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Effect of taurine on the insuline secretion isolated by the pancreatic tissue of intact and irradiated rats

Journal Article:

Abstract

The whole-body irradiation of rats (700 rads) inhibits the secretory activity of insular pancreatic tissue. Administration of taurine (200 mg/kg), on the fifth day after irradiation, five times every second day normalizes the secretory function of pancreatic islands. In the experiments in vitro, taurine (1.5 and 3.0 mg/ml) stimulated hormone secretion. The stimulating action of the amino acid manifests itself when ..beta..-receptors are blocked by obsidane (0.5 ..mu..g/ml). It is suggested that insuline secretion by ..beta..-cells of pancreas is restored and enhanced by taurine not merely through the adenylatecyclase system; other ways are also possible.
Authors:
Dokshina, G A; Silaeva, T Yu [1] 
  1. Tomskij Gosudarstvennyj Univ. (USSR). Nauchno-Issledovatel'skij Inst. Biologii i Biofiziki
Publication Date:
May 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-09-370341; EDB-78-081806
Resource Relation:
Journal Name: Radiobiologiya; (USSR); Journal Volume: 16:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; INSULIN; SECRETION; PANCREAS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; TAURINE; RADIOSENSITIVITY EFFECTS; INHIBITION; RADIOPROTECTIVE SUBSTANCES; RATS; WHOLE-BODY IRRADIATION; AMINES; ANIMALS; BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; DRUGS; ENDOCRINE GLANDS; EXTERNAL IRRADIATION; GLANDS; HORMONES; IRRADIATION; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PEPTIDE HORMONES; RADIATION EFFECTS; RECOVERY; RESPONSE MODIFYING FACTORS; RODENTS; SULFONIC ACIDS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7286929
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: RADOA
Submitting Site:
INIS
Size:
Pages: 446-449
Announcement Date:

Journal Article:

Citation Formats

Dokshina, G A, and Silaeva, T Yu. Effect of taurine on the insuline secretion isolated by the pancreatic tissue of intact and irradiated rats. USSR: N. p., 1976. Web.
Dokshina, G A, & Silaeva, T Yu. Effect of taurine on the insuline secretion isolated by the pancreatic tissue of intact and irradiated rats. USSR.
Dokshina, G A, and Silaeva, T Yu. 1976. "Effect of taurine on the insuline secretion isolated by the pancreatic tissue of intact and irradiated rats." USSR.
@misc{etde_7286929,
title = {Effect of taurine on the insuline secretion isolated by the pancreatic tissue of intact and irradiated rats}
author = {Dokshina, G A, and Silaeva, T Yu}
abstractNote = {The whole-body irradiation of rats (700 rads) inhibits the secretory activity of insular pancreatic tissue. Administration of taurine (200 mg/kg), on the fifth day after irradiation, five times every second day normalizes the secretory function of pancreatic islands. In the experiments in vitro, taurine (1.5 and 3.0 mg/ml) stimulated hormone secretion. The stimulating action of the amino acid manifests itself when ..beta..-receptors are blocked by obsidane (0.5 ..mu..g/ml). It is suggested that insuline secretion by ..beta..-cells of pancreas is restored and enhanced by taurine not merely through the adenylatecyclase system; other ways are also possible.}
journal = {Radiobiologiya; (USSR)}
volume = {16:3}
journal type = {AC}
place = {USSR}
year = {1976}
month = {May}
}