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Inhibition of insulin release by cyproheptadine: Effects on 3',5'-cyclic-AMP-content and /sup 45/Ca-accumulation of incubated mouse islets

Journal Article:

Abstract

Cyproheptadine (1, 10 and 100 ..mu..m) significantly reduced insulin release from isolated mouse islets in response to glucose. In contrast, 1 mM cyproheptadine induced a large release of insulin into the incubation medium probably due to islet cell damage, since the islets had lost a considerable amount of their protein content. 3',5'-cyclic-AMP-levels of the islets were not significantly affected by 10 ..mu..M cyproheptadine in the presence as well as in the absence of theophylline (10 mM). As the inhibitory effect of cyproheptadine on insulin release was correlated with reduced accumulation of calcium-45, the agent may inhibit insulin release by interfering with the calcium handling of the ..beta..-cell.
Authors:
Joost, H G; Beckmann, J; Lenzen, S; Hasselblatt, A [1] 
  1. Goettingen Univ. (F.R. Germany)
Publication Date:
Jan 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-07-260208; EDB-77-014734
Resource Relation:
Journal Name: Acta Endocrinol.; (Denmark); Journal Volume: 82
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CALCIUM 45; UPTAKE; AMP; DRUGS; INSULIN; MICE; PROTEINS; THEOPHYLLINE; ALKALINE EARTH ISOTOPES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CALCIUM ISOTOPES; DAYS LIVING RADIOISOTOPES; DIURETICS; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HORMONES; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; NUCLEI; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PEPTIDE HORMONES; PURINES; RADIOISOTOPES; RODENTS; VERTEBRATES; XANTHINES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
OSTI ID:
7332277
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ACENA
Submitting Site:
INIS
Size:
Pages: 121-126
Announcement Date:
Oct 01, 1976

Journal Article:

Citation Formats

Joost, H G, Beckmann, J, Lenzen, S, and Hasselblatt, A. Inhibition of insulin release by cyproheptadine: Effects on 3',5'-cyclic-AMP-content and /sup 45/Ca-accumulation of incubated mouse islets. Denmark: N. p., 1976. Web.
Joost, H G, Beckmann, J, Lenzen, S, & Hasselblatt, A. Inhibition of insulin release by cyproheptadine: Effects on 3',5'-cyclic-AMP-content and /sup 45/Ca-accumulation of incubated mouse islets. Denmark.
Joost, H G, Beckmann, J, Lenzen, S, and Hasselblatt, A. 1976. "Inhibition of insulin release by cyproheptadine: Effects on 3',5'-cyclic-AMP-content and /sup 45/Ca-accumulation of incubated mouse islets." Denmark.
@misc{etde_7332277,
title = {Inhibition of insulin release by cyproheptadine: Effects on 3',5'-cyclic-AMP-content and /sup 45/Ca-accumulation of incubated mouse islets}
author = {Joost, H G, Beckmann, J, Lenzen, S, and Hasselblatt, A}
abstractNote = {Cyproheptadine (1, 10 and 100 ..mu..m) significantly reduced insulin release from isolated mouse islets in response to glucose. In contrast, 1 mM cyproheptadine induced a large release of insulin into the incubation medium probably due to islet cell damage, since the islets had lost a considerable amount of their protein content. 3',5'-cyclic-AMP-levels of the islets were not significantly affected by 10 ..mu..M cyproheptadine in the presence as well as in the absence of theophylline (10 mM). As the inhibitory effect of cyproheptadine on insulin release was correlated with reduced accumulation of calcium-45, the agent may inhibit insulin release by interfering with the calcium handling of the ..beta..-cell.}
journal = {Acta Endocrinol.; (Denmark)}
volume = {82}
journal type = {AC}
place = {Denmark}
year = {1976}
month = {Jan}
}