Abstract
Human diploid fibroblast-like cells derived from four patients with the genetic disease ataxia telangiectasia and from two non-mutant donors were examined for the repair of x-ray induced strand breaks in DNA. The ataxia telangiectasia cultures showed no significant differences from the non-mutant cultures in the kinetics and extent of strand repair. This suggests that the increased spontaneous and x-ray induced chromatid aberrations observed in ataxia telangiectasia cells are not caused by a defect in the repair of single strand breaks as might be suspected from a general model of aberration production.
Vincent, Jr, R A;
Sheridan, III, R B;
Huang, P C
[1]
- Johns Hopkins Univ., Baltimore, Md. (USA). Dept. of Environmental and Biophysical Sciences
Citation Formats
Vincent, Jr, R A, Sheridan, III, R B, and Huang, P C.
DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells.
Netherlands: N. p.,
1975.
Web.
Vincent, Jr, R A, Sheridan, III, R B, & Huang, P C.
DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells.
Netherlands.
Vincent, Jr, R A, Sheridan, III, R B, and Huang, P C.
1975.
"DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells."
Netherlands.
@misc{etde_7360089,
title = {DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells}
author = {Vincent, Jr, R A, Sheridan, III, R B, and Huang, P C}
abstractNote = {Human diploid fibroblast-like cells derived from four patients with the genetic disease ataxia telangiectasia and from two non-mutant donors were examined for the repair of x-ray induced strand breaks in DNA. The ataxia telangiectasia cultures showed no significant differences from the non-mutant cultures in the kinetics and extent of strand repair. This suggests that the increased spontaneous and x-ray induced chromatid aberrations observed in ataxia telangiectasia cells are not caused by a defect in the repair of single strand breaks as might be suspected from a general model of aberration production.}
journal = []
volume = {33:2; 3}
journal type = {AC}
place = {Netherlands}
year = {1975}
month = {Dec}
}
title = {DNA strand breakage repair in ataxia telangiectasia fibroblast-like cells}
author = {Vincent, Jr, R A, Sheridan, III, R B, and Huang, P C}
abstractNote = {Human diploid fibroblast-like cells derived from four patients with the genetic disease ataxia telangiectasia and from two non-mutant donors were examined for the repair of x-ray induced strand breaks in DNA. The ataxia telangiectasia cultures showed no significant differences from the non-mutant cultures in the kinetics and extent of strand repair. This suggests that the increased spontaneous and x-ray induced chromatid aberrations observed in ataxia telangiectasia cells are not caused by a defect in the repair of single strand breaks as might be suspected from a general model of aberration production.}
journal = []
volume = {33:2; 3}
journal type = {AC}
place = {Netherlands}
year = {1975}
month = {Dec}
}