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Weakening of the radioprotective action of gas hypoxia with growth of ascitic tumors

Journal Article:

Abstract

It was shown previously that moderate hypoxia induced by breathing oxygen-poor air (5 percent O/sub 2/) reduces the lethal effect of the total irradiation of mice, while with local irradiation of tumors reduction of tumor growth rate is even more marked in hypoxia-protected animals than with irradiation of mice in normal air. This suggests the possible therapeutic application of hypoxia. It was found that acute gas hypoxia strongly retards radiation damage to bone marrow, both qualitatively (type of cells affected) and quantitatively. In addition, a definite weakening of the protective effect of hypoxia was observed, this being proportional to increase in tumor size. Planned future tests involving direct dynamic measurement of oxygen stress as a function of amount of ascites are expected to supply further information on reduction of radiosensitivity of normal tissues and on the selective intensification of tumor regression. Graphic data accompany the paper. (JPRS)
Publication Date:
Jun 27, 1975
Product Type:
Journal Article
Reference Number:
EDB-77-014678
Resource Relation:
Journal Name: Med. Radiol.; (USSR); Journal Volume: 1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANOXIA; RADIOSENSITIVITY EFFECTS; BONE MARROW; RADIOSENSITIVITY; EHRLICH ASCITES TUMOR; TISSUES; LOCAL IRRADIATION; MICE; OXYGEN; RADIATION PROTECTION; TRANSPLANTS; ANIMALS; BODY; CRYOGENIC FLUIDS; DISEASES; ELEMENTS; EXPERIMENTAL NEOPLASMS; FLUIDS; HEMATOPOIETIC SYSTEM; IRRADIATION; MAMMALS; NEOPLASMS; NONMETALS; ORGANS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7332307
Research Organizations:
Inst. of Experimental and Clinical Oncology, Moscow
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: MERAA
Submitting Site:
HEDB
Size:
Pages: 71-72
Announcement Date:

Journal Article:

Citation Formats

Aytmagambetova, B Z, Shmakova, N L, and Fadeyeva, T A. Weakening of the radioprotective action of gas hypoxia with growth of ascitic tumors. USSR: N. p., 1975. Web.
Aytmagambetova, B Z, Shmakova, N L, & Fadeyeva, T A. Weakening of the radioprotective action of gas hypoxia with growth of ascitic tumors. USSR.
Aytmagambetova, B Z, Shmakova, N L, and Fadeyeva, T A. 1975. "Weakening of the radioprotective action of gas hypoxia with growth of ascitic tumors." USSR.
@misc{etde_7332307,
title = {Weakening of the radioprotective action of gas hypoxia with growth of ascitic tumors}
author = {Aytmagambetova, B Z, Shmakova, N L, and Fadeyeva, T A}
abstractNote = {It was shown previously that moderate hypoxia induced by breathing oxygen-poor air (5 percent O/sub 2/) reduces the lethal effect of the total irradiation of mice, while with local irradiation of tumors reduction of tumor growth rate is even more marked in hypoxia-protected animals than with irradiation of mice in normal air. This suggests the possible therapeutic application of hypoxia. It was found that acute gas hypoxia strongly retards radiation damage to bone marrow, both qualitatively (type of cells affected) and quantitatively. In addition, a definite weakening of the protective effect of hypoxia was observed, this being proportional to increase in tumor size. Planned future tests involving direct dynamic measurement of oxygen stress as a function of amount of ascites are expected to supply further information on reduction of radiosensitivity of normal tissues and on the selective intensification of tumor regression. Graphic data accompany the paper. (JPRS)}
journal = {Med. Radiol.; (USSR)}
volume = {1}
journal type = {AC}
place = {USSR}
year = {1975}
month = {Jun}
}