Abstract
Fifteen-day pregnant Wistar/Furth rats were irradiated with 100 rads of x ray of fast neutron (14.1 MeV). Fast neutron was found to be more effective than x rays in reducing the number of live-births and in retarding the postnatal growth of the offspring. Among the various organs examined, the brain, uterus, spleen and gonads were highly radiosensitive in terms of organ weight. Microscopic examination revealed a marked dysplasia of the ovary in the fast neutron-irradiated rats. Pre-conception irradiation did not cause any deleterious effects on the offspring. No substantial difference was noted in the peripheral blood pictures or on the tumor incidence in rats born from the irradiated female rats. On the other hand, it was noteworthy that N-butylnitrosourea given transplacentally induced 3 cases of brain tumor. The incidence of leukemia and mammary tumor was significantly higher in the irradiated or carcinogen-treated pregnant rats.
Naito, Y;
Takizawa, S;
Watanabe, H;
Hirose, F
[1]
- Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology
Citation Formats
Naito, Y, Takizawa, S, Watanabe, H, and Hirose, F.
Late effects of in utero exposure to carcinogens in rats, with special reference to postnatal growth and tumorigenesis.
Japan: N. p.,
1976.
Web.
Naito, Y, Takizawa, S, Watanabe, H, & Hirose, F.
Late effects of in utero exposure to carcinogens in rats, with special reference to postnatal growth and tumorigenesis.
Japan.
Naito, Y, Takizawa, S, Watanabe, H, and Hirose, F.
1976.
"Late effects of in utero exposure to carcinogens in rats, with special reference to postnatal growth and tumorigenesis."
Japan.
@misc{etde_7282158,
title = {Late effects of in utero exposure to carcinogens in rats, with special reference to postnatal growth and tumorigenesis}
author = {Naito, Y, Takizawa, S, Watanabe, H, and Hirose, F}
abstractNote = {Fifteen-day pregnant Wistar/Furth rats were irradiated with 100 rads of x ray of fast neutron (14.1 MeV). Fast neutron was found to be more effective than x rays in reducing the number of live-births and in retarding the postnatal growth of the offspring. Among the various organs examined, the brain, uterus, spleen and gonads were highly radiosensitive in terms of organ weight. Microscopic examination revealed a marked dysplasia of the ovary in the fast neutron-irradiated rats. Pre-conception irradiation did not cause any deleterious effects on the offspring. No substantial difference was noted in the peripheral blood pictures or on the tumor incidence in rats born from the irradiated female rats. On the other hand, it was noteworthy that N-butylnitrosourea given transplacentally induced 3 cases of brain tumor. The incidence of leukemia and mammary tumor was significantly higher in the irradiated or carcinogen-treated pregnant rats.}
journal = []
volume = {1976}
journal type = {AC}
place = {Japan}
year = {1976}
month = {Nov}
}
title = {Late effects of in utero exposure to carcinogens in rats, with special reference to postnatal growth and tumorigenesis}
author = {Naito, Y, Takizawa, S, Watanabe, H, and Hirose, F}
abstractNote = {Fifteen-day pregnant Wistar/Furth rats were irradiated with 100 rads of x ray of fast neutron (14.1 MeV). Fast neutron was found to be more effective than x rays in reducing the number of live-births and in retarding the postnatal growth of the offspring. Among the various organs examined, the brain, uterus, spleen and gonads were highly radiosensitive in terms of organ weight. Microscopic examination revealed a marked dysplasia of the ovary in the fast neutron-irradiated rats. Pre-conception irradiation did not cause any deleterious effects on the offspring. No substantial difference was noted in the peripheral blood pictures or on the tumor incidence in rats born from the irradiated female rats. On the other hand, it was noteworthy that N-butylnitrosourea given transplacentally induced 3 cases of brain tumor. The incidence of leukemia and mammary tumor was significantly higher in the irradiated or carcinogen-treated pregnant rats.}
journal = []
volume = {1976}
journal type = {AC}
place = {Japan}
year = {1976}
month = {Nov}
}