Abstract
The effect of mutation to streptomycin resistance on the speed of polypeptide elongation in Escherichia coli was investigated. Translation speed was determined by measuring the time required for the first newly synthesized ..beta..-galactosidase molecules to appear after induction of the lactose operon. The results showed that ribosome speed is not a fixed parameter inherent to the protein synthetic apparatus, but a variable determined by the kinetics of translation and ultimately by the structure of the ribosome. (HLW)
Citation Formats
Galas, D J, and Branscomb, E W.
Ribosome slowed by mutation to streptomycin resistance. [Escherichia coli].
United Kingdom: N. p.,
1976.
Web.
doi:10.1038/262617b0.
Galas, D J, & Branscomb, E W.
Ribosome slowed by mutation to streptomycin resistance. [Escherichia coli].
United Kingdom.
doi:10.1038/262617b0.
Galas, D J, and Branscomb, E W.
1976.
"Ribosome slowed by mutation to streptomycin resistance. [Escherichia coli]."
United Kingdom.
doi:10.1038/262617b0.
https://www.osti.gov/servlets/purl/10.1038/262617b0.
@misc{etde_7314619,
title = {Ribosome slowed by mutation to streptomycin resistance. [Escherichia coli]}
author = {Galas, D J, and Branscomb, E W}
abstractNote = {The effect of mutation to streptomycin resistance on the speed of polypeptide elongation in Escherichia coli was investigated. Translation speed was determined by measuring the time required for the first newly synthesized ..beta..-galactosidase molecules to appear after induction of the lactose operon. The results showed that ribosome speed is not a fixed parameter inherent to the protein synthetic apparatus, but a variable determined by the kinetics of translation and ultimately by the structure of the ribosome. (HLW)}
doi = {10.1038/262617b0}
journal = {Nature (London); (United Kingdom)}
volume = {262:5569}
journal type = {AC}
place = {United Kingdom}
year = {1976}
month = {Aug}
}
title = {Ribosome slowed by mutation to streptomycin resistance. [Escherichia coli]}
author = {Galas, D J, and Branscomb, E W}
abstractNote = {The effect of mutation to streptomycin resistance on the speed of polypeptide elongation in Escherichia coli was investigated. Translation speed was determined by measuring the time required for the first newly synthesized ..beta..-galactosidase molecules to appear after induction of the lactose operon. The results showed that ribosome speed is not a fixed parameter inherent to the protein synthetic apparatus, but a variable determined by the kinetics of translation and ultimately by the structure of the ribosome. (HLW)}
doi = {10.1038/262617b0}
journal = {Nature (London); (United Kingdom)}
volume = {262:5569}
journal type = {AC}
place = {United Kingdom}
year = {1976}
month = {Aug}
}