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Endothelial cell adhesion to ion implanted polymers

Abstract

The biocompatibility of ion implanted polymers has been studied by means of adhesion measurements of bovine aorta endothelial cells in vitro. The specimens used were polystyrene (PS) and segmented polyurethane (SPU). Na{sup +}, N{sub 2}{sup +}, O{sub 2}{sup +} and Kr{sup +} ion implantations were performed at an energy of 150 keV with fluences ranging from 1x10{sup 15} to 3x10{sup 17} ions/cm{sup 2} at room temperature. The chemical and physical structures of ion-implanted polymers have been investigated in order to analyze their tissue compatibility such as improvement of endothelial cell adhesion. The ion implanted SPU have been found to exhibit remarkably higher adhesion and spreading of endothelial cells than unimplanted specimens. By contrast, ion implanted PS demonstrated a little improvement of adhesion of cells in this assay. Results of FT-IR-ATR showed that ion implantation broke the original chemical bond to form new radicals such as OH, ....C=O, SiH and condensed rings. The results of Raman spectroscopy showed that ion implantation always produced a peak near 1500 cm{sup -1}, which indicated that these ion implanted PS and SPU had the same carbon structure. This structure is considered to bring the dramatic increase in the extent of cell adhesion and spreading to  More>>
Authors:
Suzuki, Y; Kusakabe, M; [1]  Lee, J S; Kaibara, M; Iwaki, M; Sasabe, H [2] 
  1. SONY Corp., Tokyo (Japan)
  2. RIKEN (Inst. of Physical and Chemical Research), Saitama (Japan)
Publication Date:
Mar 01, 1992
Product Type:
Conference
Report Number:
CONF-910646-
Reference Number:
AIX-23-070861; EDB-92-142358
Resource Relation:
Journal Name: Nuclear Instruments and Methods in Physics Research, Section B; (Netherlands); Journal Volume: 65:1-4; Conference: 6. conference on radiation effects in insulators, Weimar (Germany), 24-28 Jun 1991
Subject:
36 MATERIALS SCIENCE; ENDOTHELIUM; ADHESION; COMPATIBILITY; POLYMERS; ION IMPLANTATION; ANNEALING; AORTA; CHEMICAL BONDS; IMPLANTS; IN VITRO; INFRARED SPECTRA; KEV RANGE 100-1000; KRYPTON IONS; MORPHOLOGY; NITROGEN IONS; OXYGEN IONS; POLYSTYRENE; POLYURETHANES; RADIATION DOSES; RADICALS; RAMAN SPECTRA; SODIUM IONS; TEMPERATURE DEPENDENCE; TISSUES; ANIMAL TISSUES; ARTERIES; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; CHARGED PARTICLES; DOSES; ENERGY RANGE; HEAT TREATMENTS; IONS; KEV RANGE; MATERIALS; ORGANIC COMPOUNDS; ORGANIC POLYMERS; ORGANS; PETROCHEMICALS; PETROLEUM PRODUCTS; PLASTICS; POLYAMIDES; POLYOLEFINS; POLYVINYLS; SPECTRA; SYNTHETIC MATERIALS; 360605* - Materials- Radiation Effects
OSTI ID:
7292472
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0168-583X; CODEN: NIMBE
Submitting Site:
NLN
Size:
Pages: 142-147
Announcement Date:

Citation Formats

Suzuki, Y, Kusakabe, M, Lee, J S, Kaibara, M, Iwaki, M, and Sasabe, H. Endothelial cell adhesion to ion implanted polymers. Netherlands: N. p., 1992. Web.
Suzuki, Y, Kusakabe, M, Lee, J S, Kaibara, M, Iwaki, M, & Sasabe, H. Endothelial cell adhesion to ion implanted polymers. Netherlands.
Suzuki, Y, Kusakabe, M, Lee, J S, Kaibara, M, Iwaki, M, and Sasabe, H. 1992. "Endothelial cell adhesion to ion implanted polymers." Netherlands.
@misc{etde_7292472,
title = {Endothelial cell adhesion to ion implanted polymers}
author = {Suzuki, Y, Kusakabe, M, Lee, J S, Kaibara, M, Iwaki, M, and Sasabe, H}
abstractNote = {The biocompatibility of ion implanted polymers has been studied by means of adhesion measurements of bovine aorta endothelial cells in vitro. The specimens used were polystyrene (PS) and segmented polyurethane (SPU). Na{sup +}, N{sub 2}{sup +}, O{sub 2}{sup +} and Kr{sup +} ion implantations were performed at an energy of 150 keV with fluences ranging from 1x10{sup 15} to 3x10{sup 17} ions/cm{sup 2} at room temperature. The chemical and physical structures of ion-implanted polymers have been investigated in order to analyze their tissue compatibility such as improvement of endothelial cell adhesion. The ion implanted SPU have been found to exhibit remarkably higher adhesion and spreading of endothelial cells than unimplanted specimens. By contrast, ion implanted PS demonstrated a little improvement of adhesion of cells in this assay. Results of FT-IR-ATR showed that ion implantation broke the original chemical bond to form new radicals such as OH, ....C=O, SiH and condensed rings. The results of Raman spectroscopy showed that ion implantation always produced a peak near 1500 cm{sup -1}, which indicated that these ion implanted PS and SPU had the same carbon structure. This structure is considered to bring the dramatic increase in the extent of cell adhesion and spreading to these ion implanted PS and SPU. (orig.).}
journal = {Nuclear Instruments and Methods in Physics Research, Section B; (Netherlands)}
volume = {65:1-4}
place = {Netherlands}
year = {1992}
month = {Mar}
}