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Renal manifestations of chronic lead poisoning: clinical, biological, and histological study

Abstract

Clinical observation of a metal worker who showed, after exposure to lead, biological disturbances typical of lead poisoning, associated with very discrete azotaemia. In-depth nephrological exploration by electronic microscope showed the existence of intra-cytoplasmic inclusions, intra-nuclear corpuscles and mitochondrial changes, without significant impairment of renal function. This case brings the authors to analyse the more recently discovered clinical, biological and histological aspects of the kidneys in chronic lead poisoning and to draw conclusions concerning prognosis and medico-legal aspects. As regards therapy, the use of chelating agents, on account of the sudden liberation of the toxic metal it causes, seems liable to aggravate kidney and other damage, and should therefore be administered under strict medical supervision.
Publication Date:
Jan 01, 1974
Product Type:
Journal Article
Reference Number:
EDB-76-043700
Resource Relation:
Journal Name: Lille Med.; (France); Journal Volume: 19:6
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LEAD; TOXICITY; OCCUPATIONAL DISEASES; CHELATING AGENTS; HISTOLOGY; INDUSTRIAL MEDICINE; KIDNEYS; METAL INDUSTRY; MITOCHONDRIA; PERSONNEL; THERAPY; BODY; CELL CONSTITUENTS; DISEASES; ELEMENTS; INDUSTRY; MEDICINE; METALS; ORGANOIDS; ORGANS; 550600* - Medicine; 550200 - Biochemistry; 560306 - Chemicals Metabolism & Toxicology- Man- (-1987)
OSTI ID:
7365206
Country of Origin:
France
Language:
French
Other Identifying Numbers:
Journal ID: CODEN: LIMEA
Submitting Site:
TIC
Size:
Pages: 651-660
Announcement Date:
Jul 01, 1976

Citation Formats

Devulder, B, Martin, J C, Mathot, J, Dequiedt, P, Durocher, A, Vanhille, P, and Tacquet, A. Renal manifestations of chronic lead poisoning: clinical, biological, and histological study. France: N. p., 1974. Web.
Devulder, B, Martin, J C, Mathot, J, Dequiedt, P, Durocher, A, Vanhille, P, & Tacquet, A. Renal manifestations of chronic lead poisoning: clinical, biological, and histological study. France.
Devulder, B, Martin, J C, Mathot, J, Dequiedt, P, Durocher, A, Vanhille, P, and Tacquet, A. 1974. "Renal manifestations of chronic lead poisoning: clinical, biological, and histological study." France.
@misc{etde_7365206,
title = {Renal manifestations of chronic lead poisoning: clinical, biological, and histological study}
author = {Devulder, B, Martin, J C, Mathot, J, Dequiedt, P, Durocher, A, Vanhille, P, and Tacquet, A}
abstractNote = {Clinical observation of a metal worker who showed, after exposure to lead, biological disturbances typical of lead poisoning, associated with very discrete azotaemia. In-depth nephrological exploration by electronic microscope showed the existence of intra-cytoplasmic inclusions, intra-nuclear corpuscles and mitochondrial changes, without significant impairment of renal function. This case brings the authors to analyse the more recently discovered clinical, biological and histological aspects of the kidneys in chronic lead poisoning and to draw conclusions concerning prognosis and medico-legal aspects. As regards therapy, the use of chelating agents, on account of the sudden liberation of the toxic metal it causes, seems liable to aggravate kidney and other damage, and should therefore be administered under strict medical supervision.}
journal = []
volume = {19:6}
journal type = {AC}
place = {France}
year = {1974}
month = {Jan}
}