Abstract
In the course of our studies directed at elucidating biological effects of the air pollutants SO/sub 2/ and NO/sub x/ it was found, that the activity of lactate dehydrogenase (LDH) is inhibited by SO/sub 2/. This effect was observed in vitro and in vivo and is based on a sulfite- and not on a sulfate-mediated action. NO/sub x/ and SO/sub 2/ reduce DNA single strand breaks induced by B(a)P in fetal hamster lung cells in vitro and SO/sub 2/ reduces DNA single strand breaks induced by AMMN in primary cultures of rat hepatocytes. The postulated mechanisms of action are discussed. Sulfite itself induces DNA-amplification in SV40 transformed CO60 cells; but an increase in the amplification rate induced by B(a)P or 7,12-DMBA was not observed. The in vitro genotoxicity (DNA single strand breaks) of 3 nitrosamines (AMMN, NDMA, NMBzA) is reduced in rat hepatocytes from donor animals pretreated with 50 ppm SO/sub 2/ for 2 weeks. Inhalation of NO/sub x/ by rats reduced the activities of AHH, NDMA-D and GST in hepatocytes and of GST in lung cells. Following SO/sub 2/ inhalation NDMA-D activity in the liver is increased and GST activity in the lung is decreased. In a current in
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Citation Formats
Zeller, W J, Klein, R G, Pool, B L, Schmezer, P, Horsch, F, Filby, W G, Fund, N, Gross, S, Hanisch, B, Kilz, E, and Seidel, A.
In vitro and in vivo studies of the carcinogenic, toxic and genotoxic activities of the air pollutants SO/sub 2/ and NO/sub x/, separately and in combination with carcinogenic polycyclic aromatic hydrocarbons and N-nitrosamines.
Germany: N. p.,
1988.
Web.
Zeller, W J, Klein, R G, Pool, B L, Schmezer, P, Horsch, F, Filby, W G, Fund, N, Gross, S, Hanisch, B, Kilz, E, & Seidel, A.
In vitro and in vivo studies of the carcinogenic, toxic and genotoxic activities of the air pollutants SO/sub 2/ and NO/sub x/, separately and in combination with carcinogenic polycyclic aromatic hydrocarbons and N-nitrosamines.
Germany.
Zeller, W J, Klein, R G, Pool, B L, Schmezer, P, Horsch, F, Filby, W G, Fund, N, Gross, S, Hanisch, B, Kilz, E, and Seidel, A.
1988.
"In vitro and in vivo studies of the carcinogenic, toxic and genotoxic activities of the air pollutants SO/sub 2/ and NO/sub x/, separately and in combination with carcinogenic polycyclic aromatic hydrocarbons and N-nitrosamines."
Germany.
@misc{etde_7961237,
title = {In vitro and in vivo studies of the carcinogenic, toxic and genotoxic activities of the air pollutants SO/sub 2/ and NO/sub x/, separately and in combination with carcinogenic polycyclic aromatic hydrocarbons and N-nitrosamines}
author = {Zeller, W J, Klein, R G, Pool, B L, Schmezer, P, Horsch, F, Filby, W G, Fund, N, Gross, S, Hanisch, B, Kilz, E, and Seidel, A}
abstractNote = {In the course of our studies directed at elucidating biological effects of the air pollutants SO/sub 2/ and NO/sub x/ it was found, that the activity of lactate dehydrogenase (LDH) is inhibited by SO/sub 2/. This effect was observed in vitro and in vivo and is based on a sulfite- and not on a sulfate-mediated action. NO/sub x/ and SO/sub 2/ reduce DNA single strand breaks induced by B(a)P in fetal hamster lung cells in vitro and SO/sub 2/ reduces DNA single strand breaks induced by AMMN in primary cultures of rat hepatocytes. The postulated mechanisms of action are discussed. Sulfite itself induces DNA-amplification in SV40 transformed CO60 cells; but an increase in the amplification rate induced by B(a)P or 7,12-DMBA was not observed. The in vitro genotoxicity (DNA single strand breaks) of 3 nitrosamines (AMMN, NDMA, NMBzA) is reduced in rat hepatocytes from donor animals pretreated with 50 ppm SO/sub 2/ for 2 weeks. Inhalation of NO/sub x/ by rats reduced the activities of AHH, NDMA-D and GST in hepatocytes and of GST in lung cells. Following SO/sub 2/ inhalation NDMA-D activity in the liver is increased and GST activity in the lung is decreased. In a current in vivo long-term inhalation study of NDMA+-SO/sub 2/ or NO/sub x/ first tumors of the nasal cavity are already observed after a total dose of 2 mg NDMA/animal.}
place = {Germany}
year = {1988}
month = {Apr}
}
title = {In vitro and in vivo studies of the carcinogenic, toxic and genotoxic activities of the air pollutants SO/sub 2/ and NO/sub x/, separately and in combination with carcinogenic polycyclic aromatic hydrocarbons and N-nitrosamines}
author = {Zeller, W J, Klein, R G, Pool, B L, Schmezer, P, Horsch, F, Filby, W G, Fund, N, Gross, S, Hanisch, B, Kilz, E, and Seidel, A}
abstractNote = {In the course of our studies directed at elucidating biological effects of the air pollutants SO/sub 2/ and NO/sub x/ it was found, that the activity of lactate dehydrogenase (LDH) is inhibited by SO/sub 2/. This effect was observed in vitro and in vivo and is based on a sulfite- and not on a sulfate-mediated action. NO/sub x/ and SO/sub 2/ reduce DNA single strand breaks induced by B(a)P in fetal hamster lung cells in vitro and SO/sub 2/ reduces DNA single strand breaks induced by AMMN in primary cultures of rat hepatocytes. The postulated mechanisms of action are discussed. Sulfite itself induces DNA-amplification in SV40 transformed CO60 cells; but an increase in the amplification rate induced by B(a)P or 7,12-DMBA was not observed. The in vitro genotoxicity (DNA single strand breaks) of 3 nitrosamines (AMMN, NDMA, NMBzA) is reduced in rat hepatocytes from donor animals pretreated with 50 ppm SO/sub 2/ for 2 weeks. Inhalation of NO/sub x/ by rats reduced the activities of AHH, NDMA-D and GST in hepatocytes and of GST in lung cells. Following SO/sub 2/ inhalation NDMA-D activity in the liver is increased and GST activity in the lung is decreased. In a current in vivo long-term inhalation study of NDMA+-SO/sub 2/ or NO/sub x/ first tumors of the nasal cavity are already observed after a total dose of 2 mg NDMA/animal.}
place = {Germany}
year = {1988}
month = {Apr}
}