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Perfusion of the isolated rat brain with (/sup 14/C)-. delta. /sup 1/-tetrahydrocannabinol

Abstract

There is controversy over whether ..delta../sup 1/-tetrahydrocannabinol (..delta../sup 1/-THC) or its metabolites is responsible for the behavioural and cardiovascular effects of cannabis. It has been shown that, even in the absence of metabolism, ..delta../sup 1/-THC was capable of altering the EEG of isolated perfused rat brain, and must therefore contribute to the psychoactivity of cannabis. TLC studies showed no evidence for brain metabolism of (/sup 14/C)-..delta../sup 1/-THC, and in particular the 7-hydroxylated metabolite (7-OH-..delta../sup 1/-THC) could not be detected. A disproportionate amount of CNS activity in the rat cannot therefore be attributed to 7-OH-..delta../sup 1/-THC on the basis that it is formed at or near its locus of action.
Authors:
Martin, B; Agurell, S; [1]  Krieglstein, J; Rieger, H
  1. Dept. of Pharmacognosy, Faculty of Pharmacy, BMC, Uppsala (Sweden)
Publication Date:
Dec 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-367588; EDB-78-081374
Resource Relation:
Journal Name: Biochem. Pharmacol.; (United Kingdom); Journal Volume: 26:23
Subject:
59 BASIC BIOLOGICAL SCIENCES; ALCOHOLS; METABOLISM; ALKALOIDS; BRAIN; HALLUCINOGENS; BIOLOGICAL EFFECTS; BIOLOGICAL LOCALIZATION; CARBON 14 COMPOUNDS; LABELLED COMPOUNDS; MOLECULAR STRUCTURE; PERFUSED ORGANS; RATS; TRACER TECHNIQUES; ANIMALS; BODY; CENTRAL NERVOUS SYSTEM; DRUGS; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; MAMMALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; PSYCHOTROPIC DRUGS; RODENTS; VERTEBRATES; 550501* - Metabolism- Tracer Techniques
OSTI ID:
7287083
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BCPCA
Submitting Site:
INIS
Size:
Pages: 2307-2309
Announcement Date:
Apr 01, 1978

Citation Formats

Martin, B, Agurell, S, Krieglstein, J, and Rieger, H. Perfusion of the isolated rat brain with (/sup 14/C)-. delta. /sup 1/-tetrahydrocannabinol. United Kingdom: N. p., 1977. Web. doi:10.1016/0006-2952(77)90295-7.
Martin, B, Agurell, S, Krieglstein, J, & Rieger, H. Perfusion of the isolated rat brain with (/sup 14/C)-. delta. /sup 1/-tetrahydrocannabinol. United Kingdom. doi:10.1016/0006-2952(77)90295-7.
Martin, B, Agurell, S, Krieglstein, J, and Rieger, H. 1977. "Perfusion of the isolated rat brain with (/sup 14/C)-. delta. /sup 1/-tetrahydrocannabinol." United Kingdom. doi:10.1016/0006-2952(77)90295-7. https://www.osti.gov/servlets/purl/10.1016/0006-2952(77)90295-7.
@misc{etde_7287083,
title = {Perfusion of the isolated rat brain with (/sup 14/C)-. delta. /sup 1/-tetrahydrocannabinol}
author = {Martin, B, Agurell, S, Krieglstein, J, and Rieger, H}
abstractNote = {There is controversy over whether ..delta../sup 1/-tetrahydrocannabinol (..delta../sup 1/-THC) or its metabolites is responsible for the behavioural and cardiovascular effects of cannabis. It has been shown that, even in the absence of metabolism, ..delta../sup 1/-THC was capable of altering the EEG of isolated perfused rat brain, and must therefore contribute to the psychoactivity of cannabis. TLC studies showed no evidence for brain metabolism of (/sup 14/C)-..delta../sup 1/-THC, and in particular the 7-hydroxylated metabolite (7-OH-..delta../sup 1/-THC) could not be detected. A disproportionate amount of CNS activity in the rat cannot therefore be attributed to 7-OH-..delta../sup 1/-THC on the basis that it is formed at or near its locus of action.}
doi = {10.1016/0006-2952(77)90295-7}
journal = {Biochem. Pharmacol.; (United Kingdom)}
volume = {26:23}
journal type = {AC}
place = {United Kingdom}
year = {1977}
month = {Dec}
}