Abstract
The oxidation of 1-/sup 14/C-erucic (Csub(22:1)) and 1-/sup 14/C-nervonic (Csub(24:1)) acid was studied compared to 1-/sup 14/C-palmitic and -oleic acid in isolated rat and pig heart mitochondria. After mitochondrial incubation with the albumin-bound fatty acids only small amounts of /sup 14/CO/sub 2/ developed from the oxidation of the long chain monoenoic acids as compared to palmitic or oleic acid. The slow down of the oxidation rate was more pronounced in rat than in pig heart mitochondria. The oxidation of palmitic or oleic acid was not found to be inhibited by the C/sub 20/-C/sub 24/-monoeneic acids, whereas palmitic or oleic acid inhibited the oxidation of erucic acid competitively. From present findings an idea may be developed of the interference on fatty acid metabolism in heart muscle by erucic and other long chain monenoic acids.
Citation Formats
Buddecke, E, Filipovic, I, Wortberg, B, and Seher, A.
Mechanism of long chain monoenoic fatty acids acting on the energy metabolism of heart.
Germany: N. p.,
1975.
Web.
Buddecke, E, Filipovic, I, Wortberg, B, & Seher, A.
Mechanism of long chain monoenoic fatty acids acting on the energy metabolism of heart.
Germany.
Buddecke, E, Filipovic, I, Wortberg, B, and Seher, A.
1975.
"Mechanism of long chain monoenoic fatty acids acting on the energy metabolism of heart."
Germany.
@misc{etde_7346964,
title = {Mechanism of long chain monoenoic fatty acids acting on the energy metabolism of heart}
author = {Buddecke, E, Filipovic, I, Wortberg, B, and Seher, A}
abstractNote = {The oxidation of 1-/sup 14/C-erucic (Csub(22:1)) and 1-/sup 14/C-nervonic (Csub(24:1)) acid was studied compared to 1-/sup 14/C-palmitic and -oleic acid in isolated rat and pig heart mitochondria. After mitochondrial incubation with the albumin-bound fatty acids only small amounts of /sup 14/CO/sub 2/ developed from the oxidation of the long chain monoenoic acids as compared to palmitic or oleic acid. The slow down of the oxidation rate was more pronounced in rat than in pig heart mitochondria. The oxidation of palmitic or oleic acid was not found to be inhibited by the C/sub 20/-C/sub 24/-monoeneic acids, whereas palmitic or oleic acid inhibited the oxidation of erucic acid competitively. From present findings an idea may be developed of the interference on fatty acid metabolism in heart muscle by erucic and other long chain monenoic acids.}
place = {Germany}
year = {1975}
month = {Jan}
}
title = {Mechanism of long chain monoenoic fatty acids acting on the energy metabolism of heart}
author = {Buddecke, E, Filipovic, I, Wortberg, B, and Seher, A}
abstractNote = {The oxidation of 1-/sup 14/C-erucic (Csub(22:1)) and 1-/sup 14/C-nervonic (Csub(24:1)) acid was studied compared to 1-/sup 14/C-palmitic and -oleic acid in isolated rat and pig heart mitochondria. After mitochondrial incubation with the albumin-bound fatty acids only small amounts of /sup 14/CO/sub 2/ developed from the oxidation of the long chain monoenoic acids as compared to palmitic or oleic acid. The slow down of the oxidation rate was more pronounced in rat than in pig heart mitochondria. The oxidation of palmitic or oleic acid was not found to be inhibited by the C/sub 20/-C/sub 24/-monoeneic acids, whereas palmitic or oleic acid inhibited the oxidation of erucic acid competitively. From present findings an idea may be developed of the interference on fatty acid metabolism in heart muscle by erucic and other long chain monenoic acids.}
place = {Germany}
year = {1975}
month = {Jan}
}