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pH dependence of the isoproterenol-induced /sup 45/Ca net uptake into the ventricular myocardium of rats

Abstract

Infarction-like or disseminated myocardial necroses can be produced in rats by high doses of isoprotenerol which stimulates the decomposition of energy-rich phosphates to a maximum. The paper shows that acidoses of different genesis (peroral administration of NH/sub 4/Cl, artificial respiration with CO/sub 2/) induced experimentally can inhibit the isoproterenol-induced /sup 45/Ca net uptake and the production of necroses. The findings suggest that Ca/sup + +/ ions play a key role in the production of myocardial necroses which has not been recognized until now - that increased Ca/sup + +/ uptake into damaged myocardial fibres is a result or, at the most, an accompanying symptom of necrosis production - should therefore be discarded.
Authors:
Publication Date:
Jan 01, 1975
Product Type:
Book
Reference Number:
AIX-07-278740; EDB-77-064477
Resource Relation:
Other Information: 8 figs.; 4 tabs.; 17 refs. Available from the library of the Freiburg Univ.; thesis
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CALCIUM 45; UPTAKE; MYOCARDIUM; NECROSIS; RADIONUCLIDE KINETICS; SYMPATHOMIMETICS; PHARMACOLOGY; MYOCARDIAL INFARCTION; RATS; ALKALINE EARTH ISOTOPES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CALCIUM ISOTOPES; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; EVEN-ODD NUCLEI; HEART; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; MUSCLES; NUCLEI; ORGANS; PATHOLOGICAL CHANGES; RADIOISOTOPES; RODENTS; VERTEBRATES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
OSTI ID:
7314449
Country of Origin:
Germany
Language:
German
Availability:
INIS
Submitting Site:
INIS
Size:
Pages: 32
Announcement Date:

Citation Formats

Haag, R. pH dependence of the isoproterenol-induced /sup 45/Ca net uptake into the ventricular myocardium of rats. Germany: N. p., 1975. Web.
Haag, R. pH dependence of the isoproterenol-induced /sup 45/Ca net uptake into the ventricular myocardium of rats. Germany.
Haag, R. 1975. "pH dependence of the isoproterenol-induced /sup 45/Ca net uptake into the ventricular myocardium of rats." Germany.
@misc{etde_7314449,
title = {pH dependence of the isoproterenol-induced /sup 45/Ca net uptake into the ventricular myocardium of rats}
author = {Haag, R}
abstractNote = {Infarction-like or disseminated myocardial necroses can be produced in rats by high doses of isoprotenerol which stimulates the decomposition of energy-rich phosphates to a maximum. The paper shows that acidoses of different genesis (peroral administration of NH/sub 4/Cl, artificial respiration with CO/sub 2/) induced experimentally can inhibit the isoproterenol-induced /sup 45/Ca net uptake and the production of necroses. The findings suggest that Ca/sup + +/ ions play a key role in the production of myocardial necroses which has not been recognized until now - that increased Ca/sup + +/ uptake into damaged myocardial fibres is a result or, at the most, an accompanying symptom of necrosis production - should therefore be discarded.}
place = {Germany}
year = {1975}
month = {Jan}
}