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Ultrastructural changes of central nervous system irradiated with ionizing radiation

Journal Article:

Abstract

Morphological changes of the central nervous tissues (cerebral and cerebellar cortices) of mice which were irradiated by a massive dose (5,000-80,000 rad) of Linac x-ray were observed with the lapse of time by electron microscopy, and changes in their ultrastructure were investigated. Capillaries and the processes of astrocytes surrounding them, when irradiated with 5,000-40,000 rad, showed swelling of endothelial cells, nuclear atrophy, destruction of basement membrane, and swelling and edematous changes of astrocytic processes. Morphological changes of the nerve cells, granule cells of cerebellum, and astrocytes increased depending on the dose of irradiation, and their injuries appeared in the early stage, showing pyknosis, chromatokinesis, and turbid swelling, transparent swelling of mitochondria, and disappearance of Nissl's bodies as cytoplasmic changes. Destruction of cell membrane was observed in the cerebellar granule cells and astrocytes; particularly in the cerebellar granule cells, pyknosis and prominent degeneration of cytoplasm appeared very early, compared with other cells. Although no definite change nor severance was observed in the marrow sheath of medullated nerve fibers within the dose range of this study, an image of degeneration was observed in the mitochondria in the axon; splitting of marrow sheath and deformity of axon membrane were more prominent in the  More>>
Authors:
Kimura, Y [1] 
  1. Keio Univ., Tokyo (Japan). School of Medicine
Publication Date:
Dec 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-08-289964; EDB-78-011282
Resource Relation:
Journal Name: Saibo.; (Japan); Journal Volume: 7:12
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CENTRAL NERVOUS SYSTEM; BIOLOGICAL RADIATION EFFECTS; ULTRASTRUCTURAL CHANGES; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIPS; ELECTRON MICROSCOPY; MICE; MITOCHONDRIA; NERVE CELLS; NERVE TISSUE; X RADIATION; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; BRAIN; CELL CONSTITUENTS; CEREBRUM; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MAMMALS; MICROSCOPY; MORPHOLOGICAL CHANGES; NERVOUS SYSTEM; ORGANOIDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7282145
Country of Origin:
Japan
Language:
Japanese
Submitting Site:
INIS
Size:
Pages: 533-547
Announcement Date:

Journal Article:

Citation Formats

Kimura, Y. Ultrastructural changes of central nervous system irradiated with ionizing radiation. Japan: N. p., 1975. Web.
Kimura, Y. Ultrastructural changes of central nervous system irradiated with ionizing radiation. Japan.
Kimura, Y. 1975. "Ultrastructural changes of central nervous system irradiated with ionizing radiation." Japan.
@misc{etde_7282145,
title = {Ultrastructural changes of central nervous system irradiated with ionizing radiation}
author = {Kimura, Y}
abstractNote = {Morphological changes of the central nervous tissues (cerebral and cerebellar cortices) of mice which were irradiated by a massive dose (5,000-80,000 rad) of Linac x-ray were observed with the lapse of time by electron microscopy, and changes in their ultrastructure were investigated. Capillaries and the processes of astrocytes surrounding them, when irradiated with 5,000-40,000 rad, showed swelling of endothelial cells, nuclear atrophy, destruction of basement membrane, and swelling and edematous changes of astrocytic processes. Morphological changes of the nerve cells, granule cells of cerebellum, and astrocytes increased depending on the dose of irradiation, and their injuries appeared in the early stage, showing pyknosis, chromatokinesis, and turbid swelling, transparent swelling of mitochondria, and disappearance of Nissl's bodies as cytoplasmic changes. Destruction of cell membrane was observed in the cerebellar granule cells and astrocytes; particularly in the cerebellar granule cells, pyknosis and prominent degeneration of cytoplasm appeared very early, compared with other cells. Although no definite change nor severance was observed in the marrow sheath of medullated nerve fibers within the dose range of this study, an image of degeneration was observed in the mitochondria in the axon; splitting of marrow sheath and deformity of axon membrane were more prominent in the 40,000 rad-irradiated group than in the other groups. Synaptic vesicles tended to increase and scatter when irradiated with 5,000 rad and 10,000 rad. However, by the irradiation with 40,000 rad, the synaptic vesicles tended to enlarge and decrease on the contrary, disappearing with the lapse of time.}
journal = {Saibo.; (Japan)}
volume = {7:12}
journal type = {AC}
place = {Japan}
year = {1975}
month = {Dec}
}