Abstract
The isolation and characteristics of metabolites excreted in rat urine and other small animals were studied following oral administration of /sup 14/C-glipizide. Five metabolites and a small amount of the unchanged compound were isolated from the urine and their structures were elucidated by thin-layer chromatography and by various spectroscopic analyses. 3-cis-, 4-trans-hydroxycyclohexyl derivatives, decyclohexyl derivative, hydroxymethyl derivative and hydroxyethyl derivative were identified or suggested. The relative amount of each metabolite excreted differed markedly according to the species of animals used. In the rat and the mouse, major metabolites were 4-trans-, 3-cis-hydroxycyclohexyl derivatives and decyclohexyl derivative; in the guinea-pig 4-trans-, 3-cis-hydroxycyclohexyl derivatives and hydroxymethyl derivative; and in the rabbit hydroxymethyl derivative. In the dog, the cat and the monkeys N-(4-carboxymethyl-benzenesulfonyl)-N'-cyclohexyl-urea was suggested to be a major metabolite.
Citation Formats
Sugihara, J, and Sato, Y.
The biological fate of glipizide (II). The metabolism of glipizide in animals.
Japan: N. p.,
1975.
Web.
Sugihara, J, & Sato, Y.
The biological fate of glipizide (II). The metabolism of glipizide in animals.
Japan.
Sugihara, J, and Sato, Y.
1975.
"The biological fate of glipizide (II). The metabolism of glipizide in animals."
Japan.
@misc{etde_7358398,
title = {The biological fate of glipizide (II). The metabolism of glipizide in animals}
author = {Sugihara, J, and Sato, Y}
abstractNote = {The isolation and characteristics of metabolites excreted in rat urine and other small animals were studied following oral administration of /sup 14/C-glipizide. Five metabolites and a small amount of the unchanged compound were isolated from the urine and their structures were elucidated by thin-layer chromatography and by various spectroscopic analyses. 3-cis-, 4-trans-hydroxycyclohexyl derivatives, decyclohexyl derivative, hydroxymethyl derivative and hydroxyethyl derivative were identified or suggested. The relative amount of each metabolite excreted differed markedly according to the species of animals used. In the rat and the mouse, major metabolites were 4-trans-, 3-cis-hydroxycyclohexyl derivatives and decyclohexyl derivative; in the guinea-pig 4-trans-, 3-cis-hydroxycyclohexyl derivatives and hydroxymethyl derivative; and in the rabbit hydroxymethyl derivative. In the dog, the cat and the monkeys N-(4-carboxymethyl-benzenesulfonyl)-N'-cyclohexyl-urea was suggested to be a major metabolite.}
journal = []
volume = {24:3}
journal type = {AC}
place = {Japan}
year = {1975}
month = {Mar}
}
title = {The biological fate of glipizide (II). The metabolism of glipizide in animals}
author = {Sugihara, J, and Sato, Y}
abstractNote = {The isolation and characteristics of metabolites excreted in rat urine and other small animals were studied following oral administration of /sup 14/C-glipizide. Five metabolites and a small amount of the unchanged compound were isolated from the urine and their structures were elucidated by thin-layer chromatography and by various spectroscopic analyses. 3-cis-, 4-trans-hydroxycyclohexyl derivatives, decyclohexyl derivative, hydroxymethyl derivative and hydroxyethyl derivative were identified or suggested. The relative amount of each metabolite excreted differed markedly according to the species of animals used. In the rat and the mouse, major metabolites were 4-trans-, 3-cis-hydroxycyclohexyl derivatives and decyclohexyl derivative; in the guinea-pig 4-trans-, 3-cis-hydroxycyclohexyl derivatives and hydroxymethyl derivative; and in the rabbit hydroxymethyl derivative. In the dog, the cat and the monkeys N-(4-carboxymethyl-benzenesulfonyl)-N'-cyclohexyl-urea was suggested to be a major metabolite.}
journal = []
volume = {24:3}
journal type = {AC}
place = {Japan}
year = {1975}
month = {Mar}
}