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Radioactively labelled vitamin B12

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Abstract

A method is described for preparing radioactively labelled vitamin B 12 (cyanocobalamin) by reacting ..cap alpha..-(5,6-dimethylbenzimidazolyl) hydrogenobamide with active (sup(57,58)Co) cobaltous ion. The latter may be in the form of cobaltous chloride or sulphate in aqueous or aqueous alcoholic medium. The reaction is effected by heating the reactants in darkness at pH 4 to 8. An excess of cyanide is added to convert the hydroxocobalamin formed to cyanocobalamin.
Authors:
Publication Date:
Dec 01, 1976
Product Type:
Patent
Report Number:
GB 1457027; A
Reference Number:
AIX-08-309631; EDB-77-095027
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; COBALT 57; CHEMICAL REACTIONS; VITAMIN B-12; LABELLING; CHEMICAL PREPARATION; COBALT 58; COBALT CHLORIDES; COBALT SULFATES; LABELLED COMPOUNDS; PRECURSOR; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHLORIDES; CHLORINE COMPOUNDS; COBALT COMPOUNDS; COBALT ISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; HALIDES; HALOGEN COMPOUNDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; OXYGEN COMPOUNDS; RADIOISOTOPES; SULFATES; SULFUR COMPOUNDS; SYNTHESIS; TRANSITION ELEMENT COMPOUNDS; VITAMIN B GROUP; VITAMINS; 400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
OSTI ID:
7313679
Country of Origin:
United Kingdom
Language:
English
Submitting Site:
INIS
Size:
Pages: 5
Announcement Date:
May 13, 2001

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Citation Formats

Charlton, J C, and Lewis, A. Radioactively labelled vitamin B12. United Kingdom: N. p., 1976. Web.
Charlton, J C, & Lewis, A. Radioactively labelled vitamin B12. United Kingdom.
Charlton, J C, and Lewis, A. 1976. "Radioactively labelled vitamin B12." United Kingdom.
@misc{etde_7313679,
title = {Radioactively labelled vitamin B12}
 author = {Charlton, J C, and Lewis, A}
 abstractNote = {A method is described for preparing radioactively labelled vitamin B 12 (cyanocobalamin) by reacting ..cap alpha..-(5,6-dimethylbenzimidazolyl) hydrogenobamide with active (sup(57,58)Co) cobaltous ion. The latter may be in the form of cobaltous chloride or sulphate in aqueous or aqueous alcoholic medium. The reaction is effected by heating the reactants in darkness at pH 4 to 8. An excess of cyanide is added to convert the hydroxocobalamin formed to cyanocobalamin.}
 place = {United Kingdom}
 year = {1976}
 month = {Dec}
 }