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Long-term changes in cell population kinetics of skin tissue after local beta-irradiation

Journal Article:

Abstract

Using /sup 3/H-thymidine autoradiography, long-term alterations in cell kinetics were studied in guinea pig skin after ..beta..irradiation with 3000 rads. After complete depopulation, epidermal basal cells at the radiation margin became proliferative 10 days postirradiation and spread over the depopulated area. When epithelization (20 days) was complete the cell cycle time of the basal cells reverted to normal, but the differentiation rate was much slower than that in unirradiated skin. This appeared to be a cause of the persistent (acanthotic) hyperplasia. Similar but slower changes were found in dermal tissue. Reparative proliferation of fibroblasts and capillary endothelial cells began at 20 and 30 days, respectively. Active fibroblastic proliferation was found as late as 110 days. This, along with the abortive nature of the reparative angiogenesis, seemed to be a cause of the later fibrosis (150 to 400 days).
Authors:
Yamaguchi, T [1] 
  1. National Inst. of Radiological Sciences, Chiba (Japan)
Publication Date:
Jun 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-07-244389; EDB-76-077002
Resource Relation:
Journal Name: Gan No Rinsho; (Japan); Journal Volume: 21:7
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EPIDERMIS; LOCAL RADIATION EFFECTS; AUTORADIOGRAPHY; BETA PARTICLES; CAPILLARIES; CELL CYCLE; CELL PROLIFERATION; DELAYED RADIATION EFFECTS; DNA; GUINEA PIGS; LOCAL IRRADIATION; RADIATION DOSES; TRITIUM COMPOUNDS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; CHARGED PARTICLES; DOSES; EPITHELIUM; IRRADIATION; LABELLED COMPOUNDS; MAMMALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RODENTS; SKIN; TISSUES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
7268699
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: GANRA
Submitting Site:
INIS
Size:
Pages: 459-463
Announcement Date:
Jul 01, 1976

Journal Article:

Citation Formats

Yamaguchi, T. Long-term changes in cell population kinetics of skin tissue after local beta-irradiation. Japan: N. p., 1975. Web.
Yamaguchi, T. Long-term changes in cell population kinetics of skin tissue after local beta-irradiation. Japan.
Yamaguchi, T. 1975. "Long-term changes in cell population kinetics of skin tissue after local beta-irradiation." Japan.
@misc{etde_7268699,
title = {Long-term changes in cell population kinetics of skin tissue after local beta-irradiation}
author = {Yamaguchi, T}
abstractNote = {Using /sup 3/H-thymidine autoradiography, long-term alterations in cell kinetics were studied in guinea pig skin after ..beta..irradiation with 3000 rads. After complete depopulation, epidermal basal cells at the radiation margin became proliferative 10 days postirradiation and spread over the depopulated area. When epithelization (20 days) was complete the cell cycle time of the basal cells reverted to normal, but the differentiation rate was much slower than that in unirradiated skin. This appeared to be a cause of the persistent (acanthotic) hyperplasia. Similar but slower changes were found in dermal tissue. Reparative proliferation of fibroblasts and capillary endothelial cells began at 20 and 30 days, respectively. Active fibroblastic proliferation was found as late as 110 days. This, along with the abortive nature of the reparative angiogenesis, seemed to be a cause of the later fibrosis (150 to 400 days).}
journal = {Gan No Rinsho; (Japan)}
volume = {21:7}
journal type = {AC}
place = {Japan}
year = {1975}
month = {Jun}
}