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Effects of subacute and chronic lead treatment on glucose homestasis and renal cyclic AMP metabolism in rats

Journal Article:

Abstract

The effects of chronic oral ingestion of lead in doses ranging from 20 to 80 ppM were compared with those seen after the subacute exposure of rats to a 10 mg/kg daily dose of the heavy metal for 7 days. Irrespective of the treatment regimen used, lead treatment significantly increased the activities of renal pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose 1,6-diphosphatase and glucose 6-phosphatase. The observed enhancement of kidney gluconeogenic enzymes in chronically treated animals was associated with a stimulation of the adenylate cyclase-cyclic AMP system, a rise in blood glucose and urea as well as a depression in hepatic glycogen and serum immunoreactive insulin (IRI) levels. In contrast, subacute exposure to lead failed to significantly alter cyclic AMP metabolism and the concentrations of liver glycogen, blood glucose, serum urea or IRI. Whereas the insulinogenic index (the ratio of serum IRI to blood glucose concentration) was markedly suppressed in chronically treated rats, this ratio remained within normal limits following subacute exposure to the heavy metal. However, a marked decrease in the insulinogenic index was observed in subacutely treated rats 15 min after the administration of a glucose load. The data provide evidence to show that increased glucose synthesis as well as  More>>
Publication Date:
Jan 01, 1976
Product Type:
Journal Article
Reference Number:
ERA-02-046650; EDB-77-122255
Resource Relation:
Journal Name: Toxicology; (Netherlands); Journal Volume: 6:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; AMP; METABOLISM; GLUCOSE; LEAD; BIOLOGICAL EFFECTS; BIOCHEMICAL REACTION KINETICS; BIOSYNTHESIS; BLOOD; BLOOD SERUM; CARBOXYLASE; CHRONIC INTAKE; ENZYMES; FRUCTOSE; GLYCOGEN; HOMEOSTASIS; INGESTION; KIDNEYS; LIVER; PANCREAS; PHOSPHATASES; PYRUVIC ACID; RATS; UREA; ALDEHYDES; AMIDES; ANIMALS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CARBOHYDRATES; CARBONIC ACID DERIVATIVES; CARBOXYLIC ACIDS; DIGESTIVE SYSTEM; ELEMENTS; ENDOCRINE GLANDS; ESTERASES; GLANDS; HEXOSES; HYDROLASES; INTAKE; KETO ACIDS; KETONES; KINETICS; LYASES; MAMMALS; METALS; MONOSACCHARIDES; NUCLEOTIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; POLYSACCHARIDES; REACTION KINETICS; RODENTS; SACCHARIDES; SYNTHESIS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550200 - Biochemistry; 550500 - Metabolism
OSTI ID:
7323723
Research Organizations:
Univ. of Ottawa
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: TXCYA
Submitting Site:
TIC
Size:
Pages: 265-275
Announcement Date:

Journal Article:

Citation Formats

Stevenson, A, Merali, Z, Kacew, S, and Singhal, R L. Effects of subacute and chronic lead treatment on glucose homestasis and renal cyclic AMP metabolism in rats. Netherlands: N. p., 1976. Web.
Stevenson, A, Merali, Z, Kacew, S, & Singhal, R L. Effects of subacute and chronic lead treatment on glucose homestasis and renal cyclic AMP metabolism in rats. Netherlands.
Stevenson, A, Merali, Z, Kacew, S, and Singhal, R L. 1976. "Effects of subacute and chronic lead treatment on glucose homestasis and renal cyclic AMP metabolism in rats." Netherlands.
@misc{etde_7323723,
title = {Effects of subacute and chronic lead treatment on glucose homestasis and renal cyclic AMP metabolism in rats}
author = {Stevenson, A, Merali, Z, Kacew, S, and Singhal, R L}
abstractNote = {The effects of chronic oral ingestion of lead in doses ranging from 20 to 80 ppM were compared with those seen after the subacute exposure of rats to a 10 mg/kg daily dose of the heavy metal for 7 days. Irrespective of the treatment regimen used, lead treatment significantly increased the activities of renal pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose 1,6-diphosphatase and glucose 6-phosphatase. The observed enhancement of kidney gluconeogenic enzymes in chronically treated animals was associated with a stimulation of the adenylate cyclase-cyclic AMP system, a rise in blood glucose and urea as well as a depression in hepatic glycogen and serum immunoreactive insulin (IRI) levels. In contrast, subacute exposure to lead failed to significantly alter cyclic AMP metabolism and the concentrations of liver glycogen, blood glucose, serum urea or IRI. Whereas the insulinogenic index (the ratio of serum IRI to blood glucose concentration) was markedly suppressed in chronically treated rats, this ratio remained within normal limits following subacute exposure to the heavy metal. However, a marked decrease in the insulinogenic index was observed in subacutely treated rats 15 min after the administration of a glucose load. The data provide evidence to show that increased glucose synthesis as well as suppressed pancreatic function may be responsible for lead-induced disturbances in glucose homeostasis.}
journal = {Toxicology; (Netherlands)}
volume = {6:3}
journal type = {AC}
place = {Netherlands}
year = {1976}
month = {Jan}
}