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DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells

Journal Article:

Abstract

Human diploid fibroblast-like cells derived from four patients with the genetic disease ataxia telangiectasia and from two non-mutant donors were examined for the repair of x-ray induced strand breaks in DNA. The ataxia telangiectasia cultures showed no significant differences from the non-mutant cultures in the kinetics and extent of strand repair. This suggests that the increased spontaneous and x-ray induced chromatid aberrations observed in ataxia telangiectasia cells are not caused by a defect in the repair of single strand breaks as might be suspected from a general model of aberration production.
Authors:
Vincent, Jr, R A; Sheridan, III, R B; Huang, P C [1] 
  1. Johns Hopkins Univ., Baltimore, Md. (USA). Dept. of Environmental and Biophysical Sciences
Publication Date:
Dec 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-245917; EDB-76-072439
Resource Relation:
Journal Name: Mutat. Res.; (Netherlands); Journal Volume: 33:2; 3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DNA; STRAND BREAKS; BIOLOGICAL REPAIR; ANIMAL CELLS; CELL CULTURES; GENETIC RADIATION EFFECTS; HEREDITARY DISEASES; PATIENTS; SEDIMENTATION; SKIN; TELANGIECTASIS; X RADIATION; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BODY; CARDIOVASCULAR DISEASES; DISEASES; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; IONIZING RADIATIONS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RECOVERY; REPAIR; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
7360089
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MUREA
Submitting Site:
INIS
Size:
Pages: 357-366
Announcement Date:
Aug 01, 1976

Journal Article:

Citation Formats

Vincent, Jr, R A, Sheridan, III, R B, and Huang, P C. DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells. Netherlands: N. p., 1975. Web.
Vincent, Jr, R A, Sheridan, III, R B, & Huang, P C. DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells. Netherlands.
Vincent, Jr, R A, Sheridan, III, R B, and Huang, P C. 1975. "DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells." Netherlands.
@misc{etde_7360089,
title = {DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells}
author = {Vincent, Jr, R A, Sheridan, III, R B, and Huang, P C}
abstractNote = {Human diploid fibroblast-like cells derived from four patients with the genetic disease ataxia telangiectasia and from two non-mutant donors were examined for the repair of x-ray induced strand breaks in DNA. The ataxia telangiectasia cultures showed no significant differences from the non-mutant cultures in the kinetics and extent of strand repair. This suggests that the increased spontaneous and x-ray induced chromatid aberrations observed in ataxia telangiectasia cells are not caused by a defect in the repair of single strand breaks as might be suspected from a general model of aberration production.}
journal = {Mutat. Res.; (Netherlands)}
volume = {33:2; 3}
journal type = {AC}
place = {Netherlands}
year = {1975}
month = {Dec}
}