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Total body irradiation (TBI) of chronic lymphocytic leukemia (CLL)

Abstract

80 patients with previously untreated CLL have been admitted to the Radiation Oncology Branch of the NCI. Fourteen of these patients have remained classified as 'indolent' until the present time and have not received any treatment. 48 patients with 'active' CLL were treated with TBI and were compared with 18 patients treated with chemotherapy and/or local irradiation. Our series of patients primarily treated with TBI have twice the median survival (57 months) measured from first therapy of the concurrent chemotherapy series (27 months). One third of the TBI group have experienced a complete or nearly complete remission and these patients showed a definite longer survival, with a median survival well in excess of five years until now. However, patients with a less complete remission failed to demonstrate a prolonged survival time with TBI in comparison to other modes of treatment. These results indicate that TBI can induce complete remissions which improve the prognosis in patients with active CLL.
Publication Date:
Jan 01, 1975
Product Type:
Conference
Report Number:
AED-CONF-75-610-002; CONF-7509152-1
Reference Number:
AIX-07-244581; EDB-76-088372
Resource Relation:
Conference: Joint meeting of the German and Austrian Society for haemotology, Bad Nauheim, F.R. Germany, 29 Sep 1975; Other Information: 4 figs.; 3 tabs. With abstract
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LEUKEMIA; RADIOTHERAPY; ALKYLATING AGENTS; CHEMOTHERAPY; ENDOXAN; LYMPHOCYTES; PATIENTS; RADIATION DOSE UNITS; SURVIVAL TIME; WHOLE-BODY IRRADIATION; ANIMAL CELLS; ANTIMITOTIC DRUGS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; DRUGS; EXTERNAL IRRADIATION; HEMIC DISEASES; IRRADIATION; LEUKOCYTES; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; RADIOLOGY; SOMATIC CELLS; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7341189
Country of Origin:
Germany
Language:
German
Availability:
INIS
Submitting Site:
INIS
Size:
Pages: 6
Announcement Date:

Citation Formats

Ruehl, U, and Johnson, R E. Total body irradiation (TBI) of chronic lymphocytic leukemia (CLL). Germany: N. p., 1975. Web.
Ruehl, U, & Johnson, R E. Total body irradiation (TBI) of chronic lymphocytic leukemia (CLL). Germany.
Ruehl, U, and Johnson, R E. 1975. "Total body irradiation (TBI) of chronic lymphocytic leukemia (CLL)." Germany.
@misc{etde_7341189,
title = {Total body irradiation (TBI) of chronic lymphocytic leukemia (CLL)}
author = {Ruehl, U, and Johnson, R E}
abstractNote = {80 patients with previously untreated CLL have been admitted to the Radiation Oncology Branch of the NCI. Fourteen of these patients have remained classified as 'indolent' until the present time and have not received any treatment. 48 patients with 'active' CLL were treated with TBI and were compared with 18 patients treated with chemotherapy and/or local irradiation. Our series of patients primarily treated with TBI have twice the median survival (57 months) measured from first therapy of the concurrent chemotherapy series (27 months). One third of the TBI group have experienced a complete or nearly complete remission and these patients showed a definite longer survival, with a median survival well in excess of five years until now. However, patients with a less complete remission failed to demonstrate a prolonged survival time with TBI in comparison to other modes of treatment. These results indicate that TBI can induce complete remissions which improve the prognosis in patients with active CLL.}
place = {Germany}
year = {1975}
month = {Jan}
}