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Ribosome slowed by mutation to streptomycin resistance. [Escherichia coli]

Journal Article:

Abstract

The effect of mutation to streptomycin resistance on the speed of polypeptide elongation in Escherichia coli was investigated. Translation speed was determined by measuring the time required for the first newly synthesized ..beta..-galactosidase molecules to appear after induction of the lactose operon. The results showed that ribosome speed is not a fixed parameter inherent to the protein synthetic apparatus, but a variable determined by the kinetics of translation and ultimately by the structure of the ribosome. (HLW)
Publication Date:
Aug 12, 1976
Product Type:
Journal Article
Reference Number:
ERA-02-030934; EDB-77-063862
Resource Relation:
Journal Name: Nature (London); (United Kingdom); Journal Volume: 262:5569
Subject:
59 BASIC BIOLOGICAL SCIENCES; ESCHERICHIA COLI; BIOCHEMICAL REACTION KINETICS; MUTATIONS; BIOLOGICAL EFFECTS; POLYPEPTIDES; PROTEINS; RIBOSOMES; BIOSYNTHESIS; BACTERIA; CELL CONSTITUENTS; KINETICS; MICROORGANISMS; ORGANIC COMPOUNDS; ORGANOIDS; PEPTIDES; REACTION KINETICS; SYNTHESIS; 550200* - Biochemistry; 550400 - Genetics
OSTI ID:
7314619
Research Organizations:
Univ. of California, Livermore
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NATUA
Submitting Site:
TIC
Size:
Pages: 617-619
Announcement Date:

Journal Article:

Citation Formats

Galas, D J, and Branscomb, E W. Ribosome slowed by mutation to streptomycin resistance. [Escherichia coli]. United Kingdom: N. p., 1976. Web. doi:10.1038/262617b0.
Galas, D J, & Branscomb, E W. Ribosome slowed by mutation to streptomycin resistance. [Escherichia coli]. United Kingdom. doi:10.1038/262617b0.
Galas, D J, and Branscomb, E W. 1976. "Ribosome slowed by mutation to streptomycin resistance. [Escherichia coli]." United Kingdom. doi:10.1038/262617b0. https://www.osti.gov/servlets/purl/10.1038/262617b0.
@misc{etde_7314619,
title = {Ribosome slowed by mutation to streptomycin resistance. [Escherichia coli]}
author = {Galas, D J, and Branscomb, E W}
abstractNote = {The effect of mutation to streptomycin resistance on the speed of polypeptide elongation in Escherichia coli was investigated. Translation speed was determined by measuring the time required for the first newly synthesized ..beta..-galactosidase molecules to appear after induction of the lactose operon. The results showed that ribosome speed is not a fixed parameter inherent to the protein synthetic apparatus, but a variable determined by the kinetics of translation and ultimately by the structure of the ribosome. (HLW)}
doi = {10.1038/262617b0}
journal = {Nature (London); (United Kingdom)}
volume = {262:5569}
journal type = {AC}
place = {United Kingdom}
year = {1976}
month = {Aug}
}