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Chelation in metal intoxication. V. Lowering of manganese content in poisoned rat organs

Abstract

Metal chelation has been considered useful in the management of manganese poisoning to a considerable extent. Our own studies in this direction have shown that some polyaminocarboxylic acids and a few amino acids are effective in not only removing manganese from the vital organs of experimentally poisoned animals but also in restoring certain metal induced biochemical and histological changes in such organs. Further, the success of p-aminosalicylic acid (PAS), a chemotherapeutic agent for tuberculosis, in manganese mobilization has led us to examine some other structurally related compounds together with a few other possible metal binding agents for their ability to remove excess metal from the organs, their sub-cellular fractions and blood cells of manganese administered rats and to investigate if there exists any relationship between the structure of such compounds and their metal mobilizing capacity. The present communication deals with the results of these investigations.
Publication Date:
Jan 01, 1976
Product Type:
Journal Article
Reference Number:
ERA-03-007596; EDB-78-006115
Resource Relation:
Journal Name: Chemosphere; (United Kingdom); Journal Volume: 5:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHELATES; MANGANESE; BIOLOGICAL EFFECTS; BIOCHEMISTRY; BLOOD; CHELATING AGENTS; METABOLISM; METALS; ORGANS; PAS; RATS; RESPONSE MODIFYING FACTORS; TISSUE DISTRIBUTION; TOXICITY; AMINO ACIDS; ANIMALS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CARBOXYLIC ACIDS; CHEMISTRY; COMPLEXES; DISTRIBUTION; DRUGS; ELEMENTS; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; RODENTS; TRANSITION ELEMENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
7285041
Research Organizations:
Industrial Toxicology Research Centre, Lucknow, India
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CMSHA
Submitting Site:
TIC
Size:
Pages: 319-325
Announcement Date:

Citation Formats

Tandon, S K, and Mathur, A K. Chelation in metal intoxication. V. Lowering of manganese content in poisoned rat organs. United Kingdom: N. p., 1976. Web. doi:10.1016/0045-6535(76)90006-0.
Tandon, S K, & Mathur, A K. Chelation in metal intoxication. V. Lowering of manganese content in poisoned rat organs. United Kingdom. doi:10.1016/0045-6535(76)90006-0.
Tandon, S K, and Mathur, A K. 1976. "Chelation in metal intoxication. V. Lowering of manganese content in poisoned rat organs." United Kingdom. doi:10.1016/0045-6535(76)90006-0. https://www.osti.gov/servlets/purl/10.1016/0045-6535(76)90006-0.
@misc{etde_7285041,
title = {Chelation in metal intoxication. V. Lowering of manganese content in poisoned rat organs}
author = {Tandon, S K, and Mathur, A K}
abstractNote = {Metal chelation has been considered useful in the management of manganese poisoning to a considerable extent. Our own studies in this direction have shown that some polyaminocarboxylic acids and a few amino acids are effective in not only removing manganese from the vital organs of experimentally poisoned animals but also in restoring certain metal induced biochemical and histological changes in such organs. Further, the success of p-aminosalicylic acid (PAS), a chemotherapeutic agent for tuberculosis, in manganese mobilization has led us to examine some other structurally related compounds together with a few other possible metal binding agents for their ability to remove excess metal from the organs, their sub-cellular fractions and blood cells of manganese administered rats and to investigate if there exists any relationship between the structure of such compounds and their metal mobilizing capacity. The present communication deals with the results of these investigations.}
doi = {10.1016/0045-6535(76)90006-0}
journal = {Chemosphere; (United Kingdom)}
volume = {5:5}
journal type = {AC}
place = {United Kingdom}
year = {1976}
month = {Jan}
}