Abstract
Gamma-irradiation of S.typhimurium cells up to a dose of 500 krad significantly reduced their toxicity. However, the antigenicity of these cells was not altered, which suggests that these cells could be used as vaccine. The protection offered by the irradiated cells was comparable to that of formalin-treated cells. The radio-vaccine, however, offered an additional advantage of significant detoxification of the endotoxin, thereby minimizing side effects. The lipopolysaccharide extracted from the irradiated S.typhimurium cells offered cross-protection against other Salmonella species tested.
Nerkar, D P;
Govekar, L G;
Kumta, U S;
Sreenivasan, A
[1]
- Bhabha Atomic Research Centre, Bombay (India). Biochemistry and Food Technology Div.
Citation Formats
Nerkar, D P, Govekar, L G, Kumta, U S, and Sreenivasan, A.
Radiovaccine of S. typhimurium cells.
United Kingdom: N. p.,
1977.
Web.
doi:10.1080/09553007714550391.
Nerkar, D P, Govekar, L G, Kumta, U S, & Sreenivasan, A.
Radiovaccine of S. typhimurium cells.
United Kingdom.
https://doi.org/10.1080/09553007714550391
Nerkar, D P, Govekar, L G, Kumta, U S, and Sreenivasan, A.
1977.
"Radiovaccine of S. typhimurium cells."
United Kingdom.
https://doi.org/10.1080/09553007714550391.
@misc{etde_7316474,
title = {Radiovaccine of S. typhimurium cells}
author = {Nerkar, D P, Govekar, L G, Kumta, U S, and Sreenivasan, A}
abstractNote = {Gamma-irradiation of S.typhimurium cells up to a dose of 500 krad significantly reduced their toxicity. However, the antigenicity of these cells was not altered, which suggests that these cells could be used as vaccine. The protection offered by the irradiated cells was comparable to that of formalin-treated cells. The radio-vaccine, however, offered an additional advantage of significant detoxification of the endotoxin, thereby minimizing side effects. The lipopolysaccharide extracted from the irradiated S.typhimurium cells offered cross-protection against other Salmonella species tested.}
doi = {10.1080/09553007714550391}
journal = []
volume = {31:4}
journal type = {AC}
place = {United Kingdom}
year = {1977}
month = {Apr}
}
title = {Radiovaccine of S. typhimurium cells}
author = {Nerkar, D P, Govekar, L G, Kumta, U S, and Sreenivasan, A}
abstractNote = {Gamma-irradiation of S.typhimurium cells up to a dose of 500 krad significantly reduced their toxicity. However, the antigenicity of these cells was not altered, which suggests that these cells could be used as vaccine. The protection offered by the irradiated cells was comparable to that of formalin-treated cells. The radio-vaccine, however, offered an additional advantage of significant detoxification of the endotoxin, thereby minimizing side effects. The lipopolysaccharide extracted from the irradiated S.typhimurium cells offered cross-protection against other Salmonella species tested.}
doi = {10.1080/09553007714550391}
journal = []
volume = {31:4}
journal type = {AC}
place = {United Kingdom}
year = {1977}
month = {Apr}
}