You need JavaScript to view this

Absorption and excretion of zinc, cadmium and mercury in the gastrointestinal tract

Journal Article:

Abstract

The absorption and excretion of inorganic zinc, cadmium and mercury in the gastrointestinal tract were compared using /sup 65/Zn, /sup 109/Cd and /sup 203/Hg. A single dose of /sup 65/Zn, /sup 109/Cd or /sup 203/Hg was administered orally or injected intravenously to investigate the distribution, excretion into bile and excretion into feces or urine. Absorption and excretion through the gastrointestinal tract of mice were studied by the tied loop method. Groups of eight mice or rats were used to measure the radioactivity in sample with a scintillation counter. Most of the orally administered /sup 65/Zn, /sup 109/Cd or /sup 203/Hg was excreted into feces and was less absorbed by the gastrointestinal tract, respectively. Absorption rate in the gastrointestinal tract was as follows: /sup 203/Hg>/sup 65/Zn>/sup 109/Cd. Intravenously injected /sup 65/Zn, /sup 109/Cd or /sup 203/Hg was escreted into the gastrointestinal tract through the gastrointestinal wall and bile duct, respectively. Excretion rate in the gastrointestinal tract was as follows: /sup 65/Zn>/sup 203/Hg>/sup 109/Cd. When comparing the absorption and excretion in each gastrointestinal tract divided into 10 parts, /sup 65/Zn, and /sup 109/Cd were relatively well absorbed from the upper and lower part of small intestine and excreted into the upper, middle,  More>>
Authors:
Shibata, H [1] 
  1. National Inst. of Radiological Sciences, Chiba (Japan)
Publication Date:
Oct 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-260389; EDB-77-033158
Resource Relation:
Journal Name: Radioisotopes (Tokyo); (Japan); Journal Volume: 24:10
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM 109; EXCRETION; INTESTINAL ABSORPTION; MERCURY 203; ZINC 65; CADMIUM COMPOUNDS; FECES; KIDNEYS; LARGE INTESTINE; LIVER; MERCURY COMPOUNDS; MICE; ORAL ADMINISTRATION; SMALL INTESTINE; STOMACH; TIME DEPENDENCE; TRACER TECHNIQUES; URINE; ZINC COMPOUNDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CADMIUM ISOTOPES; CLEARANCE; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; GASTROINTESTINAL TRACT; GLANDS; HEAVY NUCLEI; INTERMEDIATE MASS NUCLEI; INTESTINES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MERCURY ISOTOPES; NUCLEI; ORGANS; RADIOISOTOPES; RODENTS; UPTAKE; VERTEBRATES; WASTES; YEARS LIVING RADIOISOTOPES; ZINC ISOTOPES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
OSTI ID:
7338150
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: RAISA
Submitting Site:
INIS
Size:
Pages: 679-683
Announcement Date:

Journal Article:

Citation Formats

Shibata, H. Absorption and excretion of zinc, cadmium and mercury in the gastrointestinal tract. Japan: N. p., 1975. Web.
Shibata, H. Absorption and excretion of zinc, cadmium and mercury in the gastrointestinal tract. Japan.
Shibata, H. 1975. "Absorption and excretion of zinc, cadmium and mercury in the gastrointestinal tract." Japan.
@misc{etde_7338150,
title = {Absorption and excretion of zinc, cadmium and mercury in the gastrointestinal tract}
author = {Shibata, H}
abstractNote = {The absorption and excretion of inorganic zinc, cadmium and mercury in the gastrointestinal tract were compared using /sup 65/Zn, /sup 109/Cd and /sup 203/Hg. A single dose of /sup 65/Zn, /sup 109/Cd or /sup 203/Hg was administered orally or injected intravenously to investigate the distribution, excretion into bile and excretion into feces or urine. Absorption and excretion through the gastrointestinal tract of mice were studied by the tied loop method. Groups of eight mice or rats were used to measure the radioactivity in sample with a scintillation counter. Most of the orally administered /sup 65/Zn, /sup 109/Cd or /sup 203/Hg was excreted into feces and was less absorbed by the gastrointestinal tract, respectively. Absorption rate in the gastrointestinal tract was as follows: /sup 203/Hg>/sup 65/Zn>/sup 109/Cd. Intravenously injected /sup 65/Zn, /sup 109/Cd or /sup 203/Hg was escreted into the gastrointestinal tract through the gastrointestinal wall and bile duct, respectively. Excretion rate in the gastrointestinal tract was as follows: /sup 65/Zn>/sup 203/Hg>/sup 109/Cd. When comparing the absorption and excretion in each gastrointestinal tract divided into 10 parts, /sup 65/Zn, and /sup 109/Cd were relatively well absorbed from the upper and lower part of small intestine and excreted into the upper, middle, lower part. /sup 203/Hg was relatively well absorbed from the upper, lower part of small intestine and excreted into the stomach and the caecum. The major organs that accumulated absorbed /sup 65/Zn, /sup 109/Cd or /sup 203/Hg were the pancreas and liver, liver and kidney, kidney and liver, respectively.}
journal = {Radioisotopes (Tokyo); (Japan)}
volume = {24:10}
journal type = {AC}
place = {Japan}
year = {1975}
month = {Oct}
}