You need JavaScript to view this

Effect of whole-body X-irradiation on lysosomal enzymes

Journal Article:

Abstract

Effects of whole-body x irradiation with sublethal dose (400 rad) on three intestinal lysosomal enzymes, namely, arylsulphatase, cathepsin and acid phosphatases, have been studied. They are almost equally distributed throughout the entire small intestine region. X irradiation adversely affects the integrity of lysosomal membranes. ''Free'' and ''total'' lysosomal enzyme activities exhibit maxima on 6th day. These activities return to normal level on 14th day when there is rapid generation of villi, indicating that lysosomal activities correlate with the progression of injury and of repair mechanism after sublethal dose of x irradiation. The increase in total lysosomal activity may be due to its decreased breakdown, since the rate of protein synthesis in intestinal mucosa is reduced. This is evidenced by reduced incorporation of orally fed /sup 14/C leucine into acid insoluble proteins. (auth)
Authors:
D'souza, D W; Vakil, U K; Srinivasan, A [1] 
  1. Bhabha Atomic Research Centre, Bombay (India). Biochemistry and Food Technology Div.
Publication Date:
Jun 01, 1974
Product Type:
Journal Article
Reference Number:
EDB-76-050139
Resource Relation:
Journal Name: Indian J. Biochem. Biophys.; (India); Journal Volume: 11:2; Other Information: 27 refs., 6 tables
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ACID PHOSPHATASE; BIOLOGICAL RADIATION EFFECTS; CATHEPSINS; ENZYMES; BIOLOGICAL REPAIR; CARBON 14 COMPOUNDS; IN VIVO; INTESTINAL ABSORPTION; INTESTINES; LEUCINE; LYSOSOMES; PROTEINS; RADIATION INJURIES; RATS; SUBLETHAL IRRADIATION; TRACER TECHNIQUES; WHOLE-BODY IRRADIATION; X RADIATION; AMINO ACIDS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BODY; CARBOXYLIC ACIDS; CELL CONSTITUENTS; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; ESTERASES; EXTERNAL IRRADIATION; GASTROINTESTINAL TRACT; HYDROLASES; INJURIES; IONIZING RADIATIONS; IRRADIATION; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANOIDS; ORGANS; PEPTIDE HYDROLASES; PHOSPHATASES; RADIATION EFFECTS; RADIATIONS; RECOVERY; REPAIR; RODENTS; UPTAKE; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7282480
Country of Origin:
India
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IJBBB
Submitting Site:
INIS
Size:
Pages: 97-101
Announcement Date:
Jul 01, 1976

Journal Article:

Citation Formats

D'souza, D W, Vakil, U K, and Srinivasan, A. Effect of whole-body X-irradiation on lysosomal enzymes. India: N. p., 1974. Web.
D'souza, D W, Vakil, U K, & Srinivasan, A. Effect of whole-body X-irradiation on lysosomal enzymes. India.
D'souza, D W, Vakil, U K, and Srinivasan, A. 1974. "Effect of whole-body X-irradiation on lysosomal enzymes." India.
@misc{etde_7282480,
title = {Effect of whole-body X-irradiation on lysosomal enzymes}
author = {D'souza, D W, Vakil, U K, and Srinivasan, A}
abstractNote = {Effects of whole-body x irradiation with sublethal dose (400 rad) on three intestinal lysosomal enzymes, namely, arylsulphatase, cathepsin and acid phosphatases, have been studied. They are almost equally distributed throughout the entire small intestine region. X irradiation adversely affects the integrity of lysosomal membranes. ''Free'' and ''total'' lysosomal enzyme activities exhibit maxima on 6th day. These activities return to normal level on 14th day when there is rapid generation of villi, indicating that lysosomal activities correlate with the progression of injury and of repair mechanism after sublethal dose of x irradiation. The increase in total lysosomal activity may be due to its decreased breakdown, since the rate of protein synthesis in intestinal mucosa is reduced. This is evidenced by reduced incorporation of orally fed /sup 14/C leucine into acid insoluble proteins. (auth)}
journal = {Indian J. Biochem. Biophys.; (India)}
volume = {11:2}
journal type = {AC}
place = {India}
year = {1974}
month = {Jun}
}