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Experimental studies on radiation effects under high pressure oxygen

Journal Article:

Abstract

The effect of oxygen tension on the radiosensitivity of tumor cells is well known, but its clinical application for radiotherapy is not yet established. Rabbits with V x 2 carcinoma in the maxilla were irradiated by /sup 60/Co under high pressure oxygen (experimental group), and compared with those treated in air (control group). For the purpose of examining the clinical effects of high pressure oxygen, an experiment was made in vivo. The following items were compared respectively: a) Tumor regression effect b) Tumor clearance rate c) Survival days d) Half size reduction time e) Inhibition of DNA synthesis in the tumor tissue. Results obtained were as follows: a) 56 per cent of animals showed tumor regression in the experimental group, whereas it occured 26 per cent in the control group. b) 53 per cent of animals showed tumor disappearance in the experimental group, while it was observed only in 13 per cent in the control group. c) Only 2 of 30 rabbits irradiated in air survived over 180 days, whereas 11 of 30 rabbits survived meanwhile in the group irradiated under high pressure oxygen. d) About 11 days were necessary to reduce the tumor size by half after irradiation in  More>>
Authors:
Fujimura, E [1] 
  1. Osaka Univ. (Japan). School of Dentistry
Publication Date:
Jun 01, 1974
Product Type:
Journal Article
Reference Number:
EDB-76-038312
Resource Relation:
Journal Name: Osaka Daigaku Shigaku Zasshi; (Japan); Journal Volume: 19:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EXPERIMENTAL NEOPLASMS; BIOLOGICAL RADIATION EFFECTS; OXYGEN; RADIOSENSITIVITY EFFECTS; DNA; GAMMA RADIATION; HIGH PRESSURE; RABBITS; RADIOSENSITIVITY; RESPONSE MODIFYING FACTORS; SURVIVAL TIME; TIME DEPENDENCE; TUMOR CELLS; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; CRYOGENIC FLUIDS; DISEASES; ELECTROMAGNETIC RADIATION; ELEMENTS; FLUIDS; IONIZING RADIATIONS; MAMMALS; NEOPLASMS; NONMETALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7366077
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: ODSZA
Submitting Site:
INIS
Size:
Pages: 100-108
Announcement Date:

Journal Article:

Citation Formats

Fujimura, E. Experimental studies on radiation effects under high pressure oxygen. Japan: N. p., 1974. Web.
Fujimura, E. Experimental studies on radiation effects under high pressure oxygen. Japan.
Fujimura, E. 1974. "Experimental studies on radiation effects under high pressure oxygen." Japan.
@misc{etde_7366077,
title = {Experimental studies on radiation effects under high pressure oxygen}
author = {Fujimura, E}
abstractNote = {The effect of oxygen tension on the radiosensitivity of tumor cells is well known, but its clinical application for radiotherapy is not yet established. Rabbits with V x 2 carcinoma in the maxilla were irradiated by /sup 60/Co under high pressure oxygen (experimental group), and compared with those treated in air (control group). For the purpose of examining the clinical effects of high pressure oxygen, an experiment was made in vivo. The following items were compared respectively: a) Tumor regression effect b) Tumor clearance rate c) Survival days d) Half size reduction time e) Inhibition of DNA synthesis in the tumor tissue. Results obtained were as follows: a) 56 per cent of animals showed tumor regression in the experimental group, whereas it occured 26 per cent in the control group. b) 53 per cent of animals showed tumor disappearance in the experimental group, while it was observed only in 13 per cent in the control group. c) Only 2 of 30 rabbits irradiated in air survived over 180 days, whereas 11 of 30 rabbits survived meanwhile in the group irradiated under high pressure oxygen. d) About 11 days were necessary to reduce the tumor size by half after irradiation in the group under high pressure oxygen, while it took 17 days in the group treated in normal air. e) DNA synthesis was inhibited more prominently in the group irradiated under high pressure oxygen in normal air.}
journal = {Osaka Daigaku Shigaku Zasshi; (Japan)}
volume = {19:1}
journal type = {AC}
place = {Japan}
year = {1974}
month = {Jun}
}