Abstract
Effects of whole-body x irradiation with sublethal dose (400 rad) on three intestinal lysosomal enzymes, namely, arylsulphatase, cathepsin and acid phosphatases, have been studied. They are almost equally distributed throughout the entire small intestine region. X irradiation adversely affects the integrity of lysosomal membranes. ''Free'' and ''total'' lysosomal enzyme activities exhibit maxima on 6th day. These activities return to normal level on 14th day when there is rapid generation of villi, indicating that lysosomal activities correlate with the progression of injury and of repair mechanism after sublethal dose of x irradiation. The increase in total lysosomal activity may be due to its decreased breakdown, since the rate of protein synthesis in intestinal mucosa is reduced. This is evidenced by reduced incorporation of orally fed /sup 14/C leucine into acid insoluble proteins. (auth)
D'souza, D W;
Vakil, U K;
Srinivasan, A
[1]
- Bhabha Atomic Research Centre, Bombay (India). Biochemistry and Food Technology Div.
Citation Formats
D'souza, D W, Vakil, U K, and Srinivasan, A.
Effect of whole-body X-irradiation on lysosomal enzymes.
India: N. p.,
1974.
Web.
D'souza, D W, Vakil, U K, & Srinivasan, A.
Effect of whole-body X-irradiation on lysosomal enzymes.
India.
D'souza, D W, Vakil, U K, and Srinivasan, A.
1974.
"Effect of whole-body X-irradiation on lysosomal enzymes."
India.
@misc{etde_7282480,
title = {Effect of whole-body X-irradiation on lysosomal enzymes}
author = {D'souza, D W, Vakil, U K, and Srinivasan, A}
abstractNote = {Effects of whole-body x irradiation with sublethal dose (400 rad) on three intestinal lysosomal enzymes, namely, arylsulphatase, cathepsin and acid phosphatases, have been studied. They are almost equally distributed throughout the entire small intestine region. X irradiation adversely affects the integrity of lysosomal membranes. ''Free'' and ''total'' lysosomal enzyme activities exhibit maxima on 6th day. These activities return to normal level on 14th day when there is rapid generation of villi, indicating that lysosomal activities correlate with the progression of injury and of repair mechanism after sublethal dose of x irradiation. The increase in total lysosomal activity may be due to its decreased breakdown, since the rate of protein synthesis in intestinal mucosa is reduced. This is evidenced by reduced incorporation of orally fed /sup 14/C leucine into acid insoluble proteins. (auth)}
journal = []
volume = {11:2}
journal type = {AC}
place = {India}
year = {1974}
month = {Jun}
}
title = {Effect of whole-body X-irradiation on lysosomal enzymes}
author = {D'souza, D W, Vakil, U K, and Srinivasan, A}
abstractNote = {Effects of whole-body x irradiation with sublethal dose (400 rad) on three intestinal lysosomal enzymes, namely, arylsulphatase, cathepsin and acid phosphatases, have been studied. They are almost equally distributed throughout the entire small intestine region. X irradiation adversely affects the integrity of lysosomal membranes. ''Free'' and ''total'' lysosomal enzyme activities exhibit maxima on 6th day. These activities return to normal level on 14th day when there is rapid generation of villi, indicating that lysosomal activities correlate with the progression of injury and of repair mechanism after sublethal dose of x irradiation. The increase in total lysosomal activity may be due to its decreased breakdown, since the rate of protein synthesis in intestinal mucosa is reduced. This is evidenced by reduced incorporation of orally fed /sup 14/C leucine into acid insoluble proteins. (auth)}
journal = []
volume = {11:2}
journal type = {AC}
place = {India}
year = {1974}
month = {Jun}
}