Abstract
To study the role of membrane SH-groups in glucose transport of isolated rat fat cells we compared the effects of a small organic mercurial reagent p-CMB with those of a large p-CMB-derivative - p-CMB-Dextran, MW approximately 10,000 -. It could be shown that both compounds were of almost identical reactivity on fat cell homogenate metabolism. When applied to intact fat cells uncoupled p-CMB showed an 1) insulin-like enhancement of /sup 14/C incorporation from (U-/sup 14/C) glucose into CO/sub 2/ and triglyceride, 2) inhibition of the insulin-stimulatory effect on these parameters and 3) inhibition of basal glucose uptake dependent on the concentrations used. Identical concentrations of p-CMB-Dextran, however, failed to influence basal glucose uptake as well as the insulin mediated increase in glucose metabolism.
Citation Formats
Kather, H, and Simon, B.
Effects of SH-reagents of different molecular size upon glucose metabolism in isolated rat fat cells.
Germany: N. p.,
1975.
Web.
Kather, H, & Simon, B.
Effects of SH-reagents of different molecular size upon glucose metabolism in isolated rat fat cells.
Germany.
Kather, H, and Simon, B.
1975.
"Effects of SH-reagents of different molecular size upon glucose metabolism in isolated rat fat cells."
Germany.
@misc{etde_7351091,
title = {Effects of SH-reagents of different molecular size upon glucose metabolism in isolated rat fat cells}
author = {Kather, H, and Simon, B}
abstractNote = {To study the role of membrane SH-groups in glucose transport of isolated rat fat cells we compared the effects of a small organic mercurial reagent p-CMB with those of a large p-CMB-derivative - p-CMB-Dextran, MW approximately 10,000 -. It could be shown that both compounds were of almost identical reactivity on fat cell homogenate metabolism. When applied to intact fat cells uncoupled p-CMB showed an 1) insulin-like enhancement of /sup 14/C incorporation from (U-/sup 14/C) glucose into CO/sub 2/ and triglyceride, 2) inhibition of the insulin-stimulatory effect on these parameters and 3) inhibition of basal glucose uptake dependent on the concentrations used. Identical concentrations of p-CMB-Dextran, however, failed to influence basal glucose uptake as well as the insulin mediated increase in glucose metabolism.}
journal = []
volume = {7:5}
journal type = {AC}
place = {Germany}
year = {1975}
month = {Sep}
}
title = {Effects of SH-reagents of different molecular size upon glucose metabolism in isolated rat fat cells}
author = {Kather, H, and Simon, B}
abstractNote = {To study the role of membrane SH-groups in glucose transport of isolated rat fat cells we compared the effects of a small organic mercurial reagent p-CMB with those of a large p-CMB-derivative - p-CMB-Dextran, MW approximately 10,000 -. It could be shown that both compounds were of almost identical reactivity on fat cell homogenate metabolism. When applied to intact fat cells uncoupled p-CMB showed an 1) insulin-like enhancement of /sup 14/C incorporation from (U-/sup 14/C) glucose into CO/sub 2/ and triglyceride, 2) inhibition of the insulin-stimulatory effect on these parameters and 3) inhibition of basal glucose uptake dependent on the concentrations used. Identical concentrations of p-CMB-Dextran, however, failed to influence basal glucose uptake as well as the insulin mediated increase in glucose metabolism.}
journal = []
volume = {7:5}
journal type = {AC}
place = {Germany}
year = {1975}
month = {Sep}
}