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Observations on the interactions of Schwann cells and astrocytes following x irradiation of neonatal rat spinal cord

Journal Article:

Abstract

Myelination was inhibited in the spinal cord of three day-old rats with 2000 rads of x irradiation. Myelination subsequently occurred as a result of caudal migration of oligodendrocytes and extensive invasion of the cord by Schwann cells. Although oligodendrocytes were present in areas containing Schwann cells, astrocytes were absent. The presence of Schwann cells in the neuropil of the spinal cord did not stimulate production of basement membrane by astrocytes, so no new glial limiting membrane was formed. Evidence is presented which suggests that if astrocytes do not form a glial limiting membrane when opposed by large numbers of Schwann cells they are destroyed by the invading cells. It is suggested that the glial limiting membrane normally inhibits entry of Schwann cells into the central nervous system; if this is destroyed and not reconstituted, Schwann cells can migrate freely into the neuropil.
Publication Date:
Oct 01, 1975
Product Type:
Journal Article
Reference Number:
EDB-77-122115
Resource Relation:
Journal Name: J. Neurocytol.; (United Kingdom); Journal Volume: 4:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; SPINAL CORD; BIOLOGICAL RADIATION EFFECTS; ANIMAL CELLS; INHIBITION; LOCAL IRRADIATION; MYELIN; X RADIATION; BIOLOGICAL EFFECTS; CENTRAL NERVOUS SYSTEM; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; IRRADIATION; LIPIDS; LIPOPROTEINS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; PROTEINS; RADIATION EFFECTS; RADIATIONS; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7323811
Research Organizations:
Wellcome Lab. for Comparative Neurology, Cambridge, Eng.
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JNCYA
Submitting Site:
TIC
Size:
Pages: 573-585
Announcement Date:

Journal Article:

Citation Formats

Blakemore, W F, and Patterson, R C. Observations on the interactions of Schwann cells and astrocytes following x irradiation of neonatal rat spinal cord. United Kingdom: N. p., 1975. Web. doi:10.1007/BF01351538.
Blakemore, W F, & Patterson, R C. Observations on the interactions of Schwann cells and astrocytes following x irradiation of neonatal rat spinal cord. United Kingdom. doi:10.1007/BF01351538.
Blakemore, W F, and Patterson, R C. 1975. "Observations on the interactions of Schwann cells and astrocytes following x irradiation of neonatal rat spinal cord." United Kingdom. doi:10.1007/BF01351538. https://www.osti.gov/servlets/purl/10.1007/BF01351538.
@misc{etde_7323811,
title = {Observations on the interactions of Schwann cells and astrocytes following x irradiation of neonatal rat spinal cord}
author = {Blakemore, W F, and Patterson, R C}
abstractNote = {Myelination was inhibited in the spinal cord of three day-old rats with 2000 rads of x irradiation. Myelination subsequently occurred as a result of caudal migration of oligodendrocytes and extensive invasion of the cord by Schwann cells. Although oligodendrocytes were present in areas containing Schwann cells, astrocytes were absent. The presence of Schwann cells in the neuropil of the spinal cord did not stimulate production of basement membrane by astrocytes, so no new glial limiting membrane was formed. Evidence is presented which suggests that if astrocytes do not form a glial limiting membrane when opposed by large numbers of Schwann cells they are destroyed by the invading cells. It is suggested that the glial limiting membrane normally inhibits entry of Schwann cells into the central nervous system; if this is destroyed and not reconstituted, Schwann cells can migrate freely into the neuropil.}
doi = {10.1007/BF01351538}
journal = {J. Neurocytol.; (United Kingdom)}
volume = {4:5}
journal type = {AC}
place = {United Kingdom}
year = {1975}
month = {Oct}
}