You need JavaScript to view this

Radiotherapy, chemotherapy, and growth-hormone deficiency

Abstract

Measurements have been made of the growth hormone (GH) responses of nine children with acute lymphoblastic leukaemia to the insulin and arginine tolerance tests. All the patients had received induction treatment with prednisone, vincristine and doxorubicin ('Adriamycin') for 4 weeks followed by 2400 rad of orthovoltage cranial irradiation plus five intrathecal injections of methotrexate. During the study all the children were in complete remission, which had been maintained with 6-mercaptopurine and methotrexate for 4 to 26 months. No pulses of steroids were used in remission. Five patients in early remission did not respond to either stimulation test, three having longer remissions showed a late and low response to the insulin test and the one patient with the longest remission (26 months) had a normal GH response. Heights and bone ages were normal. These results, which suggest the possibility of a gradual recovery after the end of CNS treatment including orthovoltage cranial irradiation, are contrasted with those for megavoltage treatment reported by Shalet et al. (Shalet, S.M., Beardwell, C.G., Morris-Jones, P.H., Pearson, D., Archs. Dis. Childh., 1976, vol. 51, 489).
Authors:
Schiliro, G; Russo, A; Sciotto, A; Distefano, G; Vigo, R [1] 
  1. Catania Univ. (Italy). 1. and 2. Paediatric Clinics
Publication Date:
Nov 06, 1976
Product Type:
Journal Article
Reference Number:
AIX-08-293301; EDB-77-052076
Resource Relation:
Journal Name: Lancet; (United Kingdom); Journal Volume: 2:7993
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RADIOTHERAPY; SIDE EFFECTS; STH; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BRAIN; CHEMOTHERAPY; CHILDREN; ENERGY DEPENDENCE; LEUKEMIA; MERCAPTOPURINE; METHOTREXATE; ONCOVIN; PATIENTS; PREDNISONE; QUANTITY RATIO; ADRENAL HORMONES; ALKALOIDS; ANIMALS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; CORTICOSTEROIDS; DISEASES; DRUGS; GLUCOCORTICOIDS; HEMIC DISEASES; HETEROCYCLIC COMPOUNDS; HORMONES; HYDROXY COMPOUNDS; KETONES; MAMMALS; MAN; MEDICINE; NEOPLASMS; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PEPTIDE HORMONES; PITUITARY HORMONES; PREGNANES; PRIMATES; PURINES; RADIATION EFFECTS; RADIOLOGY; RECOVERY; STEROID HORMONES; STEROIDS; THERAPY; THIOLS; VERTEBRATES; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7332023
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: LANCA
Submitting Site:
INIS
Size:
Pages: 1031-1032
Announcement Date:

Citation Formats

Schiliro, G, Russo, A, Sciotto, A, Distefano, G, and Vigo, R. Radiotherapy, chemotherapy, and growth-hormone deficiency. United Kingdom: N. p., 1976. Web. doi:10.1016/S0140-6736(76)90881-3.
Schiliro, G, Russo, A, Sciotto, A, Distefano, G, & Vigo, R. Radiotherapy, chemotherapy, and growth-hormone deficiency. United Kingdom. doi:10.1016/S0140-6736(76)90881-3.
Schiliro, G, Russo, A, Sciotto, A, Distefano, G, and Vigo, R. 1976. "Radiotherapy, chemotherapy, and growth-hormone deficiency." United Kingdom. doi:10.1016/S0140-6736(76)90881-3. https://www.osti.gov/servlets/purl/10.1016/S0140-6736(76)90881-3.
@misc{etde_7332023,
title = {Radiotherapy, chemotherapy, and growth-hormone deficiency}
author = {Schiliro, G, Russo, A, Sciotto, A, Distefano, G, and Vigo, R}
abstractNote = {Measurements have been made of the growth hormone (GH) responses of nine children with acute lymphoblastic leukaemia to the insulin and arginine tolerance tests. All the patients had received induction treatment with prednisone, vincristine and doxorubicin ('Adriamycin') for 4 weeks followed by 2400 rad of orthovoltage cranial irradiation plus five intrathecal injections of methotrexate. During the study all the children were in complete remission, which had been maintained with 6-mercaptopurine and methotrexate for 4 to 26 months. No pulses of steroids were used in remission. Five patients in early remission did not respond to either stimulation test, three having longer remissions showed a late and low response to the insulin test and the one patient with the longest remission (26 months) had a normal GH response. Heights and bone ages were normal. These results, which suggest the possibility of a gradual recovery after the end of CNS treatment including orthovoltage cranial irradiation, are contrasted with those for megavoltage treatment reported by Shalet et al. (Shalet, S.M., Beardwell, C.G., Morris-Jones, P.H., Pearson, D., Archs. Dis. Childh., 1976, vol. 51, 489).}
doi = {10.1016/S0140-6736(76)90881-3}
journal = {Lancet; (United Kingdom)}
volume = {2:7993}
journal type = {AC}
place = {United Kingdom}
year = {1976}
month = {Nov}
}