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Carbon monoxide, smoking, and atherosclerosis

Abstract

Studies on the effects of carbon monoxide and smoking on atherosclerosis are reviewed. Nonsmokers do not run the risk of getting significantly elevated carboxyhemoglobin levels from automobile exhaust in the streets, however, they do run the risk of getting elevated carboxyhemoglobin levels from exposure to CO in closed areas such as garages and tunnels. Carboxyhemoglobin levels up to 20 percent may also be found in smokers. The central nervous system seems to be influenced by carboxyhemoglobin concentrations up to 20 percent. The myocardium may also be affected. Experimental work with rabbits exposed to carbon monoxide and cholesterol is described which proved that CO has a damaging effect on arterial walls, leading to increased permeability for various plasma components, to the formation of subendothelial edema, and to increased atheromatosis. The results indicate that the much higher risk of smokers of developing arterial disease in comparison to nonsmokers is mainly due to the inhaled CO in the tobacco smoke and not to nicotine. (Air Pollut. Abstr.)
Authors:
Publication Date:
Oct 01, 1973
Product Type:
Journal Article
Reference Number:
EDB-76-055377
Resource Relation:
Journal Name: Postgrad. Med. J.; (United Kingdom); Journal Volume: 49:576
Subject:
54 ENVIRONMENTAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARBON MONOXIDE; BIOLOGICAL EFFECTS; TOBACCO SMOKES; AIR POLLUTION; ARTERIES; ARTERIOSCLEROSIS; BLOOD; BLOOD PLASMA; CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM; EXHAUST GASES; AEROSOLS; BIOLOGICAL MATERIALS; BLOOD VESSELS; BODY FLUIDS; CARBON COMPOUNDS; CARBON OXIDES; CARDIOVASCULAR SYSTEM; CHALCOGENIDES; COLLOIDS; DISEASES; DISPERSIONS; GASEOUS WASTES; NERVOUS SYSTEM; OXIDES; OXYGEN COMPOUNDS; POLLUTION; RESIDUES; SMOKES; SOLS; WASTES; 510200* - Environment, Terrestrial- Chemicals Monitoring & Transport- (-1989); 560306 - Chemicals Metabolism & Toxicology- Man- (-1987)
OSTI ID:
7279542
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PGMJA
Submitting Site:
APA
Size:
Pages: 697-706
Announcement Date:
Aug 01, 1976

Citation Formats

Astrup, P. Carbon monoxide, smoking, and atherosclerosis. United Kingdom: N. p., 1973. Web.
Astrup, P. Carbon monoxide, smoking, and atherosclerosis. United Kingdom.
Astrup, P. 1973. "Carbon monoxide, smoking, and atherosclerosis." United Kingdom.
@misc{etde_7279542,
title = {Carbon monoxide, smoking, and atherosclerosis}
author = {Astrup, P}
abstractNote = {Studies on the effects of carbon monoxide and smoking on atherosclerosis are reviewed. Nonsmokers do not run the risk of getting significantly elevated carboxyhemoglobin levels from automobile exhaust in the streets, however, they do run the risk of getting elevated carboxyhemoglobin levels from exposure to CO in closed areas such as garages and tunnels. Carboxyhemoglobin levels up to 20 percent may also be found in smokers. The central nervous system seems to be influenced by carboxyhemoglobin concentrations up to 20 percent. The myocardium may also be affected. Experimental work with rabbits exposed to carbon monoxide and cholesterol is described which proved that CO has a damaging effect on arterial walls, leading to increased permeability for various plasma components, to the formation of subendothelial edema, and to increased atheromatosis. The results indicate that the much higher risk of smokers of developing arterial disease in comparison to nonsmokers is mainly due to the inhaled CO in the tobacco smoke and not to nicotine. (Air Pollut. Abstr.)}
journal = []
volume = {49:576}
journal type = {AC}
place = {United Kingdom}
year = {1973}
month = {Oct}
}