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Chemical protection of bacteria and cultured mammalian cells by sulfur--containing compounds

Journal Article:

Abstract

Protection by sulfur-containing compounds was studied using bacteria E. coli Bsub(H) and cultured mouse leukemic cells, L 5178 Y. The protective mechanisms are discussed. The dose reduction factors of non-sulfhydryl compounds observed in the bacteria were the same as those observed in mammalian cells, and the protective activity of these compounds was proportional to their reaction rates with hydroxyl radicals. On the other hand, sulfhydryl compounds, with the exception of glutathione, offered a much greater protection than was anticipated from their radical scavenging activity. From studies under anoxia, the protection of cysteine was explained by its OH scavenging and competition with oxygen. In addition, for MEA, protection against the direct action of radiation was suggested. This was supported by the significant protection in the frozen state.
Authors:
Antoku, S [1] 
  1. Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology
Publication Date:
Mar 01, 1975
Product Type:
Journal Article
Reference Number:
EDB-76-061562
Resource Relation:
Journal Name: J. Radiat. Res.; (Japan); Journal Volume: 16:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RADIATION PROTECTION; SULFUR COMPOUNDS; RADIOSENSITIVITY EFFECTS; ANIMAL CELLS; ANOXIA; BIOLOGICAL RADIATION EFFECTS; CYSTEINE; ESCHERICHIA COLI; GAMMA RADIATION; HYDROXYL RADICALS; IRRADIATION; LEUKOCYTES; MEA; MEG; MICE; MORTALITY; OXYGEN; SCAVENGING; TEMPERATURE DEPENDENCE; AMINES; AMINO ACIDS; ANIMALS; BACTERIA; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBONIC ACID DERIVATIVES; CARBOXYLIC ACIDS; CRYOGENIC FLUIDS; DRUGS; ELECTROMAGNETIC RADIATION; ELEMENTS; FLUIDS; IONIZING RADIATIONS; MAMMALS; MICROORGANISMS; NONMETALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RADICALS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; THIOLS; VERTEBRATES; 560122* - Radiation Effects on Cells- Internal Source- (-1987); 560152 - Radiation Effects on Animals- Animals
OSTI ID:
7362346
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JRARA
Submitting Site:
INIS
Size:
Pages: 28-36
Announcement Date:

Journal Article:

Citation Formats

Antoku, S. Chemical protection of bacteria and cultured mammalian cells by sulfur--containing compounds. Japan: N. p., 1975. Web.
Antoku, S. Chemical protection of bacteria and cultured mammalian cells by sulfur--containing compounds. Japan.
Antoku, S. 1975. "Chemical protection of bacteria and cultured mammalian cells by sulfur--containing compounds." Japan.
@misc{etde_7362346,
title = {Chemical protection of bacteria and cultured mammalian cells by sulfur--containing compounds}
author = {Antoku, S}
abstractNote = {Protection by sulfur-containing compounds was studied using bacteria E. coli Bsub(H) and cultured mouse leukemic cells, L 5178 Y. The protective mechanisms are discussed. The dose reduction factors of non-sulfhydryl compounds observed in the bacteria were the same as those observed in mammalian cells, and the protective activity of these compounds was proportional to their reaction rates with hydroxyl radicals. On the other hand, sulfhydryl compounds, with the exception of glutathione, offered a much greater protection than was anticipated from their radical scavenging activity. From studies under anoxia, the protection of cysteine was explained by its OH scavenging and competition with oxygen. In addition, for MEA, protection against the direct action of radiation was suggested. This was supported by the significant protection in the frozen state.}
journal = {J. Radiat. Res.; (Japan)}
volume = {16:1}
journal type = {AC}
place = {Japan}
year = {1975}
month = {Mar}
}