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Radiation-induced heart injury. Radiopathological study

Journal Article:

Abstract

In order to identify radiation-induced heart injury and to differentiate it from heart disease, an attempt was made to clarify post-irradiation heart injury by investigating the histological changes which occur during the interval between the irradiation and the time of demonstrable histological changes. A study was made of 83 autopsies in which most of the primary neoplasms were breast cancers, lung cancers and mediastinal tumors. In 43 of these autopsies the heart had been irradiated. Sixty eight dd-strain mice were also used for microautoradiographic study. Histological changes in the heart were observed in 27 of the 43 cases receiving irradiation. The limit of the tolerance dose to the heart for indicating histological changes was 1220 ret in humans. The latent period without histological changes was 2.7 months after initiation of radiation therapy. Greater heart injury was observed after re-irradiation or after the combined therapy of radiation and chemotherapy especially mitomycin (MMC). The histological findings after treatment with MMC were similar to those of radiation-induced heart injury. Results of the study indicate that the damage is secondary to radiation-induced changes of the vascula connective tissue.
Authors:
Suzuki, Y; Niibe, H [1] 
  1. Gunma Univ., Maebashi (Japan). School of Medicine
Publication Date:
Nov 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-08-296221; EDB-77-076632
Resource Relation:
Journal Name: Kitakanto Igaku; (Japan); Journal Volume: 25:6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HEART; DELAYED RADIATION EFFECTS; EARLY RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; CARCINOMAS; CARDIOVASCULAR DISEASES; LYMPHOMAS; MICE; PATHOLOGICAL CHANGES; PATIENTS; RADIATION DOSES; TIME DEPENDENCE; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARDIOVASCULAR SYSTEM; DISEASES; DOSES; MAMMALS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; RODENTS; THERAPY; VERTEBRATES; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7322846
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: KKAIA
Submitting Site:
INIS
Size:
Pages: 395-407
Announcement Date:

Journal Article:

Citation Formats

Suzuki, Y, and Niibe, H. Radiation-induced heart injury. Radiopathological study. Japan: N. p., 1975. Web.
Suzuki, Y, & Niibe, H. Radiation-induced heart injury. Radiopathological study. Japan.
Suzuki, Y, and Niibe, H. 1975. "Radiation-induced heart injury. Radiopathological study." Japan.
@misc{etde_7322846,
title = {Radiation-induced heart injury. Radiopathological study}
author = {Suzuki, Y, and Niibe, H}
abstractNote = {In order to identify radiation-induced heart injury and to differentiate it from heart disease, an attempt was made to clarify post-irradiation heart injury by investigating the histological changes which occur during the interval between the irradiation and the time of demonstrable histological changes. A study was made of 83 autopsies in which most of the primary neoplasms were breast cancers, lung cancers and mediastinal tumors. In 43 of these autopsies the heart had been irradiated. Sixty eight dd-strain mice were also used for microautoradiographic study. Histological changes in the heart were observed in 27 of the 43 cases receiving irradiation. The limit of the tolerance dose to the heart for indicating histological changes was 1220 ret in humans. The latent period without histological changes was 2.7 months after initiation of radiation therapy. Greater heart injury was observed after re-irradiation or after the combined therapy of radiation and chemotherapy especially mitomycin (MMC). The histological findings after treatment with MMC were similar to those of radiation-induced heart injury. Results of the study indicate that the damage is secondary to radiation-induced changes of the vascula connective tissue.}
journal = {Kitakanto Igaku; (Japan)}
volume = {25:6}
journal type = {AC}
place = {Japan}
year = {1975}
month = {Nov}
}