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Liver changes under the influence of chronic experimental intoxication with nitrogen oxides

Journal Article:

Abstract

Male guinea pigs were divided into three groups: a control group; a group of animals breathing air containing 1 ppM nitrogen oxides during 6 months, 8 hr/day; and third group exposed to products of reactions between nitrogen oxide and gaseous ammonia. The animals lived through the 6 mo with no increase in mortality. The body weight of the animals exposed to nitrogen oxides increased during the 6 mo by 62 g on the average, while in the control group the body weight increased by 395 g on the average. In homogenates of the livers of the animals exposed to nitrogen oxides, the activities of aldolase, lactic dehydrogenase, acid, and alkaline phosphatase increased, and the activities of cholinesterase, ceruloplasmin, and aminotransferases (aspartic and alanine) decreased. Neutralization of NO/sub x/ by gaseous ammonia restored the disorders in enzyme activities in the liver of the animals exposed to nitrogen oxides to their normal values. The study was statistically analyzed. The livers of the animals exposed to nitrogen oxides contained small foci of necrosis, and hemorrhages could be observed. In some animals, fatty degeneration of the liver could be observed. The changes in the liver can also be associated with inhibited protein synthesis, enhanced  More>>
Publication Date:
Jan 01, 1973
Product Type:
Journal Article
Reference Number:
EDB-78-018315
Resource Relation:
Journal Name: Patol. Pol.; (Poland); Journal Volume: 24:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; NITROGEN OXIDES; BIOLOGICAL EFFECTS; ALDOLASES; AMINOTRANSFERASES; AMMONIA; CATABOLISM; CERULOPLASMIN; CHOLINESTERASE; ENZYMES; GUINEA PIGS; HEMORRHAGE; HOMOGENATES; INHALATION; INHIBITION; LACTATE DEHYDROGENASE; LIVER; MORTALITY; NECROSIS; PHOSPHATASES; PROTEINS; STATISTICS; SYNTHESIS; TOXICITY; VITAMINS; WEIGHT; ANIMALS; BODY; CHALCOGENIDES; COMPLEXES; COPPER COMPLEXES; DEHYDROGENASES; DIGESTIVE SYSTEM; DISEASES; ESTERASES; GLANDS; GLOBULINS; GLOBULINS-ALPHA; HYDRIDES; HYDROGEN COMPOUNDS; HYDROLASES; INTAKE; LYASES; MAMMALS; MATHEMATICS; METABOLISM; NITROGEN COMPOUNDS; NITROGEN HYDRIDES; ORGANIC COMPOUNDS; ORGANS; OXIDES; OXIDOREDUCTASES; OXYGEN COMPOUNDS; PATHOLOGICAL CHANGES; RODENTS; SYMPTOMS; TRANSFERASES; TRANSITION ELEMENT COMPLEXES; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550900 - Pathology
OSTI ID:
7287751
Country of Origin:
Poland
Language:
Polish
Other Identifying Numbers:
Journal ID: CODEN: PAPOA
Submitting Site:
APA
Size:
Pages: 381-390
Announcement Date:

Journal Article:

Citation Formats

Kosmider, S, and Misiewicz, A. Liver changes under the influence of chronic experimental intoxication with nitrogen oxides. Poland: N. p., 1973. Web.
Kosmider, S, & Misiewicz, A. Liver changes under the influence of chronic experimental intoxication with nitrogen oxides. Poland.
Kosmider, S, and Misiewicz, A. 1973. "Liver changes under the influence of chronic experimental intoxication with nitrogen oxides." Poland.
@misc{etde_7287751,
title = {Liver changes under the influence of chronic experimental intoxication with nitrogen oxides}
author = {Kosmider, S, and Misiewicz, A}
abstractNote = {Male guinea pigs were divided into three groups: a control group; a group of animals breathing air containing 1 ppM nitrogen oxides during 6 months, 8 hr/day; and third group exposed to products of reactions between nitrogen oxide and gaseous ammonia. The animals lived through the 6 mo with no increase in mortality. The body weight of the animals exposed to nitrogen oxides increased during the 6 mo by 62 g on the average, while in the control group the body weight increased by 395 g on the average. In homogenates of the livers of the animals exposed to nitrogen oxides, the activities of aldolase, lactic dehydrogenase, acid, and alkaline phosphatase increased, and the activities of cholinesterase, ceruloplasmin, and aminotransferases (aspartic and alanine) decreased. Neutralization of NO/sub x/ by gaseous ammonia restored the disorders in enzyme activities in the liver of the animals exposed to nitrogen oxides to their normal values. The study was statistically analyzed. The livers of the animals exposed to nitrogen oxides contained small foci of necrosis, and hemorrhages could be observed. In some animals, fatty degeneration of the liver could be observed. The changes in the liver can also be associated with inhibited protein synthesis, enhanced catabolic processes, and hypovitaminosis.}
journal = {Patol. Pol.; (Poland)}
volume = {24:3}
journal type = {AC}
place = {Poland}
year = {1973}
month = {Jan}
}