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Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer`s disease: an autoradiographic study using {sup 3}H-hemicholinium-3

Abstract

H-hemicholinium-3 (H-HC-3) binding, a marker of the presynaptic high-affinity choline uptake carrier (HACU), was measured by autoradiography in several brain regions of 17 Alzheimer`s disease (AD) patients and of 11 matched controls. A significant decrease in the density of H-HC-3 binding sites was found in entorhinal cortex, hippocampus and layers I-III of the frontal cortex. By contrast, in the caudate-putamen the number of H-HC-3 binding sites in AD cases was comparable to that of control striata. These data concur with previous results using classical presynaptic markers and reflect the loss in the activity of HACU, and, hence, in the synthesis of acetylcholine, that selectively occurs in cortical areas of AD brains due to the degeneration of presynaptic cholinergic terminals arising from the basal forebrain. However, the relatively low mean reduction in HACU in cortical areas (-40 %), together with the apparent indemnity of this marker in certain severely demented AD cases, suggest that AD dementia cannot be explained simply by the loss of presynaptic terminals originating in the basal forebrain. These data seem to be a good explanation for the poor response to cholinergic replacement in AD. (author).
Authors:
Rodriguez-Puertas, R; Pazos, A; [1]  Zarranz, J J; [2]  Pascual, J [3] 
  1. Dept. of Physiology and Pharmacology, Unit of Pharmacology, Univ. of Cantabria, Santander (Spain)
  2. Dept. of Neuroscience, Univ. of the Basque Country, Leioa (Spain)
  3. Dept. of Medicine, Service of Neurology, Univ. Hospital `Marques de Valdecilla`, Univ. of Cantabria, Santander (Spain)
Publication Date:
Dec 31, 1994
Product Type:
Journal Article
Reference Number:
SCA: 560161; PA: AIX-26:063016; EDB-95:126614; SN: 95001457910
Resource Relation:
Journal Name: Journal of Neural Transmission, Parkinson`s Disease and Dementia Section; Journal Volume: 8; Other Information: PBD: 1994
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; AUTORADIOGRAPHY; CHOLINE; TRITIUM; NERVOUS SYSTEM DISEASES; CEREBRAL CORTEX; UPTAKE
OSTI ID:
97922
Country of Origin:
Austria
Language:
English
Other Identifying Numbers:
Journal ID: JNPSEJ; ISSN 0936-3076; TRN: AT9500072063016
Submitting Site:
INIS
Size:
pp. 161-169
Announcement Date:

Citation Formats

Rodriguez-Puertas, R, Pazos, A, Zarranz, J J, and Pascual, J. Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer`s disease: an autoradiographic study using {sup 3}H-hemicholinium-3. Austria: N. p., 1994. Web. doi:10.1007/BF02260937.
Rodriguez-Puertas, R, Pazos, A, Zarranz, J J, & Pascual, J. Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer`s disease: an autoradiographic study using {sup 3}H-hemicholinium-3. Austria. doi:10.1007/BF02260937.
Rodriguez-Puertas, R, Pazos, A, Zarranz, J J, and Pascual, J. 1994. "Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer`s disease: an autoradiographic study using {sup 3}H-hemicholinium-3." Austria. doi:10.1007/BF02260937. https://www.osti.gov/servlets/purl/10.1007/BF02260937.
@misc{etde_97922,
title = {Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer`s disease: an autoradiographic study using {sup 3}H-hemicholinium-3}
author = {Rodriguez-Puertas, R, Pazos, A, Zarranz, J J, and Pascual, J}
abstractNote = {H-hemicholinium-3 (H-HC-3) binding, a marker of the presynaptic high-affinity choline uptake carrier (HACU), was measured by autoradiography in several brain regions of 17 Alzheimer`s disease (AD) patients and of 11 matched controls. A significant decrease in the density of H-HC-3 binding sites was found in entorhinal cortex, hippocampus and layers I-III of the frontal cortex. By contrast, in the caudate-putamen the number of H-HC-3 binding sites in AD cases was comparable to that of control striata. These data concur with previous results using classical presynaptic markers and reflect the loss in the activity of HACU, and, hence, in the synthesis of acetylcholine, that selectively occurs in cortical areas of AD brains due to the degeneration of presynaptic cholinergic terminals arising from the basal forebrain. However, the relatively low mean reduction in HACU in cortical areas (-40 %), together with the apparent indemnity of this marker in certain severely demented AD cases, suggest that AD dementia cannot be explained simply by the loss of presynaptic terminals originating in the basal forebrain. These data seem to be a good explanation for the poor response to cholinergic replacement in AD. (author).}
doi = {10.1007/BF02260937}
journal = {Journal of Neural Transmission, Parkinson`s Disease and Dementia Section}
volume = {8}
journal type = {AC}
place = {Austria}
year = {1994}
month = {Dec}
}