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Late radiation effects in animals surviving lethal irradiation

Abstract

Animals (rats, mice, dogs) survived lethal irradiation by means of prophylactic-therapeutic treatments or previously irradiated, were studied for late radiation effects: life span, cachexia and fat growing of hypophysical type, tissue or organ hypoplasia manifested by disturbed hemopoiesis, suppressed function of adrenal gland, etc., suppressed immune reactivity of the irradiated organism, atypical biochemical changes in DNA and protein metabolism, epilation, chronic dermatitis, ulcerations, reduced reproductivity or full sterility, damage of kidneys leading to nephrosclerosis, dishormonal states, cataracts, diffuse sclerotic processes, various kinds of malignant and non-malignant tumors. In these cases hemopoiesis compensated for a definite time peripheral blood composition, but during the late period it showed features of incompleteness: shorter life survival of erythrocytes and thrombocytes manifested by a decreased binding of labelled methionine in these blood elements, anemia and relative thrombocytopenia sometimes with an increased number of polychromatic erythrocytes in peripheral blood and a decreased number of reticulocytes at the same time; lymphopenia and relative leucopenia with an increased number of hypersegmented neutrophils. Decreased reproductivity and atypical biochemical changes available in the first generation of the irradiated animals showed the probable role of mutagenic factors in the emergency of some late radiation effects. A significant part of late radiation  More>>
Authors:
Publication Date:
Jan 01, 1974
Product Type:
Book
Reference Number:
AIX-07-245959; EDB-76-067491
Resource Relation:
Other Information: Thesis
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AET; RADIOSENSITIVITY EFFECTS; DOGS; DELAYED RADIATION EFFECTS; MEA; MICE; RATS; SEROTONIN; GENETIC RADIATION EFFECTS; LETHAL IRRADIATION; MIXTURES; MORPHOLOGICAL CHANGES; PATHOGENESIS; POST-IRRADIATION THERAPY; RADIATION PROTECTION; RESPONSE MODIFYING FACTORS; SURVIVAL TIME; AMINES; ANIMALS; AZOLES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CARBONIC ACID DERIVATIVES; DISPERSIONS; DRUGS; GENETIC EFFECTS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; IRRADIATION; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PYRROLES; RADIATION EFFECTS; RADIOPROTECTIVE SUBSTANCES; RODENTS; SYMPATHOMIMETICS; THERAPY; THIOLS; THIOUREAS; TRYPTAMINES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7272834
Country of Origin:
Bulgaria
Language:
Bulgarian
Availability:
INIS
Submitting Site:
INIS
Size:
Pages: 44
Announcement Date:

Citation Formats

Dimitrov, L A. Late radiation effects in animals surviving lethal irradiation. Bulgaria: N. p., 1974. Web.
Dimitrov, L A. Late radiation effects in animals surviving lethal irradiation. Bulgaria.
Dimitrov, L A. 1974. "Late radiation effects in animals surviving lethal irradiation." Bulgaria.
@misc{etde_7272834,
title = {Late radiation effects in animals surviving lethal irradiation}
author = {Dimitrov, L A}
abstractNote = {Animals (rats, mice, dogs) survived lethal irradiation by means of prophylactic-therapeutic treatments or previously irradiated, were studied for late radiation effects: life span, cachexia and fat growing of hypophysical type, tissue or organ hypoplasia manifested by disturbed hemopoiesis, suppressed function of adrenal gland, etc., suppressed immune reactivity of the irradiated organism, atypical biochemical changes in DNA and protein metabolism, epilation, chronic dermatitis, ulcerations, reduced reproductivity or full sterility, damage of kidneys leading to nephrosclerosis, dishormonal states, cataracts, diffuse sclerotic processes, various kinds of malignant and non-malignant tumors. In these cases hemopoiesis compensated for a definite time peripheral blood composition, but during the late period it showed features of incompleteness: shorter life survival of erythrocytes and thrombocytes manifested by a decreased binding of labelled methionine in these blood elements, anemia and relative thrombocytopenia sometimes with an increased number of polychromatic erythrocytes in peripheral blood and a decreased number of reticulocytes at the same time; lymphopenia and relative leucopenia with an increased number of hypersegmented neutrophils. Decreased reproductivity and atypical biochemical changes available in the first generation of the irradiated animals showed the probable role of mutagenic factors in the emergency of some late radiation effects. A significant part of late radiation sequences were due to neuro-endocrine disintegrations. Some of the described late radiation effects were also observed in biological controls as features of ageing. After application of radioprotectors (AET, cysteamine, serotonin) a more marked protective effect is demonstrated in the early reactions (time survival till 30th day, DNA and protein metabolism, immune reactions) of the lethally irradiated animals.}
place = {Bulgaria}
year = {1974}
month = {Jan}
}