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Radiation as a processing aid for upgrading gelatin and gelatin capsules

Abstract

Gelatin for pharmaceutical use should not contain more than 1000 microorganisms per gram and must not contain pathogenic microorganisms like Salmonella species and E.Coli. For some biological studies spore free gelatin is essential. Locally available gelatin and gelatin capsules have been found to contain a good number of microorganisms. Gelatin and its capsules containing different colours were exposed to graded doses of radiation and stored at different temperatures. They were then examined for microbial content, disintegration characteristics, pH, viscosity and colour change. The study shows that radiation treatment is useful to upgrade microbiologically both gelatin and its capsules. This technique provides apparently a useful and economic method for producing spore free gelatin which in commerce is relatively expensive.
Authors:
Patel, K M; Tantry, M; Sharma, G; Gopal, N G.S. [1] 
  1. Bhabha Atomic Research Centre, Bombay (India). ISOMED
Publication Date:
Jan 01, 1979
Product Type:
Conference
Report Number:
CONF-780294-
Reference Number:
AIX-11-549083; EDB-81-015699
Resource Relation:
Conference: Symposium on applications of radioisotopes in chemical and metallurgical industries, Trombay, Bombay, India, 7 Feb 1978; Related Information: In: Proceedings of the symposium on applications of radioisotopes in chemical and metallurgical industries (held at) Bombay, February 7-8, 1978.
Subject:
60 APPLIED LIFE SCIENCES; GELATIN; RADIOSTERILIZATION; MEDICAL SUPPLIES; BACTERIAL SPORES; BIOLOGICAL RADIATION EFFECTS; CAPSULES; CHEMICAL RADIATION EFFECTS; COLOR; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; GAMMA RADIATION; MORTALITY; PHYSICAL RADIATION EFFECTS; RADIATION DOSES; VISCOSITY; BIOLOGICAL EFFECTS; CHEMISTRY; COLLOIDS; CONTAINERS; DATA; DISPERSIONS; DOSES; ELECTROMAGNETIC RADIATION; INFORMATION; IONIZING RADIATIONS; NUMERICAL DATA; OPTICAL PROPERTIES; ORGANIC COMPOUNDS; ORGANOLEPTIC PROPERTIES; PHYSICAL PROPERTIES; PROTEINS; RADIATION CHEMISTRY; RADIATION EFFECTS; RADIATIONS; SPORES; STERILIZATION; 070203* - Radiation Sources- Use in Medical Supply Sterilization- (-1987)
OSTI ID:
8488950
Country of Origin:
India
Language:
English
Submitting Site:
INIS
Size:
Pages: 153-160
Announcement Date:
Sep 01, 1980

Citation Formats

Patel, K M, Tantry, M, Sharma, G, and Gopal, N G.S. Radiation as a processing aid for upgrading gelatin and gelatin capsules. India: N. p., 1979. Web.
Patel, K M, Tantry, M, Sharma, G, & Gopal, N G.S. Radiation as a processing aid for upgrading gelatin and gelatin capsules. India.
Patel, K M, Tantry, M, Sharma, G, and Gopal, N G.S. 1979. "Radiation as a processing aid for upgrading gelatin and gelatin capsules." India.
@misc{etde_8488950,
title = {Radiation as a processing aid for upgrading gelatin and gelatin capsules}
author = {Patel, K M, Tantry, M, Sharma, G, and Gopal, N G.S.}
abstractNote = {Gelatin for pharmaceutical use should not contain more than 1000 microorganisms per gram and must not contain pathogenic microorganisms like Salmonella species and E.Coli. For some biological studies spore free gelatin is essential. Locally available gelatin and gelatin capsules have been found to contain a good number of microorganisms. Gelatin and its capsules containing different colours were exposed to graded doses of radiation and stored at different temperatures. They were then examined for microbial content, disintegration characteristics, pH, viscosity and colour change. The study shows that radiation treatment is useful to upgrade microbiologically both gelatin and its capsules. This technique provides apparently a useful and economic method for producing spore free gelatin which in commerce is relatively expensive.}
place = {India}
year = {1979}
month = {Jan}
}