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Electron microscopic study on radiosensitivity of uterine cervical cancer

Journal Article:

Abstract

The effects of 1000 R of tele-cobalt upon the changes in the primary lesions of uterine cervical cancer with time were studied with an electron microscope. In addition, twenty cases which were proven to have cancer tissues (10 cases of IInd stage of cancer, 8 cases of IIIrd stage of cancer and 2 cases of IVth stage of cancer) were studied. Four cases were favourably sensitive, 7 cases moderately sensitive and 9 cases unfavourably sensitive to radiation. In favourably radio-sensitive cases, the changes in the cancer cells first appeared in the nucleus. There were other changes such as local clumping of chromatin and, specifically, vacuolization of the nucleus. The changes in the endoplasmic reticulum appeared somewhat late. In addition, the disturbance of mitochondria and the decrease or disappearance of ribosomes were specifically due to radiation injury. From the point of view of changes with time, Golgi's apparatus was enlarged and the membrane of the endoplasmic reticulum was degenerated at the 1st day. At the 3rd day, vacuolization of the nucleus appeared, the nuclear corpuscles were increased, the nucleoplasm became thin, and mitochondria was enlarged and degenerated. At the 5th day, the nuclear membrane disappeared, the nucleus was destroyed, large vacuolization  More>>
Authors:
Iwai, S; Shiozawa, K; Tsukamoto, T; Noguchi, H; Tsukahara, Y [1] 
  1. Shinshu Univ., Matsumoto, Nagano (Japan). Faculty of Medicine
Publication Date:
Nov 01, 1974
Product Type:
Journal Article
Reference Number:
EDB-76-038271
Resource Relation:
Journal Name: Nippon Sanka Fujinka Gakkai Zasshi; (Japan); Journal Volume: 26:11; Other Information: illus. 3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOMAS; RADIOSENSITIVITY; BIOLOGICAL RADIATION EFFECTS; CELL NUCLEI; ELECTRON MICROSCOPY; GAMMA RADIATION; IRRADIATION; MITOCHONDRIA; RIBOSOMES; TIME DEPENDENCE; ULTRASTRUCTURAL CHANGES; UROGENITAL SYSTEM DISEASES; UTERUS; BIOLOGICAL EFFECTS; BODY; CELL CONSTITUENTS; DISEASES; ELECTROMAGNETIC RADIATION; FEMALE GENITALS; IONIZING RADIATIONS; MICROSCOPY; MORPHOLOGICAL CHANGES; NEOPLASMS; ORGANOIDS; ORGANS; RADIATION EFFECTS; RADIATIONS; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7366089
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NISFA
Submitting Site:
INIS
Size:
Pages: 1253-1256
Announcement Date:

Journal Article:

Citation Formats

Iwai, S, Shiozawa, K, Tsukamoto, T, Noguchi, H, and Tsukahara, Y. Electron microscopic study on radiosensitivity of uterine cervical cancer. Japan: N. p., 1974. Web.
Iwai, S, Shiozawa, K, Tsukamoto, T, Noguchi, H, & Tsukahara, Y. Electron microscopic study on radiosensitivity of uterine cervical cancer. Japan.
Iwai, S, Shiozawa, K, Tsukamoto, T, Noguchi, H, and Tsukahara, Y. 1974. "Electron microscopic study on radiosensitivity of uterine cervical cancer." Japan.
@misc{etde_7366089,
title = {Electron microscopic study on radiosensitivity of uterine cervical cancer}
author = {Iwai, S, Shiozawa, K, Tsukamoto, T, Noguchi, H, and Tsukahara, Y}
abstractNote = {The effects of 1000 R of tele-cobalt upon the changes in the primary lesions of uterine cervical cancer with time were studied with an electron microscope. In addition, twenty cases which were proven to have cancer tissues (10 cases of IInd stage of cancer, 8 cases of IIIrd stage of cancer and 2 cases of IVth stage of cancer) were studied. Four cases were favourably sensitive, 7 cases moderately sensitive and 9 cases unfavourably sensitive to radiation. In favourably radio-sensitive cases, the changes in the cancer cells first appeared in the nucleus. There were other changes such as local clumping of chromatin and, specifically, vacuolization of the nucleus. The changes in the endoplasmic reticulum appeared somewhat late. In addition, the disturbance of mitochondria and the decrease or disappearance of ribosomes were specifically due to radiation injury. From the point of view of changes with time, Golgi's apparatus was enlarged and the membrane of the endoplasmic reticulum was degenerated at the 1st day. At the 3rd day, vacuolization of the nucleus appeared, the nuclear corpuscles were increased, the nucleoplasm became thin, and mitochondria was enlarged and degenerated. At the 5th day, the nuclear membrane disappeared, the nucleus was destroyed, large vacuolization of the endoplasmic reticulum was seen, free ribosomes were decreased, and changes around the endoplasmic reticulum were observed. At the 7th day, collagen around the endoplasmic reticulum appeared. In favourably radiosensitive cases, individual tumor cells showed the same degeneration, which fairly corresponded to that evaluated by the histological observation. The disturbance of the cells was caused by radiation, so-called ''burning'' of the cells. Radiation protection of the cells against burning was considered in terms of their radiosensitivity.}
journal = {Nippon Sanka Fujinka Gakkai Zasshi; (Japan)}
volume = {26:11}
journal type = {AC}
place = {Japan}
year = {1974}
month = {Nov}
}