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Antithrombotic artificial organs

Abstract

A new antithrombotic material useful for making artificial organs (artificial blood vessel, artificial heart, etc.) can be prepared by graft-polymerizing an acrylic ester (methyl methacrylate, methyl acrylate, ethyl acrylate, etc.) with a synthetic fiber (teflon, etc.). The graft-polymerization can be carried out by means of gamma radiation with cobalt 60 (dose rate 2.6x10/sup 3/ r/min., total dose 8x10/sup 4/ to 3.5x10/sup 5/ r). A graft ratio of 5 to 80% is attainable. In one example, a tubular sample made of teflon fiber having an inner diameter of 5 to 10 mm was immersed into methyl methacrylate in an ampoule in the absence of air and exposed to cobalt 60 gamma ray at the dose rate of 3.18x10/sup 3/ rad/min. After extraction with acetone, the sample was dried. The total dose was 3.5x10/sup 5/ rad and the graft ratio was ca. 25%. The sample was transplanted to vena cava of dog. No formation of thrombus was observed by autopsy (4 months after the transplantation). In control (teflon tube not graft-polymerized) thrombus was observed by autopsy 7 days after the transplantation.
Publication Date:
Jul 12, 1971
Product Type:
Patent
Report Number:
JP 1975-32554; B
Reference Number:
AIX-08-283987; EDB-77-037482
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; ACRYLIC ACID ESTERS; CHEMICAL RADIATION EFFECTS; ARTIFICIAL ORGANS; FABRICATION; GAMMA RADIATION; GRAFT POLYMERS; MECHANICAL HEART; METHACRYLIC ACID ESTERS; TEFLON; THROMBOSIS; CARBOXYLIC ACID ESTERS; CARDIOVASCULAR DISEASES; CHEMISTRY; DISEASES; ELECTROMAGNETIC RADIATION; ESTERS; FLUORINATED ALIPHATIC HYDROCARBONS; HALOGENATED ALIPHATIC HYDROCARBONS; IONIZING RADIATIONS; MEDICAL SUPPLIES; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC POLYMERS; PETROCHEMICALS; PETROLEUM PRODUCTS; PLASTICS; POLYETHYLENES; POLYMERS; POLYOLEFINS; POLYTETRAFLUORETHYLENE; PROSTHESES; RADIATION CHEMISTRY; RADIATION EFFECTS; RADIATIONS; 400600* - Radiation Chemistry
OSTI ID:
7324581
Country of Origin:
Japan
Language:
Japanese
Submitting Site:
INIS
Size:
Pages: 6
Announcement Date:

Citation Formats

Takamatsu, T, Fukada, E, Saegusa, M, and Hasegawa, T. Antithrombotic artificial organs. Japan: N. p., 1971. Web.
Takamatsu, T, Fukada, E, Saegusa, M, & Hasegawa, T. Antithrombotic artificial organs. Japan.
Takamatsu, T, Fukada, E, Saegusa, M, and Hasegawa, T. 1971. "Antithrombotic artificial organs." Japan.
@misc{etde_7324581,
title = {Antithrombotic artificial organs}
author = {Takamatsu, T, Fukada, E, Saegusa, M, and Hasegawa, T}
abstractNote = {A new antithrombotic material useful for making artificial organs (artificial blood vessel, artificial heart, etc.) can be prepared by graft-polymerizing an acrylic ester (methyl methacrylate, methyl acrylate, ethyl acrylate, etc.) with a synthetic fiber (teflon, etc.). The graft-polymerization can be carried out by means of gamma radiation with cobalt 60 (dose rate 2.6x10/sup 3/ r/min., total dose 8x10/sup 4/ to 3.5x10/sup 5/ r). A graft ratio of 5 to 80% is attainable. In one example, a tubular sample made of teflon fiber having an inner diameter of 5 to 10 mm was immersed into methyl methacrylate in an ampoule in the absence of air and exposed to cobalt 60 gamma ray at the dose rate of 3.18x10/sup 3/ rad/min. After extraction with acetone, the sample was dried. The total dose was 3.5x10/sup 5/ rad and the graft ratio was ca. 25%. The sample was transplanted to vena cava of dog. No formation of thrombus was observed by autopsy (4 months after the transplantation). In control (teflon tube not graft-polymerized) thrombus was observed by autopsy 7 days after the transplantation.}
place = {Japan}
year = {1971}
month = {Jul}
}