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Double blind test of L-cysteine for protection against radiation-induced side effects in man

Journal Article:

Abstract

L-Cysteine (80 mg/capsule of active ingredient) or placebo (lactose) was administered to a total of 127 patients with breast cancer (postoperative irradiation) or uterine cervical cancer (post-operative and intracavitary irradiation). L-Cysteine was effective in 49.3% of all patients and in 52.0% of patients with breast cancer, the difference from the placebo group being statistically significant. Decrease in the white blood cell count was less in the group given L-cysteine than that given placebo, and this difference was significant especially in the 3rd week for all cases. Significant difference was also noted in the 2nd week for postoperative irradiation and in the 2nd and 3rd weeks for postoperative and intracavitary irradiation for uterine cervical cancer. Decrease of white blood cell count to less than 3,000 was significantly small in the group given L-cysteine than in the placebo group. The values of hematocrit and platelets remained within normal limits, but the values in the group treated with L-cysteine was considerably different (0.05  More>>
Authors:
Ohshima, T; Tsukiyama, I; Mio, A; [1]  Ito, O; Sugawara, M
  1. Tokyo Teishin Hospital (Japan)
Publication Date:
May 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-367531; EDB-78-081732
Resource Relation:
Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi; (Japan); Journal Volume: 37:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOMAS; RADIOTHERAPY; CYSTEINE; RADIOSENSITIVITY EFFECTS; ERYTHROCYTES; BIOLOGICAL RADIATION EFFECTS; KIDNEYS; LEUKOCYTES; LIVER; MAMMARY GLANDS; SIDE EFFECTS; UROGENITAL SYSTEM DISEASES; GAMMA RADIATION; PATIENTS; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; AMINO ACIDS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARBOXYLIC ACIDS; DIGESTIVE SYSTEM; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; GLANDS; IONIZING RADIATIONS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; RESPONSE MODIFYING FACTORS; THERAPY; THIOLS; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7286961
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NHGZA
Submitting Site:
INIS
Size:
Pages: 444-462
Announcement Date:

Journal Article:

Citation Formats

Ohshima, T, Tsukiyama, I, Mio, A, Ito, O, and Sugawara, M. Double blind test of L-cysteine for protection against radiation-induced side effects in man. Japan: N. p., 1977. Web.
Ohshima, T, Tsukiyama, I, Mio, A, Ito, O, & Sugawara, M. Double blind test of L-cysteine for protection against radiation-induced side effects in man. Japan.
Ohshima, T, Tsukiyama, I, Mio, A, Ito, O, and Sugawara, M. 1977. "Double blind test of L-cysteine for protection against radiation-induced side effects in man." Japan.
@misc{etde_7286961,
title = {Double blind test of L-cysteine for protection against radiation-induced side effects in man}
author = {Ohshima, T, Tsukiyama, I, Mio, A, Ito, O, and Sugawara, M}
abstractNote = {L-Cysteine (80 mg/capsule of active ingredient) or placebo (lactose) was administered to a total of 127 patients with breast cancer (postoperative irradiation) or uterine cervical cancer (post-operative and intracavitary irradiation). L-Cysteine was effective in 49.3% of all patients and in 52.0% of patients with breast cancer, the difference from the placebo group being statistically significant. Decrease in the white blood cell count was less in the group given L-cysteine than that given placebo, and this difference was significant especially in the 3rd week for all cases. Significant difference was also noted in the 2nd week for postoperative irradiation and in the 2nd and 3rd weeks for postoperative and intracavitary irradiation for uterine cervical cancer. Decrease of white blood cell count to less than 3,000 was significantly small in the group given L-cysteine than in the placebo group. The values of hematocrit and platelets remained within normal limits, but the values in the group treated with L-cysteine was considerably different (0.05 journal = {Nippon Igaku Hoshasen Gakkai Zasshi; (Japan)}
volume = {37:5}
journal type = {AC}
place = {Japan}
year = {1977}
month = {May}
}