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Polycythemia vera treated with /sup 32/P and myleran: Development of chronic granulocytic leukemia with chromosomal abnormalities in one patient

Abstract

Chronic granulocytic leukemia developed in a 59-year-old woman who had previously received a total of 21 mCl /sup 32/P for polycythemia vera. She was treated with Myleran (busulphan) for her chronic granulocytic leukemia. Cytogenetic studies revealed deletion of chromosomes No. 8 and 12, and translocation between 1 and 8. The patient also developed a severe autoimmune hemolytic anemia, for which she received prednisone treatment. She died with a perforated stomach ulcer. (INIS)
Authors:
Stavem, P; Sandnes, K; [1]  Hagen, C.B. van der; [2]  Vogt, E [3] 
  1. Rikshospitalet, Oslo (Norway)
  2. Oslo Univ. (Norway)
  3. Statens Institutt for Folkehelse, Oslo, Norway
Publication Date:
Jan 01, 1975
Product Type:
Journal Article
Reference Number:
EDB-76-043862
Resource Relation:
Journal Name: Clin. Genet.; (Denmark); Journal Volume: 7
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANEMIAS; RADIOINDUCTION; CHROMOSOMAL ABERRATIONS; LEUKEMIA; RADIOTHERAPY; SIDE EFFECTS; MYLERAN; PHOSPHORUS 32; POLYCYTHEMIA; ALKYLATING AGENTS; ANTIMITOTIC DRUGS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; HEMIC DISEASES; ISOTOPES; LIGHT NUCLEI; MEDICINE; MUTATIONS; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; PHOSPHORUS ISOTOPES; RADIOISOTOPES; RADIOLOGY; SYMPTOMS; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
7286050
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CLGNA
Submitting Site:
INIS
Size:
Pages: 227-231
Announcement Date:
Jun 01, 1976

Citation Formats

Stavem, P, Sandnes, K, Hagen, C.B. van der, and Vogt, E. Polycythemia vera treated with /sup 32/P and myleran: Development of chronic granulocytic leukemia with chromosomal abnormalities in one patient. Denmark: N. p., 1975. Web.
Stavem, P, Sandnes, K, Hagen, C.B. van der, & Vogt, E. Polycythemia vera treated with /sup 32/P and myleran: Development of chronic granulocytic leukemia with chromosomal abnormalities in one patient. Denmark.
Stavem, P, Sandnes, K, Hagen, C.B. van der, and Vogt, E. 1975. "Polycythemia vera treated with /sup 32/P and myleran: Development of chronic granulocytic leukemia with chromosomal abnormalities in one patient." Denmark.
@misc{etde_7286050,
title = {Polycythemia vera treated with /sup 32/P and myleran: Development of chronic granulocytic leukemia with chromosomal abnormalities in one patient}
author = {Stavem, P, Sandnes, K, Hagen, C.B. van der, and Vogt, E}
abstractNote = {Chronic granulocytic leukemia developed in a 59-year-old woman who had previously received a total of 21 mCl /sup 32/P for polycythemia vera. She was treated with Myleran (busulphan) for her chronic granulocytic leukemia. Cytogenetic studies revealed deletion of chromosomes No. 8 and 12, and translocation between 1 and 8. The patient also developed a severe autoimmune hemolytic anemia, for which she received prednisone treatment. She died with a perforated stomach ulcer. (INIS)}
journal = []
volume = {7}
journal type = {AC}
place = {Denmark}
year = {1975}
month = {Jan}
}