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Changes in protein metabolism after irradiation. Pt. 1. Protease activity, protease pattern, protein and free amino acids in cytoplasm and cell organelles of the rat spleen after 600 R whole body x irradiation

Journal Article:

Abstract

The protease activity of cytoplasm and cell organelles of the rat spleen against spleen protein and hemoglobin as a substrate increases during a initial reaction phase of the organism on the first day after 600 R whole body X-irradiation. The alkaline protease in the cytoplasm and the acid protease in the cell organelles increase, whereas the protease activity against externally added hemoglobin as substrate decreases below the initial values. The protein, the protease activity and the free amino acids of the cytoplasm and the cell organelles decrease during the disease phase on day 3 and 4 after irradiation. The protein loss of the spleen is therefore not explained by an increased protease activity. Acid proteases appear in the cytoplasm which derive probably from the cell organelles. The protease activity and the free amino acids are increased in the cytoplasm and the cell organelles during the regeneration phase of the organism between day 15 and 18 after irradiation.
Authors:
Valet, G [1] 
  1. Max-Planck-Institut fuer Biochemie, Muenchen (F.R. Germany). Abt. fuer Experimentelle Medizin
Publication Date:
Dec 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-242212; EDB-76-093823
Resource Relation:
Journal Name: Strahlentherapie; (Germany, Federal Republic of); Journal Volume: 6:150; Other Information: 4 figs.; 5 tabs.; 32 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ENZYMES; BIOLOGICAL RADIATION EFFECTS; PROTEINS; METABOLISM; AMINO ACIDS; CATALYSIS; CATHEPSINS; CYTOPLASM; DOSE-RESPONSE RELATIONSHIPS; HEMOGLOBIN; RADIATION DOSE UNITS; RATS; SPLEEN; WHOLE-BODY IRRADIATION; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BODY; CARBOXYLIC ACIDS; CELL CONSTITUENTS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GLOBIN; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HYDROLASES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PEPTIDE HYDROLASES; PIGMENTS; PORPHYRINS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7352958
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: STRAA
Submitting Site:
INIS
Size:
Pages: 608-617
Announcement Date:
Aug 01, 1976

Journal Article:

Citation Formats

Valet, G. Changes in protein metabolism after irradiation. Pt. 1. Protease activity, protease pattern, protein and free amino acids in cytoplasm and cell organelles of the rat spleen after 600 R whole body x irradiation. Germany: N. p., 1975. Web.
Valet, G. Changes in protein metabolism after irradiation. Pt. 1. Protease activity, protease pattern, protein and free amino acids in cytoplasm and cell organelles of the rat spleen after 600 R whole body x irradiation. Germany.
Valet, G. 1975. "Changes in protein metabolism after irradiation. Pt. 1. Protease activity, protease pattern, protein and free amino acids in cytoplasm and cell organelles of the rat spleen after 600 R whole body x irradiation." Germany.
@misc{etde_7352958,
title = {Changes in protein metabolism after irradiation. Pt. 1. Protease activity, protease pattern, protein and free amino acids in cytoplasm and cell organelles of the rat spleen after 600 R whole body x irradiation}
author = {Valet, G}
abstractNote = {The protease activity of cytoplasm and cell organelles of the rat spleen against spleen protein and hemoglobin as a substrate increases during a initial reaction phase of the organism on the first day after 600 R whole body X-irradiation. The alkaline protease in the cytoplasm and the acid protease in the cell organelles increase, whereas the protease activity against externally added hemoglobin as substrate decreases below the initial values. The protein, the protease activity and the free amino acids of the cytoplasm and the cell organelles decrease during the disease phase on day 3 and 4 after irradiation. The protein loss of the spleen is therefore not explained by an increased protease activity. Acid proteases appear in the cytoplasm which derive probably from the cell organelles. The protease activity and the free amino acids are increased in the cytoplasm and the cell organelles during the regeneration phase of the organism between day 15 and 18 after irradiation.}
journal = {Strahlentherapie; (Germany, Federal Republic of)}
volume = {6:150}
journal type = {AC}
place = {Germany}
year = {1975}
month = {Dec}
}