Abstract
Stimulated and non-stimulated human peripheral blood lymphocytes were irradiated acutely and chronically, over 24 h. Dose-effect relationships for dicentric chromosomes were established and various models were fitted to the data. At prolonged irradiations, the yield decreased in basic agreement with the linear-quadratic model of aberration induction. Dose-protraction experiments on PHA/sup +/ and PHA/sup -/ lymphocytes, irradiated under various conditions of oxygenation and suspension (culture medium, whole blood) showed that the rejoining time increased from about 3 h in non-stimulated cells to about 10 h after PHA stimulation, and that this retarded rejoining was most likely due to blastic transformation itself and not to other conditions of irradiation.
Liniecki, J;
Bajerska, A;
Wyszynska, K;
[1]
Cisowska, B
[2]
- School of Medicine, Lodz (Poland). Div. of Nuclear Medicine and Radiobiology. Medical Research Center
- Copernicus Municipal Hospital, Lodz (Poland). Oncology Center. Radiotherapy Dept.
Citation Formats
Liniecki, J, Bajerska, A, Wyszynska, K, and Cisowska, B.
Gamma radiation induced chromosal aberration in human lymphocytes: dose-rate effects in stimulated and non-stimulated cells.
Netherlands: N. p.,
1977.
Web.
Liniecki, J, Bajerska, A, Wyszynska, K, & Cisowska, B.
Gamma radiation induced chromosal aberration in human lymphocytes: dose-rate effects in stimulated and non-stimulated cells.
Netherlands.
Liniecki, J, Bajerska, A, Wyszynska, K, and Cisowska, B.
1977.
"Gamma radiation induced chromosal aberration in human lymphocytes: dose-rate effects in stimulated and non-stimulated cells."
Netherlands.
@misc{etde_7319505,
title = {Gamma radiation induced chromosal aberration in human lymphocytes: dose-rate effects in stimulated and non-stimulated cells}
author = {Liniecki, J, Bajerska, A, Wyszynska, K, and Cisowska, B}
abstractNote = {Stimulated and non-stimulated human peripheral blood lymphocytes were irradiated acutely and chronically, over 24 h. Dose-effect relationships for dicentric chromosomes were established and various models were fitted to the data. At prolonged irradiations, the yield decreased in basic agreement with the linear-quadratic model of aberration induction. Dose-protraction experiments on PHA/sup +/ and PHA/sup -/ lymphocytes, irradiated under various conditions of oxygenation and suspension (culture medium, whole blood) showed that the rejoining time increased from about 3 h in non-stimulated cells to about 10 h after PHA stimulation, and that this retarded rejoining was most likely due to blastic transformation itself and not to other conditions of irradiation.}
journal = []
volume = {43:2}
journal type = {AC}
place = {Netherlands}
year = {1977}
month = {May}
}
title = {Gamma radiation induced chromosal aberration in human lymphocytes: dose-rate effects in stimulated and non-stimulated cells}
author = {Liniecki, J, Bajerska, A, Wyszynska, K, and Cisowska, B}
abstractNote = {Stimulated and non-stimulated human peripheral blood lymphocytes were irradiated acutely and chronically, over 24 h. Dose-effect relationships for dicentric chromosomes were established and various models were fitted to the data. At prolonged irradiations, the yield decreased in basic agreement with the linear-quadratic model of aberration induction. Dose-protraction experiments on PHA/sup +/ and PHA/sup -/ lymphocytes, irradiated under various conditions of oxygenation and suspension (culture medium, whole blood) showed that the rejoining time increased from about 3 h in non-stimulated cells to about 10 h after PHA stimulation, and that this retarded rejoining was most likely due to blastic transformation itself and not to other conditions of irradiation.}
journal = []
volume = {43:2}
journal type = {AC}
place = {Netherlands}
year = {1977}
month = {May}
}