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Radiation-induced heart disease

Journal Article:

Abstract

A 45-year old woman underwent a radical mastectomy in 1965 for carcinoma of the left breast with metastasis in the left axillar lymph nodes. Fifty per cent of the heart received 4,000 rads during postoperative X-ray therapy. Patient developed radiopneumonia and symptoms of acute pericarditis in 1967. Constrictive pericarditis developed gradually from 1972 on. A pericardiectomy was performed in June 1974 and a thickened pericardium could be removed. Light and electron microscopic examination of a surgical biopsy of the left ventricular epi-myocardium revealed epicardial fibrosis, interstitial fibrosis of the myocardium and perivascular fibrosis. The diagnosis of post-radiation pericarditis was made. The myocardial involvement may be responsible for the subsequent clinical course.
Publication Date:
Jan 01, 1975
Product Type:
Journal Article
Reference Number:
EDB-77-076623
Resource Relation:
Journal Name: Acta Cardiolog.; (Belgium); Journal Volume: 30:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FIBROSIS; RADIOINDUCTION; HEART; DELAYED RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; CARCINOMAS; MAMMARY GLANDS; MYOCARDIUM; PATIENTS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARDIOVASCULAR SYSTEM; DISEASES; GLANDS; MEDICINE; MUSCLES; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7322854
Research Organizations:
University Clinic St. Rafael, Louvain, Belg.
Country of Origin:
Belgium
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ACCAA
Submitting Site:
TIC
Size:
Pages: 383-392
Announcement Date:

Journal Article:

Citation Formats

Stroobandt, R, Knieriem, H J, De Wolf, L, and Joossens, J V. Radiation-induced heart disease. Belgium: N. p., 1975. Web.
Stroobandt, R, Knieriem, H J, De Wolf, L, & Joossens, J V. Radiation-induced heart disease. Belgium.
Stroobandt, R, Knieriem, H J, De Wolf, L, and Joossens, J V. 1975. "Radiation-induced heart disease." Belgium.
@misc{etde_7322854,
title = {Radiation-induced heart disease}
author = {Stroobandt, R, Knieriem, H J, De Wolf, L, and Joossens, J V}
abstractNote = {A 45-year old woman underwent a radical mastectomy in 1965 for carcinoma of the left breast with metastasis in the left axillar lymph nodes. Fifty per cent of the heart received 4,000 rads during postoperative X-ray therapy. Patient developed radiopneumonia and symptoms of acute pericarditis in 1967. Constrictive pericarditis developed gradually from 1972 on. A pericardiectomy was performed in June 1974 and a thickened pericardium could be removed. Light and electron microscopic examination of a surgical biopsy of the left ventricular epi-myocardium revealed epicardial fibrosis, interstitial fibrosis of the myocardium and perivascular fibrosis. The diagnosis of post-radiation pericarditis was made. The myocardial involvement may be responsible for the subsequent clinical course.}
journal = {Acta Cardiolog.; (Belgium)}
volume = {30:5}
journal type = {AC}
place = {Belgium}
year = {1975}
month = {Jan}
}