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E. S. R. studies of halogenated pyrimidines in. gamma. -irradiated alkaline glasses. [Halogenated uracil bases; bromouridine; bromodeoxyuridine]

Abstract

The reactions of mobile electrons (e/sup -//sub m/) and oxygen radical anions (O./sup -/) with halogenated bases and nucleosides have been studied in ..gamma..-irradiated alkaline glasses by e.s.r. and specific halogen-ion electrode techniques. It was shown that electrons react with halogenated uracil bases (XUr where X = Cl, Br, I but not F) by dissociative electron attachment to form uracil-5-yl radicals (U.) and halogen anions. The relative rates of reaction of e/sup -//sub m/ with XUr decreased in the sequence BrUr > ClUr > FUr > IUr. Thermal annealing studies carried out on U. in H/sub 2/O and D/sub 2/O matrices supported the hypothesis that U. in H/sub 2/O hydrates across the 5-6 double bond in the temperature region 135/sup 0/ to 155/sup 0/ K, and deuterates to a much smaller extent in D/sub 2/O at temperatures above 155/sup 0/ K. Studies on bromouridine and bromodeoxyuridine suggested that e/sup -/sub(m) reacts with the base moieties to form U. type radicals which abstract H. from the sugar moieties of adjacent nucleosides.
Authors:
Simpson, L D; Zimbrick, J D [1] 
  1. Kansas Univ., Lawrence (USA)
Publication Date:
Nov 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-243008; EDB-77-003201
Resource Relation:
Journal Name: Int. J. Radiat. Biol.; (United Kingdom); Journal Volume: 28:5
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; BROMOURACILS; CHEMICAL RADIATION EFFECTS; FLUOROURACILS; ORGANIC BROMINE COMPOUNDS; ORGANIC CHLORINE COMPOUNDS; URACILS; URIDINE; ANIONS; BUDR; CHEMICAL REACTION KINETICS; COMPARATIVE EVALUATIONS; ELECTRON SPIN RESONANCE; ELECTRONS; GAMMA RADIATION; GLASS; IODOURACILS; LOW TEMPERATURE; MOLECULAR STRUCTURE; ORGANIC COMPOUNDS; PHOTON BEAMS; RADIATION CHEMISTRY; RADICALS; STRUCTURAL CHEMICAL ANALYSIS; TEMPERATURE DEPENDENCE; ANTIMETABOLITES; ANTIMITOTIC DRUGS; AZINES; BEAMS; CHARGED PARTICLES; CHEMISTRY; DRUGS; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; FERMIONS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IONIZING RADIATIONS; IONS; KINETICS; LEPTONS; MAGNETIC RESONANCE; NUCLEOSIDES; NUCLEOTIDES; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; REACTION KINETICS; RESONANCE; RIBOSIDES; 400600* - Radiation Chemistry
OSTI ID:
7335748
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IJRBA
Submitting Site:
INIS
Size:
Pages: 461-475
Announcement Date:
Aug 01, 1976

Citation Formats

Simpson, L D, and Zimbrick, J D. E. S. R. studies of halogenated pyrimidines in. gamma. -irradiated alkaline glasses. [Halogenated uracil bases; bromouridine; bromodeoxyuridine]. United Kingdom: N. p., 1975. Web. doi:10.1080/09553007514551291.
Simpson, L D, & Zimbrick, J D. E. S. R. studies of halogenated pyrimidines in. gamma. -irradiated alkaline glasses. [Halogenated uracil bases; bromouridine; bromodeoxyuridine]. United Kingdom. doi:10.1080/09553007514551291.
Simpson, L D, and Zimbrick, J D. 1975. "E. S. R. studies of halogenated pyrimidines in. gamma. -irradiated alkaline glasses. [Halogenated uracil bases; bromouridine; bromodeoxyuridine]." United Kingdom. doi:10.1080/09553007514551291. https://www.osti.gov/servlets/purl/10.1080/09553007514551291.
@misc{etde_7335748,
title = {E. S. R. studies of halogenated pyrimidines in. gamma. -irradiated alkaline glasses. [Halogenated uracil bases; bromouridine; bromodeoxyuridine]}
author = {Simpson, L D, and Zimbrick, J D}
abstractNote = {The reactions of mobile electrons (e/sup -//sub m/) and oxygen radical anions (O./sup -/) with halogenated bases and nucleosides have been studied in ..gamma..-irradiated alkaline glasses by e.s.r. and specific halogen-ion electrode techniques. It was shown that electrons react with halogenated uracil bases (XUr where X = Cl, Br, I but not F) by dissociative electron attachment to form uracil-5-yl radicals (U.) and halogen anions. The relative rates of reaction of e/sup -//sub m/ with XUr decreased in the sequence BrUr > ClUr > FUr > IUr. Thermal annealing studies carried out on U. in H/sub 2/O and D/sub 2/O matrices supported the hypothesis that U. in H/sub 2/O hydrates across the 5-6 double bond in the temperature region 135/sup 0/ to 155/sup 0/ K, and deuterates to a much smaller extent in D/sub 2/O at temperatures above 155/sup 0/ K. Studies on bromouridine and bromodeoxyuridine suggested that e/sup -/sub(m) reacts with the base moieties to form U. type radicals which abstract H. from the sugar moieties of adjacent nucleosides.}
doi = {10.1080/09553007514551291}
journal = {Int. J. Radiat. Biol.; (United Kingdom)}
volume = {28:5}
journal type = {AC}
place = {United Kingdom}
year = {1975}
month = {Nov}
}