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Content of DNA in cancerous tumours of the breast before and after large-fractionated irradiation

Journal Article:

Abstract

The article presents the results of microspectrophotometric investigation of DNA in different cancerous tumors of the breast gland before and after large-fractionated irradiation. The study of quantitative content of DNA in the non-irradiated tumors of the breast of different histological structure showed that parenchymatous cells are characterized by a definite variety in the DNA content with a different level of their polyploidy. This points to the fact that different histological forms of the breast cancer are distinguished by the character of the components differentiation. The comparative assessment of the ploidity of the cancerous cells of irradiated and non-irradiated tumors revealed that under the changed conditions of co-existence in all histological forms of cancer new modal classes of the cells develop and general quantity of the DNA content decreases. This testifies to the fact that the histological forms of the breast cancer are not equal sensitive tumors. A microspectrophotometric study of the breast tumors makes it possible to reveal the injury of the malignant tumor cells in the initial period of irradiation, when it is difficult to discover clear-cut dystrophical changes during histological investigation.
Publication Date:
Jul 01, 1976
Product Type:
Journal Article
Reference Number:
ERA-02-001661; EDB-76-082680
Resource Relation:
Journal Name: Med. Radiol.; (USSR); Journal Volume: 21:7
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DNA; BIOLOGICAL RADIATION EFFECTS; FRACTIONATED IRRADIATION; MAMMARY GLANDS; NEOPLASMS; SPECTROPHOTOMETRY; TUMOR CELLS; PLOIDY; HISTOLOGY; ANIMAL CELLS; BIOLOGICAL EFFECTS; BODY; DISEASES; GLANDS; IRRADIATION; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7356503
Research Organizations:
Scientific-Research Inst. of Medicine and Radiology, Moscow
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: MERAA
Submitting Site:
TIC
Size:
Pages: 25-29
Announcement Date:

Journal Article:

Citation Formats

Shiukashvili, N N. Content of DNA in cancerous tumours of the breast before and after large-fractionated irradiation. USSR: N. p., 1976. Web.
Shiukashvili, N N. Content of DNA in cancerous tumours of the breast before and after large-fractionated irradiation. USSR.
Shiukashvili, N N. 1976. "Content of DNA in cancerous tumours of the breast before and after large-fractionated irradiation." USSR.
@misc{etde_7356503,
title = {Content of DNA in cancerous tumours of the breast before and after large-fractionated irradiation}
author = {Shiukashvili, N N}
abstractNote = {The article presents the results of microspectrophotometric investigation of DNA in different cancerous tumors of the breast gland before and after large-fractionated irradiation. The study of quantitative content of DNA in the non-irradiated tumors of the breast of different histological structure showed that parenchymatous cells are characterized by a definite variety in the DNA content with a different level of their polyploidy. This points to the fact that different histological forms of the breast cancer are distinguished by the character of the components differentiation. The comparative assessment of the ploidity of the cancerous cells of irradiated and non-irradiated tumors revealed that under the changed conditions of co-existence in all histological forms of cancer new modal classes of the cells develop and general quantity of the DNA content decreases. This testifies to the fact that the histological forms of the breast cancer are not equal sensitive tumors. A microspectrophotometric study of the breast tumors makes it possible to reveal the injury of the malignant tumor cells in the initial period of irradiation, when it is difficult to discover clear-cut dystrophical changes during histological investigation.}
journal = {Med. Radiol.; (USSR)}
volume = {21:7}
journal type = {AC}
place = {USSR}
year = {1976}
month = {Jul}
}