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Features of aseptic granulomatous imflammation in rats subjected to the chronic action of gamma irradiation in small doses

Abstract

Wistar rats were given a Co-60 dose of 2 r/day over a period of 8 months, or a total dose of 400 r. Two sterile sponge scraps of the same size and form were introduced subcutaneously into the intracapsular space of rats in the control and irradiated groups. Cuts were made in the subcutaneous tissue near the implanted foreign bodies. A vigorous inflammatory reaction developed in the unirradiated animals. The skin granulated normally. The irradiated animals showed a general bleeding of the tissues at the implantation site. A number of deviations were noted during the tissue granulation of the irradiated rats. The migration of leucocytes into the infected site was decreased. The formation of macrophage elements and their activity was lower in the irradiated animals. The reaction of the connective tissue turned out to be a rather sensitive test of the disruptive effects of long-term irradiation. 11 refs.
Publication Date:
Apr 01, 1976
Product Type:
Journal Article
Reference Number:
EDB-76-082695
Resource Relation:
Journal Name: Med. Radiol.; (USSR); Journal Volume: 21:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; INFLAMMATION; BIOLOGICAL RADIATION EFFECTS; CHRONIC IRRADIATION; GAMMA RADIATION; RADIATION DOSES; RATS; ANIMALS; BIOLOGICAL EFFECTS; CHRONIC EXPOSURE; DISEASES; DOSES; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7356495
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: MERAA
Submitting Site:
TIC
Size:
Pages: 66-67
Announcement Date:
Oct 01, 1976

Citation Formats

Goranov, I, Krushkov, I, Statelov, V, Bratanov, M, Nacheva, V, Gospodinova, D, and Serafimov, A. Features of aseptic granulomatous imflammation in rats subjected to the chronic action of gamma irradiation in small doses. USSR: N. p., 1976. Web.
Goranov, I, Krushkov, I, Statelov, V, Bratanov, M, Nacheva, V, Gospodinova, D, & Serafimov, A. Features of aseptic granulomatous imflammation in rats subjected to the chronic action of gamma irradiation in small doses. USSR.
Goranov, I, Krushkov, I, Statelov, V, Bratanov, M, Nacheva, V, Gospodinova, D, and Serafimov, A. 1976. "Features of aseptic granulomatous imflammation in rats subjected to the chronic action of gamma irradiation in small doses." USSR.
@misc{etde_7356495,
title = {Features of aseptic granulomatous imflammation in rats subjected to the chronic action of gamma irradiation in small doses}
author = {Goranov, I, Krushkov, I, Statelov, V, Bratanov, M, Nacheva, V, Gospodinova, D, and Serafimov, A}
abstractNote = {Wistar rats were given a Co-60 dose of 2 r/day over a period of 8 months, or a total dose of 400 r. Two sterile sponge scraps of the same size and form were introduced subcutaneously into the intracapsular space of rats in the control and irradiated groups. Cuts were made in the subcutaneous tissue near the implanted foreign bodies. A vigorous inflammatory reaction developed in the unirradiated animals. The skin granulated normally. The irradiated animals showed a general bleeding of the tissues at the implantation site. A number of deviations were noted during the tissue granulation of the irradiated rats. The migration of leucocytes into the infected site was decreased. The formation of macrophage elements and their activity was lower in the irradiated animals. The reaction of the connective tissue turned out to be a rather sensitive test of the disruptive effects of long-term irradiation. 11 refs.}
journal = []
volume = {21:4}
journal type = {AC}
place = {USSR}
year = {1976}
month = {Apr}
}