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Gamma radiation induced chromosal aberration in human lymphocytes: dose-rate effects in stimulated and non-stimulated cells

Journal Article:

Abstract

Stimulated and non-stimulated human peripheral blood lymphocytes were irradiated acutely and chronically, over 24 h. Dose-effect relationships for dicentric chromosomes were established and various models were fitted to the data. At prolonged irradiations, the yield decreased in basic agreement with the linear-quadratic model of aberration induction. Dose-protraction experiments on PHA/sup +/ and PHA/sup -/ lymphocytes, irradiated under various conditions of oxygenation and suspension (culture medium, whole blood) showed that the rejoining time increased from about 3 h in non-stimulated cells to about 10 h after PHA stimulation, and that this retarded rejoining was most likely due to blastic transformation itself and not to other conditions of irradiation.
Authors:
Liniecki, J; Bajerska, A; Wyszynska, K; [1]  Cisowska, B [2] 
  1. School of Medicine, Lodz (Poland). Div. of Nuclear Medicine and Radiobiology. Medical Research Center
  2. Copernicus Municipal Hospital, Lodz (Poland). Oncology Center. Radiotherapy Dept.
Publication Date:
May 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-08-334780; EDB-77-134352
Resource Relation:
Journal Name: Mutat. Res.; (Netherlands); Journal Volume: 43:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHROMOSOMAL ABERRATIONS; RADIOINDUCTION; LYMPHOCYTES; ACUTE IRRADIATION; CELL CULTURES; CELL CYCLE; CHRONIC IRRADIATION; DICENTRIC CHROMOSOMES; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; MAN; MUTATION FREQUENCY; STIMULATION; ACUTE EXPOSURE; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CHROMOSOMES; CHRONIC EXPOSURE; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; IRRADIATION; LEUKOCYTES; MAMMALS; MUTATIONS; PRIMATES; RADIATIONS; SOMATIC CELLS; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
7319505
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MUREA
Submitting Site:
INIS
Size:
Pages: 291-304
Announcement Date:

Journal Article:

Citation Formats

Liniecki, J, Bajerska, A, Wyszynska, K, and Cisowska, B. Gamma radiation induced chromosal aberration in human lymphocytes: dose-rate effects in stimulated and non-stimulated cells. Netherlands: N. p., 1977. Web.
Liniecki, J, Bajerska, A, Wyszynska, K, & Cisowska, B. Gamma radiation induced chromosal aberration in human lymphocytes: dose-rate effects in stimulated and non-stimulated cells. Netherlands.
Liniecki, J, Bajerska, A, Wyszynska, K, and Cisowska, B. 1977. "Gamma radiation induced chromosal aberration in human lymphocytes: dose-rate effects in stimulated and non-stimulated cells." Netherlands.
@misc{etde_7319505,
title = {Gamma radiation induced chromosal aberration in human lymphocytes: dose-rate effects in stimulated and non-stimulated cells}
author = {Liniecki, J, Bajerska, A, Wyszynska, K, and Cisowska, B}
abstractNote = {Stimulated and non-stimulated human peripheral blood lymphocytes were irradiated acutely and chronically, over 24 h. Dose-effect relationships for dicentric chromosomes were established and various models were fitted to the data. At prolonged irradiations, the yield decreased in basic agreement with the linear-quadratic model of aberration induction. Dose-protraction experiments on PHA/sup +/ and PHA/sup -/ lymphocytes, irradiated under various conditions of oxygenation and suspension (culture medium, whole blood) showed that the rejoining time increased from about 3 h in non-stimulated cells to about 10 h after PHA stimulation, and that this retarded rejoining was most likely due to blastic transformation itself and not to other conditions of irradiation.}
journal = {Mutat. Res.; (Netherlands)}
volume = {43:2}
journal type = {AC}
place = {Netherlands}
year = {1977}
month = {May}
}