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Immediate x-radiation induced contractions of the isolated guinea pig terminal ileum: the localization of the effect by drugs

Journal Article:

Abstract

Tone and motility of the isolated guinea pig ileum were increased by irradiation with a dose of 10 krad. The maximal effect corresponds to that induced by 0.001 ..mu..g/ml acetylcholine or 0.3 ..mu..g/ml nicotine. The pharmacological analysis of this effect performed with acetylcholine and nicotine and several blocking agents including hexamethonium, atropine, tetrodotoxin, diphenhydramine, and verapamil suggests that radiation acts on the postganglionic parasympathetic neuron and the neuromuscular synapse. The mechanism of radiation is likely to consist of both an increased release of acetylcholine from the postganglionic neuron and a sensibilization of the cholinergic receptor site at the smooth muscle cell. The latter effect is thought to result from an increased contractile action induced by acetylcholine or nicotine in the irradiated ileal smooth muscle.
Authors:
Spruegel, W; Schubert, E; Mitznegg, P; Heim, F; [1]  Hasl, G; Pauly, H [2] 
  1. Erlangen-Nuernberg Univ., Erlangen (Germany, F.R.). Pharmakologisches Inst.
  2. Erlangen-Nuernberg Univ., Erlangen (Germany, F.R.). Inst. fuer Radiologie
Publication Date:
Apr 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-08-332371; EDB-78-011250
Resource Relation:
Journal Name: Radiat. Environ. Biophys.; (Germany, Federal Republic of); Journal Volume: 14:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; SMALL INTESTINE; BIOLOGICAL RADIATION EFFECTS; ACETYLCHOLINE; ATROPINE; DRUGS; GUINEA PIGS; IN VITRO; IRRADIATION; MECHANICAL PROPERTIES; NERVE CELLS; NICOTINE; PHARMACOLOGY; PHYSIOLOGY; X RADIATION; ALKALOIDS; AMINES; AMMONIUM COMPOUNDS; ANIMAL CELLS; ANIMALS; AZINES; AZOLES; BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; ESTERS; GASTROINTESTINAL TRACT; HETEROCYCLIC COMPOUNDS; INTESTINES; IONIZING RADIATIONS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PARASYMPATHOLYTICS; PARASYMPATHOMIMETICS; PYRIDINES; PYRROLES; PYRROLIDINES; QUATERNARY COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7291052
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: REBPA
Submitting Site:
INIS
Size:
Pages: 31-37
Announcement Date:

Journal Article:

Citation Formats

Spruegel, W, Schubert, E, Mitznegg, P, Heim, F, Hasl, G, and Pauly, H. Immediate x-radiation induced contractions of the isolated guinea pig terminal ileum: the localization of the effect by drugs. Germany: N. p., 1977. Web.
Spruegel, W, Schubert, E, Mitznegg, P, Heim, F, Hasl, G, & Pauly, H. Immediate x-radiation induced contractions of the isolated guinea pig terminal ileum: the localization of the effect by drugs. Germany.
Spruegel, W, Schubert, E, Mitznegg, P, Heim, F, Hasl, G, and Pauly, H. 1977. "Immediate x-radiation induced contractions of the isolated guinea pig terminal ileum: the localization of the effect by drugs." Germany.
@misc{etde_7291052,
title = {Immediate x-radiation induced contractions of the isolated guinea pig terminal ileum: the localization of the effect by drugs}
author = {Spruegel, W, Schubert, E, Mitznegg, P, Heim, F, Hasl, G, and Pauly, H}
abstractNote = {Tone and motility of the isolated guinea pig ileum were increased by irradiation with a dose of 10 krad. The maximal effect corresponds to that induced by 0.001 ..mu..g/ml acetylcholine or 0.3 ..mu..g/ml nicotine. The pharmacological analysis of this effect performed with acetylcholine and nicotine and several blocking agents including hexamethonium, atropine, tetrodotoxin, diphenhydramine, and verapamil suggests that radiation acts on the postganglionic parasympathetic neuron and the neuromuscular synapse. The mechanism of radiation is likely to consist of both an increased release of acetylcholine from the postganglionic neuron and a sensibilization of the cholinergic receptor site at the smooth muscle cell. The latter effect is thought to result from an increased contractile action induced by acetylcholine or nicotine in the irradiated ileal smooth muscle.}
journal = {Radiat. Environ. Biophys.; (Germany, Federal Republic of)}
volume = {14:1}
journal type = {AC}
place = {Germany}
year = {1977}
month = {Apr}
}