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Effect of radiotherapy on lymphocyte cytotoxicity in vitro

Journal Article:

Abstract

The cytotoxic functions of highly purified blood lymphocytes from patients with breast cancer were studied before and after radiotherapy. Addition of PHA or of rabbit antibodies to target cells (chicken erythrocytes) were chosen as two means of inducing lymphocyte cytotoxicity in vitro. The proportion of T and non-T lymphocytes was determined by means of E and EAC rosette tests. The antibody-induced cytotoxicity of lymphocytes decreased following radiotherapy while that mediated by PHA remained unchanged. There was some reduction in the percentage of EAC rosette-forming cells. These results, as well as earlier observations, suggest that the decrease in the peripheral blood of the proportion of lymphocytes with receptors for activated complement is responsible for changes in the antibody-mediated lymphocyte cytotoxicity.
Authors:
Wasserman, J; Melen, B; [1]  Blomgren, H; Glas, U; Perlmann, P
  1. Central Microbiological Laboratory, Stockholm County Council (Sweden)
Publication Date:
Nov 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-236875; EDB-76-093762
Resource Relation:
Journal Name: Clin. Exp. Immunol.; (United Kingdom); Journal Volume: 22:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LYMPHOCYTES; BIOLOGICAL EFFECTS; RADIOTHERAPY; SIDE EFFECTS; CYTOLOGY; MAMMARY GLANDS; NEOPLASMS; PATIENTS; RADIOSENSITIVITY; TUMOR CELLS; ANIMAL CELLS; BIOLOGICAL MATERIALS; BIOLOGY; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; GLANDS; LEUKOCYTES; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; SOMATIC CELLS; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7339145
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CEXIA
Submitting Site:
INIS
Size:
Pages: 230-239
Announcement Date:
Aug 01, 1976

Journal Article:

Citation Formats

Wasserman, J, Melen, B, Blomgren, H, Glas, U, and Perlmann, P. Effect of radiotherapy on lymphocyte cytotoxicity in vitro. United Kingdom: N. p., 1975. Web.
Wasserman, J, Melen, B, Blomgren, H, Glas, U, & Perlmann, P. Effect of radiotherapy on lymphocyte cytotoxicity in vitro. United Kingdom.
Wasserman, J, Melen, B, Blomgren, H, Glas, U, and Perlmann, P. 1975. "Effect of radiotherapy on lymphocyte cytotoxicity in vitro." United Kingdom.
@misc{etde_7339145,
title = {Effect of radiotherapy on lymphocyte cytotoxicity in vitro}
author = {Wasserman, J, Melen, B, Blomgren, H, Glas, U, and Perlmann, P}
abstractNote = {The cytotoxic functions of highly purified blood lymphocytes from patients with breast cancer were studied before and after radiotherapy. Addition of PHA or of rabbit antibodies to target cells (chicken erythrocytes) were chosen as two means of inducing lymphocyte cytotoxicity in vitro. The proportion of T and non-T lymphocytes was determined by means of E and EAC rosette tests. The antibody-induced cytotoxicity of lymphocytes decreased following radiotherapy while that mediated by PHA remained unchanged. There was some reduction in the percentage of EAC rosette-forming cells. These results, as well as earlier observations, suggest that the decrease in the peripheral blood of the proportion of lymphocytes with receptors for activated complement is responsible for changes in the antibody-mediated lymphocyte cytotoxicity.}
journal = {Clin. Exp. Immunol.; (United Kingdom)}
volume = {22:2}
journal type = {AC}
place = {United Kingdom}
year = {1975}
month = {Nov}
}