the other a normal ventilation study. Biopsy revealed metastatic carcinoma; in one case tumor was seen in both the pulmonary lymphatics and arterioles; in the other, tumor was identified but the site could not be specified. The radionuclide lung scan is a technique which can speed diagnosis and institution of therapy in lymphangitic carcinomatosis.

  11. Lung dosimetry in a linac-MRI radiotherapy unit with a longitudinal magnetic field

    SciTech Connect

    Kirkby, C.; Murray, B.; Rathee, S.; Fallone, B. G.

    2010-09-15

    Purpose: There is interest in developing linac-MR systems for MRI-guided radiation therapy. To date, the designs for such linac-MR devices have been restricted to a transverse geometry where the static magnetic field is oriented perpendicular to the direction of the incident photon beam. This work extends possibilities in this field by proposing and examining by Monte Carlo simulations, a probable longitudinal configuration where the magnetic field is oriented in the same direction as the photon beam. Methods: The EGSnrc Monte Carlo (MC) radiation transport codes with algorithms implemented to account for the magnetic field deflection of charged particles were used to compare dose distributions for linac-MR systems in transverse and longitudinal geometries. Specifically, the responses to a 6 MV pencil photon beam incident on water and lung slabs were investigated for 1.5 and 3.0 T magnetic fields. Further a five field lung plan was simulated in the longitudinal and transverse geometries across a range of magnetic field strengths from 0.2 through 3.0 T. Results: In a longitudinal geometry, the magnetic field is shown to restrict the radial spread of secondary electrons to a small degree in water, but significantly in low density tissues such as lung in contrast to the lateral shift in dose distribution seen in the transverse geometry. These effects extend to the patient case, where the longitudinal configuration demonstrated dose distributions more tightly confined to the primary photon fields, which increased dose to the planning target volume (PTV), bettered dose homogeneity within a heterogeneous (in density) PTV, and reduced the tissue interface effects associated with the transverse geometry. Conclusions: Dosimetry issues observed in a transverse linac-MR geometry such as changes to the depth dose distribution and tissue interface effects were significantly reduced or eliminated in a longitudinal geometry on a representative lung plan. Further, an increase in

  12. SU-E-T-351: Verification of Monitor Unit Calculation for Lung...

    Office of Scientific and Technical Information (OSTI)

    States Language: English Subject: 60 APPLIED LIFE SCIENCES; COMPUTERIZED TOMOGRAPHY; LUNGS; MONTE CARLO METHOD; RADIATION DOSES; RADIATION MONITORS; RADIOTHERAPY; SPATIAL...

  13. Analysis of HLA-DP association with beryllium disease susceptibility in pooled exposed populations

    SciTech Connect

    Cesare Saltini, Massimo Amicosante

    2009-12-19

    Berylliosis or Chronic Beryllium Disease is a chronic granulomatous disorder primarily involving the lung associated with the exposition to low doses of Beryllium (Be) in the workplace. Berylliosis risk has been associated with the presence of a glutamate at position 69 of the HLA-DP beta chain (HLA-DPbetaGlu69) that is expressed in about 97% of disease cases and in 27% of the unaffected Be-exposed controls (p<0.0001) (Richeldi et al. Science 1993; 262: 242-244.12). Since this first observation of an immunogenetic association between berylliosis and HLA-DPbetaGlu69 a number of studies have confirmed the role of this marker as the primary gene of susceptibility of berylliosis (Richeldi et al Am J Ind Med. 1997; 32:337-40; Wang et al J. Immunol. 1999; 163: 1647-53; Saltini et al Eur Respir J. 2001 18:677-84; Rossman et al Am J Respir Crit Care Med. 2002 165:788-94). Moreover, a structure/function interaction between HLA-DP molecules carrying Glu69 and beryllium in driving and developing the immune response against beryllium itself has been observed as: (1) Be-specific T-cells clones obtained from berylliosis patients recognize beryllium as antigen only when presented in the context of the HLA-DP{beta}Glu69 molecules but not in the context of HLA-DP allelic variants carrying Lys69 (Lombardi G et al. J Immunol 2001; 166: 3549-3555), and (2) beryllium presents an affinity for the HLA-DP2, carrying the berylliosis marker of susceptibility HLA-DPGlu69, from 40 to 100 times higher that the HLA-DP molecule carrying Lys69 (Amicosante M. et al Hum. Immunol. 2001; 62: 686-93). However, although the immunogenetic studies performed have been addressed a number of different questions about the genetic association between berylliosis and/or beryllium sensitization, exposure levels to beryllium and HLA markers, a number of questions are still open in the field mainly due to the limitation imposed by the low number of subjects carrying berylliosis or beryllium sensitization enrolled

  14. KRQE News: New Mexico scientists develop tiny, artificial lung

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    KP-AP-1-C Wholesale Power Rate Schedule KP-AP-1-C Wholesale Power Rate Schedule Area: American Electric Power System: Kerr-Philpott This rate schedule shall be available to public bodies and cooperatives (any one of whom is hereinafter called the Customer) in Virginia to whom power may be transmitted and scheduled pursuant to contracts between the Government, American Electric Power Service Corporation (hereinafter called the Company), the Company's Transmission Operator, currently PJM

  15. North American Natural Gas Markets. Volume 1

    SciTech Connect

    Not Available

    1988-12-01

    This report sunnnarizes the research by an Energy Modeling Forum working group on the evolution of the North American natural gas markets between now and 2010. The group`s findings are based partly on the results of a set of economic models of the natural gas industry that were run for four scenarios representing significantly different conditions: two oil price scenarios (upper and lower), a smaller total US resource base (low US resource case), and increased potential gas demand for electric generation (high US demand case). Several issues, such as the direction of regulatory policy and the size of the gas resource base, were analyzed separately without the use of models.

  16. North American Natural Gas Markets. Volume 2

    SciTech Connect

    Not Available

    1989-02-01

    This report summarizes die research by an Energy Modeling Forum working group on the evolution of the North American natural gas markets between now and 2010. The group`s findings are based partly on the results of a set of economic models of the natural gas industry that were run for four scenarios representing significantly different conditions: two oil price scenarios (upper and lower), a smaller total US resource base (low US resource case), and increased potential gas demand for electric generation (high US demand case). Several issues, such as the direction of regulatory policy and the size of the gas resource base, were analyzed separately without the use of models.

  17. The American nuclear power industry. A handbook

    SciTech Connect

    Pearman, W.A.; Starr, P.

    1984-01-01

    This book presents an overview of the history and current organization of the American nuclear power industry. Part I focuses on development of the industry, including the number, capacity, and type of plants in commercial operation as well as those under construction. Part II examines the safety, environmental, antitrust, and licensing issues involved in the use of nuclear power. Part III presents case studies of selected plants, such as Three Mile Island and Seabrook, to illustrate some of the issues discussed. The book also contains a listing of the Nuclear Regulatory Commission libraries and a subject index.

  18. Modifications of lung clearance mechanisms by acute influenza A infection

    SciTech Connect

    Levandowski, R.A.; Gerrity, T.R.; Garrard, C.S.

    1985-10-01

    Four volunteers with naturally acquired, culture-proved influenza A infection inhaled a radiolabeled aerosol to permit investigation of lung mucociliary clearance mechanisms during and after symptomatic illness. Mucus transport in the trachea was undetectable when monitored with an external multidetector probe within 48 hours of the onset of the illness, but was found at a normal velocity by 1 week in three of the four subjects. In two volunteers who coughed 23 to 48 times during the 4.5-hour observation period, whole lung clearance was as fast within the first 48 hours of illness as during health 3 months later in spite of the absence of measurable tracheal mucus transport. Conversely, in spite of the return 1 week later of mucus transport at velocities expected in the trachea, whole lung clearance for the 4.5-hour period was slowed in two volunteers who coughed less than once an hour. The data offer evidence that cough is important in maintaining lung clearance for at least several days after symptomatic influenza A infection when other mechanisms that depend on ciliary function are severely deficient.

  19. Memorandum of American High-Performance Buildings Coalition DOE Meeting

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    August 19, 2013 | Department of Energy Memorandum of American High-Performance Buildings Coalition DOE Meeting August 19, 2013 Memorandum of American High-Performance Buildings Coalition DOE Meeting August 19, 2013 This memorandum is intended to provide a summary of a meeting between the American HighPerformance Buildings Coalition (AHBPC), a coalition of industry organizations committed to promoting performance-based energy efficiency and sustainable building standards developed through

  20. Saving American Families and Businesses Money through Lighting Efficiency |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Saving American Families and Businesses Money through Lighting Efficiency Saving American Families and Businesses Money through Lighting Efficiency February 12, 2016 - 1:38pm Addthis Saving American Families and Businesses Money through Lighting Efficiency David Friedman David Friedman Assistant Secretary for Energy Efficiency and Renewable Energy (Acting) What are the key facts? The Department of Energy released a new proposed efficiency rule for lightbulbs to make it

  1. American Recovery and Reinvestment Act, Financial Assistance Award: 212

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Degrees Consulting, LLC | Department of Energy American Recovery and Reinvestment Act, Financial Assistance Award: 212 Degrees Consulting, LLC American Recovery and Reinvestment Act, Financial Assistance Award: 212 Degrees Consulting, LLC American Recovery and Reinvestment Act, Financial Assistance Award: 212 Degrees Consulting, LLC, Las Vegas, Nevada. Award No. DE-FC36-10GO10589, Notice of Financial Assistance Award (110.94 KB) Award No. DE-FC36-10GO10589, Special Terms and Conditions

  2. Biomass 2013: How the Advanced Bioindustry is Reshaping American Energy |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy 3: How the Advanced Bioindustry is Reshaping American Energy Biomass 2013: How the Advanced Bioindustry is Reshaping American Energy Biomass 2013 July 31-August 1, 2013 Washington, D.C. Convention Center 801 Mt. Vernon Place, NW Washington, D.C. 20001 On July 31-August 1, 2013, the Bioenergy Technologies Office (BETO) and Advanced Biofuels USA co-hosted the Office's sixth annual conference, Biomass 2013: How the Advanced Bioindustry is Reshaping American Energy, at the

  3. Fisker, Tesla, and American Auto Innovation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fisker, Tesla, and American Auto Innovation Fisker, Tesla, and American Auto Innovation October 20, 2011 - 10:36pm Addthis Dan Leistikow Dan Leistikow Former Director, Office of Public Affairs Two years ago, critics said we shouldn't be investing in American auto manufacturing because the industry wouldn't survive. They were wrong then and they're wrong today. From well established names like Ford to innovative startups like Tesla and Fisker, America's auto industry is being reinvented, and the

  4. Environmental Management American Recovery & Reinvestment Act (ARRA)

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Lessons Learned | Department of Energy Environmental Management American Recovery & Reinvestment Act (ARRA) Lessons Learned Environmental Management American Recovery & Reinvestment Act (ARRA) Lessons Learned EM has compiled many valuable lessons learned from the American Recovery and Reinvestment Act Program. Here are a few examples: Use a phased approached to the release of funding based on performance; conduct monthly project reviews to track and monitor project performance and

  5. American Recovery & Reinvestment Act, ARRA, clean energy projects, energy

    Energy.gov [DOE] (indexed site)

    American Process Inc DE-FOA-0001615 Alpena Biorefinery Request for Information (RFI) DE-FOA-0001615: Cellulosic Sugar and Lignin Production Capabilities, Published July 20, 2016 Category 1: Lignocellulosic Sugars Company name: American Process, Inc, Company contact: Vesa Pylkkanen/CTO Company address: 412 Ford Ave, PO Box 337, Alpena, MI 49707 Phone number: 404-872-8807; E-mail address: Biorefine@americanprocess.com Disclaimer and Important Notes: American Process Inc. reserves right to

  6. American Indian Policy and Relevant DOE and Executive Orders | Department

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    of Energy Tribal Programs » American Indian Policy and Relevant DOE and Executive Orders American Indian Policy and Relevant DOE and Executive Orders Over the course of American history, the Federal government's relationship with Indian Tribes has been defined and modified by treaties, executive orders, court decisions, specific legislation passed by Congress, and regulations. Important rights were guaranteed to Tribes by treaty, with many of these rights still enforceable today. Case law,

  7. American Recovery and Reinvestment Act | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    American Recovery and Reinvestment Act American Recovery and Reinvestment Act President Obama signed the American Recovery and Reinvestment Act of 2009 (Recovery Act) into law on February 17, 2009. The Recovery Act provided DOE several billion dollars in funds to accelerate research, development, demonstration, and deployment activities that support jumpstarting our economy, promoting green jobs, and focusing on addressing long-neglected challenges so our country can thrive in the twenty-first

  8. American Recovery and Reinvestment Act | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    American Recovery and Reinvestment Act American Recovery and Reinvestment Act The Geothermal Technologies Office received $368.2 million through the American Recovery and Reinvestment Act (ARRA) of 2009. We awarded funding for projects based on their potential to advance geothermal technology, to lower costs and barriers to market entry, and to foster economic growth by creating jobs. The 148 awards spanned 38 states and the District of Columbia. The advancements made by these projects will

  9. State Energy Efficient Appliance Rebate Program (SEEARP) American Recovery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    and Reinvestment Act (ARRA) Funding Opportunity Number: DE-FOA-0000119 | Department of Energy State Energy Efficient Appliance Rebate Program (SEEARP) American Recovery and Reinvestment Act (ARRA) Funding Opportunity Number: DE-FOA-0000119 State Energy Efficient Appliance Rebate Program (SEEARP) American Recovery and Reinvestment Act (ARRA) Funding Opportunity Number: DE-FOA-0000119 Funding Opportunity Announcement State Energy Efficient Appliance Rebate Program (SEEARP) American Recovery

  10. U.S. Department of Energy American Indian Policy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    American Indian Policy The Department of Energy issued its first American Indian Policy in 1992 and subsequently issued DOE Order 1230.2 establishing the responsibilities and roles of DOE management in carrying out the policy. In 1998, at the request of and in consultation with Indian Nations, DOE revised the Policy to effect greater and comprehensive implementation. A revised American Indian and Alaska Native Tribal Government Policy (DOE Indian Policy) was issued on October 31, 2000. On

  11. Los Alamos physicist honored by American Physical Society

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Physicist honored by American Physical Society Los Alamos physicist honored by American Physical Society George Kyrala is among a team honored with the American Physical Society's 2012 John Dawson Award for Excellence in Plasma Physics Research. August 29, 2012 George Kyrala George Kyrala Contact Communications Office (505) 667-7000 LOS ALAMOS, NEW MEXICO, August 29, 2012-Los Alamos National Laboratory physicist George Kyrala, along with researchers from Lawrence Livermore National Laboratory

  12. Los Alamos scientists win top American Physical Society prizes

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Los Alamos scientists win top American Physical Society prizes Los Alamos scientists win top American Physical Society prizes Two senior scientists at Los Alamos National Lab are being honored by the American Physical Society (APS) for their fundamental contributions in nuclear physics and biophysics. October 18, 2016 Alan Perelson (left), of Los Alamos' Theoretical Biology and Biophysics group, and Joe Carlson of the Lab's Nuclear and Particle Physics, Astrophysics and Cosmology group, won two

  13. Implementing the American Recovery and Reinvestment Act | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Implementing the American Recovery and Reinvestment Act Implementing the American Recovery and Reinvestment Act A presentation about the path to implement the Recovery Act, and the Department of Energy's role. Implementing the American Recovery and Reinvestment Act (1.11 MB) More Documents & Publications Recovery Act Incentives for Wind Energy Equipment Manufacturing US-China Clean Energy Forum 2010 U.S. And International Case Studies for Financing Bioeconomy Projects

  14. Competition and Reliability in North American Energy Markets: Issue Paper

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Synopses | Department of Energy Energy Markets: Issue Paper Synopses Competition and Reliability in North American Energy Markets: Issue Paper Synopses Jack Casazza, Frank Delea, and George Loehr argue that &quot;deregulation and restructuring have had a devastating effect on the reliability of the North American power system and constitute the ultimate root cause of the August 14, 2003&quot; Competition and Reliability in North American Energy Markets: Issue Paper Synopses (114.12

  15. DOE Announces Cooperative Agreement with USEC for American Centrifuge

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Demonstration Project | Department of Energy Cooperative Agreement with USEC for American Centrifuge Demonstration Project DOE Announces Cooperative Agreement with USEC for American Centrifuge Demonstration Project March 23, 2010 - 12:00am Addthis Washington, D.C. - The U.S. Department of Energy today announced that it finalized a cost-shared $90 million cooperative agreement with USEC Inc. to provide support for the continued development and demonstration of the American Centrifuge

  16. Jefferson Lab Physicist Wins American Physical Society Award | Jefferson

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Lab Physicist Wins American Physical Society Award Jefferson Lab Physicist Wins American Physical Society Award April 19, 2002 Keith Baker, from Jefferson Lab in Newport News, Va., was recently awarded the American Physical Society's 2002 Edward A. Bouchet Award for innovative research. Baker, a JLab experimental physicist is also a professor at Hampton University (Hampton, Va.). The APS award recognizes Baker for his contribution to nuclear and particle physics research, his development of

  17. Hanford Site Celebrates National Native American Heritage Month with

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Educational Workshops | Department of Energy Site Celebrates National Native American Heritage Month with Educational Workshops Hanford Site Celebrates National Native American Heritage Month with Educational Workshops November 28, 2012 - 12:23pm Addthis *Editor's Note: This article was originally posted in the Office of Environmental Management's EM Update, Volume 4, Issue 11, November 2012. RICHLAND, Wash. - Each November, in honor of Native American Heritage Month, the Richland Operations

  18. Honoring Hispanic Heritage Month and Renewing the American Dream |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Honoring Hispanic Heritage Month and Renewing the American Dream Honoring Hispanic Heritage Month and Renewing the American Dream September 15, 2011 - 11:03am Addthis Bill Valdez Bill Valdez Director of Workforce Management Today we kick-off Hispanic Heritage Month, celebrating under the theme of "Renewing the American Dream." The Energy Department joins the rest of the Administration in participating in a series of events that reflect various factors of the

  19. Inaugural American Vacuum Society award goes to Sandia technologist |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration | (NNSA) Inaugural American Vacuum Society award goes to Sandia technologist Monday, December 28, 2015 - 12:00am NNSA Blog Sandia National Laboratories technologist Catherine Sobczak prepares a silicon wafer to load into a machine. She has been honored with the inaugural Thin Film Distinguished Technologist Award from the American Vacuum Society. The American Vacuum Society has honored Sandia National Laboratories technologist Catherine Sobczak with

  20. The Taiwanese-American occultation survey project stellar variability. III. Detection of 58 new variable stars

    SciTech Connect

    Ishioka, R.; Wang, S.-Y.; Zhang, Z.-W.; Lehner, M. J.; Cook, K. H.; King, S.-K.; Lee, T.; Marshall, S. L.; Schwamb, M. E.; Wang, J.-H.; Wen, C.-Y.; Alcock, C.; Protopapas, P.; Axelrod, T.; Bianco, F. B.; Byun, Y.-I.; Chen, W. P.; Ngeow, C.-C.; Kim, D.-W.; Rice, J. A.

    2014-04-01

    The Taiwanese-American Occultation Survey project is designed for the detection of stellar occultations by small-size Kuiper Belt Objects, and it has monitored selected fields along the ecliptic plane by using four telescopes with a 3 deg{sup 2} field of view on the sky since 2005. We have analyzed data accumulated during 2005-2012 to detect variable stars. Sixteen fields with observations of more than 100 epochs were examined. We recovered 85 variables among a total of 158 known variable stars in these 16 fields. Most of the unrecovered variables are located in the fields observed less frequently. We also detected 58 variable stars which are not listed in the International Variable Star Index of the American Association of Variable Star Observers. These variable stars are classified as 3 RR Lyrae, 4 Cepheid, 1 ? Scuti, 5 Mira, 15 semi-regular, and 27 eclipsing binaries based on the periodicity and the profile of the light curves.

  1. Math and Science Academy helps Native American schools empower...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Deciding to make a difference in Native American education, Lewis earned his first master's degree and teaching credentials at Stanford University in California and taught public ...

  2. Fuel Cell Manufacturing: American Energy and Manufacturing Competitive...

    Energy.gov [DOE] (indexed site)

    Presentation on fuel cell manufacturing by Sunita Satyapal at the American Energy and Manufacturing Competitiveness Summit on December 12, 2013. Fuel Cell Manufacturing (2.61 MB) ...

  3. DOE - Office of Legacy Management -- American Machine and Foundry...

    Office of Legacy Management (LM)

    Div.) Report; American Machine & Foundry Company, Occupational Exposure to Radioactive Dust; Issued: February 18, 1952; 18 pages total NY.26-6 - ORAU Letter report; Berger to ...

  4. American Biodiesel and Community Fuels | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Biodiesel and Community Fuels Jump to: navigation, search Name: American Biodiesel and Community Fuels Address: 336 Encinitas Blvd Place: Encinitas, California Zip: 92024 Region:...

  5. 10th Annual Native American Economic Development Conference

    Energy.gov [DOE]

    The 10th Annual Native American Economic Development Conference is hosting renewable energy sessions, including Tribal Renewable Energy Projects Roundtable: Creating Sovereignty, Energy Independence, Economic Diversification and Sustainability.

  6. North American SynchroPhasor Initiative (NASPI) Technical Report...

    Office of Environmental Management (EM)

    Inaccurate models have contributed to a number of recent North American power outages. Phasor measurement units (PMUs) collect high-speed, time-synchronized data about grid ...

  7. North American Electric Reliability Council Power Outage Update...

    Office of Environmental Management (EM)

    will continue to experience rotating outages due to generating capacity availability. North American Electric Reliability Council Power Outage Update (48.2 KB) More Documents & ...

  8. FACT SHEET: Obama Administration Commitment to American Made Energy

    Energy.gov [DOE]

    President Obama highlighted his Administration’s focus on a sustained, all-of-the-above approach to developing American energy.

  9. Energy Secretary Moniz Will Host North American Energy Ministers...

    Energy.gov [DOE] (indexed site)

    Energy Secretary Moniz Will Host North American Energy Ministers in Trilateral Meeting Focused on Energy Cooperation WASHINGTON-On December 15, U.S. Energy Secretary Ernest Moniz ...

  10. Estimating global and North American methane emissions with high...

    Office of Scientific and Technical Information (OSTI)

    methane emissions with high spatial resolution using GOSAT satellite data Citation Details In-Document Search Title: Estimating global and North American methane emissions ...

  11. 43 CFR Part 10: Native American Graves Protection and Repatriation...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Indian tribes, and Native Hawaiian organizations to Native American cultural items, including human remains, funerary objects, sacred objects, and objects of cultural patrimony. ...

  12. Celebrating our work with Native American Students in STEM During...

    Office of Environmental Management (EM)

    prepares young people to succeed in college and careers." Read the full Proclamation here. ... to introduce Native American students to STEM careers and entry points to federal service. ...

  13. Socioeconomic profiles of native American communities: Duckwater Shoshone Reservation

    SciTech Connect

    Hamby, M.

    1991-10-01

    This report presents socioeconomic aspects of Native Americans of the Duckwater Shoshone Reservation. A survey is included concerning their views on the proposed Yucca Mountain waste repository. (CBS)

  14. Our Commitment to Asian American and Pacific Islanders at the...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    New Career Development Program Equips EM Employees with Leadership Skills President Barack Obama outlines the details of the American Jobs Act during an address to a Joint Session ...

  15. FAQs Docs for the Buy American Provision | Department of Energy

    Energy.gov [DOE] (indexed site)

    These documents answer the most frequently asked questions about the Buy American ... More Documents & Publications Questions and Answers for the Smart Grid Investment Grant ...

  16. Idaho Operations Office: American Recovery and Reinvestment Act Update

    ScienceCinema

    Provencher, Rick

    2016-07-12

    An update from Idaho National Laboratory, Rick Provencher addresses the progress that has been made due to the American Recovery and Reinvestment Act.

  17. Saving American Families and Businesses Money through Lighting...

    Energy.gov [DOE] (indexed site)

    Saving American Families and Businesses Money through Lighting Efficiency David Friedman ... lights end up costing consumers more money in higher electric bills in the long run. ...

  18. American Institute of Architects 2030 Commitment Enabled by Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    In addition, this data set can help DOE create comparisons to building projects that have been uploaded to the Building Performance Database. View the Presentation American ...

  19. DOE - Office of Legacy Management -- American Manufacturing Co...

    Office of Legacy Management (LM)

    Manufacturing Co of Texas - TX 08 FUSRAP Considered Sites Site: American Manufacturing Co of Texas - TX 08 ( TX.08 ) Eliminated from further consideration under FUSRAP Designated ...

  20. American Solar Energy Society ASES | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Energy Society ASES Jump to: navigation, search Name: American Solar Energy Society (ASES) Place: Boulder, Colorado Zip: 80301 Sector: Solar Product: Dedicated to advancing the use...

  1. Native American educational conference Nov. 13-14

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    business out of Placitas that specializes in serving schools with significant Native American populations; Los Alamos National Laboratory; Los Alamos National Security, LLC;...

  2. DOE - Office of Legacy Management -- American Machine and Metals...

    Office of Legacy Management (LM)

    Metals Inc - IL 24 FUSRAP Considered Sites Site: American Machine and Metals Inc (IL.24 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name:...

  3. MidAmerican Energy (Gas and Electric) - Commercial New Construction...

    Energy.gov [DOE] (indexed site)

    Utility Administrator MidAmerican Energy Website http:www.midamericanenergy.comeeiabuscommnewconstruction.aspx State Iowa Program Type Rebate Program Rebate Amount...

  4. Frequency Control Concerns in the North American Electric Power...

    Office of Scientific and Technical Information (OSTI)

    Control Concerns in the North American Electric Power System Kirby, B.J. 24 POWER TRANSMISSION AND DISTRIBUTION; EFFICIENCY; FREQUENCY CONTROL; MARKET; PERFORMANCE; POWER...

  5. 2013 Domenici Public Policy Conference: The Future of American...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Domenici Public Policy Conference: The Future of American Energy, Las Cruces, NM, ... Twitter Google + Vimeo Newsletter Signup SlideShare 2013 Domenici Public Policy ...

  6. EM Laboratory Meteorologist to Lead American Meteorological Society

    Energy.gov [DOE]

    AIKEN, S.C. – In a first for DOE, a Department-affiliated meteorologist has been named president-elect of the American Meteorological Society (AMS).

  7. Thackeray receives Murphree Award from the American Chemical...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Murphree Award in Industrial and Engineering Chemistry by the American Chemical Society (ACS). The award, sponsored by ExxonMobil Research and Engineering, recognizes outstanding...

  8. American Society of Mechanical Engineers/Savannah River National...

    Energy.gov [DOE] (indexed site)

    Standards Workshop and the DOE Hydrogen Pipeline Working Group Workshop Summary American ... Standards Workshop and the DOE Hydrogen Pipeline Working Group Meeting Attendee List ...

  9. Battery and Electric Drive Awardee List from American Recovery...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Awardee List from American Recovery and Reinvestment Act funding Battery and Electric ... and their components and to expand battery recycling capacity 500 million in grants ...

  10. Battery and Electric Drive Manufacturing Distribution Map - American...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Manufacturing Distribution Map - American Recovery and Reinvestment Act funding Battery ... and their components and to expand battery recycling capacity 500 million in grants ...

  11. American Council on Renewable Energy ACORE | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Council on Renewable Energy ACORE Jump to: navigation, search Name: American Council on Renewable Energy (ACORE) Place: Washington, Washington, DC Zip: 20006 Sector: Renewable...

  12. North American Industry Classification System (NAICS) Search Tool

    Energy.gov [DOE]

    The North American Industry Classification System (NAICS) is the standard used by Federal statistical agencies in classifying business establishments for the purpose of collecting, analyzing, and...

  13. Native American Fish and Wildlife Society Pacific Region Conference

    Energy.gov [DOE]

    The Native American Fish and Wildlife Society is hosting a two-day conference featuring tribal roundtables on harvest methods, forest service, and more.

  14. 2013 Asian American & Pacific Islander Heritage Month Resources...

    Office of Environmental Management (EM)

    ... year 2000 through 2010. Policy Priorities Info-graphic: A detailed illustration of the ... For more information, please contact: White House Initiative on Asian American and Pacific ...

  15. A Partial Mechanistic Understanding of the North American Monsoon

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    North American monsoon (NAM) supplies about 60% to 80%, 45%, and 35% of the annual precipitation for northwestern Mexico, New Mexico, and Arizona, respectively. An understanding...

  16. DOE Awards Native American, Tribally-Owned Small Business Contract...

    Energy Saver

    Small Business Contract for Support Services to Savannah River Operations Office DOE Awards Native American, Tribally-Owned Small Business Contract for Support Services to ...

  17. North American Polysilicon Technology LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Technology LLC Jump to: navigation, search Name: North American Polysilicon Technology LLC Product: A US-based company engaged in R&D of polysilicon technology. References: North...

  18. American Green Holdings LLC AGH | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Green Holdings LLC AGH Jump to: navigation, search Name: American Green Holdings LLC (AGH) Place: Montana Product: Montana-based biodiesel manufacturer, using high-pressure...

  19. Amitava Bhattacharjee Elected a Fellow of the American Geophysical...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Amitava Bhattacharjee Elected a Fellow of the American Geophysical Union By Raphael Rosen September 18, 2015 Tweet Widget Google Plus One Share on Facebook PPPL Physicist Amitava...

  20. 17th Pan-American Synchrotron Radiation Instrumentation Conference

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    17th Pan-American Synchrotron Radiation Instrumentation Conference SRI2013 is now accepting abstract submissions (until March 31, 2013). June 19-21, 2013; Gaithersburg, Maryland,...

  1. Sandia Energy - Sandians Participate in 46th Annual American...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Participate in 46th Annual American Geophysical Union (AGU) Conference Home Infrastructure Security Carbon Capture & Storage Climate Energy Partnership News Global Climate & Energy...

  2. DOE - Office of Legacy Management -- American Railway Express...

    Office of Legacy Management (LM)

    Railway Express Office - NY 0-03 FUSRAP Considered Sites Site: American Railway Express Office (NY.0-03 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated...

  3. Comments of the American Petroleum Institute | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Petroleum Institute Comments of the American Petroleum Institute Similar to the electric utility industry's implementation of smart grid, oil and natural gas companies are in the ...

  4. American Science and Technology Corporation AST | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Science and Technology Corporation AST Jump to: navigation, search Name: American Science and Technology Corporation (AST) Place: Chicago, Illinois Zip: 60622 Sector: Services...

  5. Gopalakrishnan, Sarang; Ryu, Shinsei Not Available American Physical

    Office of Scientific and Technical Information (OSTI)

    Stability of edge states in strained graphene Ghaemi, Pouyan; Gopalakrishnan, Sarang; Ryu, Shinsei Not Available American Physical Society None USDOE United States 2013-04-01...

  6. North American SynchroPhasor Initiative (NASPI) Technical Report...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    North American SynchroPhasor Initiative (NASPI) Technical Report - Synchrophasor Technology and Renewables Integration This technical report was developed in June 2012 by the North ...

  7. Federal Asian Pacific American Council - New Mexico Chapter Albuquerqu...

    National Nuclear Security Administration (NNSA)

    Asian Pacific American Council - New Mexico Chapter Albuquerque, NM | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the...

  8. NREL Research Fellow Howard Branz Named Fellow of American Physical...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Research Fellow Howard Branz Named Fellow of American Physical Society Society cites Branz's seminal work on thin-film solar cells and nanostructures January 14, 2013 A solar ...

  9. National Rotor Testbed Functional Scaling Presented at American...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Functional Scaling Presented at American Institute of Aeronautics and Astronautics 2014 ... Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, ...

  10. Obama Administration Announces Major Step Forward for the American...

    Office of Environmental Management (EM)

    The Energy Department, USEC Inc. and American Centrifuge Demonstration, LLC, have signed a set of agreements that will enable the research, development and demonstration (RD&D) ...

  11. EM Helps Create STEM Playbook for Native American Youth | Department...

    Office of Environmental Management (EM)

    ... the Junior Solar Sprint and Hydrogen Fuel Cell Car Competition in Littleton, Colorado in ... Playbook for Native American Youth The SUN Project Enhances STEM Education for Native ...

  12. DOE - Office of Legacy Management -- American Steel Foundries...

    Office of Legacy Management (LM)

    Steel Foundries Elmes-King Div - OH 36 FUSRAP Considered Sites Site: American Steel Foundries Elmes-King Div (OH.36 ) Eliminated from consideration under FUSRAP Designated Name: ...

  13. Fuel Cell Technologies Office American Energy and Manufacturing...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    eere.energy.gov Fuel Cell Technologies Office American Energy & Manufacturing Competitiveness Partnership http:www.aemcsummit.compete.org Fuel Cell Manufacturing Dr. Sunita ...

  14. Clean Energy Manufacturing Initiative: Increasing American Competitiveness Through Innovation

    Energy.gov [DOE]

    Find out how the Energy Department's Clean Energy Manufacturing Initiative is helping to boost American competitiveness, grow the economy and protect the environment.

  15. American Energy Power Systems Inc AEPS | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Sector: Solar Product: Offered distributed power systems including PV panels, solar water heating, fuel cells and radiant floor heating applications. References: American...

  16. Bootstrapping a Sustainable North American PEM Fuel Cell Industry...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    a Sustainable North American PEM Fuel Cell Industry: Could a Federal Acquisition ... for Fully Installed Fuel Cell Systems ......19 8 Logit ...

  17. North American Standard Level VI Inspection Program Update: Ensuring...

    Office of Environmental Management (EM)

    North American Standard Level VI Inspection Program Update: Ensuring Safe Transportation of Radioactive Material Presentation made by Carlisle Smith for the NTSF annual meeting ...

  18. Bacillus anthracis spores germinate extracellularly at air-liquid interface in an in vitro lung model under serum-free conditions

    SciTech Connect

    Powell, Joshua D.; Hutchison, Janine R.; Hess, Becky M.; Straub, Tim M.

    2015-07-30

    Aims: To better understand the parameters that govern spore dissemination after lung exposure using in vitro cell systems. Methods and Results: We evaluated the kinetics of uptake, germination and proliferation of B. anthracis Sterne spores in association with human primary lung epithelial cells, Calu-3, and A549 cell lines. We also analyzed the influence of various cell culture media formulations related to spore germination. Conclusions: We found negligible spore uptake by epithelial cells, but germination and proliferation of spores in the extracellular environment was evident, and was appreciably higher in A549 and Calu-3 cultures than in primary epithelial cells. Additionally, our results revealed spores in association with primary cells submerged in cell culture media germinated 1 h

  19. Bacillus anthracis spores germinate extracellularly at air-liquid interface in an in vitro lung model under serum-free conditions

    DOE PAGES [OSTI]

    Powell, Joshua D.; Hutchison, Janine R.; Hess, Becky M.; Straub, Tim M.

    2015-07-30

    Aims: To better understand the parameters that govern spore dissemination after lung exposure using in vitro cell systems. Methods and Results: We evaluated the kinetics of uptake, germination and proliferation of B. anthracis Sterne spores in association with human primary lung epithelial cells, Calu-3, and A549 cell lines. We also analyzed the influence of various cell culture media formulations related to spore germination. Conclusions: We found negligible spore uptake by epithelial cells, but germination and proliferation of spores in the extracellular environment was evident, and was appreciably higher in A549 and Calu-3 cultures than in primary epithelial cells. Additionally, ourmore » results revealed spores in association with primary cells submerged in cell culture media germinated 1 h« less

  20. Elevated epidermal growth factor receptor binding in plutonium-induced lung tumors from dogs

    SciTech Connect

    Leung, F.C.; Bohn, L.R.; Dagle, G.E. )

    1991-04-01

    The objective of this study is to examine and characterize epidermal growth factor receptor (EGF-R) binding in inhaled plutonium-induced canine lung-tumor tissue and to compare it with that in normal canine lung tissue. Crude membrane preparations from normal and lung-tumor tissue from beagle dogs were examined in a radioreceptor assay, using {sup 125}I-labeled epidermal growth factor (EGF) as a ligand. Specific EGF receptor binding was determined in the presence of excess unlabeled EGF. We have examined EGF receptor binding in eight lung-tumor samples obtained from six dogs. Epidermal growth factor receptor binding was significantly greater in lung-tumor samples (31.38%) compared with that in normal lung tissue (3.76%). Scatchard plot analysis from the displacement assay revealed that there was no statistical difference in the binding affinity but significantly higher concentration of EGF-R sites in the lung-tumor tissue (619 fmol/mg) than in normal lung tissue (53 fmol/mg). The increase in EGF-R number in plutonium-induced dog lung tumors does not seem to correlate with increase in the initial lung burden exposure to plutonium. Our results demonstrate that there is a significant increase in EGF-R binding in inhaled plutonium-induced dog lung tumors.