You need JavaScript to view this

Calcium absorption and calcium binding protein synthesis in the chick: evidence for a 1,25-dihydroxycholecalciferol-like factor in solanum malacoxylon

Abstract

Some properties of the vitamin D dependent CaBP have been briefly summarized. In addition to providing possible insight into the molecular basis of vitamin D action, the measurement of intestinal CaBP in animals subjected to different conditions and treatments has proven useful in assessing the effective vitamin D status of that animal. Using measurements of both the degree of intestinal /sup 47/Ca absorption in situ and duodenal CaBP levels, some aspects of the vitamin D-like factor in the South American plant Solanum malacoxylon were investigated. A vitamin D assay based on CaBP as end point indicated that the plant contains about 1.3 x 10/sup 5/ IU vitamin D/sub 3/ equivalents per kg. The Solanum factor, together with an adequate calcium intake, are necessary conditions for the product of gross toxic symptoms in the chick. Using experimental conditions that inhibit the conversion of 25-(OH)D/sub 3/ to 1,25-(OH)/sub 2/D/sub 3/ by the kidney enzyme system (i.e., a high stable strontium diet), it was shown that the Solanum factor can cause a reversal of this inhibition. This suggested that the Solanum factor mimics the action of 1,25-(OH)/sub 2/D/sub 3/, and this was confirmed by Walling and Kimberg (personal communication) since, in their hands,  More>>
Publication Date:
Jan 01, 1974
Product Type:
Conference
Reference Number:
ERA-01-021141; EDB-76-061442
Resource Relation:
Journal Name: Excerpta Med. Int. Congr. Ser.; (Netherlands); Journal Volume: 346; Conference: 5. parathyroid conference, Oxford, Eng., 21 Jul 1974
Subject:
59 BASIC BIOLOGICAL SCIENCES; CALCIUM; INTESTINAL ABSORPTION; METABOLISM; CHOLECALCIFEROL; BIOLOGICAL EFFECTS; ENZYMES; HORMONES; PROTEINS; BIOSYNTHESIS; VITAMIN D; CALCIUM 47; CHICKENS; PLANTS; RATS; REVIEWS; STRONTIUM; ALKALINE EARTH ISOTOPES; ALKALINE EARTH METALS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOMASS; BIRDS; CALCIUM ISOTOPES; DAYS LIVING RADIOISOTOPES; DOCUMENT TYPES; ELEMENTS; ENERGY SOURCES; EVEN-ODD NUCLEI; FOWL; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; METALS; NUCLEI; ORGANIC COMPOUNDS; RADIOISOTOPES; RENEWABLE ENERGY SOURCES; RODENTS; SYNTHESIS; UPTAKE; VERTEBRATES; VITAMINS; 550500* - Metabolism
OSTI ID:
7349100
Research Organizations:
Cornell Univ., Ithaca, NY
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EXMDA
Submitting Site:
TIC
Size:
Pages: 318-327
Announcement Date:
May 13, 2001

Citation Formats

Wasserman, R H, Bar, A, Corradino, R A, Taylor, A N, and Peterlik, M. Calcium absorption and calcium binding protein synthesis in the chick: evidence for a 1,25-dihydroxycholecalciferol-like factor in solanum malacoxylon. Netherlands: N. p., 1974. Web.
Wasserman, R H, Bar, A, Corradino, R A, Taylor, A N, & Peterlik, M. Calcium absorption and calcium binding protein synthesis in the chick: evidence for a 1,25-dihydroxycholecalciferol-like factor in solanum malacoxylon. Netherlands.
Wasserman, R H, Bar, A, Corradino, R A, Taylor, A N, and Peterlik, M. 1974. "Calcium absorption and calcium binding protein synthesis in the chick: evidence for a 1,25-dihydroxycholecalciferol-like factor in solanum malacoxylon." Netherlands.
@misc{etde_7349100,
title = {Calcium absorption and calcium binding protein synthesis in the chick: evidence for a 1,25-dihydroxycholecalciferol-like factor in solanum malacoxylon}
author = {Wasserman, R H, Bar, A, Corradino, R A, Taylor, A N, and Peterlik, M}
abstractNote = {Some properties of the vitamin D dependent CaBP have been briefly summarized. In addition to providing possible insight into the molecular basis of vitamin D action, the measurement of intestinal CaBP in animals subjected to different conditions and treatments has proven useful in assessing the effective vitamin D status of that animal. Using measurements of both the degree of intestinal /sup 47/Ca absorption in situ and duodenal CaBP levels, some aspects of the vitamin D-like factor in the South American plant Solanum malacoxylon were investigated. A vitamin D assay based on CaBP as end point indicated that the plant contains about 1.3 x 10/sup 5/ IU vitamin D/sub 3/ equivalents per kg. The Solanum factor, together with an adequate calcium intake, are necessary conditions for the product of gross toxic symptoms in the chick. Using experimental conditions that inhibit the conversion of 25-(OH)D/sub 3/ to 1,25-(OH)/sub 2/D/sub 3/ by the kidney enzyme system (i.e., a high stable strontium diet), it was shown that the Solanum factor can cause a reversal of this inhibition. This suggested that the Solanum factor mimics the action of 1,25-(OH)/sub 2/D/sub 3/, and this was confirmed by Walling and Kimberg (personal communication) since, in their hands, the administration of S. malacoxylon extract to nephrectomized rats was able to stimulate intestinal calcium transport in vitro. Similar results were brought forth at this meeting by Dr. Mautalen of Argentina. The Solanum factor was effective in an intestinal organ culture system, indicating that the factor acts directly on the gut and, if modification of the factor is needed for biological activity, the necessary enzymes are present in the intestinal tissue.}
journal = []
volume = {346}
place = {Netherlands}
year = {1974}
month = {Jan}
}