Abstract
Erythroid regeneration was studied in lethally irradiated mice given transplants containing equivalent numbers of haemopoietic stem cells (i.e. CFU) from fetal liver, neonatal marrow or adult marrow. Adult marrow was taken from normal control mice, whose CFU for the most part were not in active cell cycle, as well as from phenylhydrazine-treated groups whose CFU were in similar state of proliferation (i.e. approximately 40-50% in DNA synthesis) as those derived from fetal liver and neonatal marrow. Splenic and femoral radioiron (/sup 59/Fe) incorporation were measured at intervals after transplantation and were found to begin earliest in mice given fetal liver, then in animals given neonatal marrow and latest in recipients of adult marrow. Peripheral reticulocytes showed a similar pattern of recovery. The data reported herein suggest that the differences in erythroid regeneration evoked by transplants of fetal liver, neonatal marrow or adult marrow, are not solely attributed to the degree of proliferation in the pluripotential stem cell compartment. These data may, however, suggest a shorter doubling time for cells comprising the fetal and newborn committed erythroid compartments.
Rencricca, N J;
Howard, D;
Kubanek, B;
Stohlman, F;
[1]
Department of Biological Sciences, University of Lowell, Lowell, Massachusetts, USA)
- Boston Univ., Mass. (USA). School of Medicine
Citation Formats
Rencricca, N J, Howard, D, Kubanek, B, Stohlman, F, and Department of Biological Sciences, University of Lowell, Lowell, Massachusetts, USA).
Erythroid differentiation of fetal, newborn, and adult haemopoietic stem cells.
Denmark: N. p.,
1976.
Web.
Rencricca, N J, Howard, D, Kubanek, B, Stohlman, F, & Department of Biological Sciences, University of Lowell, Lowell, Massachusetts, USA).
Erythroid differentiation of fetal, newborn, and adult haemopoietic stem cells.
Denmark.
Rencricca, N J, Howard, D, Kubanek, B, Stohlman, F, and Department of Biological Sciences, University of Lowell, Lowell, Massachusetts, USA).
1976.
"Erythroid differentiation of fetal, newborn, and adult haemopoietic stem cells."
Denmark.
@misc{etde_7332303,
title = {Erythroid differentiation of fetal, newborn, and adult haemopoietic stem cells}
author = {Rencricca, N J, Howard, D, Kubanek, B, Stohlman, F, and Department of Biological Sciences, University of Lowell, Lowell, Massachusetts, USA)}
abstractNote = {Erythroid regeneration was studied in lethally irradiated mice given transplants containing equivalent numbers of haemopoietic stem cells (i.e. CFU) from fetal liver, neonatal marrow or adult marrow. Adult marrow was taken from normal control mice, whose CFU for the most part were not in active cell cycle, as well as from phenylhydrazine-treated groups whose CFU were in similar state of proliferation (i.e. approximately 40-50% in DNA synthesis) as those derived from fetal liver and neonatal marrow. Splenic and femoral radioiron (/sup 59/Fe) incorporation were measured at intervals after transplantation and were found to begin earliest in mice given fetal liver, then in animals given neonatal marrow and latest in recipients of adult marrow. Peripheral reticulocytes showed a similar pattern of recovery. The data reported herein suggest that the differences in erythroid regeneration evoked by transplants of fetal liver, neonatal marrow or adult marrow, are not solely attributed to the degree of proliferation in the pluripotential stem cell compartment. These data may, however, suggest a shorter doubling time for cells comprising the fetal and newborn committed erythroid compartments.}
journal = []
volume = {16}
journal type = {AC}
place = {Denmark}
year = {1976}
month = {Jan}
}
title = {Erythroid differentiation of fetal, newborn, and adult haemopoietic stem cells}
author = {Rencricca, N J, Howard, D, Kubanek, B, Stohlman, F, and Department of Biological Sciences, University of Lowell, Lowell, Massachusetts, USA)}
abstractNote = {Erythroid regeneration was studied in lethally irradiated mice given transplants containing equivalent numbers of haemopoietic stem cells (i.e. CFU) from fetal liver, neonatal marrow or adult marrow. Adult marrow was taken from normal control mice, whose CFU for the most part were not in active cell cycle, as well as from phenylhydrazine-treated groups whose CFU were in similar state of proliferation (i.e. approximately 40-50% in DNA synthesis) as those derived from fetal liver and neonatal marrow. Splenic and femoral radioiron (/sup 59/Fe) incorporation were measured at intervals after transplantation and were found to begin earliest in mice given fetal liver, then in animals given neonatal marrow and latest in recipients of adult marrow. Peripheral reticulocytes showed a similar pattern of recovery. The data reported herein suggest that the differences in erythroid regeneration evoked by transplants of fetal liver, neonatal marrow or adult marrow, are not solely attributed to the degree of proliferation in the pluripotential stem cell compartment. These data may, however, suggest a shorter doubling time for cells comprising the fetal and newborn committed erythroid compartments.}
journal = []
volume = {16}
journal type = {AC}
place = {Denmark}
year = {1976}
month = {Jan}
}