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Developing CNS mitochondria oxidative phosphorylation P/O/ADP/O index for rats

Journal Article:

Abstract

The effect of whole-body-gamma irradiation on developing CNS mitochondria oxidative phosphorylation was studied through the P/O/ADP/O index; three irradiation doses (5, 50 and 500 R) were employed at neonatal stage and both 'prompt' (10 min approx,) and 'delayed' (7 days for 500 R exposure, 21 days for 5 and 50 R) effects were observed. In the 'prompt' effects investigated after 500 R exposure, the oxidative phosphorylation diminished; the same occurred at 7 days with this dose ('delayed' effect). With doses of 5 and 50 R there was no alteration of oxidative phosphorylation as a 'prompt' effect, but it diminished at 21 days post irradiation. The uncoupling between respiration and oxidative phosphorylation should explain - at least, in part -these results.
Authors:
Egana, E; Diaz, G [1] 
  1. Institute of Experimental Medicine, Santiago (Chile). Lab. of Neurochemistry
Publication Date:
Nov 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-242190; EDB-76-093819
Resource Relation:
Journal Name: J. Inst. Nucl. Eng.; (United Kingdom); Journal Volume: 16:6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CENTRAL NERVOUS SYSTEM; MITOCHONDRIA; PHOSPHORYLATION; DELAYED RADIATION EFFECTS; ADP; DOSE-RESPONSE RELATIONSHIPS; EARLY RADIATION EFFECTS; GAMMA RADIATION; OXIDATION; OXYGEN; PHOSPHORUS; RATS; WHOLE-BODY IRRADIATION; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CELL CONSTITUENTS; CHEMICAL REACTIONS; CRYOGENIC FLUIDS; ELECTROMAGNETIC RADIATION; ELEMENTS; EXTERNAL IRRADIATION; FLUIDS; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NERVOUS SYSTEM; NONMETALS; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANOIDS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7339123
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JINEB
Submitting Site:
INIS
Size:
Pages: 175-178
Announcement Date:

Journal Article:

Citation Formats

Egana, E, and Diaz, G. Developing CNS mitochondria oxidative phosphorylation P/O/ADP/O index for rats. United Kingdom: N. p., 1975. Web.
Egana, E, & Diaz, G. Developing CNS mitochondria oxidative phosphorylation P/O/ADP/O index for rats. United Kingdom.
Egana, E, and Diaz, G. 1975. "Developing CNS mitochondria oxidative phosphorylation P/O/ADP/O index for rats." United Kingdom.
@misc{etde_7339123,
title = {Developing CNS mitochondria oxidative phosphorylation P/O/ADP/O index for rats}
author = {Egana, E, and Diaz, G}
abstractNote = {The effect of whole-body-gamma irradiation on developing CNS mitochondria oxidative phosphorylation was studied through the P/O/ADP/O index; three irradiation doses (5, 50 and 500 R) were employed at neonatal stage and both 'prompt' (10 min approx,) and 'delayed' (7 days for 500 R exposure, 21 days for 5 and 50 R) effects were observed. In the 'prompt' effects investigated after 500 R exposure, the oxidative phosphorylation diminished; the same occurred at 7 days with this dose ('delayed' effect). With doses of 5 and 50 R there was no alteration of oxidative phosphorylation as a 'prompt' effect, but it diminished at 21 days post irradiation. The uncoupling between respiration and oxidative phosphorylation should explain - at least, in part -these results.}
journal = {J. Inst. Nucl. Eng.; (United Kingdom)}
volume = {16:6}
journal type = {AC}
place = {United Kingdom}
year = {1975}
month = {Nov}
}