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Comparative studies on the effect of radiation-sensitizing agents used in radiating VX2 Carcinoma. With reference to 5-bromodeoxyuridine (BUdR)

Journal Article:

Abstract

The effects of 5-Fu and BUdR as radiation-sensitizing agents macroscopically were investigated in 122 VX2 Carcinomas transplanted into the calves of the hind legs of rabbits. Experimental groups and contrast groups are divided into six as follows: A: No treatment, B: 5-Fu infusion, C: BUdR+Antimetabolite infusion, D: Radiation, E: 5-Fu infusion and radiation, and F: BUdR+Antimetabolite infusion and radiation. The amount of agent given to each was 5 mg/kg/day of 5-Fu and 50 mg/kg/day of BUdR, and the amount of radiation was 300 rad/day. 5-Fu was used as the Antimetabolite, and its amount was one-tenth of that in the 5-Fu Infusion Group. The agent and the radiation were given for five days. 1. In the 300 rad/day Group, the radiation was not enough to result in a complete cure. 2. In the two Agent Infusion Group, 5-Fu and BUdR+Antimetabolite proved to be anti-cancer, but neither of them resulted in effective treatment. 3. The 5-Fu Infusion and Radiation Group, showed a strong degenerative change in the tumor cell and a radiosensitive effect from 5-Fu, but the tumor was not lessened. 4. In the BUdR-Antimetabolite Infusion and Radiation Group, the tumor began to reduce on the third day. On the seventh and  More>>
Authors:
Migita, H [1] 
  1. Kyushu Dental Coll., Kitakyushu, Fukuoka (Japan)
Publication Date:
Nov 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-08-328045; EDB-77-148198
Resource Relation:
Journal Name: Kyushu Shika Gakkai Zasshi; (Japan); Journal Volume: 29:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BUDR; RADIOSENSITIVITY EFFECTS; CARCINOMAS; RADIOTHERAPY; EXPERIMENTAL NEOPLASMS; BIOLOGICAL RADIATION EFFECTS; FLUOROURACILS; COMPARATIVE EVALUATIONS; INJECTION; MORPHOLOGICAL CHANGES; PARTIAL BODY IRRADIATION; RABBITS; RADIOSENSITIZERS; TIME DEPENDENCE; ANIMALS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; AZINES; BIOLOGICAL EFFECTS; BROMOURACILS; DISEASES; DRUGS; EXTERNAL IRRADIATION; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INTAKE; IRRADIATION; MAMMALS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; NUCLEOSIDES; NUCLEOTIDES; ORGANIC BROMINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATION EFFECTS; RADIOLOGY; RESPONSE MODIFYING FACTORS; RIBOSIDES; THERAPY; URACILS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7289183
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: KSGZA
Submitting Site:
INIS
Size:
Pages: 239-263
Announcement Date:
Oct 01, 1977

Journal Article:

Citation Formats

Migita, H. Comparative studies on the effect of radiation-sensitizing agents used in radiating VX2 Carcinoma. With reference to 5-bromodeoxyuridine (BUdR). Japan: N. p., 1975. Web.
Migita, H. Comparative studies on the effect of radiation-sensitizing agents used in radiating VX2 Carcinoma. With reference to 5-bromodeoxyuridine (BUdR). Japan.
Migita, H. 1975. "Comparative studies on the effect of radiation-sensitizing agents used in radiating VX2 Carcinoma. With reference to 5-bromodeoxyuridine (BUdR)." Japan.
@misc{etde_7289183,
title = {Comparative studies on the effect of radiation-sensitizing agents used in radiating VX2 Carcinoma. With reference to 5-bromodeoxyuridine (BUdR)}
author = {Migita, H}
abstractNote = {The effects of 5-Fu and BUdR as radiation-sensitizing agents macroscopically were investigated in 122 VX2 Carcinomas transplanted into the calves of the hind legs of rabbits. Experimental groups and contrast groups are divided into six as follows: A: No treatment, B: 5-Fu infusion, C: BUdR+Antimetabolite infusion, D: Radiation, E: 5-Fu infusion and radiation, and F: BUdR+Antimetabolite infusion and radiation. The amount of agent given to each was 5 mg/kg/day of 5-Fu and 50 mg/kg/day of BUdR, and the amount of radiation was 300 rad/day. 5-Fu was used as the Antimetabolite, and its amount was one-tenth of that in the 5-Fu Infusion Group. The agent and the radiation were given for five days. 1. In the 300 rad/day Group, the radiation was not enough to result in a complete cure. 2. In the two Agent Infusion Group, 5-Fu and BUdR+Antimetabolite proved to be anti-cancer, but neither of them resulted in effective treatment. 3. The 5-Fu Infusion and Radiation Group, showed a strong degenerative change in the tumor cell and a radiosensitive effect from 5-Fu, but the tumor was not lessened. 4. In the BUdR-Antimetabolite Infusion and Radiation Group, the tumor began to reduce on the third day. On the seventh and fourteenth days, necrosis of the greater part of tumor was seen, and the rest of the tumor cells were found to be in degenerative change. On the twenty first day, no live tumor cell was found, only dead remains of tumor cells. The results were confirmed both macroscopically and histopathologically. 5. BUdR can be expected to be effective in clinical application to oral malignant tumors.}
journal = {Kyushu Shika Gakkai Zasshi; (Japan)}
volume = {29:4}
journal type = {AC}
place = {Japan}
year = {1975}
month = {Nov}
}